Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.

abstract：:The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including inhibiting fear when danger has passed. The extinction of fear, however, is labile and a number of factors, including stress, cause extinguished fear to relapse. Here we show that fear relapse in rats limits single-unit activi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustino TF,Fitzgerald PJ,Ressler RL,Maren S

更新日期：2019-04-23 00:00:00

abstract：:WIN antiviral compounds bind human rhinovirus, as well as enterovirus and parechovirus, in an internal cavity located within the viral protein capsid. Access to the buried pocket necessitates deviation from the average viral protein structure identified by crystallography. We investigated the dissociation of WIN 52084...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Zhou Z,Post CB

更新日期：2005-05-24 00:00:00

abstract：:The serotonin transporter (SERT) is a major regulator of serotonergic neurotransmission and anxiety-related behaviors. SERT is expressed in two alternative polyadenylation forms that differ by an evolutionarily conserved element in the 3' untranslated region of its mRNA. Expression of SERT mRNA containing the distal p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoon Y,McKenna MC,Rollins DA,Song M,Nuriel T,Gross SS,Xu G,Glatt CE

更新日期：2013-07-09 00:00:00

abstract：:The uterine epithelium of mice and humans undergoes cyclical waves of cell proliferation and differentiation under the regulation of estradiol-17β (E2) and progesterone (P4). These epithelial cells respond to E2 with increased protein and DNA synthesis, whereas P4 inhibits only the E2-induced DNA synthetic response. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Zhu L,Kuokkanen S,Pollard JW

更新日期：2015-03-17 00:00:00

abstract：:Efficient degradation of plant cell walls by selected anaerobic bacteria is performed by large extracellular multienzyme complexes termed cellulosomes. The spatial arrangement within the cellulosome is organized by a protein called scaffoldin, which recruits the cellulolytic subunits through interactions between cohes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barth A,Hendrix J,Fried D,Barak Y,Bayer EA,Lamb DC

更新日期：2018-11-27 00:00:00

abstract：:Understanding the relationship between the structural and functional organization of the human brain is one of the most important goals of neuroscience. Individual variability in brain structure means that it is essential to obtain this information from the same subject. To date, this has been almost impossible. Even ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walters NB,Egan GF,Kril JJ,Kean M,Waley P,Jenkinson M,Watson JD

更新日期：2003-03-04 00:00:00

abstract：:Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling L,Raikhel AS

更新日期：2021-02-09 00:00:00

abstract：:Hippocampal mossy fibers, which are the axons of dentate granule cells, form powerful excitatory synapses onto the proximal dendrites of CA3 pyramidal cells. It has long been known that high-affinity binding sites for kainate, a glutamate receptor agonist, are present on mossy fibers. Here we summarize recent experime...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmitz D,Mellor J,Frerking M,Nicoll RA

更新日期：2001-09-25 00:00:00

abstract：:The effect of metabolic depletion on the maturation-associated loss of membrane functions has been studied by using sheep reticulocytes incubated in vitro at 37 degrees C for periods up to 41 hr. ATP was either maintained with glucose, adenosine plus inosine, or depleted with 2-deoxyglucose plus arsenate. Two membrane...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weigensberg AM,Blostein R

更新日期：1983-08-01 00:00:00

abstract：:An ultra-high vacuum experimental study of acetylene chemisorption on Pt(111) and Pt(100) and of the reaction of hydrogen with the acetylene adsorbate has established distinguishing features of carbon-hydrogen bond breaking and making processes as a function of pressure, temperature, and surface crystallography. The r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muetterties EL,Tasi MC,Kelemen SR

更新日期：1981-11-01 00:00:00

abstract：:The anti-Tac monoclonal antibody is known to bind to the p55 chain of the human interleukin 2 receptor and to inhibit proliferation of T cells by blocking interleukin 2 binding. However, use of anti-Tac as an immunosuppressant drug would be impaired by the human immune response against this murine antibody. We have th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Queen C,Schneider WP,Selick HE,Payne PW,Landolfi NF,Duncan JF,Avdalovic NM,Levitt M,Junghans RP,Waldmann TA

