Shear waves in the diamond-anvil cell reveal pressure-induced instability in (Mg,Fe)O.

abstract：:Mussels adhere to a variety of surfaces by depositing a highly specific ensemble of 3,4-dihydroxyphenyl-l-alanine (DOPA) containing proteins. The adhesive properties of Mytilus edulis foot proteins mfp-1 and mfp-3 were directly measured at the nano-scale by using a surface forces apparatus (SFA). An adhesion energy of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Q,Gourdon D,Sun C,Holten-Andersen N,Anderson TH,Waite JH,Israelachvili JN

更新日期：2007-03-06 00:00:00

abstract：:The law of the iterated logarithm provides a family of bounds all of the same order such that with probability one only finitely many partial sums of a sequence of independent and identically distributed random variables exceed some members of the family, while for others infinitely many do so. In the former case, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slivka J

更新日期：1969-06-01 00:00:00

abstract：:Much debate has revolved around the question of whether the mode of evolutionary and ecological turnover in the fossil record of African mammals was continuous or pulsed, and the degree to which faunal turnover tracked changes in global climate. Here, we assembled and analyzed large specimen databases of the fossil re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi F,Kiessling W

更新日期：2015-08-25 00:00:00

abstract：:Recent findings demonstrated proinflammatory functions of interleukin (IL)-9-producing T helper type (Th) 9 cells in the pathogenesis of intestinal bowel diseases (IBDs). However, also antiinflammatory properties have been ascribed to Th9 cells, pointing to a functional heterogeneity. To dissect the specific expressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanko K,Iwert C,Appelt C,Vogt K,Schumann J,Strunk FJ,Ahrlich S,Schlickeiser S,Romagnani C,Jürchott K,Meisel C,Willimsky G,Kühl AA,Sawitzki B

更新日期：2018-03-27 00:00:00

abstract：:Nitric oxide (NO) and reactive oxygen species (ROS) act independently as well as cooperatively to induce neuronal death in acute neurological disorders. Inhibition of neuronal nitric oxide synthase (nNOS) and inhibition of lipid peroxidation induced by ROS have both been proposed as neuroprotective strategies in strok...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chabrier PE,Auguet M,Spinnewyn B,Auvin S,Cornet S,Demerlé-Pallardy C,Guilmard-Favre C,Marin JG,Pignol B,Gillard-Roubert V,Roussillot-Charnet C,Schulz J,Viossat I,Bigg D,Moncada S

更新日期：1999-09-14 00:00:00

abstract：:A model of protein-ligand binding kinetics, in which slow solvent dynamics results from hydrophobic drying transitions, is investigated. Molecular dynamics simulations show that solvent in the receptor pocket can fluctuate between wet and dry states with lifetimes in each state that are long enough for the extraction ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mondal J,Morrone JA,Berne BJ

更新日期：2013-08-13 00:00:00

abstract：:Resequencing or reference-based assemblies reveal large parts of the small-scale sequence variation. However, they typically fail to separate such local variation into colinear and rearranged variation, because they usually do not recover the complement of large-scale rearrangements, including transpositions and inver...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zapata L,Ding J,Willing EM,Hartwig B,Bezdan D,Jiao WB,Patel V,Velikkakam James G,Koornneef M,Ossowski S,Schneeberger K

更新日期：2016-07-12 00:00:00

abstract：:Sarcoplasmic reticulum vesicles were exposed to various thiol-directed spin labels, and the position of the label on the inner or outer vesicle surface was investigated as a function of the ATPase (adenosinetriphosphatase; ATP phosphohydrolase, EC 3.6.1.3) chemical state. Previous measurements of label accessibility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Champeil P,Rigaud JL,Gary-Bobo CM

更新日期：1980-05-01 00:00:00

abstract：:More than 21 million prescriptions for warfarin are written yearly in the U.S. Despite its importance, warfarin's target, vitamin K epoxide reductase (VKOR), has resisted purification since its identification in 1972. Here, we report its purification and reconstitution. HPC4, a calcium-specific antibody that recognize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu PH,Huang TY,Williams J,Stafford DW

