A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs.

abstract：:Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin accessibility. We previously showed that an agent that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42, ameliorates the deficiency of adult neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benjamin JS,Pilarowski GO,Carosso GA,Zhang L,Huso DL,Goff LA,Vernon HJ,Hansen KD,Bjornsson HT

更新日期：2017-01-03 00:00:00

abstract：:Like protein enzymes, RNA enzymes (ribozymes) provide specific binding sites for their substrates. We now show that equilibrium dissociation constants for complexes between the Tetrahymena ribozyme and its RNA substrates and products can be directly measured by electrophoresis in polyacrylamide gels containing divalen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyle AM,McSwiggen JA,Cech TR

更新日期：1990-11-01 00:00:00

abstract：:Network theory provides a powerful tool for the representation and analysis of complex systems of interacting agents. Here, we investigate the U.S. House of Representatives network of committees and subcommittees, with committees connected according to "interlocks," or common membership. Analysis of this network revea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter MA,Mucha PJ,Newman ME,Warmbrand CM

更新日期：2005-05-17 00:00:00

abstract：:The accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and triggers the unfolded protein response (UPR). Failure to resolve ER stress leads to apoptotic cell death via a yet unclear mechanism. Here, we show that RNF183, a membrane-spanning RING finger protein, localizes to the ER and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Li X,Jia J,Zhang Y,Li J,Zhu Z,Wang H,Tang J,Hu J

更新日期：2018-03-20 00:00:00

abstract：:Social ties are crucial for physical and mental health. However, psychiatric patients frequently encounter social rejection. Moreover, an increased reactivity to social exclusion influences the development, progression, and treatment of various psychiatric disorders. Nevertheless, the neuromodulatory substrates of rej...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preller KH,Pokorny T,Hock A,Kraehenmann R,Stämpfli P,Seifritz E,Scheidegger M,Vollenweider FX

更新日期：2016-05-03 00:00:00

abstract：:The gel filtration behavior, in the presence of detergents, of membrane-bound IgM from normal mouse spleen B lymphocytes was compared to that of secretory IgM from mouse plasma cells. The proteins were labeled either by surface radioiodination or biosynthetically with radioactive amino acids. Cell lysates were fractio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vassalli P,Tedghi R,Lisowska-Bernstein B,Tartakoff A,Jaton JC

更新日期：1979-11-01 00:00:00

abstract：:We have developed a low stringency polymerase chain reaction (LSPCR) to isolate the unknown neighboring region around a known DNA sequence, thus allowing efficient targeted gene walking. The method involves the polymerase chain reaction (PCR) with a single primer under conditions of low stringency for primer annealing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malo MS,Srivastava K,Andresen JM,Chen XN,Korenberg JR,Ingram VM

更新日期：1994-04-12 00:00:00

abstract：:The heterodimeric Elongin BC complex has been shown to interact in vitro and in cells with a conserved BC-box motif found in an increasing number of proteins including RNA polymerase II elongation factor Elongin A, suppressor of cytokine signaling (SOCS)-box proteins, and the von Hippel-Lindau tumor suppressor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brower CS,Sato S,Tomomori-Sato C,Kamura T,Pause A,Stearman R,Klausner RD,Malik S,Lane WS,Sorokina I,Roeder RG,Conaway JW,Conaway RC

更新日期：2002-08-06 00:00:00

abstract：:The transformation of new experiences into lasting memories is thought to be mediated by postencoding reactivation or the reexpression of activity patterns that characterize prior encoding experiences during subsequent offline periods. Although hippocampal reactivation has been well-described in the rodent, evidence f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tambini A,Davachi L

更新日期：2013-11-26 00:00:00

abstract：:Ribosomal signatures, idiosyncrasies in the ribosomal RNA (rRNA) and/or proteins, are characteristic of the individual domains of life. As such, insight into the early evolution of the domains can be gained from a comparative analysis of their respective signatures in the translational apparatus. In this work, we iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts E,Sethi A,Montoya J,Woese CR,Luthey-Schulten Z

