Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice.

abstract：:Recent studies investigating the relationship between crop genetic diversity and human cultural diversity patterns showed that seed exchanges are embedded in farmers' social organization. However, our understanding of the social processes involved remains limited. We investigated how farmers' membership in three major...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Labeyrie V,Thomas M,Muthamia ZK,Leclerc C

更新日期：2016-01-05 00:00:00

abstract：:We describe a physical map of the end of the long arm of the human X chromosome encompassing the region from Xq27.2 to the q telomere, inclusive of the chromosomal band Xq28. This region is of particular interest, since it contains the highest density of genes associated with genetic diseases. The map covers a total o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poustka A,Dietrich A,Langenstein G,Toniolo D,Warren ST,Lehrach H

更新日期：1991-10-01 00:00:00

abstract：:Volcanic eruptions caused major weather and climatic changes on timescales ranging from hours to centuries in the past. Volcanic particles are injected in the atmosphere both as primary particles rapidly deposited due to their large sizes on time scales of minutes to a few weeks in the troposphere, and secondary parti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boulon J,Sellegri K,Hervo M,Laj P

更新日期：2011-07-26 00:00:00

abstract：:Trypanosomatid RNA editing is a unique process and essential for these organisms. It therefore represents a drug target for a group of protozoa that includes the causative agents for African sleeping sickness and other devastating tropical and subtropical diseases. Here, we present drug-like inhibitors of a key enzyme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amaro RE,Schnaufer A,Interthal H,Hol W,Stuart KD,McCammon JA

更新日期：2008-11-11 00:00:00

abstract：:Current structural genomics projects are yielding structures for proteins whose functions are unknown. Accordingly, there is a pressing requirement for computational methods for function prediction. Here we present PHUNCTIONER, an automatic method for structure-based function prediction using automatically extracted f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pazos F,Sternberg MJ

更新日期：2004-10-12 00:00:00

abstract：:Hierarchical cellular structures are ubiquitous in nature because of their low-density, high-specific properties, and multifunctionality. Inspired by these systems, we created lightweight ceramic architectures composed of closed-cell porous struts patterned in the form of hexagonal and triangular honeycombs by direct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muth JT,Dixon PG,Woish L,Gibson LJ,Lewis JA

更新日期：2017-02-21 00:00:00

abstract：:Eusociality is a major evolutionary innovation involving alterations in life history, morphology, and behavior. Advanced eusocial insects, such as ants, termites, and corbiculate bees, cannot provide insights into the earliest stages of eusocial evolution because eusociality in these taxa evolved long ago (in the Cret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danforth BN

更新日期：2002-01-08 00:00:00

abstract：:Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chronic wasting disease (CWD) results from shedding of prions produced at high titers in the periphery of diseased cervids. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bian J,Christiansen JR,Moreno JA,Kane SJ,Khaychuk V,Gallegos J,Kim S,Telling GC

更新日期：2019-06-18 00:00:00

abstract：:A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells. Here, we report a stimuli-responsive clustered nanoparticle to systematically overcome these multip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li HJ,Du JZ,Du XJ,Xu CF,Sun CY,Wang HX,Cao ZT,Yang XZ,Zhu YH,Nie S,Wang J

更新日期：2016-04-12 00:00:00

abstract：:P2X receptors for ATP have a wide range of physiological roles and comprise a structurally distinct family of ligand-gated trimeric ion channels. The crystal structure of a P2X4 receptor, in combination with mutagenesis studies, has provided a model of the intersubunit ATP-binding sites and identified an extracellular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts JA,Allsopp RC,El Ajouz S,Vial C,Schmid R,Young MT,Evans RJ

更新日期：2012-03-20 00:00:00

abstract：:Antibodies provide effective antiviral immunity despite the fact that viruses escape into cells when they infect. Here we show that antibodies remain attached to viruses after cell infection and mediate an intracellular immune response that disables virions in the cytosol. We have discovered that cells possess a cytos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallery DL,McEwan WA,Bidgood SR,Towers GJ,Johnson CM,James LC

