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Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.

Abstract：

:A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association (P < 4.2 x 10(-9)) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Freedman ML,Haiman CA,Patterson N,McDonald GJ,Tandon A,Waliszewska A,Penney K,Steen RG,Ardlie K,John EM,Oakley-Girvan I,Whittemore AS,Cooney KA,Ingles SA,Altshuler D,Henderson BE,Reich D

doi

10.1073/pnas.0605832103

subject

Has Abstract

pub_date

2006-09-19 00:00:00

pages

14068-73

issue

38

eissn

0027-8424

issn

1091-6490

pii

0605832103

journal_volume

103

pub_type

杂志文章

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