Cytoplasmic transfer of resistance to antimycin A in Chinese hamster cells.

abstract：:When a sensory stimulus repeats, neuronal firing rate and functional MRI blood oxygen level-dependent responses typically decline, yet perception and behavioral performance either stay constant or improve. An additional aspect of neuronal activity is neuronal synchronization, which can enhance the impact of neurons on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brunet NM,Bosman CA,Vinck M,Roberts M,Oostenveld R,Desimone R,De Weerd P,Fries P

更新日期：2014-03-04 00:00:00

abstract：:Mutations in the GABA(A) receptor gamma2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed a mouse model harboring a gamma2 subunit point mutation (R43Q) found in a large Australian family. Mice heterozygous fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan HO,Reid CA,Single FN,Davies PJ,Chiu C,Murphy S,Clarke AL,Dibbens L,Krestel H,Mulley JC,Jones MV,Seeburg PH,Sakmann B,Berkovic SF,Sprengel R,Petrou S

更新日期：2007-10-30 00:00:00

abstract：:Hookworms are hematophagous nematodes that infect a wide range of mammalian hosts, including humans. There has been speculation for nearly a century as to the identity of the anticoagulant substances) used by these organisms to subvert host hemostasis. Using molecular cloning, we describe a family of potent small prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stassens P,Bergum PW,Gansemans Y,Jespers L,Laroche Y,Huang S,Maki S,Messens J,Lauwereys M,Cappello M,Hotez PJ,Lasters I,Vlasuk GP

更新日期：1996-03-05 00:00:00

abstract：:Starburst polyamidoamine dendrimers are a new class of synthetic polymers with unique structural and physical characteristics. These polymers were investigated for the ability to bind DNA and enhance DNA transfer and expression in a variety of mammalian cell lines. Twenty different types of polyamidoamine dendrimers w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kukowska-Latallo JF,Bielinska AU,Johnson J,Spindler R,Tomalia DA,Baker JR Jr

更新日期：1996-05-14 00:00:00

abstract：:Elucidation of mechanisms that regulate hematopoietic stem cell self-renewal and differentiation would be facilitated by the identification of defined culture conditions that allow these cells to be amplified. We now demonstrate a significant net increase (3-fold, P < 0.001) in vitro of cells that are individually abl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller CL,Eaves CJ

更新日期：1997-12-09 00:00:00

abstract：:The biological realm has inherited symmetries from the physicochemical realm, but with the increasing complexity at higher phenomenological levels of life, some inherited symmetries are broken while novel symmetries appear. These symmetries are of two types, structural and operational. Biological novelties result from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García-Bellido A

更新日期：1996-12-10 00:00:00

abstract：:The insulin signaling pathway is of pivotal importance in metabolic diseases, such as diabetes, and in cellular processes, such as aging. Insulin activates a tyrosine phosphorylation cascade that branches to create a complex network affecting multiple biological processes. To understand the full spectrum of the tyrosi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krüger M,Kratchmarova I,Blagoev B,Tseng YH,Kahn CR,Mann M

更新日期：2008-02-19 00:00:00

abstract：:Acute and chronic injuries to the heart result in perturbation of intracellular calcium signaling, which leads to pathological cardiac hypertrophy and remodeling. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the transduction of calcium signals in the heart, but the specific isoforms o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backs J,Backs T,Neef S,Kreusser MM,Lehmann LH,Patrick DM,Grueter CE,Qi X,Richardson JA,Hill JA,Katus HA,Bassel-Duby R,Maier LS,Olson EN

更新日期：2009-02-17 00:00:00

abstract：:Klotho is a circulating protein, and Klotho deficiency disturbs endothelial integrity, but the molecular mechanism is not fully clarified. We report that vascular endothelium in Klotho-deficient mice showed hyperpermeability with increased apoptosis and down-regulation of vascular endothelial (VE)-cadherin because of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kusaba T,Okigaki M,Matui A,Murakami M,Ishikawa K,Kimura T,Sonomura K,Adachi Y,Shibuya M,Shirayama T,Tanda S,Hatta T,Sasaki S,Mori Y,Matsubara H

更新日期：2010-11-09 00:00:00

abstract：:Previous work has shown that serotonin induces an increase in membrane K+ conductance in Aplysia neuron R15 and that this response is mediated by cAMP. The present study examines the role of protein phosphorylation in the response to serotonin. A specific inhibitor of cAMP-dependent protein kinase was injected intrace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams WB,Levitan IB

