Evolutionary conservation of key structures and binding functions of neural cell adhesion molecules.

abstract：:An enhancer specific to erythroid cells was identified previously in the 3' flanking sequence of the chicken adult beta-globin gene and shown to act on the beta-globin promoter. This enhancer lies between the adult beta-globin gene and the embryonic epsilon-globin gene, about equidistant from the two promoters. To det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nickol JM,Felsenfeld G

更新日期：1988-04-01 00:00:00

abstract：:We examine the IFN-alpha/beta-independent activation of cellular transcription that constitutes an early antiviral response of cells against influenza A and B viruses, which cause widespread epidemics in humans. We show that influenza B virus induces the synthesis in human cells of several mature mRNAs encoded by gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim MJ,Latham AG,Krug RM

更新日期：2002-07-23 00:00:00

abstract：:The tumor suppressor protein p53 plays a crucial role in coordinating cellular processes, such as cell cycle arrest, apoptosis, and senescence. The nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a homophilic adhesion molecule and involved in nerve regeneration. Interestingly, Ninj1 is found to be overexpressed i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho SJ,Rossi A,Jung YS,Yan W,Liu G,Zhang J,Zhang M,Chen X

更新日期：2013-06-04 00:00:00

abstract：:A neuroethological approach to human and nonhuman primate behavior and cognition predicts biological specializations for social life. Evidence reviewed here indicates that ancestral mechanisms are often duplicated, repurposed, and differentially regulated to support social behavior. Focusing on recent research from no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang SW,Brent LJ,Adams GK,Klein JT,Pearson JM,Watson KK,Platt ML

更新日期：2013-06-18 00:00:00

abstract：:The role of anti-peripheral nerve myelin antibody (anti-PNM Ab) in the pathogenesis of acquired demyelination of peripheral nerve is unclear, in part, due to the poor correlation between antibody and disease activity. Previous studies show that only 27-50% of patients with acute demyelinating neuropathy or Guillain-Ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koski CL,Humphrey R,Shin ML

更新日期：1985-02-01 00:00:00

abstract：:Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an exte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai SY,Pokrass MJ,Klauer NR,Nohara H,Su TP

更新日期：2015-05-26 00:00:00

abstract：:We have previously reported that in four transcription factor families the DNA-recognition rules can be described as (i) chemical rules, which list possible pairings between the 20 amino acid residues and the four DNA bases, and (ii) stereochemical rules, which describe the base and amino acid positions in contact. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki M,Yagi N

更新日期：1994-12-20 00:00:00

abstract：:The sensitive and accurate quantification of protein biomarkers plays important roles in clinical diagnostics and biomedical research. Sandwich ELISA and its variants accomplish the capture and detection of a target protein via two antibodies that tightly bind at least two distinct epitopes of the same antigen and hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatterjee T,Knappik A,Sandford E,Tewari M,Choi SW,Strong WB,Thrush EP,Oh KJ,Liu N,Walter NG,Johnson-Buck A

更新日期：2020-09-15 00:00:00

abstract：:Unlike parasitic protist groups that are defined by the absence of mitochondria, the Pelobiontida is composed mostly of free-living species. Because of the presence of ultrastructural and cellular features that set them apart from all other eukaryotic organisms, it has been suggested that pelobionts are primitively am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiller JW,Duffield EC,Hall BD

更新日期：1998-09-29 00:00:00

abstract：:Four cell types from Vicia faba Linnaeus "Long Pod" leaflets were assayed for three enzymes unique to the photosynthetic carbon reduction pathway. The enzymes were ribulosebisphosphate carboxylase [3-phospho-D-glycerate carboxy-lyase (dimerizing), EC 4.1.1.39], phosphoribulokinase (ATP:D-ribulose-5-phosphate 1-phospho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Outlaw WH,Manchester J,Dicamelli CA,Randall DD,Rapp B,Veith GM

