Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells.

abstract：:Antidiuretic hormone (ADH) increases the water permeability of the toad urinary bladder. The increase occurs in the apical plasma membrane of granular cells that line the urinary surface of the bladder and is produced by the insertion of water permeability units that have been identified by freeze-fracture electron mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris HW Jr,Wade JB,Handler JS

更新日期：1988-03-01 00:00:00

abstract：:The growth of a small number of cells from each of two chemically induced BALB/c sarcomas was enhanced when x-irradiated (15,000 rads) cells of the same sarcoma were mixed with the tumor inoculum. This enhancement did not occur if the recipients had been given a total body x-irradiation of 450 rads. Tumor neutralizati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellström KE,Hellström I

更新日期：1978-01-01 00:00:00

abstract：:A three-plasmid system for heterologous expression of 6-deoxyerythronolide B synthase (DEBS) has been developed to facilitate combinatorial biosynthesis of polyketides made by type I modular polyketide synthases (PKSs). The eryA PKS genes encoding the three DEBS subunits were individually cloned into three compatible ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue Q,Ashley G,Hutchinson CR,Santi DV

更新日期：1999-10-12 00:00:00

abstract：:Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon cancer cells cultured as xenografts or under nonadherent conditions in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bersani F,Lee E,Kharchenko PV,Xu AW,Liu M,Xega K,MacKenzie OC,Brannigan BW,Wittner BS,Jung H,Ramaswamy S,Park PJ,Maheswaran S,Ting DT,Haber DA

更新日期：2015-12-08 00:00:00

abstract：:The spleen is the lymphoid organ that induces immune responses toward blood-borne pathogens. Specialized macrophages in the splenic marginal zone are strategically positioned to phagocytose pathogens and cell debris, but are not known to play a role in the activation of T-cell responses. Here we demonstrate that splen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backer R,Schwandt T,Greuter M,Oosting M,Jüngerkes F,Tüting T,Boon L,O'Toole T,Kraal G,Limmer A,den Haan JM

更新日期：2010-01-05 00:00:00

abstract：:Mouse serosal mast cells (SMCs) and Kirsten sarcoma virus-immortalized mast cells store large amounts of mast cell carboxypeptidase A and serine proteases in their secretory granules. Secretory granule proteins from 2.6 x 10(6) purified SMCs were separated by NaDodSO4/PAGE, trans-blotted to poly(vinylidine difluoride)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds DS,Stevens RL,Lane WS,Carr MH,Austen KF,Serafin WE

更新日期：1990-04-01 00:00:00

abstract：:We showed previously that rrn P1 promoters require unusually high concentrations of the initiating nucleoside triphosphates (ATP or GTP, depending on the promoter) for maximal transcription in vitro. We proposed that this requirement for high initiating NTP concentrations contributes to control of the rrn P1 promoters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider DA,Gaal T,Gourse RL

更新日期：2002-06-25 00:00:00

abstract：:Murine Ly-6-encoded molecules play an important role in the antigen-independent activation of lymphocytes. We have described the cloning of a cDNA encoding the protein component of an Ly-6 molecule. Hybridization studies indicated that this cDNA identified multiple DNA fragments on Southern blots. The banding pattern ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LeClair KP,Rabin M,Nesbitt MN,Pravtcheva D,Ruddle FH,Palfree RG,Bothwell A

更新日期：1987-03-01 00:00:00

abstract：:The skeletal muscle sarcoplasmic reticulum (SR) was investigated for the presence of well-known endoplasmic reticulum (ER) markers: the lumenal protein BiP and a group of membrane proteins recognized by an antibody raised against ER membrane vesicles. Western blots of SR fractions revealed the presence of BiP in fast-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volpe P,Villa A,Podini P,Martini A,Nori A,Panzeri MC,Meldolesi J

