CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling.

abstract：:Unlike other cation channels, each subunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an invariant tryptophan immediately trailing the gate-bearing S6. Recent cryo-electron microscopy of TRP vanilloid subfamily, member 1 structures revealed that this domain is a five-tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng J,Loukin SH,Anishkin A,Kung C

更新日期：2015-03-17 00:00:00

abstract：:Several dual route models of human speech processing have been proposed suggesting a large-scale anatomical division between cortical regions that support motor-phonological aspects vs. lexical-semantic aspects of speech processing. However, to date, there is no complete agreement on what areas subserve each route or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fridriksson J,Yourganov G,Bonilha L,Basilakos A,Den Ouden DB,Rorden C

更新日期：2016-12-27 00:00:00

abstract：:Monotremes have left a poor fossil record, and paleontology has been virtually mute during two decades of discussion about molecular clock estimates of the timing of divergence between the platypus and echidna clades. We describe evidence from high-resolution x-ray computed tomography indicating that Teinolophos, an E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe T,Rich TH,Vickers-Rich P,Springer M,Woodburne MO

更新日期：2008-01-29 00:00:00

abstract：:To better understand how the relatively flat antigen-combining sites of antibodies interact with the concave shaped substrate-binding clefts of proteases, we determined the structures of two antibodies in complex with the trypsin-like hepatocyte growth-factor activator (HGFA). The two inhibitory antibodies, Ab58 and A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Eigenbrot C,Liang WC,Stawicki S,Shia S,Fan B,Ganesan R,Lipari MT,Kirchhofer D

更新日期：2007-12-11 00:00:00

abstract：:Nitric oxide (NO), synthesized from L-arginine by NO synthases (NOS), plays an essential role in the regulation of cerebrovascular tone. Adenoviral vectors have been widely used to transfer recombinant genes to different vascular beds. To determine whether the recombinant endothelial NOS (eNOS) gene can be delivered i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AF,Jiang SW,Crotty TB,Tsutsui M,Smith LA,O'Brien T,Katusic ZS

更新日期：1997-11-11 00:00:00

abstract：:Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The roundworm Caenorhabditis elegans avoids 21% O2 and hypoxia and prefers intermediate O2 concentrations. We show how this O2 preference is sculpted by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oda S,Toyoshima Y,de Bono M

更新日期：2017-06-06 00:00:00

abstract：:Mechanisms of estrogen-induced tumorigenesis in the target organ are not well understood. It has been suggested that oxidative stress resulting from metabolic activation of carcinogenic estrogens plays a critical role in estrogen-induced carcinogenesis. We tested this hypothesis by using an estrogen-induced hamster re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhat HK,Calaf G,Hei TK,Loya T,Vadgama JV

更新日期：2003-04-01 00:00:00

abstract：:An intermolecular intercalation of base pairs was found at the CA step in the I222 crystal structure of the RNA.DNA hybrid, r(CAAAGAAAAG).d(CTTTTCTTTG), which contains two-thirds of the polypurine tract sequence of HIV-1 with a substitution of cytosine for the initial adenine. This sequence crystallized in both P21212...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han GW,Kopka ML,Langs D,Sawaya MR,Dickerson RE

更新日期：2003-08-05 00:00:00

abstract：:Atherosclerosis is a complex disease resulting from the interaction of multiple genes. We have used the Ldlr knockout mouse model in an interspecific genetic cross to map atherosclerosis susceptibility loci. A total of 174 (MOLF/Ei x B6.129S7-Ldlr(tm1Her)) x C57BL/6J-Ldlr(tm1Her) backcross mice, homozygous for the Ldl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welch CL,Bretschger S,Latib N,Bezouevski M,Guo Y,Pleskac N,Liang CP,Barlow C,Dansky H,Breslow JL,Tall AR

更新日期：2001-07-03 00:00:00

abstract：:The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capital...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spence MM,Rubin SM,Dimitrov IE,Ruiz EJ,Wemmer DE,Pines A,Yao SQ,Tian F,Schultz PG

