Electron transport to nitrogenase in Klebsiella pneumoniae.

abstract：:Androgen receptor (AR) protein expression and function are critical for survival and proliferation of androgen-sensitive (AS) prostate cancer cells. Besides its ability to function as a transcription factor, experimental observations suggest that AR becomes a licensing factor for DNA replication in AS prostate cancer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Litvinov IV,Vander Griend DJ,Antony L,Dalrymple S,De Marzo AM,Drake CG,Isaacs JT

更新日期：2006-10-10 00:00:00

abstract：:Pigmentation patterning has long interested biologists, integrating topics in ecology, development, genetics, and physiology. Wild-type neonatal larvae of the silkworm, Bombyx mori, are completely black. By contrast, the epidermis and head of larvae of the homozygous recessive sex-linked chocolate (sch) mutant are red...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Yamamoto K,Cheng TC,Kadono-Okuda K,Narukawa J,Liu SP,Han Y,Futahashi R,Kidokoro K,Noda H,Kobayashi I,Tamura T,Ohnuma A,Banno Y,Dai FY,Xiang ZH,Goldsmith MR,Mita K,Xia QY

更新日期：2010-07-20 00:00:00

abstract：:Memory formation requires the placement of experienced events in the same order in which they appeared. A large body of evidence from human studies indicates that structures in the medial temporal lobe are critically involved in forming and maintaining such memories, and complementing evidence from lesion and electrop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paz R,Gelbard-Sagiv H,Mukamel R,Harel M,Malach R,Fried I

更新日期：2010-03-30 00:00:00

abstract：:An endonucleolytic activity is associated with purified PM(2) bacteriophages. It converts the double-stranded supercoiled PM(2) DNA mostly into the linear form that sediments as a homogenous peak in alkaline sucrose gradients. The same activity is found in intact or detergent-lysed phages. Optimal activity is observed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laval F

更新日期：1974-12-01 00:00:00

abstract：:Adenosine has been identified in the anterior pituitary gland and is secreted from cultured folliculostellate (FS) cells. To determine whether adenosine controls the secretion of anterior pituitary hormones in vitro, adenosine was incubated with anterior pituitaries. It stimulated prolactin (PRL) release at the lowest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu WH,Kimura M,Walczewska A,Porter JC,McCann SM

更新日期：1998-06-23 00:00:00

abstract：:I describe some recent observations of large-scale structure in the galaxy distribution. The best constraints come from two-dimensional galaxy surveys and studies of angular correlation functions. Results from galaxy redshift surveys are much less precise but are consistent with the angular correlations, provided the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efstathiou G

更新日期：1993-06-01 00:00:00

abstract：:ATP-sensitive potassium (KATP) channels in the pancreatic beta cell membrane mediate insulin release in response to elevation of plasma glucose levels. They are open at rest but close in response to glucose metabolism, producing a depolarization that stimulates Ca2+ influx and exocytosis. Metabolic regulation of KATP ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gribble FM,Tucker SJ,Haug T,Ashcroft FM

更新日期：1998-06-09 00:00:00

abstract：:Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity through direct interactions with the viral capsid, by an unknown mechanism. CypA can either promote or inhibit viral infection, depending on host cell type and HIV-1 capsid (CA) protein sequence. We have examined the role of conformational dyna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu M,Hou G,Zhang H,Suiter CL,Ahn J,Byeon IJ,Perilla JR,Langmead CJ,Hung I,Gor'kov PL,Gan Z,Brey W,Aiken C,Zhang P,Schulten K,Gronenborn AM,Polenova T

更新日期：2015-11-24 00:00:00

abstract：:Obligate intracellular pathogens such as Leishmania specifically target host phagocytes for survival and replication. Phosphoinositide 3-kinase γ (PI3Kγ), a member of the class I PI3Ks that is highly expressed by leukocytes, controls cell migration by initiating actin polymerization and cytoskeletal reorganization, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cummings HE,Barbi J,Reville P,Oghumu S,Zorko N,Sarkar A,Keiser TL,Lu B,Rückle T,Varikuti S,Lezama-Davila C,Wewers MD,Whitacre C,Radzioch D,Rommel C,Seveau S,Satoskar AR