更新日期：1992-07-01 00:00:00

abstract：:The possibility that glycolate oxidation in unicellular green algae is linked to mitochondrial electron transport, rather than to peroxisomal metabolism as in higher plants and animals, was studied in a mutant of Chlamydomonas reinhardtii (dk97) deficient in cytochrome oxidase. This mutant had normal rates of dark res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Husic DW,Tolbert NE

更新日期：1987-03-01 00:00:00

abstract：:In 2009 we reported that depletion of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis in Blattella germanica. However, the precise regulatory roles of miRNAs in the process have remained elusive. In the present work, we have observed that Dicer-1 depletion results in an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lozano J,Montañez R,Belles X

更新日期：2015-03-24 00:00:00

abstract：:Sugar compartmentation into vacuoles of higher plants is a very important physiological process, providing extra space for transient and long-term sugar storage and contributing to the osmoregulation of cell turgor and shape. Despite the long-standing knowledge of this subcellular sugar partitioning, the proteins resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aluri S,Büttner M

更新日期：2007-02-13 00:00:00

abstract：:Nucleotide sequences that direct transcription of the human 5-lipoxygenase gene have been examined by ligation to the chloramphenicol acetyltransferase gene and determination of chloramphenicol acetyltransferase activity in transfected HeLa and HL-60 cells. Various lengths of 5'-flanking sequences up to 5.9 kilobase p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshiko S,Rådmark O,Samuelsson B

更新日期：1990-12-01 00:00:00

abstract：:Excitotoxicity, resulting from sustained activation of glutamate receptors of the N-methyl-d-aspartate (NMDA) subtype, is considered to play a causative role in the etiology of ischemic stroke and several neurodegenerative diseases. The NMDA receptor is therefore a target for the development of neuroprotective agents....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tai KK,Blondelle SE,Ostresh JM,Houghten RA,Montal M

更新日期：2001-03-13 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00

abstract：:Peptides from the three type I repeats of human endothelial cell thrombospondin, containing the consensus sequence-Trp-Ser-Xaa-Trp-, bind to sulfated glycoconjugates including heparin and sulfatide. The peptides are potent inhibitors for the binding of thrombospondin, laminin, or apolipoprotein E to these ligands. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo NH,Krutzsch HC,Nègre E,Vogel T,Blake DA,Roberts DD

更新日期：1992-04-01 00:00:00

abstract：:To test the hypothesis that periodic signals and chemotaxis direct later morphogenesis in Dictyostelium discoideum, we investigated cell behavior and cell movement in slugs. Trails of neutral red-stained prestalk and anterior-like cells were recorded by high-resolution digital image processing. Neutral red-stained ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siegert F,Weijer CJ

更新日期：1992-07-15 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:The major histocompatibility complex class-I (MHC-I) peptide-loading complex (PLC) is a cornerstone of the human adaptive immune system, being responsible for processing antigens that allow killer T cells to distinguish between healthy and compromised cells. Based on a recent low-resolution cryo-electron microscopy (c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisette O,Schröder GF,Schäfer LV

更新日期：2020-08-25 00:00:00

abstract：:Balanced genetic polymorphism has been proposed as a source from which to infer population history complementary to that of neutral genetic polymorphism, because genetic polymorphism maintained by balancing selection permits inferences about population size over much longer spans of time. However, empirical data for b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richman AD,Kohn JR

更新日期：1999-01-05 00:00:00

abstract：:Binding and uptake of alpha-fetoprotein (AFP) by mouse T-lymphoma YAC-1 cells exhibited the characteristics of receptor-mediated endocytosis. The binding saturation curve obtained by incubating YAC-1 cells at 4 degrees C with 125I-labeled AFP at different concentrations (50 ng/ml to 2.5 mg/ml) showed three saturation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naval J,Villacampa MJ,Goguel AF,Uriel J

