Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation.

abstract：:The ATP-dependent enzyme dethiobiotin synthetase from Escherichia coli catalyses the formation of dethiobiotin from CO2 and 7, 8-diaminopelargonic acid. The reaction is initiated by the formation of a carbamate and proceeds through a phosphorylated intermediate, a mixed carbamic phosphoric anhydride. Here, we report t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Käck H,Gibson KJ,Lindqvist Y,Schneider G

更新日期：1998-05-12 00:00:00

abstract：:The classical Euler-Poisson equations describing the motion of a heavy rigid body about a fixed point are generalized to arbitrary Lie algebras as Hamiltonian systems on coad-joint orbits of a tangent bundle Lie group. the N-dimensional Lagrange and symmetric heavy top are thereby shown to be completely integrable. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratiu T

更新日期：1981-03-01 00:00:00

abstract：:A tetramer of the Mu transposase (MuA) pairs the recombination sites, cleaves the donor DNA, and joins these ends to a target DNA by strand transfer. Juxtaposition of the recombination sites is accomplished by the assembly of a stable synaptic complex of MuA protein and Mu DNA. This initial critical step is facilitate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clubb RT,Mizuuchi M,Huth JR,Omichinski JG,Savilahti H,Mizuuchi K,Clore GM,Gronenborn AM

更新日期：1996-02-06 00:00:00

abstract：:DNA hybridization was used to compare representatives of the major groups of marsupials and a eutherian outgroup. Because of the large genetic distances separating marsupial families, trees were calculated from normalized percentages of hybridization; thermal-melting statistics, however, gave identical topologies for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirsch JA,Dickerman AW,Reig OA,Springer MS

更新日期：1991-12-01 00:00:00

abstract：:Hodgkin disease (HD) is characterized by a small number of malignant Hodgkin and Reed-Sternberg (H/RS) cells among a major population of nonmalignant cells. The analysis of H/RS cells has been hampered by their low frequency and fragility. Here, we describe the isolation of viable H/RS cells from HD affected tissues b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Irsch J,Nitsch S,Hansmann ML,Rajewsky K,Tesch H,Diehl V,Jox A,Küppers R,Radbruch A

更新日期：1998-08-18 00:00:00

abstract：:Antibody-coated latex beads (Ab-beads) were attached to Leptospira interrogans serovars illini 3055 and icterohaemorrhagiae SC1157. The movement of the Ab-beads relative to the motion of the cells was observed by direct darkfield microscopy or was recorded on videotape. When the Ab-beads were attached to the front end...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Charon NW,Lawrence CW,O'Brien S

更新日期：1981-11-01 00:00:00

abstract：:The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leadi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliveira JB,Bidère N,Niemela JE,Zheng L,Sakai K,Nix CP,Danner RL,Barb J,Munson PJ,Puck JM,Dale J,Straus SE,Fleisher TA,Lenardo MJ

更新日期：2007-05-22 00:00:00

abstract：:The NOVH protein belongs to the emerging CCN [Connective tissue growth factor (CTGF), Cyr61/Cef10, nephroblastoma overexpressed gene] family of growth regulators sharing a strikingly conserved multimodular organization but exhibiting distinctive functional features. Two members of the family (CYR61 and CTGF) are posit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perbal B,Martinerie C,Sainson R,Werner M,He B,Roizman B

更新日期：1999-02-02 00:00:00

abstract：:Treatment of cultured human tumor cells with the chloroethylnitrosourea antitumor drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) selectively induces transcription and protein synthesis of a subset of the human heat shock or stress-induced genes (HSP90 and HSP70) with little effect on other stress genes or on express...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroes RA,Abravaya K,Seidenfeld J,Morimoto RI

更新日期：1991-06-01 00:00:00

abstract：:The mechanisms that regulate insulin secretion were investigated using capacitance measurements of exocytosis in single beta cells maintained in tissue culture. Exocytosis was stimulated by voltage-clamp depolarizations to activate the voltage-dependent Ca2+ channels that mediate Ca2+ influx into the beta cell. Under ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ammälä C,Eliasson L,Bokvist K,Berggren PO,Honkanen RE,Sjöholm A,Rorsman P

