Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation.

abstract：:Type C retroviruses are endogenous in most vertebrate species. These viruses generally are of low pathogenicity in their natural hosts. Variants that contain cell-derived transforming genes have been isolated infrequently in the past upon continued passage in vivo. We report here a procedure that allows the isolation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rapp UR,Todaro GJ

更新日期：1980-01-01 00:00:00

abstract：:Myosins, a large family of actin-based motors, have one or two heavy chains with one or more light chains associated with each heavy chain. The heavy chains have a (generally) N-terminal head domain with an ATPase and actin-binding site, followed by a neck domain to which the light chains bind, and a C-terminal tail d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korn ED

更新日期：2000-11-07 00:00:00

abstract：:Closed and pH-tight membrane vesicles prepared from hypocotyls of 5-day-old dark-grown seedlings of Cucurbita pepo accumulate the plant growth hormone indole-3-acetic acid along an imposed proton gradient (pH low outside, high inside). The use of electron paramagnetic spin probes permitted quantitation both of apparen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lomax TL,Mehlhorn RJ,Briggs WR

更新日期：1985-10-01 00:00:00

abstract：:Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been identified in these regions, no causative correlations have been drawn between deletion or mutation of these and lung carcinogenesis. We identify XPC and Gadd45a as ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollander MC,Philburn RT,Patterson AD,Velasco-Miguel S,Friedberg EC,Linnoila RI,Fornace AJ Jr

更新日期：2005-09-13 00:00:00

abstract：:Toll like receptors (TLRs) use Toll-IL-1 receptor (TIR) domain-containing adapters, such as myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adapter inducing IFN-β (TRIF), to induce activation of transcription factors, including NF-κB, MAP kinases, and IFN regulatory factors. TLR sign...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Troutman TD,Hu W,Fulenchek S,Yamazaki T,Kurosaki T,Bazan JF,Pasare C

更新日期：2012-01-03 00:00:00

abstract：:Despite its theoretical prominence and sound principles, integrated pest management (IPM) continues to suffer from anemic adoption rates in developing countries. To shed light on the reasons, we surveyed the opinions of a large and diverse pool of IPM professionals and practitioners from 96 countries by using structur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parsa S,Morse S,Bonifacio A,Chancellor TC,Condori B,Crespo-Pérez V,Hobbs SL,Kroschel J,Ba MN,Rebaudo F,Sherwood SG,Vanek SJ,Faye E,Herrera MA,Dangles O

更新日期：2014-03-11 00:00:00

abstract：:Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmberg R,Refai E,Höög A,Crooke RM,Graham M,Olivecrona G,Berggren PO,Juntti-Berggren L

更新日期：2011-06-28 00:00:00

abstract：:The sustainability of irrigated agriculture in many arid and semiarid areas of the world is at risk because of a combination of several interrelated factors, including lack of fresh water, lack of drainage, the presence of high water tables, and salinization of soil and groundwater resources. Nowhere in the United Sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoups G,Hopmans JW,Young CA,Vrugt JA,Wallender WW,Tanji KK,Panday S

更新日期：2005-10-25 00:00:00

abstract：:The intestinal lamina propria (LP) is a major effector site of the mucosal immune system where antigen-specific and antigen-nonspecific factors shape the functional responses of CD4+ T helper cells. To study the functional differentiation of LP T helper cells we utilized DO11.10 T cell receptor (TCR) transgenic (Tg) m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurst SD,Sitterding SM,Ji S,Barrett TA

更新日期：1997-04-15 00:00:00

abstract：:A G to T mutation has been observed at the third position of codon 249 of the p53 tumor-suppressor gene in over 50% of the hepatocellular carcinoma cases associated with high exposure to aflatoxin B(1) (AFB(1)). Hypotheses have been put forth that AFB(1), in concert with hepatitis B virus (HBV), may play a role in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smela ME,Hamm ML,Henderson PT,Harris CM,Harris TM,Essigmann JM

