It's a bug's life.

abstract：:Climate change is expected to alter the distribution and abundance of many species. Predictions of climate-induced population extinctions are supported by geographic range shifts that correspond to climatic warming, but few extinctions have been linked mechanistically to climate change. Here we show that extinctions o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLaughlin JF,Hellmann JJ,Boggs CL,Ehrlich PR

更新日期：2002-04-30 00:00:00

abstract：:The Hippo-YAP/TAZ signaling pathway plays a pivotal role in growth control during development and regeneration and its dysregulation is widely implicated in various cancers. To further understand the cellular and molecular mechanisms underlying Hippo signaling regulation, we have found that activities of core Hippo si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim W,Cho YS,Wang X,Park O,Ma X,Kim H,Gan W,Jho EH,Cha B,Jeung YJ,Zhang L,Gao B,Wei W,Jiang J,Chung KS,Yang Y

更新日期：2019-05-07 00:00:00

abstract：:We reveal that the aragonite CaCO3 platelets in nacre of Haliotis laevigata are covered with a continuous layer of disordered amorphous CaCO3 and that there is no protein interaction with this layer. This finding contradicts classical paradigms of biomineralization, e.g., an epitaxial match between the structural orga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nassif N,Pinna N,Gehrke N,Antonietti M,Jäger C,Cölfen H

更新日期：2005-09-06 00:00:00

abstract：:In the filamentous fungus Neurospora crassa, several events in the process of conidiation are influenced by light. Two genes, con-6 and con-10, which were previously shown to be transcriptionally activated during conidiation and by exposure to light, were found to be unexpressed in mycelium maintained in constant dark...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lauter FR,Yanofsky C

更新日期：1993-09-01 00:00:00

abstract：:Overlapping cDNAs derived from the chicken alpha-fibrinogen mRNA have been sequenced, beginning from within the coding region for the signal peptide of this subunit and terminating within the poly(A) extension. The predicted size of chicken alpha-fibrinogen is 54,187 daltons, which is the smallest of any alpha chain r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissbach L,Grieninger G

更新日期：1990-07-01 00:00:00

abstract：:Inflammatory destruction of insulin-producing beta cells in the pancreatic islets is the hallmark of insulin-dependent diabetes mellitus, a spontaneous autoimmune disease of non-obese diabetic mice resembling human juvenile (type I) diabetes. Histochemical analysis of diabetic pancreata revealed that mononuclear cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss L,Slavin S,Reich S,Cohen P,Shuster S,Stern R,Kaganovsky E,Okon E,Rubinstein AM,Naor D

更新日期：2000-01-04 00:00:00

abstract：:Two continuous-suspension lymphocyte lines were isolated from the spleen and fibrosarcoma of a New Zealand Black female mouse. A C-type virus with a density of 1.16 g x cm(-3), 70S RNA, and RNA-directed DNA polymerase activity was isolated. The virus was infectious for NRK, NZB, (NZB x NZW)F(1), and (NZW x NZW)F(1) em...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerner RA,Jensen F,Kennel SJ,Dixon FJ,Des Roches G,Francke U

更新日期：1972-10-01 00:00:00

abstract：:Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on express...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroes RA,Abravaya K,Seidenfeld J,Morimoto RI

更新日期：1991-06-01 00:00:00

abstract：:A coarse-grained model for protein-folding dynamics is introduced based on a discretized representation of torsional modes. The model, based on the Ramachandran map of the local torsional potential surface and the class (hydrophobic/polar/neutral) of each residue, recognizes patterns of both torsional conformations an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Kostov K,Berry RS

更新日期：1999-11-09 00:00:00

abstract：:Drosophila Numb is a membrane associated protein of 557 amino acids (aa) that localizes asymmetrically into a cortical crescent in mitotic neural precursor cells and segregates into one of the daughter cells, where it is required for correct cell fate specification. We demonstrate here that asymmetric localization but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knoblich JA,Jan LY,Jan YN

更新日期：1997-11-25 00:00:00

abstract：:Subviral particles containing reovirus RNA transcriptase have been isolated from extracts of virus-infected mouse fibroblast cells. The purified particles which lacked the outer protein capsomeres of the mature virion had a buoyant density of 1.43-1.44 g/ml in CsCl and contained all of the double-stranded RNA genome o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin DH,Mendelsohn N,Schonberg M,Klett H,Silverstein S,Kapuler AM,Acs G

