Lag threads organize the brain's intrinsic activity.

abstract：:Models of the Fv portion (containing the variable regions of the heavy and light chains) of two monoclonal anti-alpha (1----6)dextran antibodies, W3129 and 19.1.2, were constructed from amino acid sequences and the known three-dimensional structures of the Fv portions of McPC603 and J539. The modeled combining site of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padlan EA,Kabat EA

更新日期：1988-09-01 00:00:00

abstract：:The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains unclear. We found that although Ras interfered with Myc-induced apoptosis, Myc repressed Ras-induced senescence, together abrogating two main barriers of tumori...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hydbring P,Bahram F,Su Y,Tronnersjö S,Högstrand K,von der Lehr N,Sharifi HR,Lilischkis R,Hein N,Wu S,Vervoorts J,Henriksson M,Grandien A,Lüscher B,Larsson LG

更新日期：2010-01-05 00:00:00

abstract：:After pair-bonding, male prairie voles (Microtus ochrogaster) display aggression toward novel females but not toward their female partner. Here we show that this selective aggression in pair-bonded male prairie voles is associated with increased release of vasopressin (AVP) in the anterior hypothalamus (AH). Pharmacol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gobrogge KL,Liu Y,Young LJ,Wang Z

更新日期：2009-11-10 00:00:00

abstract：:Niemann-Pick type C (NPC) 1 protein plays important roles in moving cholesterol and other lipids out of late endosomes by means of vesicular trafficking, but it is not known whether NPC1 directly interacts with cholesterol. We performed photoaffinity labeling of intact cells expressing fluorescent protein (FP)-tagged ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohgami N,Ko DC,Thomas M,Scott MP,Chang CC,Chang TY

更新日期：2004-08-24 00:00:00

abstract：:Seasonal changes of daylength (photoperiod) affect the expression of hormonal and behavioral circadian rhythms in a variety of organisms. In mammals, such effects might reflect photoperiodic changes in the circadian pace-making system [located in the suprachiasmatic nucleus (SCN) of the hypothalamus] that governs thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumová A,Trávnícková Z,Peters R,Schwartz WJ,Illnerová H

更新日期：1995-08-15 00:00:00

abstract：:The latent membrane protein (LMP1) of Epstein-Barr virus (EBV) is expressed in EBV-associated nasopharyngeal carcinoma, which is notoriously metastatic. Although it is established that LMP1 represses E-cadherin expression and enhances the invasive ability of carcinoma cells, the mechanism underlying this repression re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai CN,Tsai CL,Tse KP,Chang HY,Chang YS

更新日期：2002-07-23 00:00:00

abstract：:8-Azido[2-3H]adenine was used as a photoaffinity label for the purine-cytosine transport system. After irradiation in the presence of the photoaffinity label, the cells were converted into protoplasts, their plasma membranes were purified, and the membrane proteins were extracted and separated by NaDodSO4/PAGE. The ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt R,Manolson MF,Chevallier MR

更新日期：1984-10-01 00:00:00

abstract：:P450c17 is the single enzyme mediating both 17 alpha-hydroxylase (steroid 17 alpha-monooxygenase, EC 1.14.99.9) and 17,20 lyase activities in the synthesis of steroid hormones. It has been suggested that different P450c17 isozymes mediate these activities in the adrenal gland and testis. We sequenced 423 of the 509 am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung BC,Picado-Leonard J,Haniu M,Bienkowski M,Hall PF,Shively JE,Miller WL

更新日期：1987-01-01 00:00:00

abstract：:Breakage-fusion-bridge (BFB) is a mechanism of genomic instability characterized by the joining and subsequent tearing apart of sister chromatids. When this process is repeated during multiple rounds of cell division, it leads to patterns of copy number increases of chromosomal segments as well as fold-back inversions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zakov S,Kinsella M,Bafna V

更新日期：2013-04-02 00:00:00

abstract：:Expression of alphavbeta3- or alphavbeta5-integrins and selectins is widespread on blood cells and endothelial cells. Here we report that human tumor cells injected s.c. into mice lacking beta3- or beta3/beta5-integrins or various selectins show enhanced tumor growth compared with growth in control mice. There was inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taverna D,Moher H,Crowley D,Borsig L,Varki A,Hynes RO

