The amphisbaenian ear: Blanus cinereus and Diplometopon zarudnyi.

abstract：:Questions that still surround the origin and early dispersals of maize (Zea mays L.) result in large part from the absence of information on its early history from the Balsas River Valley of tropical southwestern Mexico, where its wild ancestor is native. We report starch grain and phytolith data from the Xihuatoxtla ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piperno DR,Ranere AJ,Holst I,Iriarte J,Dickau R

更新日期：2009-03-31 00:00:00

abstract：:We examined the MLL genomic translocation breakpoint in acute myeloid leukemia of infant twins. Southern blot analysis in both cases showed two identical MLL gene rearrangements indicating chromosomal translocation. The rearrangements were detectable in the second twin before signs of clinical disease and the intensit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Megonigal MD,Rappaport EF,Jones DH,Williams TM,Lovett BD,Kelly KM,Lerou PH,Moulton T,Budarf ML,Felix CA

更新日期：1998-05-26 00:00:00

abstract：:The electrical block to fertilization of sea urchin eggs can be overcome by very brief periods of inside-negative egg membrane potential. Lytechinus pictus eggs whose membrane potentials have been clamped at +15 mV cannot be fertilized. If the membrane potential is repolarized to inside-negative voltages for a brief i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen SS,Steinhardt RA

更新日期：1984-03-01 00:00:00

abstract：:A protein fraction from B. subtilis infected with phage SP01 (fraction LGG) stimulates the activity of RNA polymerase (EC 2.7.7.6; nucleosidetriphosphate:RNA nucleotidyltransferase) core from uninfected bacteria. Fraction LGG contains a protein (P-28, molecular weight 28,000) that is labeled after phage infection and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffy JJ,Petrusek RL,Geiduschek EP

更新日期：1975-06-01 00:00:00

abstract：:The completion of the human genome project and the development of high-throughput approaches herald a dramatic acceleration in the pace of biological research. One of the most compelling next steps will be learning the functional roles of all proteins. Achievement of this goal depends in part on the rapid expression a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braun P,Hu Y,Shen B,Halleck A,Koundinya M,Harlow E,LaBaer J

更新日期：2002-03-05 00:00:00

abstract：:Mammalian homologues of Drosophila Trp form plasma membrane channels that mediate Ca(2+) influx in response to activation of phospholipase C and internal Ca(2+) store depletion. Previous studies showed that human Trp3 is activated by inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) and identified interacting d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Z,Tang J,Tikunova S,Johnson JD,Chen Z,Qin N,Dietrich A,Stefani E,Birnbaumer L,Zhu MX

更新日期：2001-03-13 00:00:00

abstract：:Alzheimer's disease (AD) and other neurodegenerative disorders are associated with the cytoplasmic aggregation of microtubule-associated protein tau. Recent evidence supports transcellular transfer of tau misfolding (seeding) as the mechanism of spread within an affected brain, a process reminiscent of viral infection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McEwan WA,Falcon B,Vaysburd M,Clift D,Oblak AL,Ghetti B,Goedert M,James LC

更新日期：2017-01-17 00:00:00

abstract：:HetR is an essential regulator of heterocyst development in cyanobacteria. Many mutations in HetR render Anabaena incapable of nitrogen fixation. The protein binds to a DNA palindrome upstream of hetP and other genes. We have determined the crystal structures of HetR complexed with palindromic DNA targets, 21, 23, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim Y,Ye Z,Joachimiak G,Videau P,Young J,Hurd K,Callahan SM,Gornicki P,Zhao J,Haselkorn R,Joachimiak A

更新日期：2013-05-07 00:00:00

abstract：:We lack a clear understanding of the enzootic maintenance of the bacterium (Yersinia pestis) that causes plague and the sporadic epizootics that occur in its natural rodent hosts. A key to elucidating these epidemiological dynamics is determining the dominant transmission routes of plague. Plague can be acquired from ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Webb CT,Brooks CP,Gage KL,Antolin MF

