Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.

abstract：:The Ediacara biota include macroscopic, morphologically complex soft-bodied organisms that appear globally in the late Ediacaran Period (575-542 Ma). The physiology, feeding strategies, and functional morphology of the modular Ediacara organisms (rangeomorphs and erniettomorphs) remain debated but are critical for und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laflamme M,Xiao S,Kowalewski M

更新日期：2009-08-25 00:00:00

abstract：:The brain vesicular monoamine transporter (VMAT2) pumps monoamine neurotransmitters and Parkinsonism-inducing dopamine neurotoxins such as 1-methyl-4-phenyl-phenypyridinium (MPP+) from neuronal cytoplasm into synaptic vesicles, from which amphetamines cause their release. Amphetamines and MPP+ each also act at nonvesi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Miner LL,Sora I,Ujike H,Revay RS,Kostic V,Jackson-Lewis V,Przedborski S,Uhl GR

更新日期：1997-09-02 00:00:00

abstract：:The histidine periplasmic permease of Salmonella typhimurium has been partially purified and reconstituted into proteoliposomes. In this in vitro preparation, transport activity is completely dependent on the presence of all four permease proteins (HisJ, HisQ, HisM, and HisP) and on internal ATP. The reconstituted sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bishop L,Agbayani R Jr,Ambudkar SV,Maloney PC,Ames GF

更新日期：1989-09-01 00:00:00

abstract：:Sequencing of a 360-nucleotide segment of the mitochondrial control region for 63 individuals from an Amerindian tribe, the Nuu-Chah-Nulth of the Pacific Northwest, revealed the existence of 28 lineages defined by 26 variable positions. This represents a substantial level of mitochondrial diversity for a small local p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ward RH,Frazier BL,Dew-Jager K,Pääbo S

更新日期：1991-10-01 00:00:00

abstract：:Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known to impact neurogenesis. We aimed to identify molecular mediators of these effects, focusing on long-lasting epigenetic changes. In a hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Provençal N,Arloth J,Cattaneo A,Anacker C,Cattane N,Wiechmann T,Röh S,Ködel M,Klengel T,Czamara D,Müller NS,Lahti J,PREDO team.,Räikkönen K,Pariante CM,Binder EB

更新日期：2020-09-22 00:00:00

abstract：:Cell surface receptor membrane localization is strongly dependent on protein-protein interactions often involving regulation by phosphorylation/dephosphorylation of the intracellular domains of membrane proteins. The present study was carried out to identify metabotropic glutamate receptor (mGluR) 3 regulatory binding...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flajolet M,Rakhilin S,Wang H,Starkova N,Nuangchamnong N,Nairn AC,Greengard P

更新日期：2003-12-23 00:00:00

abstract：:Kinesin-73 cDNA was shown to encode a kinesin heavy chain protein that contains an N-terminal motor domain and a long central region that lacks extensive coiled-coils. The amino acid sequence of the motor domain of kinesin-73 protein is most closely related to the motor domains of Caenorhabditis elegans unc-104 and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li HP,Liu ZM,Nirenberg M

更新日期：1997-02-18 00:00:00

abstract：:Auditory speech perception enables listeners to access phonological categories from speech sounds. During speech production and speech motor learning, speakers' experience matched auditory and somatosensory input. Accordingly, access to phonetic units might also be provided by somatosensory information. The present st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patri JF,Ostry DJ,Diard J,Schwartz JL,Trudeau-Fisette P,Savariaux C,Perrier P

更新日期：2020-03-17 00:00:00

abstract：:A major calmodulin-binding protein (CaM-BP) of Mr 240,000 was demonstrated in various rat tissues by using a 125I-labeled CaM gel overlay technique. This protein (designated p240) was detected in the particulate fraction and to a lesser extent in the cytosol of all tissues studied. Binding of CaM to p240 was completel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palfrey HC,Schiebler W,Greengard P

更新日期：1982-06-01 00:00:00

abstract：:We have established a transformation system for Dictyostelium discoideum. The transformation vector contains the protein coding region of the Tn5 neomycin resistance gene fused to the proposed promoter of the Dictyostelium actin 8 gene; the vector also contains a sequence that acts as an autonomously replicating seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirth KP,Edwards CA,Firtel RA