更新日期：1970-07-01 00:00:00

abstract：:Glutaredoxins (GRXs), also known as thioltransferases, use glutathione as a cofactor for reduction of disulfides in prokaryotes and eukaryotes. We demonstrate that the vaccinia virus O2L open reading frame encodes a functional GRX, as predicted by Johnson et al. [Johnson, G. P., Goebel, S. J., Perkus, M. E., Davis, S....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahn BY,Moss B

更新日期：1992-08-01 00:00:00

abstract：:Simplified models of the protein-folding process have led to valuable insights into the generic properties of the folding of heteropolymers. On the basis of theoretical arguments, Shakhnovich and Gutin [(1993) Proc. Natl. Acad. Sci. USA 90, 7195-7199] have proposed a specific method to generate folding sequences for o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ebeling M,Nadler W

更新日期：1995-09-12 00:00:00

abstract：:DNA sequences containing short adenine tracts are intrinsically curved and play a role in transcriptional regulation. Despite many high-resolution NMR and x-ray studies, the origins of curvature remain disputed. Long-range restraints provided by 85 residual dipolar couplings were measured for a DNA decamer containing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbic A,Zimmer DP,Crothers DM

更新日期：2003-03-04 00:00:00

abstract：:We carried out a large-scale screen to identify interactions between integral membrane proteins of Saccharomyces cerevisiae by using a modified split-ubiquitin technique. Among 705 proteins annotated as integral membrane, we identified 1,985 putative interactions involving 536 proteins. To ascribe confidence levels to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller JP,Lo RS,Ben-Hur A,Desmarais C,Stagljar I,Noble WS,Fields S

更新日期：2005-08-23 00:00:00

abstract：:It has been widely reported that intrinsic brain activity, in a variety of animals including humans, is spatiotemporally structured. Specifically, propagated slow activity has been repeatedly demonstrated in animals. In human resting-state fMRI, spontaneous activity has been understood predominantly in terms of zero-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitra A,Snyder AZ,Blazey T,Raichle ME

更新日期：2015-04-28 00:00:00

abstract：:Current methodologies that monitor immune responses rely on invasive techniques that sample tissues at a given point in time. New technologies are needed to elucidate the temporal patterns of immune responses and the spatial distribution of immune cells on a whole-body scale. We describe a noninvasive, quantitative, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shu CJ,Guo S,Kim YJ,Shelly SM,Nijagal A,Ray P,Gambhir SS,Radu CG,Witte ON

更新日期：2005-11-29 00:00:00

abstract：:The lack of genetic means has been a serious limitation in studying mosquito immunity. We generated Relish-mediated immune deficiency (RMID) by transforming Aedes aegypti with the Delta Rel transgene driven by the vitellogenin (Vg) promoter using the pBac[3xP3-EGFP, afm] vector. A stable transformed line had a single ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shin SW,Kokoza V,Lobkov I,Raikhel AS

更新日期：2003-03-04 00:00:00

abstract：:The envelope spike of HIV is one of the most highly N-glycosylated structures found in nature. However, despite extensive research revealing essential functional roles in infection and immune evasion, the chemical structures of the glycans on the native viral envelope glycoprotein gp120--as opposed to recombinantly ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doores KJ,Bonomelli C,Harvey DJ,Vasiljevic S,Dwek RA,Burton DR,Crispin M,Scanlan CN

更新日期：2010-08-03 00:00:00

abstract：:This report describes an unbiased method for systematically determining gene function in mammalian cells. A total of 20,704 predicted human full-length cDNAs were tested for induction of the IL-8 promoter. A number of genes, including those for cytokines, receptors, adapters, kinases, and transcription factors, were i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iourgenko V,Zhang W,Mickanin C,Daly I,Jiang C,Hexham JM,Orth AP,Miraglia L,Meltzer J,Garza D,Chirn GW,McWhinnie E,Cohen D,Skelton J,Terry R,Yu Y,Bodian D,Buxton FP,Zhu J,Song C,Labow MA