更新日期：2008-09-16 00:00:00

abstract：:Let t --> gamma(t) be a homogeneous curve in R(n). For suitable f, define [unk](f)(x) = sup(h > 0)|(1/h) [unk](0) (h)f(x - gamma(t)) dt|. Then parallel[unk](f) parallel(p)

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein EM

更新日期：1976-07-01 00:00:00

abstract：:Two groups of mutant clones were isolated from YI adrenocortical tumor cells. One group, Y1(Kin), exhibited altered cytosolic cyclic AMP-dependent protein kinase activity; the second group, Y1(Cyc), exhibited diminished corticotropin-responsive adenylate cyclase activity. Steroidogenic responses to corticotropin and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rae PA,Gutmann NS,Tsao J,Schimmer BP

更新日期：1979-04-01 00:00:00

abstract：:Assembly of light-harvesting complexes requires synchronization of chlorophyll (Chl) biosynthesis with biogenesis of light-harvesting Chl a/b-binding proteins (LHCPs). The chloroplast signal recognition particle (cpSRP) pathway is responsible for transport of nucleus-encoded LHCPs in the stroma of the plastid and thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang P,Liang FC,Wittmann D,Siegel A,Shan SO,Grimm B

更新日期：2018-04-10 00:00:00

abstract：:The anticonvulsants phenytoin and carbamazepine interact allosterically with the batrachotoxin binding site of sodium channels. In the present study, we demonstrate an autoradiographic technique to localize the batrachotoxin binding site on sodium channels in rat brain using [3H]batrachotoxinin-A 20-alpha-benzoate (BT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Worley PF,Baraban JM

更新日期：1987-05-01 00:00:00

abstract：:Specific binding properties of the tritium-labeled delta opiate receptor agonist [3H][2-D-penicillamine, 5-D-penicillamine]enkephalin [( 3H][D-Pen2, D-Pen5]enkephalin) were characterized in the rat brain and in a mouse neuroblastoma-rat glioma hybrid cell line (NG 108-15). Saturation isotherms of [3H][D-Pen2, D-Pen5]e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama K,Gee KW,Mosberg HI,Hruby VJ,Yamamura HI

更新日期：1985-04-01 00:00:00

abstract：:Cerebral arteriovenous malformations (AVMs) are common vascular malformations, which may result in hemorrhagic strokes and neurological deficits. Bone morphogenetic protein (BMP) and Notch signaling are both involved in the development of cerebral AVMs, but the cross-talk between the two signaling pathways is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Yao J,Radparvar M,Blazquez-Medela AM,Guihard PJ,Jumabay M,Boström KI

更新日期：2013-11-19 00:00:00

abstract：:The protooncogene src encodes two proteins, designated pp60c-src+ and pp60c-src.pp60c-src+ is expressed only in neurons, whereas pp60c-src is expressed in neuronal and nonneuronal cells. pp60c-src+ differs from pp60c-src in that it contains an insert of 6 amino acids. To study the evolutionary conservation of the 6-am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang XM,Martinez R,Le Beau J,Wiestler O,Walter G

更新日期：1989-06-01 00:00:00

abstract：:The mechanism of contrast enhancement of tumors using magnetic resonance imaging was investigated in MCF7 human breast cancer implanted in nude mice. Dynamic contrast-enhanced images recorded at high spatial resolution were analyzed by an image analysis method based on a physiological model, which included the blood c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furman-Haran E,Margalit R,Grobgeld D,Degani H

更新日期：1996-06-25 00:00:00

abstract：:Metagenomics is expanding our knowledge of the gene content, functional significance, and genetic variability in natural microbial communities. Still, there exists limited information concerning the regulation and dynamics of genes in the environment. We report here global analysis of expressed genes in a naturally oc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frias-Lopez J,Shi Y,Tyson GW,Coleman ML,Schuster SC,Chisholm SW,Delong EF

