当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.

Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain.

Abstract：

:The Mecp2 gene has been shown to be mutated in most cases of human Rett syndrome, and mouse models deleted for the ortholog have been generated. Lineage-specific deletion of the gene indicated that the Rett-like phenotype is caused by Mecp2 deficiency in neurons. Biochemical evidence suggests that Mecp2 acts as a global transcriptional repressor, predicting that mutant mice should have genome-wide transcriptional deregulation. We tested this hypothesis by comparing global gene expression in wild-type and Mecp2 mutant mice. The results of numerous microarray analyses revealed no dramatic changes in transcription even in mice displaying overt disease symptoms, although statistical power analyses of the data indicated that even a small number of relatively subtle changes in transcription would have been detected if present. However, a classifier consisting of a combined small set of genes was able to distinguish between mutant and wild-type samples with high accuracy. This result suggests that Mecp2 deficiency leads to subtle gene expression changes in mutant brains which may be associated with the phenotypic changes observed.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Tudor M,Akbarian S,Chen RZ,Jaenisch R

doi

10.1073/pnas.242566899

keywords:

subject

Has Abstract

pub_date

2002-11-26 00:00:00

pages

15536-41

issue

24

eissn

0027-8424

issn

1091-6490

pii

242566899

journal_volume

99

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase.

    abstract：:In our earlier work we showed that either spermidine or spermine could support the growth of spe2Delta or spe3Delta polyamine-requiring mutants, but it was unclear whether the cells had a specific requirement for either of these amines. In the current work, we demonstrate that spermidine is specifically required for t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1835918100

    authors： Chattopadhyay MK,Tabor CW,Tabor H

    更新日期：2003-11-25 00:00:00

  • Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.

    abstract：:Regulation of irreversible cell lineage commitment depends on a delicate balance between positive and negative regulators, which comprise a sophisticated network of transcription factors. Receptor activator of NF-kappaB ligand (RANKL) stimulates the differentiation of bone-resorbing osteoclasts through the induction o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0912779107

    authors： Nishikawa K,Nakashima T,Hayashi M,Fukunaga T,Kato S,Kodama T,Takahashi S,Calame K,Takayanagi H

    更新日期：2010-02-16 00:00:00

  • Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.

    abstract：:Inhibition of mitochondrial complex I is one of the leading hypotheses for dopaminergic neuron death associated with Parkinson's disease (PD). To test this hypothesis genetically, we used a mouse strain lacking functional Ndufs4, a gene encoding a subunit required for complete assembly and function of complex I. Delet...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0807581105

    authors： Choi WS,Kruse SE,Palmiter RD,Xia Z

    更新日期：2008-09-30 00:00:00

  • Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects.

    abstract：:The essential eukaryotic pre-mRNA splicing factor U2AF (U2 small nuclear ribonucleoprotein auxiliary factor) is required to specify the 3' splice at an early step in spliceosome assembly. U2AF binds site-specifically to the intron polypyrimidine tract and recruits U2 small nuclear ribonucleoprotein to the branch site....

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.19.10333

    authors： Rudner DZ,Kanaar R,Breger KS,Rio DC

    更新日期：1996-09-17 00:00:00

  • Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene.

    abstract：:Sex determination in mammals is governed by antagonistic interactions of two genetic pathways, imbalance in which may lead to disorders/differences of sex development (DSD) in human. Among 46,XX individuals with testicular DSD (TDSD) or ovotesticular DSD (OTDSD), testicular tissue is present in the gonad. Although the...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1921676117

    authors： Eozenou C,Gonen N,Touzon MS,Jorgensen A,Yatsenko SA,Fusee L,Kamel AK,Gellen B,Guercio G,Singh P,Witchel S,Berman AJ,Mainpal R,Totonchi M,Mohseni Meybodi A,Askari M,Merel-Chali T,Bignon-Topalovic J,Migale R,Costanzo

    更新日期：2020-06-16 00:00:00

  • Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans.

    abstract：:Type II platelet-activating factor-acetylhydrolase [PAF-AH (II)] is an N-myristoylated enzyme that contains a lipase/esterase catalytic motif and selectively hydrolyzes the sn-2 acetyl ester of PAF and other short-chain acyl groups attached to phosphoglycerides. However, the physiological role of this enzyme remains t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0405507101

    authors： Inoue T,Sugimoto A,Suzuki Y,Yamamoto M,Tsujimoto M,Inoue K,Aoki J,Arai H

    更新日期：2004-09-07 00:00:00

  • Sequence-specific binding of counterions to B-DNA.

    abstract：:Recent studies by x-ray crystallography, NMR, and molecular simulations have suggested that monovalent counterions can penetrate deeply into the minor groove of B form DNA. Such groove-bound ions potentially could play an important role in AT-tract bending and groove narrowing, thereby modulating DNA function in vivo....

