Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.

abstract：:Filamentous actin (F-actin) cytoskeletal remodeling is critical for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells, and its dysregulation causes type 2 diabetes. The adaptor protein APPL1 promotes first-phase GSIS by up-regulating soluble N-ethylmaleimide-sensitive factor attachment protein receptor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang B,Lin H,Li X,Lu W,Kim JB,Xu A,Cheng KKY

更新日期：2020-11-10 00:00:00

abstract：:Cyanogen bromide fragments were isolated from the heavy chains of three human IgG myeloma proteins of the V(H)III subgroup, sequenced by an automated method, and localized to the variable region. Inspection of these sequences, together with corresponding stretches from both human and animal proteins (studied in other ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kehoe JM,Capra JD

更新日期：1971-09-01 00:00:00

abstract：:Quantitative studies of protein abundance rarely span more than a small number of experimental conditions and replicates. In contrast, quantitative studies of transcript abundance often span hundreds of experimental conditions and replicates. This situation exists, in part, because extracting quantitative data from la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan Z,Bloom JS,Garcia BA,Singh M,Kruglyak L

更新日期：2009-09-15 00:00:00

abstract：:The ecological niche is a key concept for elucidating patterns of species distributions and developing strategies for conserving biodiversity. However, recent times are seeing a widespread debate whether species niches are conserved across space and time (niche conservatism hypothesis). Biological invasions represent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Wolter C,Xian W,Jeschke JM

更新日期：2020-09-22 00:00:00

abstract：:Although in decline after successful anti-HIV therapy, B-cell lymphomas are still elevated in HIV-1-seropositive (HIV+) persons, and the mechanisms are obscure. The HIV-1 matrix protein p17 persists in germinal centers long after HIV-1 drug suppression, and some p17 variants (vp17s) activate Akt signaling and promote ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dolcetti R,Giagulli C,He W,Selleri M,Caccuri F,Eyzaguirre LM,Mazzuca P,Corbellini S,Campilongo F,Marsico S,Giombini E,Muraro E,Rozera G,De Paoli P,Carbone A,Capobianchi MR,Ippolito G,Fiorentini S,Blattner WA,Lu W,

更新日期：2015-11-17 00:00:00

abstract：:The increasing frequency of antibiotic resistance in hospital-acquired infections is a major public health concern that has both biological and economic causes. Here we develop conceptual mathematical models that couple the economic incentives and population biology of hospital infection control (HIC). We show that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DL,Levin SA,Laxminarayan R

更新日期：2005-02-22 00:00:00

abstract：:Mechanisms by which macrophages discriminate between "mature-self" and "senescent-self" were investigated using the human red blood cell (RBC) system as a model. Conditions simulating those encountered in situ were adhered to as closely as possible by using short term culture techniques and incubating with autologous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM

更新日期：1975-09-01 00:00:00

abstract：:Endothelial cells (ECs) line the mammalian vascular system and respond to the hemodynamic stimulus of fluid shear stress, the frictional force produced by blood flow. When ECs are exposed to shear stress, one of the fastest responses is an increase of K(+) conductance, which suggests that ion channels are involved in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoger JH,Ilyin VI,Forsyth S,Hoger A

更新日期：2002-05-28 00:00:00

abstract：:We have isolated lentivirus strains that are related to the human immunodeficiency virus (HIV) from African green monkeys (Cercopithecus aethiops; AGM). Although immunologically related, these SIVagm are clearly distinct from other simian immunodeficiency virus (SIV) isolates, including isolates from Macaca mulatta (S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus G,Werner A,Baier M,Binniger D,Ferdinand FJ,Norley S,Kurth R

更新日期：1989-04-01 00:00:00

abstract：:A technique is described for isolation of plasmid DNA in closed and open circular double-stranded forms from bacterial cells, by use of ATP-dependent deoxyribonuclease purified from Micrococcus luteus. This DNase, acting only upon linear DNA molecules, degrades all bacterial chromosomal DNA extracted in the linear for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukai T,Matsubara K,Takagi Y

