当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > The effect of gene interactions on the long-term response to selection.

The effect of gene interactions on the long-term response to selection.

Abstract：

:The role of gene interactions in the evolutionary process has long been controversial. Although some argue that they are not of importance, because most variation is additive, others claim that their effect in the long term can be substantial. Here, we focus on the long-term effects of genetic interactions under directional selection assuming no mutation or dominance, and that epistasis is symmetrical overall. We ask by how much the mean of a complex trait can be increased by selection and analyze two extreme regimes, in which either drift or selection dominate the dynamics of allele frequencies. In both scenarios, epistatic interactions affect the long-term response to selection by modulating the additive genetic variance. When drift dominates, we extend Robertson's [Robertson A (1960)Proc R Soc Lond B Biol Sci153(951):234-249] argument to show that, for any form of epistasis, the total response of a haploid population is proportional to the initial total genotypic variance. In contrast, the total response of a diploid population is increased by epistasis, for a given initial genotypic variance. When selection dominates, we show that the total selection response can only be increased by epistasis when some initially deleterious alleles become favored as the genetic background changes. We find a simple approximation for this effect and show that, in this regime, it is the structure of the genotype-phenotype map that matters and not the variance components of the population.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Paixão T,Barton NH

doi

10.1073/pnas.1518830113

subject

Has Abstract

pub_date

2016-04-19 00:00:00

pages

4422-7

issue

16

eissn

0027-8424

issn

1091-6490

pii

1518830113

journal_volume

113

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information.

    abstract：:Participation of two medial temporal lobe structures, the hippocampal region and the amygdala, in long-term declarative memory encoding was examined by using positron emission tomography of regional cerebral glucose. Positron emission tomography scanning was performed in eight healthy subjects listening passively to a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.24.14506

    authors： Alkire MT,Haier RJ,Fallon JH,Cahill L

    更新日期：1998-11-24 00:00:00

  • Germ-line expression of an oncogenic erbB2 allele confers resistance to erbB2-induced mammary tumorigenesis.

    abstract：:We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary adenocarcinomas. To assess whether mammary tumorigenesis in this model is influenced by the developmental window of expression, we...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0306802101

    authors： Andrechek ER,Hardy WR,Laing MA,Muller WJ

    更新日期：2004-04-06 00:00:00

  • CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling.

    abstract：:The balance between cell survival and cell death is critical for normal lymphoid development. This balance is maintained by signals through lymphocyte antigen receptors and death receptors such as CD95/Fas. In some cells, ligating the B cell antigen receptor can protect the cell from apoptosis induced by CD95. Here we...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.111158598

    authors： Yankee TM,Draves KE,Ewings MK,Clark EA,Graves JD

    更新日期：2001-06-05 00:00:00

  • BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

    abstract：:The BCL2 protooncogene encodes an inner mitochondrial membrane protein that blocks programmed cell death. BCL2 was isolated from the chromosomal breakpoint of follicular B-cell lymphoma. Transgenic mice that overexpress BCL2 display extended survival of resting B cells. In this study we use a monospecific anti-human B...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.16.6961

    authors： Hockenbery DM,Zutter M,Hickey W,Nahm M,Korsmeyer SJ

    更新日期：1991-08-15 00:00:00

  • Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe.

    abstract：:Autonomously replicating sequence (ARS) elements of the fission yeast Schizosaccharomyces pombe contain multiple imperfect copies of the consensus sequence reported by Maundrell et al. [Maundrell K., Hutchison, A. & Shall, S. (1988) EMBO J. 7, 2203-2209]. When cell free extracts of S. pombe were incubated with a dimer...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.1.502

    authors： Murakami Y,Huberman JA,Hurwitz J

    更新日期：1996-01-09 00:00:00

  • Inhibition of cellular protein synthesis by double-stranded RNA: inactivation of an initiation factor.

    abstract：:Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA is caused by the inactivation of IF-3, an initiation factor required for the recycling of ribosomes and for their binding to messenger RNA. The evidence for this is that (i) the inhibition can be overcome by addition of exogenous If-...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.70.4.1222

    authors： Kaempfer R,Kaufman J

    更新日期：1973-04-01 00:00:00

  • The energy of substituted ethanes. Asymmetry orbitals.

