Induction of multiple signaling loops by MuSK during neuromuscular synapse formation.

abstract：:Previously, we showed using a computational agent-based model that a group of animals moving together can make a collective decision on direction of motion, even if there is a conflict between the directional preferences of two small subgroups of "informed" individuals and the remaining "uninformed" individuals have n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard NE,Shen T,Nabet B,Scardovi L,Couzin ID,Levin SA

更新日期：2012-01-03 00:00:00

abstract：:In the mouse, axons of olfactory sensory neurons (OSNs) that express the same odorant receptor (OR) gene coalesce into one or a few glomeruli in the olfactory bulb. The positions of OR-specific glomeruli are traditionally described as stereotyped. Here, we have assessed quantitatively the positions of OR-specific glom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zapiec B,Mombaerts P

更新日期：2015-10-27 00:00:00

abstract：:Two photochromic activators of the electrogenic membrane of the electroplax of Electrophorus electricus are described. Trans-3,3'-bis[alpha-(trimethylammonium)methyl]azobenzene dibromide (Bis-Q), one of the most potent ever reported, is active at concentrations of less than 10(-7) M. Its cis isomer, which is obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartels E,Wassermann NH,Erlanger BF

更新日期：1971-08-01 00:00:00

abstract：:Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure, but the cellular mechanisms for CaMKII-targeted proteins causing disordered cell membrane excitability and myocardial dysfunction remain uncertain. Failing human cardiomyocytes exhibit increased CaMKII and voltage-gated Ca(2+) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koval OM,Guan X,Wu Y,Joiner ML,Gao Z,Chen B,Grumbach IM,Luczak ED,Colbran RJ,Song LS,Hund TJ,Mohler PJ,Anderson ME

更新日期：2010-03-16 00:00:00

abstract：:The genomic concentrations of certain middle repetitive DNA sequences vary considerably among closely related species of Drosophila. In fact, the chromosomes of D. melanogaster appear to carry approximately 3 times as much middle repetitive DNA as those of the sibling species D. simulans. Although most of the middle r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowsett AP,Young MW

更新日期：1982-08-01 00:00:00

abstract：:Human genetic diversity in southern Europe is higher than in other regions of the continent. This difference has been attributed to postglacial expansions, the demic diffusion of agriculture from the Near East, and gene flow from Africa. Using SNP data from 2,099 individuals in 43 populations, we show that estimates o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Botigué LR,Henn BM,Gravel S,Maples BK,Gignoux CR,Corona E,Atzmon G,Burns E,Ostrer H,Flores C,Bertranpetit J,Comas D,Bustamante CD

更新日期：2013-07-16 00:00:00

abstract：:Zeolite and zeolite-like molecular sieves are being used in a large number of applications such as adsorption and catalysis. Achievement of the long-standing goal of creating a chiral, polycrystalline molecular sieve with bulk enantioenrichment would enable these materials to perform enantioselective functions. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brand SK,Schmidt JE,Deem MW,Daeyaert F,Ma Y,Terasaki O,Orazov M,Davis ME

更新日期：2017-05-16 00:00:00

abstract：:Colon carcinoma is one of the leading causes of death from cancer and is characterized by a heterogenic pool of cells with distinct differentiation patterns. Recently, it was reported that a population of undifferentiated cells from a primary tumor, so-called cancer stem cells (CSC), can reconstitute the original tumo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vermeulen L,Todaro M,de Sousa Mello F,Sprick MR,Kemper K,Perez Alea M,Richel DJ,Stassi G,Medema JP

更新日期：2008-09-09 00:00:00

abstract：:Amphibian eggs and embryos as well as mammalian cells have been reported to contain an activity that unwinds double-stranded RNA. We have now found that adenosine residues have been modified in the RNA products of this unwinding activity. Although the modified RNA remains double-stranded, the modification causes the R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner RW,Smith JE,Cooperman BS,Nishikura K

更新日期：1989-04-01 00:00:00

abstract：:Plasma of normal human individuals was shown to contain an inhibitor of Trypanosoma cruzi neuraminidase (NAase; acylneuraminyl hydrolase, sialidase, EC 3.2.1.18). The inhibitor has been purified to homogeneity by PEG precipitation, CM Affi-Gel Blue Sepharose chromatography, and gel filtration. The purified preparation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prioli RP,Rosenberg I,Pereira ME