更新日期：2012-01-24 00:00:00

abstract：:DNA polymerases (DNAPs) responsible for genome replication are highly faithful enzymes that nonetheless cannot deal with damaged DNA. In contrast, translesion synthesis (TLS) DNAPs are suitable for replicating modified template bases, although resulting in very low-fidelity products. Here we report the biochemical cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berjón-Otero M,Villar L,de Vega M,Salas M,Redrejo-Rodríguez M

更新日期：2015-07-07 00:00:00

abstract：:Colloidal particles with directional interactions are key in the realization of new colloidal materials with possibly unconventional phase behaviors. Here we exploit DNA self-assembly to produce bulk quantities of "DNA stars" with three or four sticky terminals, mimicking molecules with controlled limited valence. Sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biffi S,Cerbino R,Bomboi F,Paraboschi EM,Asselta R,Sciortino F,Bellini T

更新日期：2013-09-24 00:00:00

abstract：:Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of presynaptic Ca(2+) inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baumgart JP,Zhou ZY,Hara M,Cook DC,Hoppa MB,Ryan TA,Hemmings HC Jr

更新日期：2015-09-22 00:00:00

abstract：:Mutations in the gene encoding the endothelin receptor type B (EDNRB) produce congenital aganglionic megacolon and pigment abnormalities in mice and humans. Here we report a naturally occurring null mutation of the EDNRB gene in spotting lethal (sl) rats, which exhibit aganglionic megacolon associated with white coat ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gariepy CE,Cass DT,Yanagisawa M

更新日期：1996-01-23 00:00:00

abstract：:Very-long-baseline interferometry images of the nuclear region of the radio galaxy Cygnus A reveal a pronounced "core" and a knotty jet and counterjet. The knots are moving away from the core at apparent speeds which are subluminal for h = 1 [h = H0/100 km.s-1.Mpc-1;1 parsec (pc) = 3.09 x 10(16)m] and about c for h = ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartel N,Sorathia B,Bietenholz MF,Carilli CL,Diamond P

更新日期：1995-12-05 00:00:00

abstract：:Chronic morphine administration is associated with the development of tolerance, both clinically and in animal models. Many assume that tolerance is a continually progressive response to chronic opioid dosing. However, clinicians have long appreciated the ability to manage cancer pain in patients for months on stable ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Faskowitz AJ,Rossi GC,Xu M,Lu Z,Pan YX,Pasternak GW

更新日期：2015-01-06 00:00:00

abstract：:Protein-protein interactions are essential for life. Yet, our understanding of the general principles governing binding is not complete. In the present study, we show that the interface between proteins is built in a modular fashion; each module is comprised of a number of closely interacting residues, with few intera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reichmann D,Rahat O,Albeck S,Meged R,Dym O,Schreiber G

更新日期：2005-01-04 00:00:00

abstract：:Endothelium-derived relaxing factor (EDRF) activity has been attributed to the highly labile nitric oxide radical (NO). In view of the fact that the plasma and cellular milieux contain reactive species that can rapidly inactivate NO, it has been postulated that NO is stabilized by a carrier molecule that preserves its...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamler JS,Simon DI,Osborne JA,Mullins ME,Jaraki O,Michel T,Singel DJ,Loscalzo J

更新日期：1992-01-01 00:00:00

abstract：:Studies of the fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene in membranes of normal, transformed, and revertant 3T3 cells allowed estimation of microviscosities (eta) of the lipid bilayers of these cells. Fluorescence polarization values observed with normal cells were significantly lower than those obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuchs P,Parola A,Robbins PW,Blout ER

更新日期：1975-09-01 00:00:00

abstract：:The mechanism of Ca2+-dependent protein-protein interaction and enzyme activation by calmodulin was investigated with the phosphoprotein phosphatase, calcineurin. Dimethylaminonaphthalene (dansyl)-calmodulin, a fluorescent derivative used to monitor complex formation, produced similar maximal activation (10- to 12-fol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kincaid RL,Vaughan M