更新日期：1982-06-01 00:00:00

abstract：:Translation initiation of the hepatitis C virus (HCV) RNA genome occurs through an internal ribosome entry site in a cap-independent manner. Here, we have examined the interaction between La antigen and the HCV 5' noncoding region (5'NCR). In this analysis, competitor RNAs derived from HCV 5'NCR carrying deletions and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ali N,Siddiqui A

更新日期：1997-03-18 00:00:00

abstract：:STAT1 is an essential transcription factor for macrophage activation by IFN-gamma and requires phosphorylation of the C-terminal Ser727 for transcriptional activity. In macrophages, Ser727 phosphorylation in response to bacterial lipopolysaccharide (LPS), UV irradiation, or TNF-alpha occurred through a signaling path ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovarik P,Stoiber D,Eyers PA,Menghini R,Neininger A,Gaestel M,Cohen P,Decker T

更新日期：1999-11-23 00:00:00

abstract：:An association of the dopamine receptor D4 (DRD4) gene located on chromosome 11p15.5 and attention deficit/hyperactivity disorder (ADHD) has been demonstrated and replicated by multiple investigators. A specific allele [the 7-repeat of a 48-bp variable number of tandem repeats (VNTR) in exon 3] has been proposed as an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson J,Oosterlaan J,Murias M,Schuck S,Flodman P,Spence MA,Wasdell M,Ding Y,Chi HC,Smith M,Mann M,Carlson C,Kennedy JL,Sergeant JA,Leung P,Zhang YP,Sadeh A,Chen C,Whalen CK,Babb KA,Moyzis R,Posner MI

更新日期：2000-04-25 00:00:00

abstract：:We previously characterized a methionine aminopeptidase (EC 3.4.11.18; Met-AP1; also called peptidase M) in Saccharomyces cerevisiae, which differs from its prokaryotic homologues in that it (i) contains an N-terminal zinc-finger domain and (ii) does not produce lethality when disrupted, although it does slow growth d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Chang YH

更新日期：1995-12-19 00:00:00

abstract：:The introduction of foreign genes into early mouse embryos and embryonic stem (ES) cells is invaluable for the analysis of gene function and regulation in the living animal. The use of vectors derived from retroviruses as gene transfer vehicles in this setting has had limited success because of silencing of transgene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeifer A,Ikawa M,Dayn Y,Verma IM

更新日期：2002-02-19 00:00:00

abstract：:Cell-specific activation of the transcription factor sigma F during sporulation in Bacillus subtilis is controlled by a regulatory pathway involving the proteins SpoIIE, SpoIIAA, and SpoIIAB. SpoIIAB is an antagonist of sigma F, and SpoIIAA, which is capable of overcoming SpoIIAB-mediated inhibition of sigma F, is an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arigoni F,Duncan L,Alper S,Losick R,Stragier P

更新日期：1996-04-16 00:00:00

abstract：:A cofactor needed for the reduction of CDP-4-keto-6-deoxy-D-glucose to CDP-4-keto-3,6-dideoxy D-glucose has been detected and purified. Its spectra in neutral, acid, and basic solutions, its behavior on thin-layer chromatography, and other properties led to its identification as pyridoxamine-5'-phosphate. Moreover, au...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Porque P,Strominger JL

更新日期：1972-06-01 00:00:00

abstract：:We have developed a culture system, simulating in vivo conditions of human immunodeficiency virus type 1 (HIV-1) infection, to evaluate the long-term efficacy of antisense oligonucleotide treatment. Five oligonucleotide phosphorothioates (28-mers), complementary to different regions of HIV-1 RNA, blocked replication o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisziewicz J,Sun D,Klotman M,Agrawal S,Zamecnik P,Gallo R

更新日期：1992-12-01 00:00:00

abstract：:The protein kinase A stimulator cAMP can potentiate the ability of progestins to induce the transactivation function of the human progesterone receptor (hPR). We questioned in the present study whether cAMP could functionally cooperate with the progestin antagonist RU486. In T47D human breast cancer cells, RU486 behav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beck CA,Weigel NL,Moyer ML,Nordeen SK,Edwards DP

更新日期：1993-05-15 00:00:00

abstract：:I describe the self-splicing of an RNA that consists of exon sequences flanked by group II intron sequences. I find that this RNA undergoes accurate splicing in vitro, yielding an excised exon circle. This splicing reaction involves the joining of the 5' splice site at the end of an exon to the 3' splice site at the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarrell KA