更新日期：2010-11-16 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE), an autoimmune model of multiple sclerosis, is a complex disease influenced by genetic, intrinsic, and environmental factors. In this study, we questioned whether parent-of-origin effects influence EAE, using reciprocal F2 intercross progeny generated between EAE-susceptib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teuscher C,Noubade R,Spach K,McElvany B,Bunn JY,Fillmore PD,Zachary JF,Blankenhorn EP

更新日期：2006-05-23 00:00:00

abstract：:A 23-kilobase-pair segment of DNA containing the entire mouse serum albumin gene as well as 2.2 kilobase pairs of 5' and 4.3 kilobase pairs of 3' flanking sequences has been introduced into pSV2dhfr, a plasmid in which expression of the mouse dihydrofolate reductase cDNA is under the control of simian virus 40 sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deschatrette J,Fougere-Deschatrette C,Corcos L,Schimke RT

更新日期：1985-02-01 00:00:00

abstract：:Understanding the relationship between the structural and functional organization of the human brain is one of the most important goals of neuroscience. Individual variability in brain structure means that it is essential to obtain this information from the same subject. To date, this has been almost impossible. Even ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walters NB,Egan GF,Kril JJ,Kean M,Waley P,Jenkinson M,Watson JD

更新日期：2003-03-04 00:00:00

abstract：:A water-soluble component of membranes of cells from a Burkitt's lymphoma cultured cell line was used to develop an antiserum that detects an antigen(s) on acute leukemia cells. This antiserum did not react with nonlymphoid cultured cell lines except for human embryonic kidney cells infected with the Rauscher murine l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mann DL,Halterman R,Leventhal BG

更新日期：1973-02-01 00:00:00

abstract：:The simultaneous addition of [D-Ala2, D-Leu5]-enkephalin and morphiceptin at concentrations at which 98% of enkephalin (delta) and morphine (mu) receptors are occupied only partially inhibits the binding of [3H]diprenorphine to rat brain membranes. These conditions, furthermore, do not affect the curves for displaceme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang KJ,Hazum E,Cuatrecasas P

更新日期：1981-07-01 00:00:00

abstract：:A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue cells. Here we report that T cells eradicated 2-wk-old solid tumors that expressed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu RB,Engels B,Schreiber K,Ciszewski C,Schietinger A,Schreiber H,Jabri B

更新日期：2013-05-14 00:00:00

abstract：:Polymorphism in materials often leads to significantly different physical properties--the rutile and anatase polymorphs of TiO2 are a prime example. Polytypism is a special type of polymorphism, occurring in layered materials when the geometry of a repeating structural layer is maintained but the layer-stacking sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo H,Xie W,Tao J,Inoue H,Gyenis A,Krizan JW,Yazdani A,Zhu Y,Cava RJ

更新日期：2015-03-17 00:00:00

abstract：:The enhancer-binding factor NF-kappa B, which is found only in cells that transcribe immunoglobulin light chain genes, has been purified from nuclear extracts of Namalwa cells (human Burkitt lymphoma cells) by sequence-specific DNA affinity chromatography. The purified NF-kappa B has been identified as a 51-kDa polype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami K,Scheidereit C,Roeder RG

更新日期：1988-07-01 00:00:00

abstract：:Lipoproteins are emulsion particles that consist of lipids and apolipoproteins. Their natural function is to transport lipids and/or cholesterol to different tissues. We have taken advantage of the hydrophobic interior of these natural emulsions to solubilize DNA. Negatively charged DNA was first complexed with cation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hara T,Tan Y,Huang L

更新日期：1997-12-23 00:00:00

abstract：:Invasive organisms pose a global threat and are exceptionally difficult to eradicate after they become abundant in their new habitats. We report a successful multitactic strategy for combating the pink bollworm (Pectinophora gossypiella), one of the world's most invasive pests. A coordinated program in the southwester...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tabashnik BE,Liesner LR,Ellsworth PC,Unnithan GC,Fabrick JA,Naranjo SE,Li X,Dennehy TJ,Antilla L,Staten RT,Carrière Y