更新日期：1989-12-01 00:00:00

abstract：:Unlike parasitic protist groups that are defined by the absence of mitochondria, the Pelobiontida is composed mostly of free-living species. Because of the presence of ultrastructural and cellular features that set them apart from all other eukaryotic organisms, it has been suggested that pelobionts are primitively am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiller JW,Duffield EC,Hall BD

更新日期：1998-09-29 00:00:00

abstract：:The gap junctional protein connexin32 is expressed in hepatocytes, exocrine pancreatic cells, Schwann cells, and other cell types. We have inactivated the connexin32 gene by homologous recombination in the mouse genome and have generated homozygous connexin32-deficient mice that were viable and fertile but weighed on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelles E,Bützler C,Jung D,Temme A,Gabriel HD,Dahl U,Traub O,Stümpel F,Jungermann K,Zielasek J,Toyka KV,Dermietzel R,Willecke K

更新日期：1996-09-03 00:00:00

abstract：:Although antibodies to HLA play a role in the pathogenesis of diseases processes such as rejection of transplanted organs, the precise mechanisms by which antibodies cause tissue injury are not completely understood. We hypothesized that antibodies to host tissues cause inflammation in part by activating endothelial e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamakuchi M,Kirkiles-Smith NC,Ferlito M,Cameron SJ,Bao C,Fox-Talbot K,Wasowska BA,Baldwin WM 3rd,Pober JS,Lowenstein CJ

更新日期：2007-01-23 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is believed to arise through a multistep model comprised of putative precursor lesions known as pancreatic intraepithelial neoplasia (PanIN). Recent genetically engineered mouse models of PDAC demonstrate a comparable morphologic spectrum of murine PanIN (mPanIN) lesions. The hi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Habbe N,Shi G,Meguid RA,Fendrich V,Esni F,Chen H,Feldmann G,Stoffers DA,Konieczny SF,Leach SD,Maitra A

更新日期：2008-12-02 00:00:00

abstract：:In the developing CNS, Notch1 and its ligand, Jagged1, regulate oligodendrocyte differentiation and myelin formation, but their role in repair of demyelinating lesions in diseases such as multiple sclerosis remains unresolved. To address this question, we generated a mouse model in which we targeted Notch1 inactivatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Argaw AT,Gurfein BT,Zameer A,Snyder BJ,Ge C,Lu QR,Rowitch DH,Raine CS,Brosnan CF,John GR

更新日期：2009-11-10 00:00:00

abstract：:Studies of the fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene in membranes of normal, transformed, and revertant 3T3 cells allowed estimation of microviscosities (eta) of the lipid bilayers of these cells. Fluorescence polarization values observed with normal cells were significantly lower than those obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuchs P,Parola A,Robbins PW,Blout ER

更新日期：1975-09-01 00:00:00

abstract：:Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular structures and metabolic pathways. The finding that patients with mutations in mitochondrial rRNA are hypersusceptible to aminoglycoside-induced hearing loss has indicated a possible role for mitochondrial protein synthesis. To stud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie SN,Akshay S,Kalapala SK,Bruell CM,Shcherbakov D,Böttger EC

更新日期：2008-12-30 00:00:00

abstract：:DNA origami enables the precise fabrication of nanoscale geometries. We demonstrate an approach to engineer complex and reversible motion of nanoscale DNA origami machine elements. We first design, fabricate, and characterize the mechanical behavior of flexible DNA origami rotational and linear joints that integrate s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marras AE,Zhou L,Su HJ,Castro CE

更新日期：2015-01-20 00:00:00

abstract：:The interaction between DNA polymerases and sliding clamp proteins confers processivity in DNA synthesis. This interaction is critical for most DNA replication machines from viruses and prokaryotes to higher eukaryotes. The clamp proteins also participate in a variety of dynamic and competing protein-protein interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dalrymple BP,Kongsuwan K,Wijffels G,Dixon NE,Jennings PA