更新日期：2006-04-18 00:00:00

abstract：:Grasslands cover more than 20% of the Earth's terrestrial surface, and their rise to dominance is one of the most dramatic events of biome evolution in Earth history. Grasses possess two main photosynthetic pathways: the C(3) pathway that is typical of most plants and a specialized C(4) pathway that minimizes photores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards EJ,Smith SA

更新日期：2010-02-09 00:00:00

abstract：:Rapid development of genetic variability may contribute to the pathogenicity of lentiviruses as it may allow escape from immune surveillance and/or from suppression of virus replication. Although apathogenic in African green monkeys, simian immunodeficiency virus isolated from African green monkeys is shown to display...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baier M,Dittmar MT,Cichutek K,Kurth R

更新日期：1991-09-15 00:00:00

abstract：:Alterations in the activity/levels of the extralarge G protein α-subunit (XLαs) are implicated in various human disorders, such as perinatal growth retardation. Encoded by GNAS, XLαs is partly identical to the α-subunit of the stimulatory G protein (Gsα), but the cellular actions of XLαs remain poorly defined. Followi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He Q,Bouley R,Liu Z,Wein MN,Zhu Y,Spatz JM,Wang CY,Divieti Pajevic P,Plagge A,Babitt JL,Bastepe M

更新日期：2017-11-07 00:00:00

abstract：:In this study we examine how the introduction of a reference lottery with nonrandom outcomes alters the way in which choices among pairs of lotteries are made, even if it does not alter the choices. We use different domains (some of the lotteries produce gains, other losses) and different contexts (one member of the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickhaut J,McCabe K,Nagode JC,Rustichini A,Smith K,Pardo JV

更新日期：2003-03-18 00:00:00

abstract：:Small molecules that specifically bind with high affinity to any designated DNA sequence in the human genome would be useful tools in molecular biology and potentially in human medicine. Simple rules have been developed to rationally alter the sequence specificity of minor groove-binding polyamides containing N-methyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho J,Parks ME,Dervan PB

更新日期：1995-10-24 00:00:00

abstract：:In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous cellular membranes in a transporter-mediated manner. However, the protein transporters involved in the final excretion step are poorly understood. Here, we show th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Otsuka M,Matsumoto T,Morimoto R,Arioka S,Omote H,Moriyama Y

更新日期：2005-12-13 00:00:00

abstract：:Staphylococcus aureus forms biofilms on indwelling medical devices using a variety of cell-surface proteins. There is growing evidence that specific homophilic interactions between these proteins represent an important mechanism of cell accumulation during biofilm formation, but the underlying molecular mechanisms are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feuillie C,Formosa-Dague C,Hays LM,Vervaeck O,Derclaye S,Brennan MP,Foster TJ,Geoghegan JA,Dufrêne YF

更新日期：2017-04-04 00:00:00

abstract：:Xenopus laevis tadpole tails contain fast muscle fibers oriented in chevrons and two pairs of slow muscle "cords" along the length of the tail. When tail resorption is inhibited by a number of different treatments, fast muscle but not the slow cord muscle still is lost, demonstrating that the fast tail muscle is a dir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das B,Schreiber AM,Huang H,Brown DD

更新日期：2002-09-17 00:00:00

abstract：:Hydrothermal vents are a well-known source of energy that powers chemosynthesis in the deep sea. Recent work suggests that microbial chemosynthesis is also surprisingly pervasive throughout the dark oceans, serving as a significant CO(2) sink even at sites far removed from vents. Ammonia and sulfur have been identifie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anantharaman K,Breier JA,Sheik CS,Dick GJ

更新日期：2013-01-02 00:00:00

abstract：:Transcriptional regulation of gene expression is a major mechanism used by plants to confer phenotypic plasticity, and yet compared with other eukaryotes or bacteria, little is known about the design principles. We generated an extensive catalog of nascent and steady-state transcripts in Arabidopsis thaliana seedlings...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hetzel J,Duttke SH,Benner C,Chory J

更新日期：2016-10-25 00:00:00

abstract：:Five patients with advanced breast cancer were treated with pooled dialyzable transfer factor from healthy adult donors. The period of treatment ranged from 21 to 310 days, the total dose from 20 to 257 ml. Transfer factor did not elicit inflammatory or hypersensitivity reactions or detectable formation of antibody to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oettgen HF,Old LJ,Farrow JH,Valentine FT,Lawrence HS,Thomas L

