FMS mutations in myelodysplastic, leukemic, and normal subjects.

abstract：:Following carcinogen exposure in vitro, normal rat tracheal epithelial cells are transformed in a multistage process in which the cultured cells become immortal and, ultimately, neoplastic. Five cell lines derived from tumors produced by neoplastically transformed rat tracheal epithelial cells were examined for the ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walker C,Nettesheim P,Barrett JC,Gilmer TM

更新日期：1987-04-01 00:00:00

abstract：:The intracellular activation of trypsinogen, which is both pH- and calcium-dependent, is an important early step in the development of acute pancreatitis. The cellular compartment in which trypsinogen activation occurs currently is unknown. We therefore investigated the site of intracellular trypsinogen activation by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sherwood MW,Prior IA,Voronina SG,Barrow SL,Woodsmith JD,Gerasimenko OV,Petersen OH,Tepikin AV

更新日期：2007-03-27 00:00:00

abstract：:Whether the regulatory protein of an inducible operon for a catabolic pathway is a positive or a negative element in the control of expression is correlated with the frequent or infrequent presence, respectively, of the system's substrate in the natural environment. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Savageau MA

更新日期：1974-06-01 00:00:00

abstract：:Excitatory amino acid transporters (EAATs) buffer and remove synaptically released L-glutamate and maintain its concentrations below neurotoxic levels. EAATs also mediate a thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability. Here, we demonstrate that modification of a cys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seal RP,Shigeri Y,Eliasof S,Leighton BH,Amara SG

更新日期：2001-12-18 00:00:00

abstract：:A major challenge in interpreting genome sequences is understanding how the genome encodes the information that specifies when and where a gene will be expressed. The first step in this process is the identification of regions of the genome that contain regulatory information. In higher eukaryotes, this cis-regulatory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berman BP,Nibu Y,Pfeiffer BD,Tomancak P,Celniker SE,Levine M,Rubin GM,Eisen MB

更新日期：2002-01-22 00:00:00

abstract：:We describe here a simple and easily manipulatable Escherichia coli-based genetic system that permits us to identify bacterial gene products that modulate the sensitivity of bacteria to tumoricidal agents, such as DMP 840, a bisnaphthalimide drug. To the extent that the action of these agents is conserved, these studi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatterjee PK,Sternberg NL

更新日期：1995-09-12 00:00:00

abstract：:The phenotype and antigenic specificity of cells secreting interleukin (IL) 4, IL-6, and interferon gamma was studied in mice during primary and secondary immune responses. T lymphocytes were the major source of interferon gamma, whereas non-B/non-T cells were the dominant source of IL-4 and IL-6 in the spleens of imm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aoki I,Kinzer C,Shirai A,Paul WE,Klinman DM

更新日期：1995-03-28 00:00:00

abstract：:Electron spectroscopic imaging, a new technique that permits the quantitative detection of the spatial distributions of atomic elements at high resolution, has been applied to the epiphyseal zone of hypertrophy in the mouse for the visualization of calcium, phosphorus, and sulfur. Longitudinally sectioned epiphyseal g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsenault AL,Ottensmeyer FP

更新日期：1983-03-01 00:00:00

abstract：:Glycan-protein interactions are emerging as important modulators of membrane protein organization and dynamics, regulating multiple cellular functions. In particular, it has been postulated that glycan-mediated interactions regulate surface residence time of glycoproteins and endocytosis. How this precisely occurs is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torreno-Pina JA,Castro BM,Manzo C,Buschow SI,Cambi A,Garcia-Parajo MF

更新日期：2014-07-29 00:00:00

abstract：:Starting with assignments of proton nuclear magnetic resonance previously made for oxytocin in deuterated dimethylsulfoxide at 220 MHz, we have assigned resonances for the mammalian antidiuretic hormone, lysine vasopressin. The results demonstrate that spectral assignments of neurohypophyseal hormones and their congen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Glickson JD,Schwartz IL,Havran RT,Meienhofer J,Urry DW