更新日期：1987-05-01 00:00:00

abstract：:Regulation of the sterol-synthesizing mevalonate pathway occurs in part through feedback-regulated endoplasmic reticulum degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-R). In yeast, the Hmg2p isozyme of HMG-R is regulated in this manner. We have tested the involvement of ubiquitination in the regulated d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampton RY,Bhakta H

更新日期：1997-11-25 00:00:00

abstract：:Phosphatidylinositol 3,4,5-triphosphate (PIP3) plays a key role in neuronal polarization and axon formation. PIP3-containing vesicles are transported to axon tips by the kinesin KIF13B via an adaptor protein, centaurin α1 (CENTA1). KIF13B interacts with CENTA1 through its forkhead-associated (FHA) domain. We solved th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tong Y,Tempel W,Wang H,Yamada K,Shen L,Senisterra GA,MacKenzie F,Chishti AH,Park HW

更新日期：2010-11-23 00:00:00

abstract：:The TATA box-binding activity of transcription factor IID (TFIID) is autoinhibited by the N-terminal domain of the Drosophila TATA box-binding protein- (TBP) associated factor 230/yeast TBP-associated factor 145 subunit, which binds to the TATA box-binding domain of TBP by mimicking the TATA box structure. Here, we pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotani T,Banno K,Ikura M,Hinnebusch AG,Nakatani Y,Kawaichi M,Kokubo T

更新日期：2000-06-20 00:00:00

abstract：:Destruction of mitotic cyclins by ubiquitin-dependent proteolysis is required for cells to complete mitosis and enter interphase of the next cell cycle. In clam eggs, this process is catalyzed by a cyclin-selective ubiquitin carrier protein, E2-C, and the cyclosome/anaphase promoting complex (APC), a 20S particle cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Townsley FM,Aristarkhov A,Beck S,Hershko A,Ruderman JV

更新日期：1997-03-18 00:00:00

abstract：:Gene expression in higher organisms is thought to be regulated by a complex network of transcription factor binding and chromatin modifications, yet the relative importance of these two factors remains a matter of debate. Here, we show that a computational approach allows surprisingly accurate prediction of histone mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benveniste D,Sonntag HJ,Sanguinetti G,Sproul D

更新日期：2014-09-16 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes malignant and inflammatory diseases in ∼10% of infected people. A typical host has between 10(4) and 10(5) clones of HTLV-1-infected T lymphocytes, each clone distinguished by the genomic integration site of the single-copy HTLV-1 provirus. The HTL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Satou Y,Miyazato P,Ishihara K,Yaguchi H,Melamed A,Miura M,Fukuda A,Nosaka K,Watanabe T,Rowan AG,Nakao M,Bangham CR

更新日期：2016-03-15 00:00:00

abstract：:Renal cell carcinoma (RCC) and normal kidney tissues have been examined from 34 patients with sporadic, nonhereditary RCC. Eighteen of the 21 cytogenetically examined tumors (86%) had a detectable anomaly of chromosome arm 3p distal to band 3p11.2-p13, manifested as a deletion, combined with the nonreciprocal transloc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovacs G,Erlandsson R,Boldog F,Ingvarsson S,Müller-Brechlin R,Klein G,Sümegi J

更新日期：1988-03-01 00:00:00

abstract：:The tissue-specific transcriptional coactivator OCA-B is required for antigen-dependent B cell differentiation events, including germinal center formation. However, the identity of OCA-B target genes involved in this process is unknown. This study has used large-scale cDNA arrays to monitor changes in gene expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim U,Siegel R,Ren X,Gunther CS,Gaasterland T,Roeder RG

更新日期：2003-07-22 00:00:00

abstract：:During an investigation of the role of ions in growth regulation, it was found that ethylene diamine tetraacetate (EDTA) inhibits DNA synthesis about 10-fold in cultures of chick embryo cells, while ethylene glycol bis(beta-amino ethyl ether)-N,N'-tetraacetate has no effect. RNA synthesis is only slightly inhibited by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubin H

更新日期：1972-03-01 00:00:00

abstract：:Glycoprotein Ib is a surface membrane glycoprotein of platelets that functions as a receptor for von Willebrand factor. It is a heterodimer composed of an alpha and a beta chain linked by a disulfide bond(s). A phage lambda gt11 cDNA expression library prepared from mRNA from a human erythroleukemia cell line, HEL, wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez JA,Chung DW,Fujikawa K,Hagen FS,Papayannopoulou T,Roth GJ

