Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis.

abstract：:The expression of interleukin-4 (IL-4) is viewed as the hallmark of a Th2 lymphocyte, whereas the subsequent action of IL-4 and IL-13, mediated through the STAT6 signaling pathway, is seen as a prerequisite for the full development of Th2 immune responses to parasites and allergens. G4 mice, whose IL-4 gene locus cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Panhuys N,Tang SC,Prout M,Camberis M,Scarlett D,Roberts J,Hu-Li J,Paul WE,Le Gros G

更新日期：2008-08-26 00:00:00

abstract：:The product of the Escherichia coli secB gene is required for efficient export of proteins across the cytoplasmic membrane. The studies described in this report show that in wild-type growing cells, SecB protein associates with precursor forms of exported proteins, such as the periplasmic maltose-binding protein (MBP)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumamoto CA

更新日期：1989-07-01 00:00:00

abstract：:The ability to control the placement of individual protein molecules on surfaces could enable advances in a wide range of areas, from the development of nanoscale biomolecular devices to fundamental studies in cell biology. Such control, however, remains a challenge in nanobiotechnology due to the limitations of curre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chai J,Wong LS,Giam L,Mirkin CA

更新日期：2011-12-06 00:00:00

abstract：:Previous reports have shown that γδ T cells are important for the elimination of malaria parasites in humans and mice. However, how γδ T cells are involved in protective immunity against blood-stage malaria remains unknown. We infected γδ T-cell-deficient (TCRδ-KO) mice and control wild-type mice with Plasmodium bergh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue S,Niikura M,Takeo S,Mineo S,Kawakami Y,Uchida A,Kamiya S,Kobayashi F

更新日期：2012-07-24 00:00:00

abstract：:Transgenic mice expressing the Pim-1 kinase are predisposed to develop T-cell lymphomas with a long latency period of about 7-9 months. However, the exact functional basis of the oncogenic activity of Pim-1 remains obscure. C57BL/6 mice homozygous for the lpr mutation develop a well-described lymphoproliferative syndr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Möröy T,Grzeschiczek A,Petzold S,Hartmann KU

更新日期：1993-11-15 00:00:00

abstract：:We have investigated the differentiation potential of precursor cells within the developing spinal cord of mice and have shown that spinal cord cells from embryonic day 10 specifically give rise to neurons when plated onto an astrocytic monolayer, Ast-1. These neurons had the morphology of motor neurons and > 83% expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richards LJ,Murphy M,Dutton R,Kilpatrick TJ,Puche AC,Key B,Tan SS,Talman PS,Bartlett PF

更新日期：1995-10-24 00:00:00

abstract：:The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the HER2 gene in oncogenesis, we found that overexpression of unalter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hudziak RM,Schlessinger J,Ullrich A

更新日期：1987-10-01 00:00:00

abstract：:The remarkable fidelity of most DNA polymerases depends on a series of early steps in the reaction pathway which allow the selection of the correct nucleotide substrate, while excluding all incorrect ones, before the enzyme is committed to the chemical step of nucleotide incorporation. The conformational transitions t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santoso Y,Joyce CM,Potapova O,Le Reste L,Hohlbein J,Torella JP,Grindley ND,Kapanidis AN

更新日期：2010-01-12 00:00:00

abstract：:Division of labor among the workers of insect societies is a conspicuous feature of their biology. Social tasks are commonly shared among age groups but not between larvae and adults with completely different morphologies, as in bees, wasps, ants, and beetles (i.e., Holometabola). A unique yet hardly studied holometab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biedermann PH,Taborsky M

更新日期：2011-10-11 00:00:00

abstract：:IscR (iron-sulfur cluster regulator) is encoded by an ORF located immediately upstream of genes coding for the Escherichia coli Fe-S cluster assembly proteins, IscS, IscU, and IscA. IscR shares amino acid similarity with MarA, a member of the MarA/SoxS/Rob family of transcription factors. In this study, we found that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz CJ,Giel JL,Patschkowski T,Luther C,Ruzicka FJ,Beinert H,Kiley PJ