更新日期：1972-07-01 00:00:00

abstract：:Gene-regulatory networks are ubiquitous in nature and critical for bottom-up engineering of synthetic networks. Transcriptional repression is a fundamental function that can be tuned at the level of DNA, protein, and cooperative protein-protein interactions, necessitating high-throughput experimental approaches for in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swank Z,Laohakunakorn N,Maerkl SJ

更新日期：2019-03-26 00:00:00

abstract：:Rat liver glutamine synthetase (s(20,w) 15.0 S; MW about 352,000) resembles ovine brain glutamine synthetase in that it (a) has 8 subunits, (b) acts on both L- and D-glutamate and certain glutamate analogs (e.g., beta-glutamate, cis-cycloglutamate, and alpha-methyl-L-glutamate), and (c) is irreversibly inhibited by L-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate SS,Meister A

更新日期：1971-04-01 00:00:00

abstract：:Social networks exhibit strikingly systematic patterns across a wide range of human contexts. Although genetic variation accounts for a significant portion of the variation in many complex social behaviors, the heritability of egocentric social network attributes is unknown. Here, we show that 3 of these attributes (i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH,Dawes CT,Christakis NA

更新日期：2009-02-10 00:00:00

abstract：:The innate immune system detects viral nucleic acids and induces type I interferon (IFN) responses. The RNA- and DNA-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor IFN-regulatory factor 3 (IRF3). Activation of the IFN signaling pathway is known to trigger the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seo M,Lee SO,Kim JH,Hong Y,Kim S,Kim Y,Min DH,Kong YY,Shin J,Ahn K

更新日期：2016-12-13 00:00:00

abstract：:The poly(A) site of bovine prolactin (bPRL) mRNA was examined by phased priming of cDNA synthesis with oligodeoxynucleotides of the general sequence d(pT8-N-N'). The existence of multiple poly(A)-adjacent sequences in bPRL mRNA was indicated by the production of specific chain-termination fragments with at least three...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasavage NL,Smith M,Gillam S,Woychik RP,Rottman FM

更新日期：1982-01-01 00:00:00

abstract：:Nonnative species richness typically declines along environmental gradients such as elevation. It is usually assumed that this is because few invaders possess the necessary adaptations to succeed under extreme environmental conditions. Here, we show that nonnative plants reaching high elevations around the world are n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alexander JM,Kueffer C,Daehler CC,Edwards PJ,Pauchard A,Seipel T,MIREN Consortium.

更新日期：2011-01-11 00:00:00

abstract：:We discuss the generic time behavior of reaction-diffusion processes capable of modeling various types of biological transport processes, such as ligand migration in proteins and gating fluctuations in ion channel proteins. The main observable in these two cases, the fraction of unbound ligands and the probability of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadler W,Stein DL

更新日期：1991-08-01 00:00:00

abstract：:For length and area, a central fact is that the value of the length of a curve or the area of a surface, as given by the Lebesgue theory, is at least as great as that given by the classical formula, whenever the latter has meaning. This is now found not to be valid in higher dimensions. We give an example of a continu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goffman C

更新日期：1969-05-01 00:00:00

abstract：:p150(glued) belongs to a group of proteins accumulating at microtubule plus ends (+TIPs). It plays a key role in initiating retrograde transport by recruiting and tethering endosomes and dynein to microtubules. p150(glued) contains an N-terminal microtubule-binding cytoskeleton-associated protein glycine-rich (CAP-Gly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Q,Crevenna AH,Kunze I,Mizuno N

更新日期：2014-08-05 00:00:00

abstract：:By adapting to sustained stimuli, hair cells in the internal ear retain their sensitivity to minute transient displacements. Because one model for adaptation asserts that this process is mediated by a myosin isozyme, we reasoned that we should be able to arrest adaptation by interfering with myosin's ATPase cycle thou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillespie PG,Hudspeth AJ

