Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.

abstract：:Classical feed-forward inhibition involves an excitation-inhibition sequence that enhances the temporal precision of neuronal responses by narrowing the window for synaptic integration. In the input layer of the cerebellum, feed-forward inhibition is thought to preserve the temporal fidelity of granule cell spikes dur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duguid I,Branco T,Chadderton P,Arlt C,Powell K,Häusser M

更新日期：2015-10-20 00:00:00

abstract：:Historical data provide a baseline against which to judge the significance of recent ecological shifts and guide conservation strategies, especially for species decimated by pre-20th century harvesting. Northern fur seals (NFS; Callorhinus ursinus) are a common pinniped species in archaeological sites from southern Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newsome SD,Etnier MA,Gifford-Gonzalez D,Phillips DL,van Tuinen M,Hadly EA,Costa DP,Kennett DJ,Guilderson TP,Koch PL

更新日期：2007-06-05 00:00:00

abstract：:Repeat proteins have recently been of great interest as potential alternatives to immunoglobulin antibodies due to their unique structural and biophysical features. We here present the development of a binding scaffold based on variable lymphocyte receptors, which are nonimmunoglobulin antibodies composed of Leucine-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SC,Park K,Han J,Lee JJ,Kim HJ,Hong S,Heu W,Kim YJ,Ha JS,Lee SG,Cheong HK,Jeon YH,Kim D,Kim HS

更新日期：2012-02-28 00:00:00

abstract：:Weber's law can be explained either by a compressive scaling of sensory response with stimulus magnitude or by a proportional scaling of response variability. These two mechanisms can be distinguished by asking how quantities are added or subtracted. We trained Rhesus monkeys to associate 26 distinct symbols with 0-25...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livingstone MS,Pettine WW,Srihasam K,Moore B,Morocz IA,Lee D

更新日期：2014-05-06 00:00:00

abstract：:The majority of outer membrane proteins (OMPs) from gram-negative bacteria and many of mitochondria and chloroplasts are β-barrels. Insertion and assembly of these proteins are catalyzed by the Omp85 protein family in a seemingly conserved process. All members of this family exhibit a characteristic N-terminal polypep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommer MS,Daum B,Gross LE,Weis BL,Mirus O,Abram L,Maier UG,Kühlbrandt W,Schleiff E

更新日期：2011-08-16 00:00:00

abstract：:The light-harvesting chlorophyll a/b protein (LHCP) is an integral thylakoid membrane protein. It is made in the cytosol as a precursor (pLHCP), imported into chloroplasts, and subsequently integrated into thylakoids. Integration of pLHCP into thylakoids requires a stromal protein factor that functions in part to main...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuan J,Henry R,Cline K

更新日期：1993-09-15 00:00:00

abstract：:Embryonic stem cells (derived from 129/Ola mice) containing a mutant hypoxanthine phosphoribosyltransferase gene that had been corrected in vitro in a planned manner by homologous recombination were injected into blastocysts obtained from C57BL/6J mice. The injected blastocysts were introduced into pseudopregnant fema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koller BH,Hagemann LJ,Doetschman T,Hagaman JR,Huang S,Williams PJ,First NL,Maeda N,Smithies O

更新日期：1989-11-01 00:00:00

abstract：:The circadian clock is a global regulatory mechanism that controls the expression of 50 to 80% of transcripts in mammals. Some of the genes controlled by the circadian clock are oncogenes or tumor suppressors. Among these Myc has been the focus of several studies which have investigated the effect of clock genes and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Selby CP,Yang Y,Lindsey-Boltz LA,Cao X,Eynullazada K,Sancar A

更新日期：2020-09-01 00:00:00

abstract：:MST1, mammalian STE20-like kinase 1, is a serine/threonine kinase that is cleaved and activated by caspases during apoptosis. MST1 is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. In this study, we show that MST1 contains two functional nuclear export signals (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ura S,Masuyama N,Graves JD,Gotoh Y

更新日期：2001-08-28 00:00:00

abstract：:Oil spills can lead to irreversible environmental degradation and are a potential hazard to human health. We study how onshore oil spills affect neonatal and infant mortality by combining spatial data from the Nigerian Oil Spill Monitor with Demographic and Health Surveys. To identify a causal effect, we compare sibli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruederle A,Hodler R