    abstract：:The leading terms in the energy of a general substituted ethane are derived in explicit form as a function of the torsional angle theta, the substituent electronegativities, and their mutual overlaps. The energy is found to be the sum of all four overlaps between pairs of asymmetry orbitals, and satisfies the requisit...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.70.2.531

    authors： Salem L,Hoffmann R,Otto P

    更新日期：1973-02-01 00:00:00

  • Changes in neuromuscular junction endplate current time constants produced by sulfhydryl reagents.

    abstract：:The acetylcholine receptor is a protein that contains certain critical disulfide bonds. Experiments were designed to determine the role such bonds might play in the physiological activity of the receptor. Modification of the receptor with sodium bisulfite and diamide produced an increase in the time constants of the m...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.12.7806

    authors： Steinacker A,Zuazaga DC

    更新日期：1981-12-01 00:00:00

  • Correlated protein conformational states and membrane dynamics during attack by pore-forming toxins.

    abstract：:Pore-forming toxins (PFTs) are a class of proteins implicated in a wide range of virulent bacterial infections and diseases. These toxins bind to target membranes and subsequently oligomerize to form functional pores that eventually lead to cell lysis. While the protein undergoes large conformational changes on the bi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1821897116

    authors： Ponmalar II,Cheerla R,Ayappa KG,Basu JK

    更新日期：2019-06-25 00:00:00

  • Monoclonal antibodies with exclusive reactivity against parathyroid cells and tubule cells of the kidney.

    abstract：:Four monoclonal anti-parathyroid antibodies were generated after immunization of mice with intact cells from human parathyroid tissue. All four monoclonal antibodies reacted in immunohistochemistry with structures present on parathyroid epithelial cells and proximal-tubule cells of the kidney but were unreactive with ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.9.2990

    authors： Juhlin C,Holmdahl R,Johansson H,Rastad J,Akerström G,Klareskog L

    更新日期：1987-05-01 00:00:00

  • Molecular dynamics analysis of a buckyball-antibody complex.

    abstract：:This is a multinanosecond molecular dynamics study of a bio-nano complex formed by a carbon nanoparticle, a buckyball C(60), and a biological molecule, an antibody, with high binding affinity and specificity. In the simulation, the ball is completely desolvated by the binding site of the antibody by means of a nearly ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.022532599

    authors： Noon WH,Kong Y,Ma J

    更新日期：2002-04-30 00:00:00

  • In vitro modulation of antigen-primed T cells by a glycosylation-inhibiting factor that regulates the formation of antigen-specific suppressive factors.

    abstract：:BDF1 [(C57BL/6 X DBA/2)F1] mice were primed with alum-absorbed ovalbumin, and their spleen cells were cultured with ovalbumin to activate antigen-primed T cells. The activated T cells were then propagated in interleukin 2-containing medium in the presence or absence of affinity-purified glycosylation-inhibiting factor...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.8.2444

    authors： Iwata M,Ishizaka K

    更新日期：1987-04-01 00:00:00

  • Expression of a human acetylcholinesterase promoter-reporter construct in developing neuromuscular junctions of Xenopus embryos.

    abstract：:We have employed Xenopus embryos to express human acetylcholinesterase (AcChoEase; EC 3.1.1.7) in developing synapses. Transcription of AcChoEase mRNA was driven by a 2.2-kb sequence upstream from the initiator AUG in the ACHE gene encoding AcChoEase, with multiple potential sites for binding universal and tissue-spec...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.6.2471

    authors： Ben Aziz-Aloya R,Seidman S,Timberg R,Sternfeld M,Zakut H,Soreq H

    更新日期：1993-03-15 00:00:00

  • Pupil dilation reflects perceptual selection and predicts subsequent stability in perceptual rivalry.

    abstract：:During sustained viewing of an ambiguous stimulus, an individual's perceptual experience will generally switch between the different possible alternatives rather than stay fixed on one interpretation (perceptual rivalry). Here, we measured pupil diameter while subjects viewed different ambiguous visual and auditory st...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0707727105

    authors： Einhäuser W,Stout J,Koch C,Carter O

    更新日期：2008-02-05 00:00:00

  • Next-generation sequencing identifies rare variants associated with Noonan syndrome.