更新日期：2003-10-14 00:00:00

abstract：:The phosphorylation of diacylglycerol (DG), a reaction catalyzed by DG kinase, may be critical in the termination of effector-induced signals mediated by protein kinase C. Synapsin I is a principal target of intracellular protein kinases and is thought to be involved in the release of neurotransmitter from axon termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn DW,Besterman JM

更新日期：1991-07-15 00:00:00

abstract：:The absence of tools for mapping the forces that drive morphogenetic movements in embryos has impeded our understanding of animal development. Here we describe a unique approach, video force microscopy (VFM), that allows detailed, dynamic force maps to be produced from time-lapse images. The forces at work in an embry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodland GW,Conte V,Cranston PG,Veldhuis J,Narasimhan S,Hutson MS,Jacinto A,Ulrich F,Baum B,Miodownik M

更新日期：2010-12-21 00:00:00

abstract：:Human appropriation of net primary production (HANPP), the aggregate impact of land use on biomass available each year in ecosystems, is a prominent measure of the human domination of the biosphere. We present a comprehensive assessment of global HANPP based on vegetation modeling, agricultural and forestry statistics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haberl H,Erb KH,Krausmann F,Gaube V,Bondeau A,Plutzar C,Gingrich S,Lucht W,Fischer-Kowalski M

更新日期：2007-07-31 00:00:00

abstract：:During clathrin-mediated endocytosis, adaptor proteins recognize specific internalization signals on cargo receptors, either recruiting cargos into clathrin-coated pits (CCPs) or initiating clathrin-coat assembly around the cargo molecules. Here, we identify epsin 1, a clathrin-, ubiquitin-, and phospholipid-interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen C,Zhuang X

更新日期：2008-08-19 00:00:00

abstract：:Regulation of IFN signaling is critical in host recognition and response to pathogens while its dysregulation underlies the pathogenesis of several chronic diseases. STimulator of IFN Genes (STING) has been identified as a critical mediator of IFN inducing innate immune pathways, but little is known about direct coreg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,James SJ,Wyllie DH,Wynne C,Czibula A,Bukhari A,Pye K,Bte Mustafah SM,Fajka-Boja R,Szabo E,Angyal A,Hegedus Z,Kovacs L,Hill AVS,Jefferies CA,Wilson HL,Yongliang Z,Kiss-Toth E

更新日期：2019-08-13 00:00:00

abstract：:The uni1 mutant of Chlamydomonas reinhardtii lacks one of the paired flagella seen in wild-type cells. The missing flagellum is cis to the eye spot and at this site the basal body is incomplete, lacking a transition zone. Together with nine other loci affecting flagellar assembly and two loci affecting flagellar funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramanis Z,Luck DJ

更新日期：1986-01-01 00:00:00

abstract：:A juvenile male zebra finch, Taeniopygia guttata, kept singly with its father develops a fairly complete imitation of the father's song. The imitation is less complete when other male siblings are present, possibly because as imitation commences, model abundance increases. Here we examine the consequences of allowing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tchernichovski O,Lints T,Mitra PP,Nottebohm F

更新日期：1999-10-26 00:00:00

abstract：:The structure of DNA toroids made of individual DNA molecules of various lengths (3,000 to 55,000 bp) was studied, by using partially filled bacteriophage capsids in conjunction with cryoelectron microscopy. The tetravalent cation spermine was diffused through the capsid to condense the DNA under conditions that were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leforestier A,Livolant F

更新日期：2009-06-09 00:00:00

abstract：:To visualize histone acetylation in living cells, we developed a genetically encoded fluorescent resonance energy transfer (FRET)-based indicator. Response of the indicator reflects changes in the acetylation state of both K5 and K8 in histone H4. Using this acetylation indicator, we were able to monitor the dynamic f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasaki K,Ito T,Nishino N,Khochbin S,Yoshida M

更新日期：2009-09-22 00:00:00

abstract：:The requirement and influence of the peripheral nervous system on tissue replacement in mammalian appendages remain largely undefined. To explore this question, we have performed genetic lineage tracing and clonal analysis of individual cells of mouse hind limb tissues devoid of nerve supply during regeneration of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinkevich Y,Montoro DT,Muhonen E,Walmsley GG,Lo D,Hasegawa M,Januszyk M,Connolly AJ,Weissman IL,Longaker MT

更新日期：2014-07-08 00:00:00