更新日期：2019-03-19 00:00:00

abstract：:We recently reported that CD3- natural killer (NK) cells express the zeta chain of the T-cell receptor complex (zeta NK) in association with higher molecular weight structures whose expression differs between individual NK cell clones. Because NK cell cytolytic activity is known to be triggered by perturbation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson P,Caligiuri M,O'Brien C,Manley T,Ritz J,Schlossman SF

更新日期：1990-03-01 00:00:00

abstract：:Ubiquitin E3 ligases are crucial for eliminating misfolded proteins before they form cytotoxic aggregates that threaten cell fitness and survival. However, it remains unclear how emerging misfolded proteins in the cytoplasm can be selectively recognized and eliminated by E3 ligases in plants. We found that Misfolded P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim JH,Cho SK,Oh TR,Ryu MY,Yang SW,Kim WT

更新日期：2017-11-14 00:00:00

abstract：:We have shown that 3-nitropropionate, an isoelectronic analogue of succinate, is a suicide inactivator of succinate dehydrogenase [succinate:(acceptor) oxidoreductase, EC 1.3.99.1] as follows. (i) When rat liver mitochondria oxidize succinate in the presence of 3-nitropropionate carbanion, the rate of O(2) consumption...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alston TA,Mela L,Bright HJ

更新日期：1977-09-01 00:00:00

abstract：:The productivity of aquatic ecosystems depends on the supply of limiting nutrients. The invasion of the Laurentian Great Lakes, the world's largest freshwater ecosystem, by dreissenid (zebra and quagga) mussels has dramatically altered the ecology of these lakes. A key open question is how dreissenids affect the cycli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Ianaiev V,Huff A,Zalusky J,Ozersky T,Katsev S

更新日期：2021-02-09 00:00:00

abstract：:The robustness of eight common food web properties is examined with respect to web size. We show that the current controversy concerning the scale dependence or scale invariance of these properties can be resolved by accounting for scaling constraints introduced by webs of very small size. We demonstrate statistically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bersier LF,Sugihara G

更新日期：1997-02-18 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report the identification of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang SW,Liu X,Yepes M,Shepherd KR,Miller GW,Liu Y,Wilson WD,Xiao G,Blanchi B,Sun YE,Ye K

更新日期：2010-02-09 00:00:00

abstract：:Ecosystem restoration aims to restore biodiversity and valuable functions that have been degraded or lost. The Coral Triangle is a hotspot for marine biodiversity held in its coral reefs, seagrass meadows, and mangrove forests, all of which are in global decline. These coastal ecosystems support valuable fisheries and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams SL,Ambo-Rappe R,Sur C,Abbott JM,Limbong SR

更新日期：2017-11-07 00:00:00

abstract：:Evolutionary thinking can be applied to both cultural microevolution and macroevolution. However, much of the current literature focuses on cultural microevolution. In this article, we argue that the growing availability of large cross-cultural datasets facilitates the use of computational methods derived from evoluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray RD,Watts J

更新日期：2017-07-25 00:00:00

abstract：:During response of budding yeast to peptide mating pheromone, the cell becomes markedly polarized and MAPK scaffold protein Ste5 localizes to the resulting projection (shmoo tip). We demonstrated before that this recruitment is essential for sustained MAPK signaling and requires interaction of a pleckstrin homology (P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garrenton LS,Stefan CJ,McMurray MA,Emr SD,Thorner J

更新日期：2010-06-29 00:00:00

abstract：:Programmed cell death (PCD) of mammary alveolar cells during involution commences within hours of the end of suckling. Locally, milk accumulates within alveolar lumens; systemically, levels of lactogenic hormones fall. Four experimental models were used to define the role of local factors as compared with systemic hor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li M,Liu X,Robinson G,Bar-Peled U,Wagner KU,Young WS,Hennighausen L,Furth PA