    abstract：:Noonan syndrome (NS) is a relatively common genetic disorder, characterized by typical facies, short stature, developmental delay, and cardiac abnormalities. Known causative genes account for 70-80% of clinically diagnosed NS patients, but the genetic basis for the remaining 20-30% of cases is unknown. We performed ne...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1324128111

    authors： Chen PC,Yin J,Yu HW,Yuan T,Fernandez M,Yung CK,Trinh QM,Peltekova VD,Reid JG,Tworog-Dube E,Morgan MB,Muzny DM,Stein L,McPherson JD,Roberts AE,Gibbs RA,Neel BG,Kucherlapati R

    更新日期：2014-08-05 00:00:00

  • Enhancement of biomixing by swimming algal cells in two-dimensional films.

    abstract：:Fluid mixing in active suspensions of microorganisms is important to ecological phenomena and presents a fascinating stochastic process. We investigate the mixing produced by swimming unicellular algal cells (Chlamydomonas) in quasi-two-dimensional liquid films by simultaneously tracking the motion of the cells and th...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1107046108

    authors： Kurtuldu H,Guasto JS,Johnson KA,Gollub JP

    更新日期：2011-06-28 00:00:00

  • A maize sesquiterpene cyclase gene induced by insect herbivory and volicitin: characterization of wild-type and mutant alleles.

    abstract：:Plants can defend themselves from herbivorous insects by emitting volatile chemical signals that attract natural enemies of the herbivore. For example, maize seedlings attacked by beet armyworm larvae (Spodoptera exigua) produce a mixture of terpenoid and indole volatiles that serve to attract parasitic wasps. A key s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.240284097

    authors： Shen B,Zheng Z,Dooner HK

    更新日期：2000-12-19 00:00:00

  • A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits.

    abstract：:The suprachiasmatic nucleus (SCN) is the principal circadian pacemaker of mammals, coordinating daily rhythms of behavior and metabolism. Circadian timekeeping in SCN neurons revolves around transcriptional/posttranslational feedback loops, in which Period (Per) and Cryptochrome (Cry) genes are negatively regulated by...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1101767108

    authors： Maywood ES,Chesham JE,O'Brien JA,Hastings MH

    更新日期：2011-08-23 00:00:00

  • Glutamatergic reinnervation through peripheral nerve graft dictates assembly of glutamatergic synapses at rat skeletal muscle.

    abstract：:Acetylcholine is the main neurotransmitter at the mammalian neuromuscular junction (NMJ) where nicotinic acetylcholine receptors mediate the signaling between nerve terminals and muscle fibers. We show that under glutamatergic transmission, rat NMJ switches from cholinergic type synapse to glutamatergic synapse. Conne...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0500530102

    authors： Brunelli G,Spano P,Barlati S,Guarneri B,Barbon A,Bresciani R,Pizzi M

    更新日期：2005-06-14 00:00:00

  • Vaccine protection against simian immunodeficiency virus infection.

    abstract：:Rhesus monkeys were immunized by multiple inoculations with purified, disrupted, noninfectious simian immunodeficiency virus (SIV) in adjuvant. Immunized monkeys developed anti-SIV antibodies detectable by whole-virus ELISA and by immunoblot reactivity; these antibodies had weak neutralizing activity. One week after t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.16.6353

    authors： Desrosiers RC,Wyand MS,Kodama T,Ringler DJ,Arthur LO,Sehgal PK,Letvin NL,King NW,Daniel MD

    更新日期：1989-08-01 00:00:00

  • Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids.

    abstract：:Evidence is presented for the simultaneous release of platelet-activating factor (PAF-acether) and of its deacetylated derivative (lyso-PAF-acether) from hog leukocytes. On the basis of spectroscopy and chemical reactions, the structure of O-deacetyl-PAF is shown to be 1-O-alkylglyceryl 3-phosphorylcholine, an alkyl e...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.12.7019

    authors： Polonsky J,Tencé M,Varenne P,Das BC,Lunel J,Benveniste J

    更新日期：1980-12-01 00:00:00

  • Inducible response required for repair of low-dose radiation damage in human fibroblasts.