更新日期：1985-05-01 00:00:00

abstract：:The lactate racemase enzyme (LarA) of Lactobacillus plantarum harbors a (SCS)Ni(II) pincer complex derived from nicotinic acid. Synthesis of the enzyme-bound cofactor requires LarB, LarC, and LarE, which are widely distributed in microorganisms. The functions of the accessory proteins are unknown, but the LarB C termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desguin B,Soumillion P,Hols P,Hausinger RP

更新日期：2016-05-17 00:00:00

abstract：:We have studied the expression of simian virus 40 (SV40) specific tumor antigen (T-antigen) and viral RNA in SV40-transformed mouse 3T3 cells that are temperature-sensitive for the expression of the transformed phenotype (ts SV3T3). Although transformed by wild-type SV40, ts SV3T3 cells at 32 degrees behave like stand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basilico C,Zouzias D

更新日期：1976-06-01 00:00:00

abstract：:Phonoangiography, the quantitative analysis of sounds produced by blood flow, has been used to investigate local fluid motion in arteries narrowed by atherosclerosis. The sound spectra measured in vivo were found to be identical to those obtained in laboratory investigations of turbulent pipe flow. A theoretical model...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lees RS,Dewey CF Jr

更新日期：1970-10-01 00:00:00

abstract：:Photo-triggered alpha-helix formation of a 16-residue peptide featuring a built-in conformational photoswitch is monitored by time-resolved IR spectroscopy. An experimental approach with 2-ps time resolution and a scanning range up to 30 micros is used to cover all time scales of the peptide dynamics. Experiments are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bredenbeck J,Helbing J,Kumita JR,Woolley GA,Hamm P

更新日期：2005-02-15 00:00:00

abstract：:Physical and gene mapping studies reveal that chloroplast DNA from geranium (Pelargonium hortorum) has sustained a number of extensive duplications and inversions, resulting in a genome arrangement radically unlike that of other plants. At 217 kilobases in size, the circular chromosome is about 50% larger than the typ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palmer JD,Nugent JM,Herbon LA

更新日期：1987-02-01 00:00:00

abstract：:Excitatory amino acid transporters (EAATs) buffer and remove synaptically released L-glutamate and maintain its concentrations below neurotoxic levels. EAATs also mediate a thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability. Here, we demonstrate that modification of a cys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seal RP,Shigeri Y,Eliasof S,Leighton BH,Amara SG

更新日期：2001-12-18 00:00:00

abstract：:The Hippo pathway is an evolutionarily conserved regulator of organ growth and tumorigenesis. In Drosophila, oncogenic RasV12 cooperates with loss-of-cell polarity to promote Hippo pathway-dependent tumor growth. To identify additional factors that modulate this signaling, we performed a genetic screen utilizing the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo X,Sun Y,Azad T,Janse van Rensburg HJ,Luo J,Yang S,Liu P,Lv Z,Zhan M,Lu L,Zhou Y,Ma X,Zhang X,Yang X,Xue L

更新日期：2020-12-01 00:00:00

abstract：:Neuroinflammation is an important contributor to neuronal pathology and death in neurodegenerative diseases and neuronal injury. Therapeutic interventions blocking the activity of the inflammatory kinase IKKβ, a key regulator of neuroinflammatory pathways, is protective in several animal models of neurodegenerative di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochaba J,Fote G,Kachemov M,Thein S,Yeung SY,Lau AL,Hernandez S,Lim RG,Casale M,Neel MJ,Monuki ES,Reidling J,Housman DE,Thompson LM,Steffan JS

更新日期：2019-05-28 00:00:00

abstract：:Somatic copy number variations (CNVs) exist in the brain, but their genesis, prevalence, forms, and biological impact remain unclear, even within experimentally tractable animal models. We combined a transposase-based amplification (TbA) methodology for single-cell whole-genome sequencing with a bioinformatic approach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rohrback S,April C,Kaper F,Rivera RR,Liu CS,Siddoway B,Chun J

更新日期：2018-10-16 00:00:00