Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.

abstract：:We outline a theory to quantify the interplay of entropic and selective forces on nucleotide organization and apply it to the genomes of single-stranded RNA viruses. We quantify these forces as intensive variables that can easily be compared between sequences, outline a computationally efficient transfer-matrix method...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenbaum BD,Cocco S,Levine AJ,Monasson R

更新日期：2014-04-01 00:00:00

abstract：:The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosphorylation of the necroptotic effector pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) by the upstream protein kinase RIPK3 is a hallmark of pathway activation, the precise checkpoints ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrie EJ,Birkinshaw RW,Koide A,Denbaum E,Hildebrand JM,Garnish SE,Davies KA,Sandow JJ,Samson AL,Gavin X,Fitzgibbon C,Young SN,Hennessy PJ,Smith PPC,Webb AI,Czabotar PE,Koide S,Murphy JM

更新日期：2020-04-14 00:00:00

abstract：:The stability of an immunogen against enzymatic degradation is considered an important factor for the design of synthetic vaccines. For our studies, we have selected an epitope from the tandem-repeat unit of the high-molecular-weight MUC2 mucin glycoprotein, which can be underglycosylated in case of colon cancer. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tugyi R,Uray K,Iván D,Fellinger E,Perkins A,Hudecz F

更新日期：2005-01-11 00:00:00

abstract：:Natural killer (NK) cells play a critical role in controlling malignancies. Susceptibility or resistance to lung cancer, for example, specifically depends on NK cell function. Nevertheless, intrinsic factors that control NK cell-mediated clearance of lung cancer are unknown. Here we report that NK cells exposed to exo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi L,Li K,Guo Y,Banerjee A,Wang Q,Lorenz UM,Parlak M,Sullivan LC,Onyema OO,Arefanian S,Stelow EB,Brautigan DL,Bullock TNJ,Brown MG,Krupnick AS

更新日期：2018-11-13 00:00:00

abstract：:Evolutionary theory reveals that punishment is effective in promoting cooperation and maintaining social norms. Although it is accepted that emotions are connected to punishment decisions, there remains substantial debate over why humans use costly punishment. Here we show experimentally that constraints on emotion ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao E,Houser D

更新日期：2005-05-17 00:00:00

abstract：:Mutations in genes that encode components of the phosphatidyl-inositol 3-kinase (PI3-kinase) signaling pathway are common in human cancer. The recent discovery of nonrandom somatic mutations in the PIK3CA gene of many human tumors suggests an oncogenic role for the mutated enzyme. We have determined the growth-regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang S,Bader AG,Vogt PK

更新日期：2005-01-18 00:00:00

abstract：:Variation is the raw material for natural selection, but the factors shaping variation are still poorly understood. Genetic and developmental interactions can direct variation, but there has been little synthesis of these effects with the extrinsic factors that can shape biodiversity over large scales. The study of ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goswami A,Binder WJ,Meachen J,O'Keefe FR

更新日期：2015-04-21 00:00:00

abstract：:Circumnutation and winding in plants are universal growth movements that allow plants to survive despite their sessile nature. However, the detailed molecular mechanisms controlling these phenomena remain unclear. We previously found that a gravitropic mutant of Japanese morning glory (Pharbitis nil or Ipomoea nil), S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitazawa D,Hatakeda Y,Kamada M,Fujii N,Miyazawa Y,Hoshino A,Iida S,Fukaki H,Morita MT,Tasaka M,Suge H,Takahashi H

更新日期：2005-12-20 00:00:00

abstract：:The catalytic generation of chiral ester enolate equivalents from α,β-unsaturated aldehydes with chiral N-hetereocyclic carbene catalysts makes possible highly enantioselective hetero-Diels-Alder reactions. The reactions proceed under simple, mild conditions with both aliphatic and aromatic substituted enals as substr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaeobamrung J,Kozlowski MC,Bode JW