更新日期：1979-12-01 00:00:00

abstract：:Actin polymerization provides a powerful propulsion force for numerous types of cell motility. Although tremendous progress has been made in identifying the biochemical components necessary for actin-based motility, the precise biophysical mechanisms of force generation remain unclear. To probe the polymerization forc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Upadhyaya A,Chabot JR,Andreeva A,Samadani A,van Oudenaarden A

更新日期：2003-04-15 00:00:00

abstract：:Massively parallel signature sequencing (MPSS) generates millions of short sequence tags corresponding to transcripts from a single RNA preparation. Most MPSS tags can be unambiguously assigned to genes, thereby generating a comprehensive expression profile of the tissue of origin. From the comparison of MPSS data fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YT,Scanlan MJ,Venditti CA,Chua R,Theiler G,Stevenson BJ,Iseli C,Gure AO,Vasicek T,Strausberg RL,Jongeneel CV,Old LJ,Simpson AJ

更新日期：2005-05-31 00:00:00

abstract：:During primate evolution, a major factor in lengthening life-span and decreasing age-specific cancer rates may have been improved protective mechanisms against oxygen radicals. We propose that one of these protective systems is plasma uric acid, the level of which increased markedly during primate evolution as a conse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ames BN,Cathcart R,Schwiers E,Hochstein P

更新日期：1981-11-01 00:00:00

abstract：:The emergence of Vibrio cholerae O139 Bengal during 1992-1993 was associated with large epidemics of cholera in India and Bangladesh and, initially, with a total displacement of the existing V. cholerae O1 strains. However, the O1 strains reemerged in 1994 and initiated a series of disappearance and reemergence of eit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faruque SM,Sack DA,Sack RB,Colwell RR,Takeda Y,Nair GB

更新日期：2003-02-04 00:00:00

abstract：:Look-through mutagenesis (LTM) is a multidimensional mutagenesis method that simultaneously assesses and optimizes combinatorial mutations of selected amino acids. The process focuses on a precise distribution within one or more complementarity determining region (CDR) domains and explores the synergistic contribution...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rajpal A,Beyaz N,Haber L,Cappuccilli G,Yee H,Bhatt RR,Takeuchi T,Lerner RA,Crea R

更新日期：2005-06-14 00:00:00

abstract：:In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated. Expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin Z,Barthel LK,Raymond PA

更新日期：2009-06-09 00:00:00

abstract：:In typical force spectroscopy experiments, a small biomolecule is attached to a soft polymer linker that is pulled with a relatively large bead or cantilever. At constant force, the total extension stochastically changes between two (or more) values, indicating that the biomolecule undergoes transitions between two (o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cossio P,Hummer G,Szabo A

更新日期：2015-11-17 00:00:00

abstract：:Criegee intermediates are thought to play a role in atmospheric chemistry, in particular, the oxidation of SO2, which produces SO3 and subsequently H2SO4, an important constituent of aerosols and acid rain. However, the impact of such oxidation reactions is affected by the reactions of Criegee intermediates with water...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang HL,Chao W,Lin JJ

更新日期：2015-09-01 00:00:00

abstract：:Cell walls of Mycobacterium leprae, prepared by differential solvent extraction, were shown to contain arabinogalactan, mycolates, and peptidoglycan. In addition, amino acid analysis revealed the unexpected presence of large amounts of protein that retained potent immunological reactivity. Purified cell walls stimulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melancon-Kaplan J,Hunter SW,McNeil M,Stewart C,Modlin RL,Rea TH,Convit J,Salgame P,Mehra V,Bloom BR

更新日期：1988-03-01 00:00:00

abstract：:What can be done to reduce unhealthy eating among adolescents? It was hypothesized that aligning healthy eating with important and widely shared adolescent values would produce the needed motivation. A double-blind, randomized, placebo-controlled experiment with eighth graders (total n = 536) evaluated the impact of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryan CJ,Yeager DS,Hinojosa CP,Chabot A,Bergen H,Kawamura M,Steubing F