更新日期：2006-12-19 00:00:00

abstract：:In RBL-2H3 rat tumor mast cells, cross-linking the high-affinity IgE receptor Fc epsilon RI causes tyrosine phosphorylation of multiple proteins. These phosphoproteins include phospholipase C gamma 1, the beta and gamma subunits of the Fc epsilon RI, the Src family protein-tyrosine kinase Lyn, and a 72-kDa protein tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hutchcroft JE,Geahlen RL,Deanin GG,Oliver JM

更新日期：1992-10-01 00:00:00

abstract：:Dimers of bacteriochlorophyll a (Bchla) with optical absorption maximum at 853 nm and a nonconservative circular dichroism spectrum are formed in a solution of formamide/water that contains micelles of Triton X-100. The apparent equilibrium constant and the corresponding Gibbs energy change for the Bchl self-organizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherz A,Rosenbach-Belkin V

更新日期：1989-03-01 00:00:00

abstract：:A segment of DNA containing cya, the gene for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], has been isolated from Salmonella typhimurium. The phage lambda gt4 was used as a cloning vector and adenylate cyclase-positive hybrid phages were isolated that complemented adenylate cyclase-negative bac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang JY,Clegg DO,Koshland DE Jr

更新日期：1981-08-01 00:00:00

abstract：:In photosynthesis, light is captured by antenna proteins. These proteins transfer the excitation energy with almost 100% quantum efficiency to the reaction centers, where charge separation takes place. The time scale and pathways of this transfer are controlled by the protein scaffold, which holds the pigments at opti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müh F,Madjet Mel-A,Adolphs J,Abdurahman A,Rabenstein B,Ishikita H,Knapp EW,Renger T

更新日期：2007-10-23 00:00:00

abstract：:ADP activates a family of cell surface receptors that modulate signaling pathways in a broad range of cells. ADP receptor antagonists are widely used to treat cardiovascular disease states. These studies identify a critical role for the stable reactive oxygen species hydrogen peroxide (H2O2) in mediating cellular resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalwa H,Sartoretto JL,Martinelli R,Romero N,Steinhorn BS,Tao M,Ozaki CK,Carman CV,Michel T

更新日期：2014-03-04 00:00:00

abstract：:Suppressor T cells have been shown to be much more radiosensitive than other lymphoïd cells, and we have tried to reduce tumor growth by low-dose irradiation. Syngeneic DBA/2 mice received whole-body irradiation (150 rads; 1 rad = 0.01 J/kg) 6 days after P815 tumor inoculation. Tumor growth is significantly reduced in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilkin AF,Schaaf-Lafontaine N,Van Acker A,Boccadoro M,Urbain J

更新日期：1981-03-01 00:00:00

abstract：:Cancer therapies using genes and other macromolecules might realize their full clinical potential if they could be delivered to tumor tissue in optimal quantities. Unfortunately, the compromised circulation within tumors poses a formidable resistance to adequate and uniform penetration of these agents. Previously, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Netti PA,Hamberg LM,Babich JW,Kierstead D,Graham W,Hunter GJ,Wolf GL,Fischman A,Boucher Y,Jain RK

更新日期：1999-03-16 00:00:00

abstract：:Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same period...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-Emmenegger C,Xiao Q,Kostina NY,Sherman SE,Rahimi K,Partridge BE,Li S,Sahoo D,Reveron Perez AM,Buzzacchera I,Han H,Kerzner M,Malhotra I,Möller M,Wilson CJ,Good MC,Goulian M,Baumgart T,Klein ML,Percec V

更新日期：2019-03-19 00:00:00

abstract：:We report the isolation and sequencing of cDNAs encoding two human glutamate decarboxylases (GADs; L-glutamate 1-carboxy-lyase, EC 4.1.1.15), GAD65 and GAD67. Human GAD65 cDNA encodes a Mr 65,000 polypeptide, with 585 amino acid residues, whereas human GAD67 encodes a Mr 67,000 polypeptide, with 594 amino acid residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bu DF,Erlander MG,Hitz BC,Tillakaratne NJ,Kaufman DL,Wagner-McPherson CB,Evans GA,Tobin AJ

更新日期：1992-03-15 00:00:00

abstract：:Small ubiquitin-like modifier (SUMO) modification is emerging as an important control in transcription regulation. Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine resid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuo HY,Chang CC,Jeng JC,Hu HM,Lin DY,Maul GG,Kwok RP,Shih HM