更新日期：1973-10-01 00:00:00

abstract：:Isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) represent the two central intermediates in the biosynthesis of isoprenoids. The recently discovered deoxyxylulose 5-phosphate pathway generates a mixture of IPP and DMAPP in its final step by reductive dehydroxylation of 1-hydroxy-2-methyl-2-butenyl 4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gräwert T,Span I,Eisenreich W,Rohdich F,Eppinger J,Bacher A,Groll M

更新日期：2010-01-19 00:00:00

abstract：:GABAergic dysfunction is present in the hippocampus in schizophrenia (SZ) and bipolar disorder (BD). The trisynaptic pathway was "deconstructed" into various layers of sectors CA3/2 and CA1 and gene expression profiling performed. Network association analysis was used to uncover genes that may be related to regulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benes FM,Lim B,Matzilevich D,Walsh JP,Subburaju S,Minns M

更新日期：2007-06-12 00:00:00

abstract：:Global warming is expected to lead to a large increase in atmospheric water vapor content and to changes in the hydrological cycle, which include an intensification of precipitation extremes. The intensity of precipitation extremes is widely held to increase proportionately to the increase in atmospheric water vapor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Gorman PA,Schneider T

更新日期：2009-09-01 00:00:00

abstract：:Attending to a stimulus is known to enhance the neural responses to that stimulus. Recent experiments on visual attention have shown that this modulation can have object-based characteristics, such that, when certain parts of a visual object are attended, other parts automatically also receive enhanced processing. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busse L,Roberts KC,Crist RE,Weissman DH,Woldorff MG

更新日期：2005-12-20 00:00:00

abstract：:Before they even speak, infants become attuned to the sounds of the language(s) they hear, processing native phonetic contrasts more easily than nonnative ones. For example, between 6 to 8 mo and 10 to 12 mo, infants learning American English get better at distinguishing English and [l], as in "rock" vs. "lock," relat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schatz T,Feldman NH,Goldwater S,Cao XN,Dupoux E

更新日期：2021-02-09 00:00:00

abstract：:Normal human cells whether embryonic, neonatal, or adult are resistant to experimentally induced tumorigenesis in contrast to rodent or chicken cells. We showed previously that neither transformation with simian virus 40 DNA nor transfection with human mutant HRAS DNA immortalized FS-2 cells (diploid, neonatal human f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Brien W,Stenman G,Sager R

更新日期：1986-11-01 00:00:00

abstract：:Homologous recombination is an important biological process that occurs in all organisms and facilitates genome rearrangements and repair of DNA double-strand breaks. Eukaryotic Rad51 proteins (Rad51sp or Rhp51 in fission yeast) are functional and structural homologs of bacterial RecA protein, an evolutionarily conser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akamatsu Y,Dziadkowiec D,Ikeguchi M,Shinagawa H,Iwasaki H

更新日期：2003-12-23 00:00:00

abstract：:The Paramyxoviridae family of enveloped viruses enters cells through the concerted action of two viral glycoproteins. The receptor-binding protein, hemagglutinin-neuraminidase (HN), H, or G, binds its cellular receptor and activates the fusion protein, F, which, through an extensive refolding event, brings viral and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bose S,Zokarkar A,Welch BD,Leser GP,Jardetzky TS,Lamb RA

更新日期：2012-09-25 00:00:00

abstract：:We examine how presentations of organ donation cases in the media may affect people's willingness to sign organ donation commitment cards, donate the organs of a deceased relative, support the transition to an "opt-out" policy, or donate a kidney while alive. We found that providing identifying information about the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harel I,Kogut T,Pinchas M,Slovic P

更新日期：2017-05-16 00:00:00

abstract：:Antibody to poly(ADP-ribose) has been covalently coupled to Sepharose and utilized to isolate selectively oligonucleosomes undergoing the poly(ADP-ribosyl)ation reaction from the bulk of chromatin. Approximately 12% of the unfractionated oligonucleosomes were bound to the immunoaffinity column and these represented es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malik N,Miwa M,Sugimura T,Thraves P,Smulson M