更新日期：1994-05-10 00:00:00

abstract：:Inactivation of the recently identified murMN operon in penicillin-resistant strains of Streptococcus pneumoniae was shown already to cause two major effects: elimination of branched-structured muropeptides from the cell wall and complete loss of penicillin resistance. We now show that cells with inactivated murMN als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filipe SR,Severina E,Tomasz A

更新日期：2002-02-05 00:00:00

abstract：:Night-shift workers are at high risk of drowsiness-related motor vehicle crashes as a result of circadian disruption and sleep restriction. However, the impact of actual night-shift work on measures of drowsiness and driving performance while operating a real motor vehicle remains unknown. Sixteen night-shift workers ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee ML,Howard ME,Horrey WJ,Liang Y,Anderson C,Shreeve MS,O'Brien CS,Czeisler CA

更新日期：2016-01-05 00:00:00

abstract：:Ferredoxin:NADPH oxidoreductase (FNR) is a key enzyme of photosynthetic electron transport required for generation of reduction equivalents. Recently, two proteins were found to be involved in membrane-anchoring of FNR by specific interaction via a conserved Ser/Pro-rich motif: Tic62 and Trol. Our crystallographic stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alte F,Stengel A,Benz JP,Petersen E,Soll J,Groll M,Bölter B

更新日期：2010-11-09 00:00:00

abstract：:A mutant strain deficient in RNase T was isolated and used to study the role of this enzyme in Escherichia coli. Strains lacking as much as 70% of RNase T activity, alone or in combination with the absence of other RNases, display normal growth properties. However, in cca strains, which lack tRNA nucleotidyltransferas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deutscher MP,Marlor CW,Zaniewski R

更新日期：1985-10-01 00:00:00

abstract：:Not having enough of what one needs has long been shown to have detrimental consequences for decision making. Recent work suggests that the experience of insufficient resources can create a "scarcity" mindset; increasing attention toward the scarce resource itself, but at the cost of attention for unrelated aspects. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huijsmans I,Ma I,Micheli L,Civai C,Stallen M,Sanfey AG

更新日期：2019-06-11 00:00:00

abstract：:Phycobilisomes isolated from eight different species of cyanobacteria contain in addition to the light-harvesting phycobiliproteins, a small number of colorless polypeptides with molecular weights higher than those of the chromopolypeptide subunits of the phycobiliproteins. In the phycobilisomes of the species examin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Marsac NT,Cohen-bazire G

更新日期：1977-04-01 00:00:00

abstract：:The effects of selected heme analogues on heme oxygenase activity in tissues and on human and rabbit bone marrow hematopoietic colony growth were examined. Zinc protoporphyrin (ZnPP) and zinc mesoporphyrin (ZnMP), at concentrations ranging between 1 and 20 microM, produced significant inhibition of human and rabbit bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lutton JD,Abraham NG,Drummond GS,Levere RD,Kappas A

更新日期：1997-02-18 00:00:00

abstract：:Sponges (Porifera), the simplest and earliest multicellular organisms, are thought to have evolved from their unicellular ancestors about 1 billion years ago by developing cell-recognition and adhesion mechanisms to discriminate against "non-self." Consequently, they are used as models for investigating recognition ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haseley SR,Vermeer HJ,Kamerling JP,Vliegenthart JF

更新日期：2001-07-31 00:00:00

abstract：:By using titin as a model system, we have demonstrated that fluorescence quenching can be used to study protein folding at the single molecule level. The unfolded titin molecules with multiple dye molecules attached are able to fold to the native state. In the native folded state, the fluorescence from dye molecules i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang X,Ha T,Kim HD,Centner T,Labeit S,Chu S

更新日期：2000-12-19 00:00:00

abstract：:5-enol-Pyruvylshikimate-3-phosphate synthase (EPSP synthase; phosphoenolpyruvate:3-phosphoshikimate 1-carboxyvinyltransferase, EC 2.5.1.19) is an enzyme on the pathway toward the synthesis of aromatic amino acids in plants, fungi, and bacteria and is the target of the broad-spectrum herbicide glyphosate. The three-dim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stallings WC,Abdel-Meguid SS,Lim LW,Shieh HS,Dayringer HE,Leimgruber NK,Stegeman RA,Anderson KS,Sikorski JA,Padgette SR,Kishore GM