更新日期：2001-12-18 00:00:00

abstract：:In an effort to understand the factors that influence protein glycosylation, we are studying the expression of the chicken ovalbumin gene in a heterologous cell. Ovalbumin synthesized in mouse L-353 cells is glycosylated, as judged by incorporation of [3H]mannose and susceptibility to endo-beta-N-acetylglucosaminidase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheares BT,Robbins PW

更新日期：1986-04-01 00:00:00

abstract：:We have shown that rat glioma tumors contain a protein that crossreacts with antibody against mouse 2.5S nerve growth factor prepared in rabbit in microcomplement fixation assays and has analogous isoelectric points to all the hybrids of 2.5S nerve growth factor (a dimer). Partially purified protein preparations from ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Longo AM,Penhoet EE

更新日期：1974-06-01 00:00:00

abstract：:The Tol2 element of the medaka fish Oryzias latipes belongs to the hAT family of transposons (hobo/Ac/Tam3). We report here identification of a functional transposase of Tol2 that is capable of catalyzing its transposition in the germ line of zebrafish Danio rerio. A transcript produced from Tol2 encodes a putative tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami K,Shima A,Kawakami N

更新日期：2000-10-10 00:00:00

abstract：:Therapeutics for cerebral ischemia/hypoxia, which often results in ischemic stroke in humans, are a global unmet medical need. Here, we report that bryostatin-1, a highly potent protein kinase C (PKC) activator, interrupts pathophysiological molecular cascades and apoptosis triggered by cerebral ischemia/hypoxia, enha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun MK,Hongpaisan J,Alkon DL

更新日期：2009-08-25 00:00:00

abstract：:Recently, we described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor alpha (RAR alpha). We have now cloned cDNAs encoding PLZF-RAR alpha chimeric proteins and studied the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Guidez F,Rousselot P,Agadir A,Chen SJ,Wang ZY,Degos L,Zelent A,Waxman S,Chomienne C

更新日期：1994-02-01 00:00:00

abstract：:The light-harvesting phycobilisome in cyanobacteria and red algae requires the lyase-catalyzed chromophorylation of phycobiliproteins. There are three functionally distinct lyase families known. The heterodimeric E/F type is specific for attaching bilins covalently to α-subunits of phycocyanins and phycoerythrins. Unl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Höppner A,Xu QZ,Gärtner W,Scheer H,Zhou M,Zhao KH

更新日期：2017-12-12 00:00:00

abstract：:The dorsolateral striatum (DLS) is essential for motor and procedure learning, but the role of DLS spiny projection neurons (SPNs) of direct and indirect pathways, as marked, respectively, by D1 and D2 receptor (D1R and D2R) expression, remains to be clarified. Long-term two-photon calcium imaging of the same neuronal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng MJ,Lu D,Shen ZM,Poo MM

更新日期：2019-05-28 00:00:00

abstract：:Less than 100 cis-regulatory DNAs have been characterized in the context of transgenic metazoan embryos. Here we investigate the feasibility of conducting a genome-wide search for tissue-specific enhancers in the ascidian Ciona intestinalis. A total of 138 random genomic DNA fragments with an average size of 1.7 kb we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harafuji N,Keys DN,Levine M

更新日期：2002-05-14 00:00:00

abstract：:Wild and managed bees are well documented as effective pollinators of global crops of economic importance. However, the contributions by pollinators other than bees have been little explored despite their potential to contribute to crop production and stability in the face of environmental change. Non-bee pollinators ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rader R,Bartomeus I,Garibaldi LA,Garratt MP,Howlett BG,Winfree R,Cunningham SA,Mayfield MM,Arthur AD,Andersson GK,Bommarco R,Brittain C,Carvalheiro LG,Chacoff NP,Entling MH,Foully B,Freitas BM,Gemmill-Herren B,Ghazoul

更新日期：2016-01-05 00:00:00

abstract：:T7 gene 5 DNA polymerase (gp5) and its processivity factor, Escherichia coli thioredoxin, together with the T7 gene 4 DNA helicase, catalyze strand displacement synthesis on duplex DNA processively (>17,000 nucleotides per binding event). The processive DNA synthesis is resistant to the addition of a DNA trap. However...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson DE,Takahashi M,Hamdan SM,Lee SJ,Richardson CC