更新日期：2004-01-20 00:00:00

abstract：:Tryptophan biosynthesis is subject to exquisite control in species of Bacillus and has become one of the best-studied model systems in gene regulation. The protein TRAP (trp RNA-binding attenuation protein) predominantly forms a ring-shaped 11-mer, which binds cognate RNA in the presence of tryptophan to suppress expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe M,Heddle JG,Kikuchi K,Unzai S,Akashi S,Park SY,Tame JR

更新日期：2009-02-17 00:00:00

abstract：:Eukaryotic translation initiation factor eIF-4E plays a central role in the recognition of the 7-methylguanosine-containing cap structure of mRNA and the formation of initiation complexes during protein synthesis. eIF-4E exists in both phosphorylated and nonphosphorylated forms, and the primary site of phosphorylation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minich WB,Balasta ML,Goss DJ,Rhoads RE

更新日期：1994-08-02 00:00:00

abstract：:Neuronal dynamics display a complex spatiotemporal structure involving the precise, context-dependent coordination of activation patterns across a large number of spatially distributed regions. Functional magnetic resonance imaging (fMRI) has played a central role in demonstrating the nontrivial spatial and topologica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalesky A,Fornito A,Cocchi L,Gollo LL,Breakspear M

更新日期：2014-07-15 00:00:00

abstract：:Corticotropin (ACTH) and melanotropin (MSH) peptides (melanocortins) are produced not only in the pituitary but also in the brain, with highest concentrations in the arcuate nucleus of the hypothalamus and the commisural nucleus of the solitary tract. We have identified a receptor for MSH and ACTH peptides that is spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roselli-Rehfuss L,Mountjoy KG,Robbins LS,Mortrud MT,Low MJ,Tatro JB,Entwistle ML,Simerly RB,Cone RD

更新日期：1993-10-01 00:00:00

abstract：:The water channel aquaporin 1 (AQP1) and certain Rh-family members are permeable to CO(2) and NH(3). Here, we use changes in surface pH (pH(S)) to assess relative CO(2) vs. NH(3) permeability of Xenopus oocytes expressing members of the AQP or Rh family. Exposed to CO(2) or NH(3), AQP1 oocytes exhibit a greater maxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Musa-Aziz R,Chen LM,Pelletier MF,Boron WF

更新日期：2009-03-31 00:00:00

abstract：:Bacterial chemotaxis receptors can detect a small concentration gradient of attractants and repellents in the environment over a wide range of background concentration. The clustering of these receptors to form patches observed in vivo and in vitro has been suspected as a reason for the high sensitivity, and such wide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SH,Wang W,Kim KK

更新日期：2002-09-03 00:00:00

abstract：:Scattering of light from dielectric particles whose size is on the order of an optical wavelength underlies a plethora of visual phenomena in nature and is a foundation for optical coatings and paints. Tailoring the internal nanoscale geometry of such "photonic particles" allows tuning their optical scattering charact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao G,Kaufman JJ,Shabahang S,Rezvani Naraghi R,Sukhov SV,Joannopoulos JD,Fink Y,Dogariu A,Abouraddy AF

更新日期：2016-06-21 00:00:00

abstract：:A regeneration chamber was created in vivo by suturing a synthetic tube sealed at its distal end onto the proximal stump of a severed rat sciatic nerve. Nerves regenerated into tubes coated with laminin at a rate of 0.33 mm/day after a lag of about 2 days. At 25 days, regenerating nerves had extended 23% farther into ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyota B,Carbonetto S,David S

更新日期：1990-02-01 00:00:00

abstract：:The RuvC protein of Escherichia coli catalyzes the resolution of recombination intermediates during genetic recombination and the recombinational repair of damaged DNA. Resolution involves specific recognition of the Holliday structure to form a complex that exhibits twofold symmetry with the DNA in an open configurat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett RJ,West SC

