Irreversibility of cellular aging and neoplastic transformation: a clonal analysis.

abstract：:Lymphangioleiomyomatosis (LAM) is an often fatal disease primarily affecting young women in which tuberin (TSC2)-null cells metastasize to the lungs. The mechanisms underlying the striking female predominance of LAM are unknown. We report here that 17-beta-estradiol (E(2)) causes a 3- to 5-fold increase in pulmonary m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu JJ,Robb VA,Morrison TA,Ariazi EA,Karbowniczek M,Astrinidis A,Wang C,Hernandez-Cuebas L,Seeholzer LF,Nicolas E,Hensley H,Jordan VC,Walker CL,Henske EP

更新日期：2009-02-24 00:00:00

abstract：:cDNA clones corresponding to the polypeptide that has been shown to be an endogenous diazepam binding inhibitor and may act as a physiological ligand for the benzodiazepine/beta-carboline receptor have been isolated from bacteriophage lambda recombinant libraries from rat hypothalamus, total brain, and liver. The clon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mocchetti I,Einstein R,Brosius J

更新日期：1986-10-01 00:00:00

abstract：:Replication through a diverse array of DNA lesions occurs by the sequential action of two translesion synthesis (TLS) DNA polymerases (Pols), in which one inserts the nucleotide opposite the lesion and the other carries out the subsequent extension. By extending from the nucleotide inserted by another Pol, Polζ plays ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson RE,Prakash L,Prakash S

更新日期：2012-07-31 00:00:00

abstract：:There is not a single pharmaceutical that halts or even slows any neurodegenerative disease. Mounting evidence shows that prions cause many neurodegenerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best therapeutic targets. We report here that the previously identified 2-amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry DB,Lu D,Geva M,Watts JC,Bhardwaj S,Oehler A,Renslo AR,DeArmond SJ,Prusiner SB,Giles K

更新日期：2013-10-29 00:00:00

abstract：:p97/VCP (Cdc48 in yeast) is an essential and abundant member of the AAA+ family of ATPases and is involved in a number of diverse cellular pathways through interactions with different adaptor proteins. The two most characterized adaptors for p97 are p47 and the Ufd1 (ubiquitin fusion degradation 1)-Npl4 (nuclear prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pye VE,Beuron F,Keetch CA,McKeown C,Robinson CV,Meyer HH,Zhang X,Freemont PS

更新日期：2007-01-09 00:00:00

abstract：:Ablation of inhibitory agouti-related protein (AgRP)-expressing neurons in the arcuate nucleus that also synthesize gamma-amino-butyric acid (GABA) and neuropeptide Y in adult mice leads to starvation within 1 week. The removal of inhibition from the AgRP neurons onto neighboring proopiomelanocortin neurons and their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Q,Howell MP,Cowley MA,Palmiter RD

更新日期：2008-02-19 00:00:00

abstract：:Using [3H]quinuclidinyl benzilate as a specific cholinergic muscarinic ligand, it has been demonstrated that lymphocytes have muscarinic binding sites. There are approximately 200 sites per cell and the dissociation constant for quinuclidinyl benzilate is approximately 1 X 10(-9) M. Quinuclidinyl benzilate receptor bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon MA,Cohen JJ,Wilson IB

更新日期：1978-06-01 00:00:00

abstract：:Energy-storing artificial-photosynthetic systems for CO2 reduction must derive the reducing equivalents from a renewable source rather than from sacrificial donors. To this end, a homogeneous, integrated chromophore/two-catalyst system is described that is thermodynamically capable of photochemically driving the energ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： La Porte NT,Moravec DB,Hopkins MD

更新日期：2014-07-08 00:00:00

abstract：:Well-differentiated liposarcoma (WDLPS), one of the most common human sarcomas, is poorly responsive to radiation and chemotherapy, and the lack of animal models suitable for experimental analysis has seriously impeded functional investigation of its pathobiology and development of effective targeted therapies. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gutierrez A,Snyder EL,Marino-Enriquez A,Zhang YX,Sioletic S,Kozakewich E,Grebliunaite R,Ou WB,Sicinska E,Raut CP,Demetri GD,Perez-Atayde AR,Wagner AJ,Fletcher JA,Fletcher CD,Look AT

