Protease and cyclooxygenase inhibitors synergistically prevent activation of human platelets.

abstract：:The biological function of the soluble form of the amyloid beta-protein (ABP) was examined by assaying its interaction with neuronal receptors expressed in Xenopus oocytes. ABP weakly activated tachykinin receptors, but in the presence of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4- propionate-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura H,Schubert D

更新日期：1993-08-15 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a heterogeneous degenerative motor neuron disease linked to numerous genetic mutations in apparently unrelated proteins. These proteins, including SOD1, TDP-43, and FUS, are highly aggregation-prone and form a variety of intracellular inclusion bodies that are characteristic of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ciryam P,Lambert-Smith IA,Bean DM,Freer R,Cid F,Tartaglia GG,Saunders DN,Wilson MR,Oliver SG,Morimoto RI,Dobson CM,Vendruscolo M,Favrin G,Yerbury JJ

更新日期：2017-05-16 00:00:00

abstract：:In this work, we report on studies of the nature of the dynamics and hydrophobic binding in cyclodextrins and human serum albumin protein complexes with orange II. With femtosecond time resolution, we examined the proton-transfer and trans-cis isomerization reactions of the ligand in these nanocavities and in pure sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Douhal A,Sanz M,Tormo L

更新日期：2005-12-27 00:00:00

abstract：:The redox potentials of electron transfer proteins vary over a wide range, even when the type of redox center is the same. Rees [Proc. Natl. Acad. Sci. USA (1985) 82, 3082-3085] proposed that this variation of redox potential partly reflects the different net charges of the proteins, and he presented a linear correlat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore GR,Pettigrew GW,Rogers NK

更新日期：1986-07-01 00:00:00

abstract：:The emerging picture of Earth's deep interior from seismic tomography indicates more complexity than previously thought. The presence of lateral anisotropy and heterogeneity in Earth's mantle highlights the need for fully anisotropic elasticity data from mineral physics. A breakthrough in high-frequency (gigahertz) ul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobsen SD,Spetzler H,Reichmann HJ,Smyth JR

更新日期：2004-04-20 00:00:00

abstract：:The most common monogenic cause of small-vessel disease leading to ischemic stroke and vascular dementia is the neurodegenerative syndrome cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is associated with mutations in the Notch 3 receptor. CADASIL pathology ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arboleda-Velasquez JF,Manent J,Lee JH,Tikka S,Ospina C,Vanderburg CR,Frosch MP,Rodríguez-Falcón M,Villen J,Gygi S,Lopera F,Kalimo H,Moskowitz MA,Ayata C,Louvi A,Artavanis-Tsakonas S

更新日期：2011-05-24 00:00:00

abstract：:Food choices are shifting globally in ways that are negatively affecting both human health and the environment. Here we consider how consuming an additional serving per day of each of 15 foods is associated with 5 health outcomes in adults and 5 aspects of agriculturally driven environmental degradation. We find that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark MA,Springmann M,Hill J,Tilman D

更新日期：2019-11-12 00:00:00

abstract：:Treatment of myoblast cell lines with 3-deazaadenosine stimulates differentiation into myofibers. Myoblast clone L5/ 3B5 , which does not form myofibers after 6 days in fusion medium, was stimulated to form myofibers after 5 days of culture in fusion medium containing 50 microM 3-deazaadenosine. Myoblast clone L5/ 3C4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scarpa S,Strom R,Bozzi A,Aksamit RR,Backlund PS Jr,Chen J,Cantoni GL

更新日期：1984-05-01 00:00:00

abstract：:Molecular junctions are essentially modified electrodes familiar to electrochemists where the electrolyte is replaced by a conducting "contact." It is generally hypothesized that changing molecular structure will alter system energy levels leading to a change in the transport barrier. Here, we show the conductance of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sayed SY,Fereiro JA,Yan H,McCreery RL,Bergren AJ