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.2.629

    authors： Denisov VP,Halle B

    更新日期：2000-01-18 00:00:00

  • Identification of a receptor required for the anti-inflammatory activity of IVIG.

    abstract：:The anti-inflammatory activity of intravenous Ig (IVIG) results from a minor population of the pooled IgG molecules that contains terminal alpha2,6-sialic acid linkages on their Fc-linked glycans. These anti-inflammatory properties can be recapitulated with a fully recombinant preparation of appropriately sialylated I...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0810163105

    authors： Anthony RM,Wermeling F,Karlsson MC,Ravetch JV

    更新日期：2008-12-16 00:00:00

  • Behavior of three types of ribovirus-like particles in segregating hamster times mouse somatic hybrids.

    abstract：:An electron microscopic study of somatic hybrids resulting from a cross between hamster melanoma cells harboring R-type particles and mouse fibroblasts harboring intracisternal A-type and (mostly) immature C-type particles was performed. The major findings are: (a) hybrid cells that retain a large fraction of both ham...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.71.11.4575

    authors： Yotsuyanagi Y,Ephrussi B

    更新日期：1974-11-01 00:00:00

  • Purification to homogeneity of an active opioid receptor from rat brain by affinity chromatography.

    abstract：:Active opioid binding proteins were solubilized from rat brain membranes in high yield with sodium deoxycholate in the presence of NaCl. Purification of opioid binding proteins was accomplished by opioid antagonist affinity chromatography. Chromatography using the delta-opioid antagonist N,N-diallyl-Tyr-D-Leu-Gly-Tyr-...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.10.4574

    authors： Loukas S,Mercouris M,Panetsos F,Zioudrou C

    更新日期：1994-05-10 00:00:00

  • Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.

    abstract：:Human IL-10 (hIL-10) modulates critical immune and inflammatory responses by way of interactions with its high- (IL-10R1) and low-affinity (IL-10R2) cell surface receptors. Human cytomegalovirus exploits the IL-10 signaling pathway by expressing a functional viral IL-10 homolog (cmvIL-10), which shares only 27% sequen...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.152147499

    authors： Jones BC,Logsdon NJ,Josephson K,Cook J,Barry PA,Walter MR

    更新日期：2002-07-09 00:00:00

  • Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase.

    abstract：:Destruction of mitotic cyclins by ubiquitin-dependent proteolysis is required for cells to complete mitosis and enter interphase of the next cell cycle. In clam eggs, this process is catalyzed by a cyclin-selective ubiquitin carrier protein, E2-C, and the cyclosome/anaphase promoting complex (APC), a 20S particle cont...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.6.2362

    authors： Townsley FM,Aristarkhov A,Beck S,Hershko A,Ruderman JV

    更新日期：1997-03-18 00:00:00

  • Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

    abstract：:To examine the influence of interferon gamma (IFN-gamma) on tumorigenicity, we established constitutively IFN-gamma-producing cell lines from a malignant mouse neuroblastoma, C1300, by retroviral transfer of a mouse IFN-gamma cDNA. The gene-transferred cells generally showed an enhanced high-level expression of the ma...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.23.9456

    authors： Watanabe Y,Kuribayashi K,Miyatake S,Nishihara K,Nakayama E,Taniyama T,Sakata T

    更新日期：1989-12-01 00:00:00

  • The selection of acceptable protein mutations.

    abstract：:We have determined the general constraints that govern sequence divergence in proteins that retain entirely, or very largely, the same structure and function. To do this we collected data from three different groups of orthologous sequences: those found in humans and mice, in humans and chickens, and in Escherichia co...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0703737104

    authors： Sasidharan R,Chothia C

    更新日期：2007-06-12 00:00:00

  • The Great Recession, genetic sensitivity, and maternal harsh parenting.

