Abstract:
:Two groups of mutant clones were isolated from YI adrenocortical tumor cells. One group, Y1(Kin), exhibited altered cytosolic cyclic AMP-dependent protein kinase activity; the second group, Y1(Cyc), exhibited diminished corticotropin-responsive adenylate cyclase activity. Steroidogenic responses to corticotropin and cyclic nucleotides closely paralleled cyclic AMP-dependent protein kinase activity in the Y1(Kin) mutants. In Y1(Cyc) mutants, corticotropin had little effect on steroidogenesis, whereas cyclic nucleotides were fully active. These data imply that adenylate cyclase and cyclic AMP-dependent protein kinase are obligatory components of the corticotropin-stimulated steroidogenic pathway.
journal_name
Proc Natl Acad Sci U S Aauthors
Rae PA,Gutmann NS,Tsao J,Schimmer BPdoi
10.1073/pnas.76.4.1896subject
Has Abstractpub_date
1979-04-01 00:00:00pages
1896-900issue
4eissn
0027-8424issn
1091-6490journal_volume
76pub_type
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