更新日期：1993-09-15 00:00:00

abstract：:Overexpression of ErbB-2/Neu has been causally associated with mammary epithelial transformation. Here we report that blockade of the epidermal growth factor receptor (EGFR) kinase with AG-1478 markedly delays breast tumor formation in mouse mammary tumor virus (MMTV)/Neu + MMTV/transforming growth factor alpha bigeni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lenferink AE,Simpson JF,Shawver LK,Coffey RJ,Forbes JT,Arteaga CL

更新日期：2000-08-15 00:00:00

abstract：:Proteolytic removal of the pre-segment from growing nascent chains of pre-human placental lactogen (hPL) occurred during in vitro translation of placental mRNA if crude membranes derived from ascites lysates, dog pancreas, or rat liver rough endoplasmic reticulum were added to the translation mixtures. The cotranslati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strauss AW,Zimmerman M,Boime I,Ashe B,Mumford RA,Alberts AW

更新日期：1979-09-01 00:00:00

abstract：:We have recently shown that p-terphenyl-3,5,3',5'-tetracarboxylic acid adsorbed on graphite self-assembles into a two-dimensional rhombus random tiling. This tiling is close to ideal, displaying long-range correlations punctuated by sparse localized tiling defects. In this article we explore the analogy between dynami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garrahan JP,Stannard A,Blunt MO,Beton PH

更新日期：2009-09-08 00:00:00

abstract：:Alcoholism causes serious neurologic disease that may be due, in part, to the ability of ethanol to interact with neural cell membranes and change neuronal function. Adenosine receptors are membrane-bound proteins that appear to mediate some of the effects of ethanol in the brain. Human lymphocytes also have adenosine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diamond I,Wrubel B,Estrin W,Gordon A

更新日期：1987-03-01 00:00:00

abstract：:Biochemical and genetic studies have implicated alpha-gustducin as a key component in the transduction of both bitter or sweet taste. Yet, alpha-gustducin-null mice are not completely unresponsive to bitter or sweet compounds. To gain insights into how gustducin mediates responses to bitter and sweet compounds, and to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Avila L,Wong GT,Damak S,Margolskee RF

更新日期：2001-07-17 00:00:00

abstract：:Simplified models of the protein-folding process have led to valuable insights into the generic properties of the folding of heteropolymers. On the basis of theoretical arguments, Shakhnovich and Gutin [(1993) Proc. Natl. Acad. Sci. USA 90, 7195-7199] have proposed a specific method to generate folding sequences for o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ebeling M,Nadler W

更新日期：1995-09-12 00:00:00

abstract：:T-cell anergy is a state of T cells that is hyporesponsive to stimulation via the T-cell receptor and costimulatory molecules and is thought to be important for self-tolerance. How T-cell anergy is regulated is still poorly understood. We report here that tuberous sclerosis (TSC)1 is critical for T-cell anergy. Defici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie DL,Wu J,Lou YL,Zhong XP

更新日期：2012-08-28 00:00:00

abstract：:Selective lodgement or homing of transplanted hemopoietic stem cells in the recipient's bone marrow (BM) is a critical step in the establishment of long-term hemopoiesis after BM transplantation. However, despite its biologic and clinical significance, little is understood about the process of homing. In the present s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papayannopoulou T,Craddock C,Nakamoto B,Priestley GV,Wolf NS

更新日期：1995-10-10 00:00:00

abstract：:The MoxR family of AAA+ ATPases is widespread throughout bacteria and archaea but remains poorly characterized. We recently found that the Escherichia coli MoxR protein, RavA (Regulatory ATPase variant A), tightly interacts with the inducible lysine decarboxylase, LdcI/CadA, to form a unique cage-like structure. Here,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Bakkouri M,Gutsche I,Kanjee U,Zhao B,Yu M,Goret G,Schoehn G,Burmeister WP,Houry WA

更新日期：2010-12-28 00:00:00

abstract：:Guanylin and uroguanylin are intestinal peptides that stimulate chloride secretion by activating a common set of receptor-guanylate cyclase signaling molecules located on the mucosal surface of enterocytes. High mucosal acidity, similar to the pH occurring within the fluid microclimate domain at the mucosal surface of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamra FK,Eber SL,Chin DT,Currie MG,Forte LR

更新日期：1997-03-18 00:00:00