更新日期：1983-05-01 00:00:00

abstract：:Polycomb group genes (PcGs) have been implicated in cancer based on altered levels of expression observed in certain tumors and the behavior of cultured cells containing inserted PcG transgenes. Endometrial stromal tumors provide evidence for a direct causal relationship because they contain several chromosomal transl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Ma X,Wang J,Koontz J,Nucci M,Sklar J

更新日期：2007-12-11 00:00:00

abstract：:TCL1 and TCL1b genes on human chromosome 14q23.1 are activated in T cell leukemias by translocations and inversions at 14q32.1, juxtaposing them to regulatory elements of T cell receptor genes. In this report we present the cloning, mapping, and expression analysis of the human and murine TCL1/Tcl1 locus. In addition ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hallas C,Pekarsky Y,Itoyama T,Varnum J,Bichi R,Rothstein JL,Croce CM

更新日期：1999-12-07 00:00:00

abstract：:Scleroderma is a chronic systemic disease that leads to fibrosis of affected organs. Transforming growth factor (TGF) beta has been implicated in the pathogenesis of scleroderma. Smad proteins are signaling transducers downstream from TGF-beta receptors. Three families of Smads have been identified: (i) receptor-regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong C,Zhu S,Wang T,Yoon W,Li Z,Alvarez RJ,ten Dijke P,White B,Wigley FM,Goldschmidt-Clermont PJ

更新日期：2002-03-19 00:00:00

abstract：:There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bravo JA,Forsythe P,Chew MV,Escaravage E,Savignac HM,Dinan TG,Bienenstock J,Cryan JF

更新日期：2011-09-20 00:00:00

abstract：:The Escherichia coli galactokinase gene (galK) was inserted into a modified early region transcription unit of simian virus 40 (SV40) contained on a bacterial plasmid. Introduction of this pSVK vector into monkey, mouse, and hamster cell lines by transfection resulted in efficient expression of the bacterial galK gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schümperli D,Howard BH,Rosenberg M

更新日期：1982-01-01 00:00:00

abstract：:The bacterial TATAAT -10 region sequence was the first promoter element to be identified, but how it functions is still not clear. Because the duplex element is melted during initiation, the effects of substitutions were studied in both single-and double-strand contexts. Band-shift results were particularly unexpected...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fenton MS,Gralla JD

更新日期：2001-07-31 00:00:00

abstract：:The Max gene encodes a protein that interacts specifically with the Myc protein to form a heterodimer with high affinity for the specific cognate DNA binding site of Myc. Here we examine the expression of Max RNA in comparison to Myc RNA during cell growth and differentiation. Two species of RNA, a major 2.0- and a mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner AJ,Le Beau MM,Diaz MO,Hay N

更新日期：1992-04-01 00:00:00

abstract：:Single-cell RNA sequencing (scRNA-seq) enables the quantification of each gene's expression distribution across cells, thus allowing the assessment of the dispersion, nonzero fraction, and other aspects of its distribution beyond the mean. These statistical characterizations of the gene expression distribution are cri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang J,Huang M,Torre E,Dueck H,Shaffer S,Murray J,Raj A,Li M,Zhang NR

更新日期：2018-07-10 00:00:00

abstract：:A deficit in early clearance of Pseudomonas aeruginosa (P. aeruginosa) is crucial in nosocomial pneumonia and in chronic lung infections. Few studies have addressed the role of Toll-like receptors (TLRs), which are early pathogen associated molecular pattern receptors, in pathogen uptake and clearance by alveolar macr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Descamps D,Le Gars M,Balloy V,Barbier D,Maschalidi S,Tohme M,Chignard M,Ramphal R,Manoury B,Sallenave JM

更新日期：2012-01-31 00:00:00

abstract：:Nitric oxide (NO) plays diverse and significant roles in biological processes despite its cytotoxicity, raising the question of how biological systems control the action of NO to minimize its cytotoxicity in cells. As a great example of such a system, we found a possibility that NO-generating nitrite reductase (NiR) f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terasaka E,Yamada K,Wang PH,Hosokawa K,Yamagiwa R,Matsumoto K,Ishii S,Mori T,Yagi K,Sawai H,Arai H,Sugimoto H,Sugita Y,Shiro Y,Tosha T

更新日期：2017-09-12 00:00:00