更新日期：1997-04-01 00:00:00

abstract：:Newly synthesized rat islet proteins have been analyzed by polyacrylamide slab gel electrophoresis and fluorography. A minor component having an apparent molecular weight of 11,100 was identified as preproinsulin by the sensitivity of its synthesis to glucose, the pattern of NH2-terminal leucine residues, and the rapi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patzelt C,Labrecque AD,Duguid JR,Carroll RJ,Keim PS,Heinrikson RL,Steiner DF

更新日期：1978-03-01 00:00:00

abstract：:Unlike other predators that use vision as their primary sensory system, bats compute the three-dimensional (3D) position of flying insects from discrete echo snapshots, which raises questions about the strategies they employ to track and intercept erratically moving prey from interrupted sensory information. Here, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salles A,Diebold CA,Moss CF

更新日期：2020-11-17 00:00:00

abstract：:"Head-to-head" terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. Here, we report the structures of Staphylococcus aureus dehydrosqualene synthase (CrtM) complexe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin FY,Liu CI,Liu YL,Zhang Y,Wang K,Jeng WY,Ko TP,Cao R,Wang AH,Oldfield E

更新日期：2010-12-14 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are a class of cell surface receptors that, upon ligand binding, stimulate a variety of critical cellular functions. The orphan receptor anaplastic lymphoma kinase (ALK) is one of very few RTKs that remain without a firmly established protein ligand. Here we present a novel cytokine, F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reshetnyak AV,Murray PB,Shi X,Mo ES,Mohanty J,Tome F,Bai H,Gunel M,Lax I,Schlessinger J

更新日期：2015-12-29 00:00:00

abstract：:Changes in hippocampal function seem critical for cognitive impairment in Alzheimer's disease (AD). Although there is eventual loss of synapses in both AD and animal models of AD, deficits in spatial memory and inhibition of long-term potentiation (LTP) precede morphological alterations in the models, suggesting earli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vitolo OV,Sant'Angelo A,Costanzo V,Battaglia F,Arancio O,Shelanski M

更新日期：2002-10-01 00:00:00

abstract：:At the neuromuscular junction, two motor neuron-derived signals have been implicated in the regulation of synaptogenesis. Neuregulin-1 is thought to induce transcription of acetylcholine receptor (AChR) genes in subsynaptic muscle nuclei by activating ErbB receptors. Neural agrin aggregates AChRs by activating the rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore C,Leu M,Müller U,Brenner HR

更新日期：2001-12-04 00:00:00

abstract：:Myosin X (MyoX), encoded by Myo10, is a representative member of the MyTH4-FERM domain-containing myosins, and this family of unconventional myosins shares common functions in promoting formation of filopodia/stereocilia structures in many cell types with unknown mechanisms. Here, we present the structure of the MyoX ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Z,Yan J,Lu Q,Pan L,Zhang M

更新日期：2011-03-01 00:00:00

abstract：:Here, we report the isolation and characterization of an endogenous peptide ligand of GPR103 from rat brains. The purified peptide was found to be the 43-residue RF-amide peptide QRFP. We also describe two mouse homologues of human GPR103, termed mouse GPR103A and GPR103B. QRFP binds and activates the human GPR103, as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takayasu S,Sakurai T,Iwasaki S,Teranishi H,Yamanaka A,Williams SC,Iguchi H,Kawasawa YI,Ikeda Y,Sakakibara I,Ohno K,Ioka RX,Murakami S,Dohmae N,Xie J,Suda T,Motoike T,Ohuchi T,Yanagisawa M,Sakai J

更新日期：2006-05-09 00:00:00

abstract：:The regular spacing of somites during vertebrate embryogenesis involves a dynamic gradient of FGF signaling that controls the timing of maturation of cells in the presomitic mesoderm (PSM). How the FGF signal is transduced by PSM cells is unclear. Here, we first show that the FGF gradient is translated into graded act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delfini MC,Dubrulle J,Malapert P,Chal J,Pourquié O

更新日期：2005-08-09 00:00:00

abstract：:Chemical coding in the sympathetic nervous system involves both noradrenergic and, for a minority of neurons, cholinergic neurotransmission. The expression of the cholinergic phenotype in the developing sympathetic nervous system was examined to determine if coding for cholinergic transmission occurs before or after i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer MK,Schütz B,Weihe E,Eiden LE

更新日期：1997-04-15 00:00:00