更新日期：2008-03-11 00:00:00

abstract：:Despite the widespread use of silicon in modern technology, its peculiar thermal expansion is not well understood. Adapting harmonic phonons to the specific volume at temperature, the quasiharmonic approximation, has become accepted for simulating the thermal expansion, but has given ambiguous interpretations for micr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DS,Hellman O,Herriman J,Smith HL,Lin JYY,Shulumba N,Niedziela JL,Li CW,Abernathy DL,Fultz B

更新日期：2018-02-27 00:00:00

abstract：:The v-jun oncogene encodes a nuclear DNA binding protein that functions as a transcription factor and is part of the activator protein 1 complex. Oncogenic transformation by v-jun is thought to be mediated by the aberrant expression of specific target genes. To identify such Jun-regulated genes and to explore the mech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kruse U,Iacovoni JS,Goller ME,Vogt PK

更新日期：1997-11-11 00:00:00

abstract：:With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pereira AC,Huddleston DE,Brickman AM,Sosunov AA,Hen R,McKhann GM,Sloan R,Gage FH,Brown TR,Small SA

更新日期：2007-03-27 00:00:00

abstract：:The phosphorylation of diacylglycerol (DG), a reaction catalyzed by DG kinase, may be critical in the termination of effector-induced signals mediated by protein kinase C. Synapsin I is a principal target of intracellular protein kinases and is thought to be involved in the release of neurotransmitter from axon termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn DW,Besterman JM

更新日期：1991-07-15 00:00:00

abstract：:We hypothesized that a substantial portion of the mutagenic alterations produced in the basal layer of human skin by sunlight are induced by wavelengths in the UVA range. Using laser capture microdissection we examined separately basal and suprabasal keratinocytes from human skin squamous cell carcinomas and premalign...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agar NS,Halliday GM,Barnetson RS,Ananthaswamy HN,Wheeler M,Jones AM

更新日期：2004-04-06 00:00:00

abstract：:The structure of respiratory cytochrome c551 of Pseudomonas aeruginosa, with 82 amino acids, has been solved by x-ray analysis and refined to a crystallographic R factor of 16.2%. It has the same basic folding pattern and hydrophobic heme environment as cytochromes c, c2, and c550, except for a large deletion at the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Almassy RJ,Dickerson RE

更新日期：1978-06-01 00:00:00

abstract：:Ribonuclease H (EC 3.1.4.34) has been used to remove selectively much of the 3'-terminal poly(adenylic acid) [poly(A)] from poliovirus RNA by treating the RNA with the enzyme in the presence of poly(dT). Over 80% of the poly(A) could be removed and the residuum was found as oligo(A) stretches attached to many or all o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spector DH,Baltimore D

更新日期：1974-08-01 00:00:00

abstract：:Glycosylation is one of the most common posttranslational modifications to occur in protein biosynthesis, yet its effect on the thermodynamics and kinetics of proteins is poorly understood. A minimalist model based on the native protein topology, in which each amino acid and sugar ring was represented by a single bead...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shental-Bechor D,Levy Y

更新日期：2008-06-17 00:00:00

abstract：:To reduce greenhouse gas emissions from deforestation, Indonesia instituted a nationwide moratorium on new license areas ("concessions") for oil palm plantations, timber plantations, and logging activity on primary forests and peat lands after May 2011. Here we indirectly evaluate the effectiveness of this policy usin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busch J,Ferretti-Gallon K,Engelmann J,Wright M,Austin KG,Stolle F,Turubanova S,Potapov PV,Margono B,Hansen MC,Baccini A

更新日期：2015-02-03 00:00:00

abstract：:The global configuration of individual, surface-adsorbed molecules of the giant muscle protein titin, labeled with rhodamine conjugates, was followed with confocal microscopy. Fluorescence-emission intensity was reduced because of self-quenching caused by the close spacing between rhodamine dye molecules that formed d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grama L,Somogyi B,Kellermayer MS

更新日期：2001-12-04 00:00:00

abstract：:A crucial step in recent theories of human origins is the emergence of strong pair-bonding between males and females accompanied by a dramatic reduction in the male-to-male conflict over mating and an increased investment in offspring. How such a transition from promiscuity to pair-bonding could be achieved is puzzlin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gavrilets S

更新日期：2012-06-19 00:00:00