更新日期：1982-12-01 00:00:00

abstract：:In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopaminergic neurotransmi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibb JA,Yan Z,Svenningsson P,Snyder GL,Pieribone VA,Horiuchi A,Nairn AC,Messer A,Greengard P

更新日期：2000-06-06 00:00:00

abstract：:This article reports the development of an optical imaging technique, confocal light absorption and scattering spectroscopic (CLASS) microscopy, capable of noninvasively determining the dimensions and other physical properties of single subcellular organelles. CLASS microscopy combines the principles of light-scatteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Itzkan I,Qiu L,Fang H,Zaman MM,Vitkin E,Ghiran IC,Salahuddin S,Modell M,Andersson C,Kimerer LM,Cipolloni PB,Lim KH,Freedman SD,Bigio I,Sachs BP,Hanlon EB,Perelman LT

更新日期：2007-10-30 00:00:00

abstract：:The timing of human colonization of East Polynesia, a vast area lying between Hawai'i, Rapa Nui, and New Zealand, is much debated and the underlying causes of this great migration have been enigmatic. Our study generates evidence for human dispersal into eastern Polynesia from islands to the west from around AD 900 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sear DA,Allen MS,Hassall JD,Maloney AE,Langdon PG,Morrison AE,Henderson ACG,Mackay H,Croudace IW,Clarke C,Sachs JP,Macdonald G,Chiverrell RC,Leng MJ,Cisneros-Dozal LM,Fonville T,Pearson E

更新日期：2020-04-21 00:00:00

abstract：:The detection, stabilization, and repair of stress-induced damage are essential requirements for cellular life. All cells respond to osmotic stress-induced water loss with increased expression of genes that mediate accumulation of organic osmolytes, solutes that function as chemical chaperones and restore osmotic home...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamitina T,Huang CG,Strange K

更新日期：2006-08-08 00:00:00

abstract：:Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently been recognized as contributing to the efficacy of most bactericidal antibiotics, irrespective of their primary macromolecular targets. Inhibitors of targets involved in both combating oxidative stress as well as being required for in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tiwari S,van Tonder AJ,Vilchèze C,Mendes V,Thomas SE,Malek A,Chen B,Chen M,Kim J,Blundell TL,Parkhill J,Weinrick B,Berney M,Jacobs WR Jr

更新日期：2018-09-25 00:00:00

abstract：:Recent studies have suggested that Paleozoic hyperoxia enabled animal gigantism, and the subsequent hypoxia drove a reduction in animal size. This evolutionary hypothesis depends on the argument that gas exchange in many invertebrates and skin-breathing vertebrates becomes compromised at large sizes because of distanc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaiser A,Klok CJ,Socha JJ,Lee WK,Quinlan MC,Harrison JF

更新日期：2007-08-07 00:00:00

abstract：:Small ubiquitin-like modifier (SUMO) modification is emerging as an important control in transcription regulation. Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine resid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuo HY,Chang CC,Jeng JC,Hu HM,Lin DY,Maul GG,Kwok RP,Shih HM

更新日期：2005-11-22 00:00:00

abstract：:Two prominent timekeeping systems, the cell cycle, which controls cell division, and the circadian system, which controls 24-h rhythms of physiology and behavior, are found in nearly all living organisms. A distinct feature of circadian rhythms is that they are temperature-compensated such that the period of the rhyth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeom M,Pendergast JS,Ohmiya Y,Yamazaki S

更新日期：2010-05-25 00:00:00

abstract：:IFN-gamma is well known as the signature cytokine of CD4+ T helper 1, CD8+, and natural killer cells, but recent studies demonstrate that antigen-presenting cells, in particular dendritic cells (DCs), are another potent source for this proinflammatory cytokine. T-bet, a transcription factor that controls IFN-gamma exp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lugo-Villarino G,Maldonado-Lopez R,Possemato R,Penaranda C,Glimcher LH

更新日期：2003-06-24 00:00:00

abstract：:The method of anticodon loop replacement has been used to make derivatives of yeast tRNAPhe. By constructing tRNAs with a CUA anticodon, complementary to the amber (UAG) terminator, functional amber suppressor tRNAs were produced. The activity of these tRNAs was assayed in a mammalian cell-free protein synthesizing sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruce AG,Atkins JF,Wills N,Uhlenbeck O,Gesteland RF