更新日期：2002-05-14 00:00:00

abstract：:While the concept of intercellular mechanical communication has been revealed, the mechanistic insights have been poorly evidenced in the context of myofibroblast-fibroblast interaction during fibrosis expansion. Here we report and systematically investigate the mechanical force-mediated myofibroblast-fibroblast cross...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Yu H,Zhao H,Wu Z,Long Y,Zhang J,Yan X,You Z,Zhou L,Xia T,Shi Y,Xiao B,Wang Y,Huang C,Du Y

更新日期：2020-05-19 00:00:00

abstract：:The mammalian hair follicle unit consists of a central follicle and a series of associated structures: sebaceous glands, arrector pili muscles, Merkel cells, and sensory nerve endings. The architecture of this multicellular structure is highly polarized with respect to the body axes. Previous work has implicated Frizz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang H,Nathans J

更新日期：2013-03-05 00:00:00

abstract：:One of the most long-lived models in plant science is the belief that the long-distance transport and ratio of two plant hormones, auxin and cytokinin, at the site of action control major developmental events such as apical dominance. We have used in vivo deuterium labeling and mass spectrometry to investigate the dyn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nordström A,Tarkowski P,Tarkowska D,Norbaek R,Astot C,Dolezal K,Sandberg G

更新日期：2004-05-25 00:00:00

abstract：:Gut microbial composition depends on different dietary habits just as health depends on microbial metabolism, but the association of microbiota with different diets in human populations has not yet been shown. In this work, we compared the fecal microbiota of European children (EU) and that of children from a rural Af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Filippo C,Cavalieri D,Di Paola M,Ramazzotti M,Poullet JB,Massart S,Collini S,Pieraccini G,Lionetti P

更新日期：2010-08-17 00:00:00

abstract：:Recombination between unirradiated chromosomes was induced by UV or x-ray irradiation of haploids followed by a mating with heteroallelic diploids of Saccharomyces cerevisiae. The selected event of intragenic recombination did not involve the participation of the irradiated chromosome and apparently was not caused by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fabre F,Roman H

更新日期：1977-04-01 00:00:00

abstract：:Interphase chromosomes were isolated in good yield from four species of fungi. In no case does the chromatin contain histones such as are characteristic of the chromosomes of other eukaryotic organisms. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leighton TJ,Dill BC,Stock JJ,Phillips C

更新日期：1971-03-01 00:00:00

abstract：:We demonstrate the application of molecular rotational spectroscopy to measure the conformation isomerization rate of vibrationally excited pent-1-en-4-yne (pentenyne). The rotational spectra of single quantum states of pentenyne are acquired by using a combination of IR-Fourier transform microwave double-resonance sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dian BC,Brown GG,Douglass KO,Rees FS,Johns JE,Nair P,Suenram RD,Pate BH

更新日期：2008-09-02 00:00:00

abstract：:Hypertension, a remediable risk factor for stroke, cardiovascular disease, and renal failure, affects 50 million individuals in the United States alone. African Americans (blacks) have a higher incidence and prevalence of hypertension and hypertension-associated target organ damage compared with Caucasian Americans (w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suthanthiran M,Li B,Song JO,Ding R,Sharma VK,Schwartz JE,August P

更新日期：2000-03-28 00:00:00

abstract：:Millions of individuals routinely remain awake for more than 18 h daily, which causes performance decrements. It is unknown if these functional impairments are the result of that extended wakefulness or from the associated shortened sleep durations. We therefore examined changes in objective reaction time performance ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McHill AW,Hull JT,Wang W,Czeisler CA,Klerman EB

更新日期：2018-06-05 00:00:00

abstract：:A temperature-sensitive (ts) mutant, GA 907/7, was isolated after mutagen treatment of avian myeloblastosis virus. When bone marrow cells or secondary yolk sac macrophages were infected with GA 907/7, the expression of transformation was greatly reduced at 41 degrees C. The results of temperature-shift experiments sug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moscovici MG,Moscovici C