更新日期：2001-09-11 00:00:00

abstract：:Progressive amyloid deposition in senile plaques and cortical blood vessels may play a central role in the pathogenesis of Alzheimer disease. We have used x-ray diffraction and electron microscopy to study the molecular organization and morphology of macromolecular assemblies formed by three synthetic peptides homolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirschner DA,Inouye H,Duffy LK,Sinclair A,Lind M,Selkoe DJ

更新日期：1987-10-01 00:00:00

abstract：:The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis. We found that cAMP-dependent protein kinase phosphorylated heterologously expressed ASIC1 and endogenous ASIC1 in brain slices. ASIC1 also showed significant phosphorylation under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard AS,Yermolaieva O,Hruska-Hageman A,Askwith CC,Price MP,Wemmie JA,Welsh MJ

更新日期：2003-02-18 00:00:00

abstract：:To assess the effect of transforming growth factor beta 1 on the skin in vivo, we have targeted its expression to the epidermis of transgenic mice. To ensure that active TGF-beta 1 was expressed, we used a porcine TGF-beta 1 cDNA with mutations of Cys-223-->Ser and Cys-225-->Ser, which allow constitutive activation. M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sellheyer K,Bickenbach JR,Rothnagel JA,Bundman D,Longley MA,Krieg T,Roche NS,Roberts AB,Roop DR

更新日期：1993-06-01 00:00:00

abstract：:The voltage-gated proton channel Hv1 plays a critical role in the fast proton translocation that underlies a wide range of physiological functions, including the phagocytic respiratory burst, sperm motility, apoptosis, and metastatic cancer. Both voltage activation and proton conduction are carried out by a voltage-se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Q,Shen R,Treger JS,Wanderling SS,Milewski W,Siwowska K,Bezanilla F,Perozo E

更新日期：2015-11-03 00:00:00

abstract：:Identifying causal effects in nonexperimental data is an enduring challenge. One proposed solution that recently gained popularity is the idea to use genes as instrumental variables [i.e., Mendelian randomization (MR)]. However, this approach is problematic because many variables of interest are genetically correlated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiPrete TA,Burik CAP,Koellinger PD

更新日期：2018-05-29 00:00:00

abstract：:Although most experimental and theoretical studies of protein folding involve proteins in vitro, the effects of spatial confinement may complicate protein folding in vivo. In this study, we examine the folding dynamics of villin (a small fast folding protein) with explicit solvent confined to an inert nanopore. We hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lucent D,Vishal V,Pande VS

更新日期：2007-06-19 00:00:00

abstract：:The nucleotide sequences of eight origin-defective mutants of simian virus 40 have been determined. All of the mutants have suffered deletions, which range in size from 4 to 241 nucleotides. Some of the mutants induce the synthesis of tumor (T) antigen, others do not. Viral mRNA extracted from rat cells transformed by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gluzman Y,Sambrook JF,Frisque RJ

更新日期：1980-07-01 00:00:00

abstract：:Population intelligence quotients increased throughout the 20th century-a phenomenon known as the Flynn effect-although recent years have seen a slowdown or reversal of this trend in several countries. To distinguish between the large set of proposed explanations, we categorize hypothesized causal factors by whether t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bratsberg B,Rogeberg O

更新日期：2018-06-26 00:00:00

abstract：:The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The balance between its active and inactive form is tightly controlled to ensure cellular integrity. We report that the transcriptional repressor C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherrier T,Le Douce V,Eilebrecht S,Riclet R,Marban C,Dequiedt F,Goumon Y,Paillart JC,Mericskay M,Parlakian A,Bausero P,Abbas W,Herbein G,Kurdistani SK,Grana X,Van Driessche B,Schwartz C,Candolfi E,Benecke AG,Van Lin

更新日期：2013-07-30 00:00:00

abstract：:The 24 human chromosome types of normal diploid fibroblast cell strain were classified into 15 groups by high-resolution flow cytometry on the basis of 33258 Hoechst fluorescence. Chromosomes associated with each group were flow sorted onto microscope slides and identified by quinacrine banding analysis. DNA cytophoto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrano AV,Gray JW,Langlois RG,Burkhart-Schultz KJ,Van Dilla MA