    abstract：:Ionizing radiation (IR) induces a variety of DNA lesions among which DNA double-strand breaks (DSBs) are the biologically most significant. It is currently unclear if DSB repair is equally efficient after low and high doses. Here, we use gamma-H2AX, phospho-ATM (pATM), and 53BP1 foci analysis to monitor DSB repair. We...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1002213107

    authors： Grudzenski S,Raths A,Conrad S,Rübe CE,Löbrich M

    更新日期：2010-08-10 00:00:00

  • CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

    abstract：:The nuclear factor-κB (NFκB) family of transcription factors has been implicated in inflammatory disorders, viral infections, and cancer. Most of the drugs that inhibit NFκB show significant side effects, possibly due to sustained NFκB suppression. Drugs affecting induced, but not basal, NFκB activity may have the pot...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1710467114

    authors： Chen M,Liang J,Ji H,Yang Z,Altilia S,Hu B,Schronce A,McDermott MSJ,Schools GP,Lim CU,Oliver D,Shtutman MS,Lu T,Stark GR,Porter DC,Broude EV,Roninson IB

    更新日期：2017-09-19 00:00:00

  • Action video game play facilitates the development of better perceptual templates.

    abstract：:The field of perceptual learning has identified changes in perceptual templates as a powerful mechanism mediating the learning of statistical regularities in our environment. By measuring threshold-vs.-contrast curves using an orientation identification task under varying levels of external noise, the perceptual templ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1417056111

    authors： Bejjanki VR,Zhang R,Li R,Pouget A,Green CS,Lu ZL,Bavelier D

    更新日期：2014-11-25 00:00:00

  • Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

    abstract：:We have developed an approach for deriving and characterizing antigen-receptor (CD3/Ti) signal-transduction mutants. This strategy combines receptor-mediated growth inhibition and fluorescence-activated cell sorting with the Ca2+-indicator indo-1. Despite the expression of structurally normal CD3/Ti complexes, one suc...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.19.6879

    authors： Goldsmith MA,Weiss A

    更新日期：1987-10-01 00:00:00

  • Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo.

    abstract：:Activation of JAK2 by chromosomal translocation or point mutation is a recurrent event in hematopoietic malignancies, including acute leukemias and myeloproliferative disorders. Although the effects of activated JAK2 signaling have been examined in cell lines and murine models, the functional consequences of deregulat...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0604902103

    authors： Kennedy JA,Barabé F,Patterson BJ,Bayani J,Squire JA,Barber DL,Dick JE

    更新日期：2006-11-07 00:00:00

  • Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation.

    abstract：:Skeletal muscle cells have served as a paradigm for understanding mechanisms leading to cellular differentiation. The proliferation and differentiation of muscle precursor cells require the concerted activity of myogenic regulatory factors including MyoD. In addition, chromatin modifiers mediate dynamic modifications ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1111628109

    authors： Ling BM,Bharathy N,Chung TK,Kok WK,Li S,Tan YH,Rao VK,Gopinadhan S,Sartorelli V,Walsh MJ,Taneja R

    更新日期：2012-01-17 00:00:00

  • Specific regulation by steroid hormones of the amount of type I cyclic AMP-dependent protein kinase holoenzyme.

    abstract：:The total amounts of type I and type II cytoplasmic cyclic AMP-dependent protein kinase activities were measured in various tissues of intact rats and rats subjected to castration, hypophysectomy, or adrenalectomy. After castration, the total amount of type I activity decreased rapidly in classifically steroid-respons...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.1.223

    authors： Fuller DJ,Byus CV,Russell DH

    更新日期：1978-01-01 00:00:00

  • Sequence-independent and reversible photocontrol of transcription/expression systems using a photosensitive nucleic acid binder.

    abstract：:To understand non-trivial biological functions, it is crucial to develop minimal synthetic models that capture their basic features. Here, we demonstrate a sequence-independent, reversible control of transcription and gene expression using a photosensitive nucleic acid binder (pNAB). By introducing a pNAB whose affini...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0904382106

    authors： Estévez-Torres A,Crozatier C,Diguet A,Hara T,Saito H,Yoshikawa K,Baigl D

    更新日期：2009-07-28 00:00:00

  • An antimicrobial peptide essential for bacterial survival in the nitrogen-fixing symbiosis.

    abstract：:In the nitrogen-fixing symbiosis between legume hosts and rhizobia, the bacteria are engulfed by a plant cell membrane to become intracellular organelles. In the model legume Medicago truncatula, internalization and differentiation of Sinorhizobium (also known as Ensifer) meliloti is a prerequisite for nitrogen fixati...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1500123112

    authors： Kim M,Chen Y,Xi J,Waters C,Chen R,Wang D

    更新日期：2015-12-08 00:00:00