更新日期：1983-03-01 00:00:00

abstract：:Transcriptional regulation by nuclear hormone receptors is thought to involve interactions with putative cofactors that may potentiate receptor function. Here we show that human thyroid hormone receptor alpha purified from HeLa cells grown in the presence of thyroid hormone (T3) is associated with a group of distinct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fondell JD,Ge H,Roeder RG

更新日期：1996-08-06 00:00:00

abstract：:The small-component origins of herpes simplex virus 1 DNA synthesis are transcribed late in infection by an RNA with heterogeneous initiation sites approximately 290-360 base pairs from the origins. We report that cellular proteins react with a labeled RNA probe representing the 5' terminus of a subset of this RNA but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roller RJ,McCormick AL,Roizman B

更新日期：1989-09-01 00:00:00

abstract：:A mutant subline of V79 Chinese hamster cells resistant to antimycin A (ANT) was obtained by treatment with ethyl methanesulfonate followed by serial selection in ANT-containing medium. Clonal derivatives of the resistant line are less susceptible than parent cells to growth inhibition by ANT in mass populations and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris M

更新日期：1978-11-01 00:00:00

abstract：:In response to the challenges of cancer chemotherapeutics, including poor physicochemical properties, low tumor targeting, insufficient tumor cell internalization/bioavailability, and side effects, we developed a unique tumor-targeted micellar drug-delivery platform. Using paclitaxel as a model therapeutic, a nanoprep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu L,Wang T,Perche F,Taigind A,Torchilin VP

更新日期：2013-10-15 00:00:00

abstract：:Both stem cells and mast cells express c-kit and proliferate after exposure to c-kit ligand. Mutations in c-kit may enhance or interfere with the ability of c-kit receptor to initiate the intracellular pathways resulting in cell proliferation. These observations suggested to us that mastocytosis might in some patients...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagata H,Worobec AS,Oh CK,Chowdhury BA,Tannenbaum S,Suzuki Y,Metcalfe DD

更新日期：1995-11-07 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a potent inducer of differentiation of osteoblasts both in vivo and in vitro. We examined the action of BMP-2 on expression of a helix-loop-helix-type transcription factor, Id (inhibitor of differentiation), in osteoblast-like cells, as well as in osteoblast-enriched cells and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogata T,Wozney JM,Benezra R,Noda M

更新日期：1993-10-01 00:00:00

abstract：:A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity in the basal ganglia orchestrates the control of coordinated movement in human subjects. Although human mutations in the PDE10A gene manifest in hyperkinetic movement disorders that phenocopy many features of early Huntington's...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tejeda GS,Whiteley EL,Deeb TZ,Bürli RW,Moss SJ,Sheridan E,Brandon NJ,Baillie GS

更新日期：2020-01-07 00:00:00

abstract：:In phylogenetic reconstruction, two types of bacterial tyrosyl-tRNA synthetases (TyrRS) form distinct clades with many bacterial phyla represented in both clades. Very few taxa possess both forms, and maximum likelihood analysis of the distribution of TyrRS types suggests horizontal gene transfer (HGT), rather than an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andam CP,Williams D,Gogarten JP

更新日期：2010-06-08 00:00:00

abstract：:During the periimplantation period of pregnancy, pig blastocysts undergo morphological changes and differentiation requiring secretion and transport of nutrients (histotroph) into the uterine lumen. Of these nutrients, glucose is converted to fructose, an isomer of glucose, by conceptus trophectoderm. Although glucose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim J,Song G,Wu G,Bazer FW

更新日期：2012-06-19 00:00:00

abstract：:Bacteriophytochromes sense light in the near-infrared window, the spectral region where absorption by mammalian tissues is minimal, and their chromophore, biliverdin IXα, is naturally present in animal cells. These properties make bacteriophytochromes particularly attractive for optogenetic applications. However, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryu MH,Kang IH,Nelson MD,Jensen TM,Lyuksyutova AI,Siltberg-Liberles J,Raizen DM,Gomelsky M

更新日期：2014-07-15 00:00:00