Abstract:
:A cofactor needed for the reduction of CDP-4-keto-6-deoxy-D-glucose to CDP-4-keto-3,6-dideoxy D-glucose has been detected and purified. Its spectra in neutral, acid, and basic solutions, its behavior on thin-layer chromatography, and other properties led to its identification as pyridoxamine-5'-phosphate. Moreover, authentic pyridoxamine-5'-phosphate substituted for the purified cofactor with about the same specific activity. Other vitamin B(6) derivatives did not stimulate the reaction, and inhibition was observed with some of them.
journal_name
Proc Natl Acad Sci U S Aauthors
Gonzalez-Porque P,Strominger JLdoi
10.1073/pnas.69.6.1625subject
Has Abstractpub_date
1972-06-01 00:00:00pages
1625-8issue
6eissn
0027-8424issn
1091-6490journal_volume
69pub_type
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