更新日期：1996-10-29 00:00:00

abstract：:Wild-type newborn mice are characterized by the ability of certain liver-specific genes encoding various enzymes and mapping on different chromosomes to respond to glucocorticoid induction. Newborn mice homozygous for deletions at and around the albino locus on chromosome 7 fail to develop this competence for hormone-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeFranco D,Bali D,Torres R,DePinho RA,Erickson RP,Gluecksohn-Waelsch S

更新日期：1991-07-01 00:00:00

abstract：:Awareness that our planet is a self-supporting biosphere with sunlight as its major source of energy for life has resulted in a long-term historical fascination with the workings of self-supporting ecological systems. However, the studies of such systems have never entered the canon of ecological or evolutionary tools...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rillig MC,Antonovics J

更新日期：2019-06-04 00:00:00

abstract：:Using cell-based aptamer selection, we have developed a strategy to use the differences at the molecular level between any two types of cells for the identification of molecular signatures on the surface of targeted cells. A group of aptamers have been generated for the specific recognition of leukemia cells. The sele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shangguan D,Li Y,Tang Z,Cao ZC,Chen HW,Mallikaratchy P,Sefah K,Yang CJ,Tan W

更新日期：2006-08-08 00:00:00

abstract：:We have previously described a gene delivery system based upon the receptor-mediated endocytosis of DNA complexed with transferrin-polycation conjugates. This delivery system has been found to be very effective for both the internalization and the expression of genetic material in cells that have many transferrin rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Cotten M,Foisner R,Birnstiel ML

更新日期：1991-05-15 00:00:00

abstract：:The neural cell adhesion molecule N-CAM is a sialic acid-rich, cell surface glycoprotein that mediates cell adhesion by a homophilic mechanism. Its binding function has been implicated in both morphogenesis and histogenesis; during development it changes in amount at the cell surface and perinatally it undergoes a dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman S,Chuong CM,Edelman GM

更新日期：1984-11-01 00:00:00

abstract：:Autophagy is a cellular catabolic pathway by which long-lived proteins and damaged organelles are targeted for degradation. Activation of autophagy enhances cellular tolerance to various stresses. Recent studies indicate that a class of anticancer agents, histone deacetylase (HDAC) inhibitors, can induce autophagy. On...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gammoh N,Lam D,Puente C,Ganley I,Marks PA,Jiang X

更新日期：2012-04-24 00:00:00

abstract：:We have previously identified a generally occurring short-range mobility of nucleosome cores on DNA in relatively low ionic strength conditions. Here we report that this mobility of histone octamers positioned on constructs of 5S rDNA is suppressed by the binding of histone H1 or H5 to the nucleosome. Histone H5 is th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pennings S,Meersseman G,Bradbury EM

更新日期：1994-10-25 00:00:00

abstract：:High-affinity ligands of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) were isolated by the SELEX procedure (systematic evolution of ligands by exponential enrichment) from RNA populations randomized at 32 positions. Analysis of these ligands revealed a pseudoknot consensus with primary sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuerk C,MacDougal S,Gold L

更新日期：1992-08-01 00:00:00

abstract：:The role of geographic isolation in marine microbial speciation is hotly debated because of the high dispersal potential and large population sizes of planktonic microorganisms and the apparent lack of strong dispersal barriers in the open sea. Here, we show that gene flow between distant populations of the globally d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casteleyn G,Leliaert F,Backeljau T,Debeer AE,Kotaki Y,Rhodes L,Lundholm N,Sabbe K,Vyverman W

更新日期：2010-07-20 00:00:00

abstract：:The phytohormone cytokinin influences many aspects of plant growth and development, several of which also involve the cellular process of autophagy, including leaf senescence, nutrient remobilization, and developmental transitions. The Arabidopsis type-A response regulators (type-A ARR) are negative regulators of cyto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acheampong AK,Shanks C,Cheng CY,Schaller GE,Dagdas Y,Kieber JJ

更新日期：2020-10-27 00:00:00

abstract：:Metallophilicity is defined as the interaction among closed-shell metal centers, the origin of which remains controversial, particularly for the roles of spd orbital hybridization (mixing of the spd atomic orbitals of the metal atom in the molecular orbitals of metal complex) and the relativistic effect. Our studies r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wan Q,Yang J,To WP,Che CM

更新日期：2021-01-05 00:00:00