更新日期：1986-03-01 00:00:00

abstract：:Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao W,Rovin BH,Friedman A

更新日期：2014-09-30 00:00:00

abstract：:High-performance anion-exchange (HPAE) chromatography under alkaline conditions (pH congruent to 13) has been found to efficiently separate neutral oligosaccharides (triose to undecaose) according to molecular size, sugar composition, and linkage of monosaccharide units. The method was able to resolve 1----3, 1----4, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hardy MR,Townsend RR

更新日期：1988-05-01 00:00:00

abstract：:Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2',5'-oligoadenylate (2-5A) synthetases (OASs) and ribonuclease (RNase) L are components of a potent host antiviral pathway. We previously showed that murine coronavirus (MHV) accessory protein n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Jha BK,Ogden KM,Dong B,Zhao L,Elliott R,Patton JT,Silverman RH,Weiss SR

更新日期：2013-08-06 00:00:00

abstract：:Levels of inter-male aggression, both in laboratory encounters and in the field, rise dramatically during the breeding season, closely paralleling the seasonal rise in testosterone. However, post-pubertally castrated males also show the dramatic seasonal rise in aggression in laboratory encounters with castrated oppon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caldwell GS,Glickman SE,Smith ER

更新日期：1984-08-01 00:00:00

abstract：:We previously developed a biological containment system using recombinant Salmonella Typhimurium strains that are attenuated yet capable of synthesizing protective antigens. The regulated delayed attenuation and programmed self-destructing features designed into these S. Typhimurium strains enable them to efficiently ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong W,Brovold M,Koeneman BA,Clark-Curtiss J,Curtiss R 3rd

更新日期：2012-11-20 00:00:00

abstract：:Glutaredoxins (GRXs), also known as thioltransferases, use glutathione as a cofactor for reduction of disulfides in prokaryotes and eukaryotes. We demonstrate that the vaccinia virus O2L open reading frame encodes a functional GRX, as predicted by Johnson et al. [Johnson, G. P., Goebel, S. J., Perkus, M. E., Davis, S....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahn BY,Moss B

更新日期：1992-08-01 00:00:00

abstract：:The translocation of lipids from the inner to the outer membrane of Escherichia coli has been investigated by pulse-chase experiments. After a pulse with [2-3H]glycerol, the specific activity of the newly synthesized [3H]phosphatidylethanolamine was 5 times greater in the inner than in the outer membrane. During the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donohue-Rolfe AM,Schaechter M

更新日期：1980-04-01 00:00:00

abstract：:The improvement of motor behavior, based on experience, is a form of learning that is critically dependent on the cerebellum. A well studied example of cerebellar motor learning is short-term saccadic adaptation (STSA). In STSA, information on saccadic errors is used to improve future saccades. The information optimiz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catz N,Dicke PW,Thier P

更新日期：2008-05-20 00:00:00

abstract：:The fluorescent probes acridine orange and oxonol-V were used as indicators of pH gradients (DeltapH) and membrane potential differences (DeltaPsi), respectively, in membrane vesicles believed to be derived from the tonoplast of Beta vulgaris L. Low concentrations of nitrate (1-5 mM) caused a partial dissipation of bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumwald E,Poole RJ

更新日期：1985-06-01 00:00:00

abstract：:Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for maintenance of bulk DNA methylation and is essential for mouse development. However, somatic disruption of DNMT1 in the human cancer cell line HCT116 was not lethal and caused only minor decreases in methylation. Here, we report the identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egger G,Jeong S,Escobar SG,Cortez CC,Li TW,Saito Y,Yoo CB,Jones PA,Liang G

更新日期：2006-09-19 00:00:00

abstract：:The opportunistic pathogen Candida albicans can undergo phenotypic switching between a benign, unicellular phenotype and an invasive, multicellular form that causes candidiasis. Increasingly, strains of Candida are becoming resistant to antifungal drugs, making the treatment of candidiasis difficult, especially in imm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchida M,McDermott G,Wetzler M,Le Gros MA,Myllys M,Knoechel C,Barron AE,Larabell CA

更新日期：2009-11-17 00:00:00