更新日期：2012-07-17 00:00:00

abstract：:Immobilizing a protein, that is fully compatible with the patient, on the surface of a biomedical device should make it possible to avoid adverse responses such as inflammation, rejection, or excessive fibrosis. A surface that strongly binds and does not denature the compatible protein is required. Hydrophilic surface...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bilek MM,Bax DV,Kondyurin A,Yin Y,Nosworthy NJ,Fisher K,Waterhouse A,Weiss AS,dos Remedios CG,McKenzie DR

更新日期：2011-08-30 00:00:00

abstract：:In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by a single amino acid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Chollier M,Watson LC,Cooper SB,Pufall MA,Liu JS,Borzym K,Vingron M,Yamamoto KR,Meijsing SH

更新日期：2013-10-29 00:00:00

abstract：:We describe the use of a series of gradually expanded thymine nucleobase analogs in probing steric effects in DNA polymerase efficiency and fidelity. In these nonpolar compounds, the base size was increased incrementally over a 1.0-A range by use of variably sized atoms (H, F, Cl, Br, and I) to replace the oxygen mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim TW,Delaney JC,Essigmann JM,Kool ET

更新日期：2005-11-01 00:00:00

abstract：:Two prominent timekeeping systems, the cell cycle, which controls cell division, and the circadian system, which controls 24-h rhythms of physiology and behavior, are found in nearly all living organisms. A distinct feature of circadian rhythms is that they are temperature-compensated such that the period of the rhyth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeom M,Pendergast JS,Ohmiya Y,Yamazaki S

更新日期：2010-05-25 00:00:00

abstract：:A dynamical theory for the evolution of the genetic code is presented, which accounts for its universality and optimality. The central concept is that a variety of collective, but non-Darwinian, mechanisms likely to be present in early communal life generically lead to refinement and selection of innovation-sharing pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vetsigian K,Woese C,Goldenfeld N

更新日期：2006-07-11 00:00:00

abstract：:Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that form at the surfaces o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Hope LW,Brasch M,Reinhard C,Cohen SN

更新日期：2003-06-24 00:00:00

abstract：:The mitogenic neuropeptides bombesin and vasopressin markedly increased tyrosine and serine phosphorylation of multiple substrates in quiescent Swiss 3T3 fibroblasts, including two major bands of Mr 90,000 and 115,000. Tyrosine phosphorylation of these proteins was increased as judged by immunoprecipitation of 32Pi-la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zachary I,Gil J,Lehmann W,Sinnett-Smith J,Rozengurt E

更新日期：1991-06-01 00:00:00

abstract：:We examine a nonreciprocally coupled dynamical model of a mixture of two diffusing species. We demonstrate that nonreciprocity, which is encoded in the model via antagonistic cross-diffusivities, provides a generic mechanism for the emergence of traveling patterns in purely diffusive systems with conservative dynamics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： You Z,Baskaran A,Marchetti MC

更新日期：2020-08-18 00:00:00

abstract：:Previous studies have shown changes in membrane properties of neurons in rat deep cerebellar nuclei (DCN) as a function of development, but due to technical difficulties in obtaining viable DCN slices from adult animals, it remains unclear whether there are learning-related alterations in the membrane properties of DC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Smith-Bell CA,Burhans LB,O'Dell DE,Bell RW,Schreurs BG

更新日期：2018-10-02 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae, mutations in either of two unlinked genes, RAM1 or RAM2, abolish the farnesyltransferase activity responsible for prenylation of Ras proteins and the a-factor mating pheromone. Here we report that the function of RAM1 and RAM2 genes is required for the membrane localization of Ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He B,Chen P,Chen SY,Vancura KL,Michaelis S,Powers S

更新日期：1991-12-15 00:00:00

abstract：:Argonaute (Ago) proteins are the key component of the RNA-induced silencing complex and mediate RNA interference (RNAi) in association with small RNAs. Although overall the mechanism of RNAi is well understood, many molecular details of this complex process are not. Here we report about in-depth steady-state and, in p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deerberg A,Willkomm S,Restle T