更新日期：2010-11-30 00:00:00

abstract：:Heterosis is widely applied in agriculture; however, the underlying molecular mechanisms for superior performance are not well understood. Ethylene biosynthesis and signaling genes are shown to be down-regulated in Arabidopsis interspecific hybrids. Ethylene is a plant hormone that promotes fruit ripening and maturati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song Q,Ando A,Xu D,Fang L,Zhang T,Huq E,Qiao H,Deng XW,Chen ZJ

更新日期：2018-05-22 00:00:00

abstract：:A retrovirus containing the entire human platelet-derived growth factor B-chain (PDGF-B) gene was constructed in order to investigate the in vivo biological activity of its encoded growth factor. When this virus was introduced into newborn mice, it reproducibly generated fibrosarcomas at the site of inoculation. Provi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pech M,Gazit A,Arnstein P,Aaronson SA

更新日期：1989-04-01 00:00:00

abstract：:The ability to respond selectively to particular frequency components of sensory inputs is fundamental to signal processing in the ear. The frog (Rana pipiens) sacculus, which is used for social communication and escape behaviors, is an exquisitely sensitive detector of sounds and ground-borne vibrations in the 5- to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rutherford MA,Roberts WM

更新日期：2006-02-21 00:00:00

abstract：:Explants of human endometrium were cultured to study the release of matrix metalloproteinases (MMPs). Analysis of conditioned media by zymography revealed latent and active forms of collagenase (MMP-1, EC 3.4.24.7), 72-kDa gelatinase A (MMP-2, EC 3.4.24.24), and 92-kDa gelatinase B (MMP-9, EC 3.4.24.35). These protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marbaix E,Donnez J,Courtoy PJ,Eeckhout Y

更新日期：1992-12-15 00:00:00

abstract：:The use of probes to genes (IG and TCRB) encoding immunoglobulins (IG) and the beta chain of the T-cell antigen receptor (TCRB), respectively, have become a sensitive means to assess clonality and lineage in lymphoid malignancies. It has become apparent that some individual cases show rearrangements of both IG and TCR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davey MP,Bongiovanni KF,Kaulfersch W,Quertermous T,Seidman JG,Hershfield MS,Kurtzberg J,Haynes BF,Davis MM,Waldmann TA

更新日期：1986-11-01 00:00:00

abstract：:Sensory neurons perceive environmental cues and are important of organismal survival. Peripheral sensory neurons interact intimately with glial cells. While the function of axonal ensheathment by glia is well studied, less is known about the functional significance of glial interaction with the somatodendritic compart...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yadav S,Younger SH,Zhang L,Thompson-Peer KL,Li T,Jan LY,Jan YN

更新日期：2019-03-12 00:00:00

abstract：:Expression of amino acid biosynthesis genes in bacteria is often repressed when abundant supplies of the cognate amino acid are available. Repression of the Bacillus subtilis lysC gene by lysine was previously shown to occur at the level of premature termination of transcription. In this study we show that lysine dire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grundy FJ,Lehman SC,Henkin TM

更新日期：2003-10-14 00:00:00

abstract：:Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, relevant to addiction disorders. We examined polymorphisms of proenkephalin (PENK) and prodynorphin (PDYN) genes in relation to heroin abuse and gene expression in the human striatum and the relevance of genetic dopamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikoshkov A,Drakenberg K,Wang X,Horvath MC,Keller E,Hurd YL

更新日期：2008-01-15 00:00:00

abstract：:Transcription initiation in eukaryotes is controlled by nucleoprotein complexes formed through cooperative interactions among multiple transcription regulatory proteins. These complexes may be assembled via stochastic collisions or defined pathways. We investigated the dynamics of Fos-Jun-NFAT1 complexes by using a mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramirez-Carrozzi VR,Kerppola TK

更新日期：2001-04-24 00:00:00

abstract：:The NOVH protein belongs to the emerging CCN [Connective tissue growth factor (CTGF), Cyr61/Cef10, nephroblastoma overexpressed gene] family of growth regulators sharing a strikingly conserved multimodular organization but exhibiting distinctive functional features. Two members of the family (CYR61 and CTGF) are posit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perbal B,Martinerie C,Sainson R,Werner M,He B,Roizman B