更新日期：2001-09-25 00:00:00

abstract：:Buffering variability in morphogen distribution is essential for reproducible patterning. A theoretically proposed class of mechanisms, termed "distal pinning," achieves robustness by combining local sensing of morphogen levels with global modulation of gradient spread. Here, we demonstrate a critical role for morphog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rahimi N,Carmon S,Averbukh I,Khajouei F,Sinha S,Schejter ED,Barkai N,Shilo BZ

更新日期：2020-01-21 00:00:00

abstract：:Erythropoietin (Epo) is a glycoprotein factor that specifically regulates the proliferation and differentiation of erythroid progenitor cells. Here we describe the isolation of Epo-responsive mouse erythroleukemia cell line SKT6, the characterization of the specific binding of biologically active 125I-labeled human Ep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Todokoro K,Kanazawa S,Amanuma H,Ikawa Y

更新日期：1987-06-01 00:00:00

abstract：:Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ros-Bernal F,Hunot S,Herrero MT,Parnadeau S,Corvol JC,Lu L,Alvarez-Fischer D,Carrillo-de Sauvage MA,Saurini F,Coussieu C,Kinugawa K,Prigent A,Höglinger G,Hamon M,Tronche F,Hirsch EC,Vyas S

更新日期：2011-04-19 00:00:00

abstract：:The heat-stable enterotoxin B (STB) of Escherichia coli is a 48-amino acid extracellular peptide that induces rapid fluid accumulation in animal intestinal models. Unlike other E. coli enterotoxins that elicit cAMP or cGMP responses in the gut [heat-labile toxin (LT) and heat-stable toxin A (STA), respectively], STB i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dreyfus LA,Harville B,Howard DE,Shaban R,Beatty DM,Morris SJ

更新日期：1993-04-15 00:00:00

abstract：:Many pathological conditions of the central nervous system involve damage to and removal of myelin membrane. Very little is known about initiation of this membrane damage and the mechanisms of disposal of the damaged tissue. We are interested in the interaction between complement (the components of complement are desi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vanguri P,Koski CL,Silverman B,Shin ML

更新日期：1982-05-01 00:00:00

abstract：:Quinacrine's ability to reduce levels of pathogenic prion protein (PrP(Sc)) in mouse cells infected with experimentally adapted prions led to several unsuccessful clinical studies in patients with prion diseases, a 10-y investment to understand its mechanism of action, and the production of related compounds with expe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bian J,Kang HE,Telling GC

更新日期：2014-04-22 00:00:00

abstract：:Eukaryotic cells irradiated with high doses of UV exhibit cell-cycle responses referred to as G(1)/S, intraS, and G(2)/M checkpoints. After a moderate UV dose that approximates sunlight exposure and is lethal to fission yeast checkpoint mutants, we found unexpectedly that these cell-cycle responses do not occur. Inste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callegari AJ,Kelly TJ

更新日期：2006-10-24 00:00:00

abstract：:Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Q,Wu D,Chen W,Yan Z,Yan C,He T,Liang Q,Shi Y

更新日期：2014-11-18 00:00:00

abstract：:Plasmons, the collective oscillations of interacting electrons, possess emergent properties that dramatically alter the optical response of metals. We predict the existence of a new class of plasmons-chiral Berry plasmons (CBPs)-for a wide range of 2D metallic systems including gapped Dirac materials. As we show, in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song JC,Rudner MS

更新日期：2016-04-26 00:00:00

abstract：:Gastrin-releasing peptide (GRP) is a 27-amino acid neuroendocrine hormone that may play a role in the pathophysiology of small cell lung carcinoma. GRP and bombesin, a structurally related peptide, stimulate the growth of some cultured cell types. C-terminal GRP peptide analogs were developed that inhibited 6 nM bombe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leban JJ,Kull FC Jr,Landavazo A,Stockstill B,McDermed JD

更新日期：1993-03-01 00:00:00