更新日期：2013-10-29 00:00:00

abstract：:The stator ring of the bacterial flagellar motor is composed of the MotA and MotB proteins that act together to generate a turning force (torque) acting on the FliG ring of the rotor. The C-terminal domain of MotB (MotB-C) is believed to anchor the MotA/MotB complex to peptidoglycan (PG) of the cell wall. The first cr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roujeinikova A

更新日期：2008-07-29 00:00:00

abstract：:New Zealand Black (NZB) mice develop after 16 weeks of age an autoimmune and lymphoproliferative disease which is a model for systemic lupus erythematosus and lymphoid malignancy in humans. At this age, the mice manifest a progressive decline in T lymphocyte (thymus-derived lymphocyte) functions and serum thymosin lev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dauphinee MJ,Talal N,Goldstein AL,White A

更新日期：1974-07-01 00:00:00

abstract：:Far-red radiation (FR) reflected by green tissues is a key signal that plants use to detect the proximity of future competitors. Perception of increased levels of FR elicits a suite of responses collectively known as the shade-avoidance syndrome, which includes increased stem elongation, production of erect leaves, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Izaguirre MM,Mazza CA,Biondini M,Baldwin IT,Ballaré CL

更新日期：2006-05-02 00:00:00

abstract：:Whether the mate sampling and choice performed by females in nature influences offspring performance is a controversial issue in theory and an open empirical question. Pronghorn (Antilocapra americana) females engage in an obvious and energetically expensive mate sampling process to identify vigorous males. Although i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Byers JA,Waits L

更新日期：2006-10-31 00:00:00

abstract：:Tissue kallikrein (TK) is a serine protease synthetized in renal tubular cells located upstream from the collecting duct where renal potassium balance is regulated. Because secretion of TK is promoted by K+ intake, we hypothesized that this enzyme might regulate plasma K+ concentration ([K+]). We showed in wild-type m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Moghrabi S,Houillier P,Picard N,Sohet F,Wootla B,Bloch-Faure M,Leviel F,Cheval L,Frische S,Meneton P,Eladari D,Chambrey R

更新日期：2010-07-27 00:00:00

abstract：:An unusual cAMP signaling system mediates many of the events that prepare spermatozoa to meet the egg. Its components include the atypical, bicarbonate-stimulated, sperm adenylyl cyclase and a cAMP-dependent protein kinase (PKA) with the unique catalytic subunit termed Calpha(2) or C(s). We generated mice that lack Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nolan MA,Babcock DF,Wennemuth G,Brown W,Burton KA,McKnight GS

更新日期：2004-09-14 00:00:00

abstract：:A peptide containing 31 amino acids with inhibin-like activity has been synthesized by the solid-phase method. The synthetic product was shown to be homogeneous in high-performance liquid chromatography and paper electrophoresis. In the mouse pituitary incubation system, the follitropin-suppressing activity of the syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamashiro D,Li CH,Ramasharma K,Sairam MR

更新日期：1984-09-01 00:00:00

abstract：:This paper provides transcendental and algebraic framework for the classification of identities expressing pi and other logarithms of algebraic numbers as rapidly convergent generalized hypergeometric series in rational parameters. Algebraic and arithmetic relations between values of p+1Fp hypergeometric functions and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chudnovsky DV,Chudnovsky GV

更新日期：1998-03-17 00:00:00

abstract：:The receptor for acetylcholine was partially purified by affinity chromatography of an extract in Triton X-100 of membrane fragments from electric tissue. The receptor was assayed, after its reduction with dithiothreitol, by reaction with the affinity-alkylating agent, [methyl-(3)H]4-(N-maleimido)-benzyltrimethylammon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karlin A,Cowburn D

更新日期：1973-12-01 00:00:00

abstract：:Conflicts of interest between the community and its members are at the core of human social dilemmas. If observed selfishness has future costs, individuals may hide selfish acts but display altruistic ones, and peers aim at identifying the most selfish persons to avoid them as future social partners. An interaction in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rockenbach B,Milinski M

更新日期：2011-11-08 00:00:00