更新日期：1979-03-01 00:00:00

abstract：:The traG protein of the F sex factor is an inner membrane protein with a molecular weight of 116,000. Mutants in traG (or in traN) are able to trigger conjugal DNA replication even though they cannot efficiently form stable mating aggregates with F(-) cells. The traG protein (and the traN protein) probably acts in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manning PA,Morelli G,Achtman M

更新日期：1981-12-01 00:00:00

abstract：:Thiostrepton (TSR), an archetypal bimacrocyclic thiopeptide antibiotic that arises from complex posttranslational modifications of a genetically encoded precursor peptide, possesses a quinaldic acid (QA) moiety within the side-ring system of a thiopeptide-characteristic framework. Focusing on selective engineering of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng Q,Wang S,Duan P,Liao R,Chen D,Liu W

更新日期：2016-12-13 00:00:00

abstract：:We compared students' self-reported perception of learning with their actual learning under controlled conditions in large-enrollment introductory college physics courses taught using 1) active instruction (following best practices in the discipline) and 2) passive instruction (lectures by experienced and highly rated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deslauriers L,McCarty LS,Miller K,Callaghan K,Kestin G

更新日期：2019-09-24 00:00:00

abstract：:Recent findings suggest that neurons can efficiently repair oxidatively damaged DNA, and that both DNA damage and repair are enhanced by activation of excitatory glutamate receptors. However, in pathological conditions such as ischemic stroke, excessive DNA damage can trigger the death of neurons. Oxidative DNA damage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canugovi C,Yoon JS,Feldman NH,Croteau DL,Mattson MP,Bohr VA

更新日期：2012-09-11 00:00:00

abstract：:Mutant Escherichia coli strains in which export of the LamB protein (coded for by the lamB gene) to the outer membrane of the cell is prevented have been described previously. One of these mutant strains contains a small (12-base pair) deletion mutation within the region of the lamB gene that codes for the NH2-termina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emr SD,Silhavy TJ

更新日期：1983-08-01 00:00:00

abstract：:The presynaptic plasma membrane protein SNAP-25 (synaptosome-associated protein of 25 kDa) has been implicated as one of several neural-specific components that direct constitutive fusion mechanisms to the regulated vesicle trafficking and exocytosis of neurotransmitter release. There exist two alternatively spliced i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bark IC,Hahn KM,Ryabinin AE,Wilson MC

更新日期：1995-02-28 00:00:00

abstract：:A nonselective ex vivo assay was used to directly detect and quantify zidovudine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) in the blood of treated and untreated patients. In contrast to previous reports, drug-resistant virus was detected in peripheral blood mononuclear cells of a few of the patients ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohri H,Singh MK,Ching WT,Ho DD

更新日期：1993-01-01 00:00:00

abstract：:The vast majority of biologists engaged in evolutionary studies interpret virtually every aspect of biodiversity in adaptive terms. This narrow view of evolution has become untenable in light of recent observations from genomic sequencing and population-genetic theory. Numerous aspects of genomic architecture, gene st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynch M

更新日期：2007-05-15 00:00:00

abstract：:Compressional waves that sample the lowermost mantle west of Central America show a rapid change in travel times of up to 4 s over a sampling distance of 300 km and a change in waveforms. The differential travel times of the PKP waves (which traverse Earth's core) correlate remarkably well with predictions for S-wave ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun X,Song X,Zheng S,Helmberger DV

更新日期：2007-01-02 00:00:00

abstract：:Marine ecosystems are sensitive to stochastic environmental variability, with higher-amplitude, lower-frequency--i.e., "redder"--variability posing a greater threat of triggering large ecosystem changes. Here we show that fluctuations in the Pacific Decadal Oscillation (PDO) index have slowed down markedly over the ob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boulton CA,Lenton TM

更新日期：2015-09-15 00:00:00