更新日期：1993-04-01 00:00:00

abstract：:The neural pathway that governs an escape response of Drosophila to sudden changes in light intensity can be artificially induced by electrical stimulation of the brain and monitored by electrical recording from the effector muscles. We have refined previous work in this system to permit reliable ascertainment of two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin M,Nash HA

更新日期：1996-09-17 00:00:00

abstract：:Fluid mixing in active suspensions of microorganisms is important to ecological phenomena and presents a fascinating stochastic process. We investigate the mixing produced by swimming unicellular algal cells (Chlamydomonas) in quasi-two-dimensional liquid films by simultaneously tracking the motion of the cells and th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurtuldu H,Guasto JS,Johnson KA,Gollub JP

更新日期：2011-06-28 00:00:00

abstract：:The peripheral axonal branch of primary sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which courses in the dorsal columns of the spinal cord, does not. However, if a peripheral nerve is transected before a spinal cord injury, sensory neurons that course in the dorsal column...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neumann S,Skinner K,Basbaum AI

更新日期：2005-11-15 00:00:00

abstract：:p53, the most commonly mutated gene in human tumors, is believed to play a crucial role in the prevention of cancer by protecting cells from mutation, a theory commonly known as the "Guardian of the Genome" hypothesis. There are two hypotheses as to how this can occur. In the first, p53 protects the genome by retardin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bielas JH,Heddle JA

更新日期：2003-10-28 00:00:00

abstract：:A 978-base-pair gene that encodes thymidylate synthase (TS; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45) from Lactobacillus casei has been synthesized and inserted into Escherichia coli expression vectors. The DNA sequence contains 35 unique restriction sites that are located an average of 28 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Climie S,Santi DV

更新日期：1990-01-01 00:00:00

abstract：:Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. Accordingly, reversal of structural remodelin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czéh B,Michaelis T,Watanabe T,Frahm J,de Biurrun G,van Kampen M,Bartolomucci A,Fuchs E

更新日期：2001-10-23 00:00:00

abstract：:In the presence of N(alpha),N(epsilon)-diacetyl-L-Lys-D-Ala-D-Ala as donor, and either D-[(14)C]alanine, [(14)C]-glycine, or meso-[(3)H]diaminopimelic acid as acceptor, the DD carboxypeptidases from Streptomyces R61 and R39 catalyze a transpeptidation reaction with the release of terminal D-alanine from the donor and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pollock JJ,Ghuysen JM,Linder R,Salton MR,Perkins HR,Nieto M,Leyh-Bouille M,Frere JM,Johnson K

更新日期：1972-03-01 00:00:00

abstract：:Cathepsin B (CTSB) is overexpressed in tumors of the lung, prostate, colon, breast, and stomach. However, evidence of primary genomic alterations in the CTSB gene during tumor initiation or progression has been lacking. We have found a novel amplicon at 8p22-23 that results in CTSB overexpression in esophageal adenoca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes SJ,Glover TW,Zhu XX,Kuick R,Thoraval D,Orringer MB,Beer DG,Hanash S

更新日期：1998-10-13 00:00:00

abstract：:The association between nicotinic acetylcholine receptor (nAChR) dysfunction and cognitive decline in Alzheimer's disease (AD) has been widely exploited for its therapeutic potential. The effects of chronic nicotine exposure on Abeta accumulation have been studied in both humans and animal models, but its therapeutic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oddo S,Caccamo A,Green KN,Liang K,Tran L,Chen Y,Leslie FM,LaFerla FM

更新日期：2005-02-22 00:00:00

abstract：:Pyrrolysine (Pyl), the 22nd natural amino acid and genetically encoded by UAG, becomes attached to its cognate tRNA by pyrrolysyl-tRNA synthetase (PylRS). We have determined three crystal structures of the Methanosarcina mazei PylRS complexed with either AMP-PNP, Pyl-AMP plus pyrophosphate, or the Pyl analogue N-epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavran JM,Gundllapalli S,O'Donoghue P,Englert M,Söll D,Steitz TA

更新日期：2007-07-03 00:00:00