更新日期：2021-01-05 00:00:00

abstract：:Early abstract reasoning has typically been characterized by a "relational shift," in which children initially focus on object features but increasingly come to interpret similarity in terms of structured relations. An alternative possibility is that this shift reflects a learned bias, rather than a typical waypoint a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carstensen A,Zhang J,Heyman GD,Fu G,Lee K,Walker CM

更新日期：2019-07-09 00:00:00

abstract：:In a recent article, Hunter uses the late George Varley and George Gradwell's long-term data on the winter moth (Operophtera brumata) and green tortrix (Tortrix viridana) populations to propose a method of quantifying the relative importance of top-down effects (because of natural enemies) and bottom-up effects (becau...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hassell MP,Crawley MJ,Godfray HC,Lawton JH

更新日期：1998-09-01 00:00:00

abstract：:Mating elicits two major changes in the reproductive behavior of many insect females. The egg-laying rate increases and the readiness to accept males (receptivity) is reduced. These postmating responses last approximately 1 week in Drosophila melanogaster. Males that do not transfer sperm but transfer seminal fluid du...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Kubli E

更新日期：2003-08-19 00:00:00

abstract：:The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkage disequilibrium across the region. Furthermore, most studies to date have been limited to the examination of a subset of the HLA an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： International MHC and Autoimmunity Genetics Network.,Rioux JD,Goyette P,Vyse TJ,Hammarström L,Fernando MM,Green T,De Jager PL,Foisy S,Wang J,de Bakker PI,Leslie S,McVean G,Padyukov L,Alfredsson L,Annese V,Hafler DA,Pan-

更新日期：2009-11-03 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) cells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting nerves. However, we hypothesized the opposite process, that precancerous pancreatic cells secrete chemokines that chemoattract Schwann cells (SC) of nerves and thus induce read...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demir IE,Kujundzic K,Pfitzinger PL,Saricaoglu ÖC,Teller S,Kehl T,Reyes CM,Ertl LS,Miao Z,Schall TJ,Tieftrunk E,Haller B,Diakopoulos KN,Kurkowski MU,Lesina M,Krüger A,Algül H,Friess H,Ceyhan GO

更新日期：2017-01-03 00:00:00

abstract：:A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freedman ML,Haiman CA,Patterson N,McDonald GJ,Tandon A,Waliszewska A,Penney K,Steen RG,Ardlie K,John EM,Oakley-Girvan I,Whittemore AS,Cooney KA,Ingles SA,Altshuler D,Henderson BE,Reich D

更新日期：2006-09-19 00:00:00

abstract：:Melanocyte stimulating hormone coupled to Sepharose effects an increase in tryosinase (EC 1.14.18.1; monophenol monoxygenase) activity of cultivated mouse melanoma cells. Synchronized cells are found to respond to melanocyte stimulating hormone only in the G2 phase of the cell cycle, although their response to cyclic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varga JM,Dipasquale A,Pawelek J,McGuire JS,Lerner AB

更新日期：1974-05-01 00:00:00

abstract：:It has long been recognized that the renal proximal tubular epithelium of the hamster is a bona fide estrogen target tissue. The effect of estrogens on the growth of proximal tubule cell explants and dissociated single cells derived from these explant outgrowths has been studied in culture. Renal tubular cells were gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberley TD,Lauchner LJ,Pugh TD,Gonzalez A,Goldfarb S,Li SA,Li JJ

更新日期：1989-03-01 00:00:00

abstract：:Even in the absence of sensory stimulation, the neocortex shows complex spontaneous activity patterns, often consisting of alternating "DOWN" states of generalized neural silence and "UP" states of massive, persistent network activity. To investigate how this spontaneous activity propagates through neuronal assemblies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luczak A,Barthó P,Marguet SL,Buzsáki G,Harris KD

更新日期：2007-01-02 00:00:00