更新日期：1991-06-01 00:00:00

abstract：:Transcription in eukaryotic nuclei is carried out by DNA-dependent RNA polymerases I, II, and III. Human RNA polymerase III (Pol III) transcribes small untranslated RNAs that include tRNAs, 5S RNA, U6 RNA, and some microRNAs. Increased Pol III transcription has been reported to accompany or cause cell transformation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haurie V,Durrieu-Gaillard S,Dumay-Odelot H,Da Silva D,Rey C,Prochazkova M,Roeder RG,Besser D,Teichmann M

更新日期：2010-03-02 00:00:00

abstract：:Total nuclear proteins extracted from cell lines representing various stages of differentiation of mouse B lymphocytes were studied by computer analysis of two-dimensional gels. Of the 1438 spots present on the gels, 55 varied significantly in intensity during differentiation. The variations occurred most often in ste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rabilloud T,Pennetier JL,Hibner U,Vincens P,Tarroux P,Rougeon F

更新日期：1991-03-01 00:00:00

abstract：:Assembly of light-harvesting complexes requires synchronization of chlorophyll (Chl) biosynthesis with biogenesis of light-harvesting Chl a/b-binding proteins (LHCPs). The chloroplast signal recognition particle (cpSRP) pathway is responsible for transport of nucleus-encoded LHCPs in the stroma of the plastid and thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang P,Liang FC,Wittmann D,Siegel A,Shan SO,Grimm B

更新日期：2018-04-10 00:00:00

abstract：:The detrimental effects of elevated intensities of mid-UV radiation (UVB), a result of stratospheric ozone depletion during the austral spring, on the primary producers of the Antarctic marine ecosystem have been well documented. Here we report that natural populations of Antarctic zooplankton also sustain significant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malloy KD,Holman MA,Mitchell D,Detrich HW 3rd

更新日期：1997-02-18 00:00:00

abstract：:Previous studies have shown that in mammalian cells proteins of large molecular weight are degraded more rapidly than small ones. Evidence is presented here that half-lives of proteins are also related to their isoelectric points. A double-isotope method was used to compare degradative rates of soluble proteins separa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dice JF,Goldberg AL

更新日期：1975-10-01 00:00:00

abstract：:Sensitization of defensive gill and siphon withdrawal reflexes in Aplysia results, in part, from presynaptic facilitation of transmitter release from mechanoreceptor sensory neurons that innervate the siphon skin and synapse with interneurons and motor neurons. Presynaptic facilitation also can be elicited by applicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hochner B,Klein M,Schacher S,Kandel ER

更新日期：1986-11-01 00:00:00

abstract：:Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity, mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV-G-pseudotyped viral vectors are being developed for gene therapy, vaccination, and viral oncolysis and are extensively used for gene transd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finkelshtein D,Werman A,Novick D,Barak S,Rubinstein M

更新日期：2013-04-30 00:00:00

abstract：:The pathophysiology of systemic inflammation and sepsis involves peripheral organs, causing gastrointestinal, renal, and cardiovascular alterations, as well as the central nervous system (CNS), affecting sleep, temperature regulation, behavior, and neuroendocrine function. The molecular basis of the CNS effects of sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong ML,Bongiorno PB,Rettori V,McCann SM,Licinio J

更新日期：1997-01-07 00:00:00

abstract：:The monoclonal antibodies (mAb) DA6.147, DA6.164, and HIG.48 against human Ia antigens, but not the W6/32 mAb against human class I major histocompatibility complex antigens or the anti-monocyte OKM1 and 63D3 mAb, stimulated monocytes to secrete interleukin 1 (IL-1). IL-1 was measured by its property of promoting the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palacios R

更新日期：1985-10-01 00:00:00

abstract：:Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs). The Escherichia coli class Ia RNR uses a mechanism of radical propagation by which a cysteine in the active site of the RNR large (α2) subunit is transiently oxidized by a stable tyrosyl radical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minnihan EC,Ando N,Brignole EJ,Olshansky L,Chittuluru J,Asturias FJ,Drennan CL,Nocera DG,Stubbe J

更新日期：2013-03-05 00:00:00