更新日期：1999-02-02 00:00:00

abstract：:Changes in external light patterns can alter cell activities in peripheral tissues through slow entrainment of the central clock in suprachiasmatic nucleus (SCN). It remains unclear whether cells in otherwise photo-insensitive tissues can achieve rapid responses to changes in external light. Here we show that light st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan SM,Chang YT,Chen CL,Wang WH,Pan MK,Chen WP,Huang WY,Xu Z,Huang HE,Chen T,Plikus MV,Chen SK,Lin SJ

更新日期：2018-07-17 00:00:00

abstract：:The wide diversity of dendritic trees is one of the most striking features of neural circuits. Here we develop a general quantitative theory relating the total length of dendritic wiring to the number of branch points and synapses. We show that optimal wiring predicts a 2/3 power law between these measures. We demonst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cuntz H,Mathy A,Häusser M

更新日期：2012-07-03 00:00:00

abstract：:Selected aspects of the evolutionary process and more specifically of the genetic variation are considered, with an emphasis in studies performed by my group. One key aspect of evolution seems to be the concomitant occurrence of dichotomic, contradictory (dialect) processes. Genetic variation is structured, and the dy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salzano FM

更新日期：2000-05-09 00:00:00

abstract：:Spinocerebellar ataxia type 7 (SCA7) is characterized by cone-rod dystrophy retinal degeneration and is caused by a polyglutamine [poly(Q)] expansion within ataxin-7, a protein of previously unknown function. Here, we report that ataxin-7 is an integral component of the mammalian STAGA (SPT3-TAF9-ADA-GCN5 acetyltransf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palhan VB,Chen S,Peng GH,Tjernberg A,Gamper AM,Fan Y,Chait BT,La Spada AR,Roeder RG

更新日期：2005-06-14 00:00:00

abstract：:Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin, CyaA, that is able to deliver its N-terminal catalytic domain (400-aa residues) into the cytosol of eukaryotic target cells, directly through the cytoplasmic membrane. We have previously shown that CyaA can be used as a vehicle to deliver T ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karimova G,Fayolle C,Gmira S,Ullmann A,Leclerc C,Ladant D

更新日期：1998-10-13 00:00:00

abstract：:Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a newly recognized condition in children with recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These children and adult patients with severe hyperinflammation present with a constellation of symptoms that st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng MH,Zhang S,Porritt RA,Noval Rivas M,Paschold L,Willscher E,Binder M,Arditi M,Bahar I

更新日期：2020-10-13 00:00:00

abstract：:Ca(2+) is known to have important roles in sperm chemotaxis, although the relationship between intracellular Ca(2+) concentration ([Ca(2+)](i)) and modulation of the swimming and chemotactic behavior of spermatozoa has not been elucidated. Using a high-speed Ca(2+) imaging system, we examined the chemotactic behavior ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiba K,Baba SA,Inoue T,Yoshida M

更新日期：2008-12-09 00:00:00

abstract：:The DNA in chromatin of isolated thymus nuclei, and in two different preparations of deoxyribonucleoprotein extracted from chromatin, has been digested with DNase. By variation of the time of reaction and the concentration of enzyme, and by comparison of the action of the enzyme on (protein-free) DNA with its action o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirsky AE

更新日期：1971-12-01 00:00:00

abstract：:Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nunberg JH,Doyle MV,York SM,York CJ

更新日期：1989-06-01 00:00:00

abstract：:Many cancers have substantial genomic heterogeneity within a given tumor, and to fully understand that diversity requires the ability to perform single cell analysis. We performed targeted sequencing of a panel of single nucleotide variants (SNVs), deletions, and IgH sequences in 1,479 single tumor cells from six acut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gawad C,Koh W,Quake SR

更新日期：2014-12-16 00:00:00

abstract：:"Functional connectivity" techniques are commonplace tools for studying brain organization. A critical element of these analyses is to distinguish variance due to neurobiological signals from variance due to nonneurobiological signals. Multiecho fMRI techniques are a promising means for making such distinctions based ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Power JD,Plitt M,Gotts SJ,Kundu P,Voon V,Bandettini PA,Martin A

更新日期：2018-02-27 00:00:00