更新日期：1982-12-01 00:00:00

abstract：:Disruption of Rauscher leukemia virus (RLV) with low levels of Nonidet P-40 yielded "immature" cores. These cores have a diameter of about 920 A, as opposed to the 1300-A diameter of RLV, possess knob-like protuberances, and contain a concentrically coiled internal strand apposed to the core shell. The two major polyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshinaka Y,Luftig RB

更新日期：1977-08-01 00:00:00

abstract：:Mice lacking major histocompatibility complex (MHC) antigens were generated by mating beta 2-microglobulin-deficient, and therefore class I-deficient, animals with MHC class II-deficient animals. When housed under sterile conditions, the resulting MHC-deficient mice appear healthy, survive for many months, and breed s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grusby MJ,Auchincloss H Jr,Lee R,Johnson RS,Spencer JP,Zijlstra M,Jaenisch R,Papaioannou VE,Glimcher LH

更新日期：1993-05-01 00:00:00

abstract：:We have identified a gene, rig (rat insulinoma gene), that is activated in chemically induced rat insulinomas but not in normal pancreatic islets or in regenerating islets. In the present study, we have found that the insulinoma gene was activated in a BK virus-induced hamster insulinoma cell line and in a spontaneous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue C,Shiga K,Takasawa S,Kitagawa M,Yamamoto H,Okamoto H

更新日期：1987-10-01 00:00:00

abstract：:The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells. Mice with germ-line (null) deletion of SHIP develop a myeloproliferative-like syndrome that causes early lethality. Lymphocyte anomalies have been obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarasenko T,Kole HK,Chi AW,Mentink-Kane MM,Wynn TA,Bolland S

更新日期：2007-07-03 00:00:00

abstract：:Weber's law can be explained either by a compressive scaling of sensory response with stimulus magnitude or by a proportional scaling of response variability. These two mechanisms can be distinguished by asking how quantities are added or subtracted. We trained Rhesus monkeys to associate 26 distinct symbols with 0-25...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livingstone MS,Pettine WW,Srihasam K,Moore B,Morocz IA,Lee D

更新日期：2014-05-06 00:00:00

abstract：:Significant attention has focused on the role of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, recent advances have identified triglyceride-rich lipoproteins [e.g., very LDL (VLDL)] as independent risk predictors for this disease. We have previously demonstrated peroxisome proliferator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CH,Kang K,Mehl IR,Nofsinger R,Alaynick WA,Chong LW,Rosenfeld JM,Evans RM

更新日期：2006-02-14 00:00:00

abstract：:Explants of human endometrium were cultured to study the release of matrix metalloproteinases (MMPs). Analysis of conditioned media by zymography revealed latent and active forms of collagenase (MMP-1, EC 3.4.24.7), 72-kDa gelatinase A (MMP-2, EC 3.4.24.24), and 92-kDa gelatinase B (MMP-9, EC 3.4.24.35). These protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marbaix E,Donnez J,Courtoy PJ,Eeckhout Y

更新日期：1992-12-15 00:00:00

abstract：:Nuclear receptor SET domain containing protein 2 (NSD2) catalyzes the methylation of histone H3 lysine 36 (H3K36). It is a determinant in Wolf-Hirschhorn syndrome and is overexpressed in human multiple myeloma. Despite the relevance of NSD2 to cancer, there are no potent, selective inhibitors of this enzyme reported. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulin MB,Schneck JL,Matico RE,McDevitt PJ,Huddleston MJ,Hou W,Johnson NW,Thrall SH,Meek TD,Schramm VL

更新日期：2016-02-02 00:00:00

abstract：:We introduce a coarse-grained model for atomic glass formers. Its elements are physically motivated local microscopic dynamical rules parameterized by observables. Results of the model are established and used to interpret the measured behaviors of supercooled fluids approaching glass transitions. The model predicts t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garrahan JP,Chandler D

更新日期：2003-08-19 00:00:00

abstract：:This paper describes the state of the art in applications of voice-processing technologies. In the first part, technologies concerning the implementation of speech recognition and synthesis algorithms are described. Hardware technologies such as microprocessors and DSPs (digital signal processors) are discussed. Softw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakatsu R,Suzuki Y

更新日期：1995-10-24 00:00:00