    abstract：:Using data from the Fragile Families and Child Wellbeing Study, this study examined the effects of the Great Recession on maternal harsh parenting. We found that changes in macroeconomic conditions, rather than current conditions, affected harsh parenting, that declines in macroeconomic conditions had a stronger impac...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 历史文章,杂志文章

    doi：10.1073/pnas.1312398110

    authors： Lee D,Brooks-Gunn J,McLanahan SS,Notterman D,Garfinkel I

    更新日期：2013-08-20 00:00:00

  • Tracking evolving communities in large linked networks.

    abstract：:We are interested in tracking changes in large-scale data by periodically creating an agglomerative clustering and examining the evolution of clusters (communities) over time. We examine a large real-world data set: the NEC CiteSeer database, a linked network of >250,000 papers. Tracking changes over time requires a c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0307750100

    authors： Hopcroft J,Khan O,Kulis B,Selman B

    更新日期：2004-04-06 00:00:00

  • Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.

    abstract：:In RBL-2H3 rat tumor mast cells, cross-linking the high-affinity IgE receptor Fc epsilon RI causes tyrosine phosphorylation of multiple proteins. These phosphoproteins include phospholipase C gamma 1, the beta and gamma subunits of the Fc epsilon RI, the Src family protein-tyrosine kinase Lyn, and a 72-kDa protein tha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.19.9107

    authors： Hutchcroft JE,Geahlen RL,Deanin GG,Oliver JM

    更新日期：1992-10-01 00:00:00

  • Absence of increase of histidine decarboxylase activity in mast cell-deficient W/W mouse embryos before parturition.

    abstract：:The histidine decarboxylase (L-histidine carboxylase, EC 4.1.1.22) activity of whole W/W mouse embryos, which are devoid of mast cells, remained very low and did not show the rapid increase before birth (17-20 days of gestation) seen in wild-type +/+ embryos. During the same period, the histamine content also remained...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.7.4209

    authors： Watanabe T,Kitamura Y,Maeyama K,Go S,Yamatodani A,Wada H

    更新日期：1981-07-01 00:00:00

  • PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.

    abstract：:Insulin resistance drives the development of type 2 diabetes (T2D). In liver, diacylglycerol (DAG) is a key mediator of lipid-induced insulin resistance. DAG activates protein kinase C ε (PKCε), which phosphorylates and inhibits the insulin receptor. In rats, a 3-day high-fat diet produces hepatic insulin resistance t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1804379115

    authors： Gassaway BM,Petersen MC,Surovtseva YV,Barber KW,Sheetz JB,Aerni HR,Merkel JS,Samuel VT,Shulman GI,Rinehart J

    更新日期：2018-09-18 00:00:00

  • Temperature-sensitive tumorigenicity of cells transformed by a mutant of Moloney sarcoma virus.

    abstract：:Normal rat kidney cells were nonproductively infected either with CP27, a mutant of Moloney sarcoma virus that is temperature-sensitive for maintenance of transformation, or with the parental wild-type virus. The nonproducer cells were inoculated into the tails of athymic nude mice that were subsequently incubated at ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.3.1501

    authors： Klarlund JK,Forchhammer J

    更新日期：1980-03-01 00:00:00

  • Identification of a subunit-specific antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate/kainate receptor channels.

    abstract：:Excitatory synaptic transmission in the mammalian central nervous system is mediated predominantly by glutamate receptor (GluR) channels of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate/kainate (AMPA/KA) receptor type. A major improvement in our understanding of glutamatergic synaptic transmission has been ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.2.605

    authors： Keller BU,Blaschke M,Rivosecchi R,Hollmann M,Heinemann SF,Konnerth A

    更新日期：1993-01-15 00:00:00

  • Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.