更新日期：2005-11-22 00:00:00

abstract：:During mitosis, the mammalian Golgi vesiculates and, upon partitioning, reassembles in each daughter cell; however, it is not clear whether the disassembly process per se is important for partitioning or is merely an outcome of mitotic entry. Here, we show that Golgi vesiculation is required for progression to metapha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guizzunti G,Seemann J

更新日期：2016-10-25 00:00:00

abstract：:The complexity and specificity of metazoan transcription are determined by combinatorial control of the composition and activity of regulatory complexes. To investigate the basis of this specificity, we focused on the glucocorticoid receptor (GR), a single regulatory factor that integrates multiple signals to give ris...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen SH,Masuno K,Cooper SB,Yamamoto KR

更新日期：2013-01-29 00:00:00

abstract：:The treatment of PC12 cells with either nerve growth factor or phorbol 12-myristate 13-acetate caused a decrease in the phosphorylation of a soluble 100-kDa protein (Nsp100). After treatment with nerve growth factor, the activity of Ca2+/phospholipid-dependent protein kinase (protein kinase C) in the cytosol was incre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hama T,Huang KP,Guroff G

更新日期：1986-04-01 00:00:00

abstract：:Painful peripheral neuropathies are precipitated by nerve injury from disease or trauma. All such injuries will be accompanied by an inflammatory reaction, a neuritis, that will mobilize the immune system. The role of the inflammation itself is difficult to determine in the presence of structural damage to the nerve. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett GJ

更新日期：1999-07-06 00:00:00

abstract：:Neurons in the cochlear nuclei of duck embryos become responsive to tonal stimuli in an orderly spatial and temporal sequence. Cells responding to lower frequencies are recorded before those responding to higher frequencies. Auditory neurons are spatially arranged according to their characteristic frequencies, indicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Konishi M

更新日期：1973-06-01 00:00:00

abstract：:Our understanding of the mechanisms of neural circuit assembly is far from complete. Identification of wiring molecules with novel mechanisms of action will provide insights into how complex and heterogeneous neural circuits assemble during development. In the Drosophila olfactory system, 50 classes of olfactory recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie Q,Wu B,Li J,Xu C,Li H,Luginbuhl DJ,Wang X,Ward A,Luo L

更新日期：2019-08-06 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine that has been implicated in various inflammatory diseases. Chronic inflammation is a mainstay of liver fibrosis, a leading cause of morbidity worldwide, but the role of MIF in liver scarring has not yet been elucidated. Here we have un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heinrichs D,Knauel M,Offermanns C,Berres ML,Nellen A,Leng L,Schmitz P,Bucala R,Trautwein C,Weber C,Bernhagen J,Wasmuth HE

更新日期：2011-10-18 00:00:00

abstract：:Irrigation of the dog's oxyntic glandular mucosa contained in a chronically prepared, vagally denervated, separated pouch of the dog's stomach with a solution (0.5 mg ml-1) of lyophilized venom of the hooded cobra (Naja naja) increases the permeability of the mucosa. If irrigation with venom solution is repeated at we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davenport HW

更新日期：1976-03-01 00:00:00

abstract：:Modified bovine leukemia virus (BLV) glycoproteins were expressed by using vaccinia virus recombinants, and their fusogenic capacities were examined by a syncytia-formation assay. This analysis indicates that (i) both BLV envelope glycoproteins gp51 and gp30 are necessary for cell fusion; (ii) insertion of the N-termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonèche V,Portetelle D,Kettmann R,Willems L,Limbach K,Paoletti E,Ruysschaert JM,Burny A,Brasseur R

更新日期：1992-05-01 00:00:00

abstract：:Using data from the North American Breeding Bird Survey, we determined that most neotropical migrant bird species that breed in forests of the eastern United States and Canada have recently (1978-1987) declined in abundance after a period of stable or increasing populations. Most permanent residents and temperate-zone...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robbins CS,Sauer JR,Greenberg RS,Droege S

更新日期：1989-10-01 00:00:00

abstract：:NaeI is a remarkable type II restriction endonuclease. It must bind two recognition sequences to cleave DNA, forms a covalent protein-DNA intermediate, and is only 1 aa change away from topoisomerase and recombinase activity. The latter activities apparently derive from reactivation of a cryptic DNA ligase active site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colandene JD,Topal MD

更新日期：1998-03-31 00:00:00