更新日期：2011-09-27 00:00:00

abstract：:Fodrin, a protein composed of two polypeptides with molecular weights of 250,000 and 240,000, is concentrated in the cortical cytoplasm of neurons, and moves down the axons by the process of axonal transport. We have used immunofluorescence techniques to determine whether fodrin antigens also move in non-neuronal cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine J,Willard M

更新日期：1983-01-01 00:00:00

abstract：:Behavioral models indicate that persistent small afferent input, as generated by tissue injury, results in a hyperalgesia at the site of injury and a tactile allodynia in areas adjacent to the injury site. Hyperalgesia reflects a sensitization of the peripheral terminal and a central facilitation evoked by the persist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaksh TL,Hua XY,Kalcheva I,Nozaki-Taguchi N,Marsala M

更新日期：1999-07-06 00:00:00

abstract：:Human brain functional networks are embedded in anatomical space and have topological properties--small-worldness, modularity, fat-tailed degree distributions--that are comparable to many other complex networks. Although a sophisticated set of measures is available to describe the topology of brain networks, the selec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vértes PE,Alexander-Bloch AF,Gogtay N,Giedd JN,Rapoport JL,Bullmore ET

更新日期：2012-04-10 00:00:00

abstract：:The properties of a recently synthesized photolabile chelator for divalent cations are described, the affinity of which for Ca2+ changes by some 5 orders of magnitude on illumination. The compound 1-(2-nitro-4,5-dimethoxyphenyl)-N,N,N',N'-tetrakis[(oxycarbonyl)me thyl]-1,2-ethanediamine (DM-nitrophen) binds Ca2+ (Kd a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan JH,Ellis-Davies GC

更新日期：1988-09-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health problem. Evasion of IFN-mediated antiviral signaling is a common defense strategy that pathogenic viruses use to replicate and propagate in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miorin L,Kehrer T,Sanchez-Aparicio MT,Zhang K,Cohen P,Patel RS,Cupic A,Makio T,Mei M,Moreno E,Danziger O,White KM,Rathnasinghe R,Uccellini M,Gao S,Aydillo T,Mena I,Yin X,Martin-Sancho L,Krogan NJ,Chanda SK,Schot

更新日期：2020-11-10 00:00:00

abstract：:Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veesler D,Spinelli S,Mahony J,Lichière J,Blangy S,Bricogne G,Legrand P,Ortiz-Lombardia M,Campanacci V,van Sinderen D,Cambillau C

更新日期：2012-06-05 00:00:00

abstract：:Reactions of a membrane-bound multienzyme complex (electron-transport chain of rat-liver microsomes) suspended in aqueous-organic solvent used as antifreeze at temperatures below 0 degrees were studied. In the presence of a relatively high concentration of ethylene glycol, electron transfer can still be observed and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debey P,Balny C,Douzou P

更新日期：1973-09-01 00:00:00

abstract：:Transfer RNA (tRNA) is essential for decoding the genome sequence into proteins. In Archaea, previous studies have revealed unique multiple intron-containing tRNAs and tRNAs that are encoded on 2 separate genes, so-called split tRNAs. Here, we discovered 10 fragmented tRNA genes in the complete genome of the hyperther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujishima K,Sugahara J,Kikuta K,Hirano R,Sato A,Tomita M,Kanai A

更新日期：2009-02-24 00:00:00

abstract：:The assembly of regional biotas and organismal responses to anthropogenic climate change both depend on the capacity of organisms to adapt to novel ecological conditions. Here we demonstrate the concept of evolutionary lag time, the time between when a climatic regime or habitat develops in a region and when it is col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guerrero PC,Rosas M,Arroyo MT,Wiens JJ

更新日期：2013-07-09 00:00:00

abstract：:A method has been developed that enables us to identify intracellular degradation intermediates of fructose-bisphosphate aldolase B (D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase, EC 4.1.2.13). This method is based on the use of antibody against thoroughly denatured purified aldolase. This antibody ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reznick AZ,Rosenfelder L,Shpund S,Gershon D