    abstract：:Mature peripheral T cells respond to foreign but not to self-antigens. During development in the thymus, deletion of high-affinity self-reactive immature thymocytes contributes to tolerance of mature T cells. However, double-positive thymocytes are positively selected to survive if they respond to self-peptide-MHC com...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1119272109

    authors： Stephen TL,Wilson BS,Laufer TM

    更新日期：2012-05-08 00:00:00

  • Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

    abstract：:siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing effects in mice (ED50 ∼ 0.002 mg/kg), rats (ED50 < 0...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1322937111

    authors： Dong Y,Love KT,Dorkin JR,Sirirungruang S,Zhang Y,Chen D,Bogorad RL,Yin H,Chen Y,Vegas AJ,Alabi CA,Sahay G,Olejnik KT,Wang W,Schroeder A,Lytton-Jean AK,Siegwart DJ,Akinc A,Barnes C,Barros SA,Carioto M,Fitzgerald

    更新日期：2014-03-18 00:00:00

  • A pathogen-inducible endogenous siRNA in plant immunity.

    abstract：:RNA interference, mediated by small interfering RNAs (siRNAs), is a conserved regulatory process that has evolved as an antiviral defense mechanism in plants and animals. It is not known whether host cells also use siRNAs as an antibacterial defense mechanism in eukaryotes. Here, we report the discovery of an endogeno...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0608258103

    authors： Katiyar-Agarwal S,Morgan R,Dahlbeck D,Borsani O,Villegas A Jr,Zhu JK,Staskawicz BJ,Jin H

    更新日期：2006-11-21 00:00:00

  • Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination.

    abstract：:Ig class-switch recombination (CSR) is directed by the long and repetitive switch regions and requires activation-induced cytidine deaminase (AID). One of the conserved switch-region sequence motifs (AGCT) is a preferred site for AID-mediated DNA-cytosine deamination. By using somatic gene targeting and recombinase-me...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1018726108

    authors： Han L,Masani S,Yu K

    更新日期：2011-07-12 00:00:00

  • Alternative splicing, muscle calcium sensitivity, and the modulation of dragonfly flight performance.

    abstract：:Calcium sensitivity of myosin cross-bridge activation in striated muscles commonly varies during ontogeny and in response to alterations in muscle usage, but the consequences for whole-organism physiology are not well known. Here we show that the relative abundances of alternatively spliced transcripts of the calcium ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.26.15304

    authors： Marden JH,Fitzhugh GH,Wolf MR,Arnold KD,Rowan B

    更新日期：1999-12-21 00:00:00

  • AP4 encodes a c-MYC-inducible repressor of p21.

    abstract：:In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. Induction of AP4 was required for c-MYC-mediated cell cycle reentry of anti-estrogen arrested breast cancer ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0801773105

    authors： Jung P,Menssen A,Mayr D,Hermeking H

    更新日期：2008-09-30 00:00:00

  • Screening by negative chemical ionization mass spectrometry for environmental contamination with toxic residues: Application to human urines.

    abstract：:A screening procedure based on solvent extraction with minimal clean up followed by examination with negative chemical ionization mass spectrometry has been developed for organochlorine residues and related compounds with masses greater than 130 daltons. The procedure has been made quantitative for analysis of pentach...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.73.6.1777

    authors： Dougherty RC,Piotrowska K

    更新日期：1976-06-01 00:00:00

  • Oxygen equilibrium and kinetics of isolated subunits from hemoglobin Kansas.

    abstract：:The isolated beta subunit of hemoglobin Kansas has an oxygen affinity that is as low relative to the oxygen affinity of the beta(A) subunit as the affinity of hemoglobin Kansas is low relative to hemoglobin A. Thus the low affinity properties of hemoglobin Kansas are almost completely reflected in the properties of th...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.70.6.1718

    authors： Riggs A,Gibson QH

    更新日期：1973-06-01 00:00:00

  • Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

    abstract：:Protein biosynthesis, the translation of the genetic code into polypeptides, occurs on ribonucleoprotein particles called ribosomes. Although X-ray structures of bacterial ribosomes are available, high-resolution structures of eukaryotic 80S ribosomes are lacking. Using cryoelectron microscopy and single-particle reco...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1009999107

    authors： Armache JP,Jarasch A,Anger AM,Villa E,Becker T,Bhushan S,Jossinet F,Habeck M,Dindar G,Franckenberg S,Marquez V,Mielke T,Thomm M,Berninghausen O,Beatrix B,Söding J,Westhof E,Wilson DN,Beckmann R

    更新日期：2010-11-16 00:00:00