更新日期：2007-03-27 00:00:00

abstract：:Healthy ocean ecosystems are needed to sustain people and livelihoods and to achieve the United Nations Sustainable Development Goals. Using the ocean sustainably requires overcoming many formidable challenges: overfishing, climate change, ocean acidification, and pollution. Despite gloomy forecasts, there is reason f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lubchenco J,Cerny-Chipman EB,Reimer JN,Levin SA

更新日期：2016-12-20 00:00:00

abstract：:Dantu is a rare antigen of the human MNSs blood group system carried by a hybrid glycophorin on the erythrocyte membrane. To delineate its structure and relationship to alpha and delta glycophorins at the genomic level, we analyzed DNA from a three-generation family, in which both the presence of Dantu and Mi-III (ano...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CH,Blumenfeld OO

更新日期：1988-12-01 00:00:00

abstract：:During differentiation of 3T3-L1 preadipocytes into adipocytes, transcription of the C/EBP alpha (CCA-AT/enhancer binding protein alpha) gene is activated. The promoter of the C/EBP alpha gene contains a bipartite cis element with binding sites for C/EBP alpha undifferentiated protein (CUP) and an Sp1-like GT box bind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasseur-Cognet M,Lane MD

更新日期：1993-08-01 00:00:00

abstract：:Cryopreservation is widely used to maintain backups of cells as it enables the semipermanent storage of cells. During the freezing process, ice crystals that are generated inside and outside the cells can lethally damage the cells. All conventional cryopreservation methods use at least one cryoprotective agent (CPA) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama Y,Shinose M,Watanabe H,Yamada S,Kanda Y

更新日期：2019-04-16 00:00:00

abstract：:Unlike αβ-T lineage cells, where the role of ligand in intrathymic selection is well established, the role of ligand in the development of γδ-T cells remains controversial. Here we provide evidence for the role of a bona fide selecting ligand in shaping the γδ-T cell-receptor (TCR) repertoire. Reactivity of the γδ-TCR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fahl SP,Coffey F,Kain L,Zarin P,Dunbrack RL Jr,Teyton L,Zúñiga-Pflücker JC,Kappes DJ,Wiest DL

更新日期：2018-02-20 00:00:00

abstract：:Switch from non-syncytium-inducing (NSI) to syncytium-inducing (SI) HIV type 1 (HIV-1) is associated with accelerated CD4(+) T cell depletion, which might partially be explained by higher virulence of SI variants compared with NSI variants. Because NSI and SI variants use different coreceptors for entry of target cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blaak H,van't Wout AB,Brouwer M,Hooibrink B,Hovenkamp E,Schuitemaker H

更新日期：2000-02-01 00:00:00

abstract：:The uterine epithelium of mice and humans undergoes cyclical waves of cell proliferation and differentiation under the regulation of estradiol-17β (E2) and progesterone (P4). These epithelial cells respond to E2 with increased protein and DNA synthesis, whereas P4 inhibits only the E2-induced DNA synthetic response. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Zhu L,Kuokkanen S,Pollard JW

更新日期：2015-03-17 00:00:00

abstract：:Many studies have reported age-related changes in immune responses that could be due to alterations in lymphoid cell numbers or functions. Here we report the results of studies using immunofluorescent staining and in vitro assays of cellular function to compare the expression of cell surface antigens on lymphocytes fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidman CL,Luther EA,Marshall JD,Nguyen KA,Roopenian DC,Worthen SM

更新日期：1987-11-01 00:00:00

abstract：:Contemporary climate change is characterized both by increasing mean temperature and increasing climate variability such as heat waves, storms, and floods. How populations and communities cope with such climatic extremes is a question central to contemporary ecology and biodiversity conservation. Previous work has sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reusch TB,Ehlers A,Hämmerli A,Worm B

更新日期：2005-02-22 00:00:00

abstract：:DNA methylation at CpG dinucleotides is an important epigenetic regulator common to virtually all mammalian cell types, but recent evidence indicates that during early postnatal development neuronal genomes also accumulate uniquely high levels of two alternative forms of methylation, non-CpG methylation and hydroxymet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinde B,Gabel HW,Gilbert CS,Griffith EC,Greenberg ME

更新日期：2015-06-02 00:00:00