更新日期：1985-09-01 00:00:00

abstract：:The role of the cerebellar cortex in motor learning was investigated by comparing the paramedian lobule of adult rats given difficult acrobatic training to that of rats that had been given extensive physical exercise or had been inactive. The paramedian lobule is activated during limb movements used in both acrobatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black JE,Isaacs KR,Anderson BJ,Alcantara AA,Greenough WT

更新日期：1990-07-01 00:00:00

abstract：:There exists a properly embedded minimal surface of genus one with a single end asymptotic to the end of the helicoid. This genus-one helicoid is constructed as the limit of a continuous one-parameter family of screw-motion invariant minimal surfaces, also asymptotic to the helicoid, that have genus equal to one in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber M,Hoffman D,Wolf M

更新日期：2005-11-15 00:00:00

abstract：:An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti, was en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise de Valdez MR,Nimmo D,Betz J,Gong HF,James AA,Alphey L,Black WC 4th

更新日期：2011-03-22 00:00:00

abstract：:The segmented body plan of vertebrates is prefigured by reiterated embryonic mesodermal structures called somites. In the mouse embryo, timely somite formation from the presomitic mesoderm (PSM) is controlled by the "segmentation clock," a molecular oscillator that triggers progressive waves of Notch activity througho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez TP,Fan CM

更新日期：2013-05-28 00:00:00

abstract：:The combustion of fossil fuels has enriched levels of CO(2) in the world's oceans and decreased ocean pH. Although the continuation of these processes may alter the growth, survival, and diversity of marine organisms that synthesize CaCO(3) shells, the effects of ocean acidification since the dawn of the industrial re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Talmage SC,Gobler CJ

更新日期：2010-10-05 00:00:00

abstract：:Policy folklists present a set of alleged historical facts seen as relevant to some social issue. Although the validity of these folklists is dubious, leaders and writers circulate them in the media, variants arise, and the lists continue on, sometimes for decades. Folklists are repeated because their messages are app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill B

更新日期：2014-07-22 00:00:00

abstract：:We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated endocytosis to carry DNA macromolecules into cells. We accomplished this by conjugating the iron-transport protein transferrin to polycations that bind nucleic acids. Human transferrin, as well as the chicken homologue conalbu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Zenke M,Cotten M,Beug H,Birnstiel ML

更新日期：1990-05-01 00:00:00

abstract：:Large changes in solvent accessibility to aspartate transcarbamylase (aspartate carbamoyltransferase, carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2), as monitored by tritium exchange, result from binding of substrates and substrate analogs to the catalytic subunit (c3), binding of nucleoside triphosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lennick M,Allewell NM

更新日期：1981-11-01 00:00:00

abstract：:Several proteins have been identified that protect Drosophila telomeres from fusion events. They include UbcD1, HP1, HOAP, the components of the Mre11-Rad50-Nbs (MRN) complex, the ATM kinase, and the putative transcription factor Woc. Of these proteins, only HOAP has been shown to localize specifically at telomeres. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raffa GD,Siriaco G,Cugusi S,Ciapponi L,Cenci G,Wojcik E,Gatti M

更新日期：2009-02-17 00:00:00

abstract：:This communication reports a modulating effect of intracellular ATP on the steady-state and kinetic properties of the delayed rectifier of the giant axon of the squid. When internally dialyzed or perfused giant axons from Loligo plei or Loligo pealei are voltage clamped at -60 mV and washed free of ATP, the potassium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bezanilla F,Caputo C,DiPolo R,Rojas H

更新日期：1986-04-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the number of polyglutamine-encoding CAG repeats in the gene that encodes the huntingtin (htt) protein. A property of the mutant protein that is intimately involved in the development of the disease is the propensity of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colby DW,Chu Y,Cassady JP,Duennwald M,Zazulak H,Webster JM,Messer A,Lindquist S,Ingram VM,Wittrup KD

更新日期：2004-12-21 00:00:00