更新日期：1987-08-01 00:00:00

abstract：:Elevation of cytosolic free Ca2+ concentration ([Ca2+]i) in excitable cells often acts as a negative feedback signal on firing of action potentials and the associated voltage-gated Ca2+ influx. Increased [Ca2+]i stimulates Ca2+-sensitive K+ channels (IK-Ca), and this, in turn, hyperpolarizes the cell and inhibits Ca2+...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Goor F,Krsmanovic LZ,Catt KJ,Stojilkovic SS

更新日期：1999-03-30 00:00:00

abstract：:During exercise, increased energy demands are met by increased glucose production that occurs simultaneously with the increased glucose uptake. We had previously observed that, during exercise, metabolic clearance rate of glucose (MCR) increases markedly in normal, but only marginally in poorly controlled diabetic dog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles PD,Yamatani K,Lickley HL,Vranic M

更新日期：1991-02-15 00:00:00

abstract：:Despite the importance of Mg(2+) for numerous cellular activities, the mechanisms underlying its import and homeostasis are poorly understood. The CorA family is ubiquitous and is primarily responsible for Mg(2+) transport. However, the key questions-such as, the ion selectivity, the transport pathway, and the gating ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guskov A,Nordin N,Reynaud A,Engman H,Lundbäck AK,Jong AJ,Cornvik T,Phua T,Eshaghi S

更新日期：2012-11-06 00:00:00

abstract：:Biochemical evidence is presented for the disintegration of the lens fiber plasma membrane in human cataracts. The intrinsic membrane proteins are found in both the water-soluble and water-insoluble nonmembrane fractions of the cataract lens but not in the normal tissue. Furthermore, in contrast to the normal lens, no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garner MH,Roy D,Rosenfeld L,Garner WH,Spector A

更新日期：1981-03-01 00:00:00

abstract：:We present a method for designing a funnel-shaped free-energy surface that reproducibly assembles secondary structure elements of proteins into their native conformations from a random extended configuration. Assuming a priori knowledge of secondary structure, our method can design a funnel-shaped surface for folding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fain B,Levitt M

更新日期：2003-09-16 00:00:00

abstract：:Phosducin is a soluble phosphoprotein found in retinal photoreceptor cells and in the pineal gland. It binds to the beta gamma subunits of guanine nucleotide-binding proteins (G proteins) (G beta gamma) and may regulate G-protein function. In this study, the ability of specific regions of phosducin to bind G beta gamm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Wu D,Slepak VZ,Simon MI

更新日期：1995-03-14 00:00:00

abstract：:Muscle plasminogen activators (PAs), such as urokinase-like PA and, to a lesser extent, tissue PA, increase dramatically after denervation induced by axotomy. The PA/plasmin system has also been implicated in degradation of specific components of the muscle fiber basement membrane after local activation of plasminogen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hantaï D,Rao JS,Festoff BW

更新日期：1990-04-01 00:00:00

abstract：:We investigated the effect of actin filament barbed end uncapping on Arp23 complex function both in vivo and in vitro. Arp23 complex redistributes rapidly and uniformly to the lamellar edge of activated wild-type platelets and fibroblasts but clusters in marginal actin filament clumps in gelsolin-null cells. Treatment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falet H,Hoffmeister KM,Neujahr R,Italiano JE Jr,Stossel TP,Southwick FS,Hartwig JH

更新日期：2002-12-24 00:00:00

abstract：:Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a progression that is closely associated with oxidative stress. It has long been speculated that the reactive oxygen species (ROS) level in AD brains is much higher than that in healthy brains. However, evidence from living beings is scarc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Zhang X,Yuan P,Yang J,Xu Y,Grutzendler J,Shao Y,Moore A,Ran C

更新日期：2017-11-21 00:00:00

abstract：:We show here that a cell-wall invertase encoded by the Incw1 gene is regulated at both the transcriptional and posttranscriptional levels by sugars in a heterotrophic cell suspension culture of maize. The Incw1 gene encoded two transcripts: Incw1-S (small) and Incw1-L (large); the size variation was attributable to di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng WH,Taliercio EW,Chourey PS

更新日期：1999-08-31 00:00:00