更新日期：2016-09-27 00:00:00

abstract：:An isoform of the mammalian renal type II Na/Pi-cotransporter is described. Homology of this isoform to described mammalian and nonmammalian type II cotransporters is between 57 and 75%. Based on major diversities at the C terminus, the new isoform is designed as type IIb Na/Pi-cotransporter. Na/Pi-cotransport mediate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilfiker H,Hattenhauer O,Traebert M,Forster I,Murer H,Biber J

更新日期：1998-11-24 00:00:00

abstract：:The recent observation of superconductivity in [Formula: see text] has raised fundamental questions about the hierarchy of the underlying electronic structure. Calculations suggest that this system falls in the Mott-Hubbard regime, rather than the charge-transfer configuration of other nickel oxides and the supercondu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodge BH,Li D,Lee K,Osada M,Wang BY,Sawatzky GA,Hwang HY,Kourkoutis LF

更新日期：2021-01-12 00:00:00

abstract：:Renal medullary cells contain high concentrations of myo-inositol, sorbitol, betaine, and glycerophosphocholine, whose levels vary with urinary osmolality. Accumulation of these "compatible" organic osmolytes is believed to help the cells osmoregulate in response to the high extracellular osmolality that occurs as par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakanishi T,Turner RJ,Burg MB

更新日期：1989-08-01 00:00:00

abstract：:Gene therapy of the brain is hindered by the presence of the blood-brain barrier (BBB), which prevents the brain uptake of bloodborne gene formulations. Exogenous genes have been expressed in the brain after invasive routes of administration, such as craniotomy or intracarotid arterial infusion of noxious agents causi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi N,Pardridge WM

更新日期：2000-06-20 00:00:00

abstract：:The FMS gene encodes the functional cell surface receptor for colony-stimulating factor 1, the macrophage- and monocyte-specific growth factor. Codons 969 and 301 have been identified as potentially involved in promoting the transforming activity of FMS. Mutations at codon 301 are believed to lead to neoplastic transf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ridge SA,Worwood M,Oscier D,Jacobs A,Padua RA

更新日期：1990-02-01 00:00:00

abstract：:Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to incorporate and metabolize stearic acid. Unstimulated T and B cells incorporated identical amounts of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buttke TM,Van Cleave S,Steelman L,McCubrey JA

更新日期：1989-08-01 00:00:00

abstract：:The human epidermal growth factor receptor (EGFR) is a key representative of tyrosine kinase receptors, ubiquitous actors in cell signaling, proliferation, differentiation, and migration. Although the receptor is well-studied, a central issue remains: How does the compositional diversity and functional diversity of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coskun Ü,Grzybek M,Drechsel D,Simons K

更新日期：2011-05-31 00:00:00

abstract：:Unintended block of HERG K+ channels is a side effect of many common medications and is the most common cause of acquired long QT syndrome associated with increased risk of life-threatening arrhythmias. The molecular mechanism of high-affinity HERG block by structurally diverse compounds has been attributed to pi-stac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Seebohm G,Sanguinetti MC

更新日期：2002-09-17 00:00:00

abstract：:Visual information is conveyed from the eye to the brain by distinct types of retinal ganglion cells (RGCs). It is largely unknown how RGCs acquire their defining morphological and physiological features and connect to upstream and downstream synaptic partners. The three Brn3/Pou4f transcription factors (TFs) particip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sajgo S,Ghinia MG,Brooks M,Kretschmer F,Chuang K,Hiriyanna S,Wu Z,Popescu O,Badea TC

更新日期：2017-05-16 00:00:00

abstract：:Epigenetics regulation plays a critical role in determining cell identity by controlling the accessibility of lineage-specific regulatory regions. In muscle stem cells, epigenetic mechanisms of how chromatin accessibility is modulated during cell fate determination are not fully understood. Here, we identified a long ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong A,Preusch CB,So WK,Lin K,Luan S,Yi R,Wong JW,Wu Z,Cheung TH

更新日期：2020-12-22 00:00:00