更新日期：1974-06-01 00:00:00

abstract：:Splenic cells from one BALB/c mouse and one C57/BL mouse, immunized with purified rat liver glucocorticoid receptor (GR), were fused with the mouse myeloma cell line Sp 2/0-Ag 14. Screening for production of anti-GR-antibodies by the hybridomas was carried out with an enzyme-linked immunosorbent assay, using partially...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okret S,Wikström AC,Wrange O,Andersson B,Gustafsson JA

更新日期：1984-03-01 00:00:00

abstract：:Progesterone is involved in the development and progression of breast cancers, and progesterone receptors (PR) are important markers of hormone dependence and disease prognosis. We have used a human PR cDNA probe, genomic DNA blotting of a series of Chinese hamster-human cell hybrids, and in situ hybridization to map ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Law ML,Kao FT,Wei Q,Hartz JA,Greene GL,Zarucki-Schulz T,Conneely OM,Jones C,Puck TT,O'Malley BW

更新日期：1987-05-01 00:00:00

abstract：:Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibility to colorectal cancer tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fearnhead NS,Wilding JL,Winney B,Tonks S,Bartlett S,Bicknell DC,Tomlinson IP,Mortensen NJ,Bodmer WF

更新日期：2004-11-09 00:00:00

abstract：:A family of proteins involved in cell cycle progression, DNA recombination, and the detection of DNA damage has been recently identified. One of the members of this family, human ATM, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged DNA. Oth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cimprich KA,Shin TB,Keith CT,Schreiber SL

更新日期：1996-04-02 00:00:00

abstract：:A number of studies have noted that nucleotide substitution rates at the chloroplast-encoded rbcL locus violate the molecular clock principle. Substitution rate variation at this plastid gene is particularly pronounced between palms and grasses; for example, a previous study estimated that substitution rates in rbcL s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaut BS,Morton BR,McCaig BC,Clegg MT

更新日期：1996-09-17 00:00:00

abstract：:The human tumor necrosis factor alpha (TNF-alpha) gene encodes a cytokine whose activities have been implicated in many immunopathological processes, including the activation and differentiation of lymphocytes. Originally identified as a monocyte factor, our studies and those of others have demonstrated that B and T l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldfeld AE,Flemington EK,Boussiotis VA,Theodos CM,Titus RG,Strominger JL,Speck SH

更新日期：1992-12-15 00:00:00

abstract：:Fumarase C was strongly induced by paraquat in a parental strain of Escherichia coli but was not induced in a strain lacking the soxRS response. Moreover, a strain that constitutively expresses the soxRS regulon contained more fumarase C than did the parental strain. The Mn-containing superoxide dismutase and glucose-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liochev SI,Fridovich I

更新日期：1992-07-01 00:00:00

abstract：:A new class of Escherichia coli mutants, referred to as grn, has been isolated by localized mutagenesis. These mutations affect the sigma subunit of DNA-dependent RNA polymerase (ribonucleoside 5'-triphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) by abolishing the expression of the lambda N gene, and they are close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,Kurihara T,Saito H,Uchida H

更新日期：1979-09-01 00:00:00

abstract：:The nuclear exosome-targeting (NEXT) complex functions as an RNA exosome cofactor and is involved in surveillance and turnover of aberrant transcripts and noncoding RNAs. NEXT is a ternary complex composed of the RNA-binding protein RBM7, the scaffold zinc-knuckle protein ZCCHC8, and the helicase MTR4. While RNA inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puno MR,Lima CD

更新日期：2018-06-12 00:00:00

abstract：:Replication of the murine leukemia viruses is strongly suppressed in mouse embryonic stem (ES) cells. Proviral DNAs are formed normally but are then silenced by a large complex bound to DNA by the ES cell-specific zinc-finger protein ZFP809. We show here that ZFP809 expression is not regulated by transcription but rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Goff SP

更新日期：2017-02-07 00:00:00