Abstract:
:The rat W3/25 antigen was the first marker antigen of helper T lymphocytes to be identified. Subsequently, the human OKT4 antigen (now called CD4) was described, and cell distribution and functional data suggested that W3/25 and OKT4 antigens were homologous. This is now confirmed by the matching of peptide sequences from W3/25 antigen with sequence predicted from rat cDNA clones detected by cross-hybridization with a cDNA probe for human CD4. Analysis of the two sequences suggests an evolutionary origin from a structure with four immunoglobulin-related domains, although only domain 1 at the NH2 terminus meets the standard criteria for an immunoglobulin-related sequence. CD4 domains 2 and 4 contain disulfide bonds but seem like truncated immunoglobulin domains, whereas domain 3 may have a pattern of beta-strands like an immunoglobulin variable domain, but without the disulfide bond.
journal_name
Proc Natl Acad Sci U S Aauthors
Clark SJ,Jefferies WA,Barclay AN,Gagnon J,Williams AFdoi
10.1073/pnas.84.6.1649subject
Has Abstractpub_date
1987-03-01 00:00:00pages
1649-53issue
6eissn
0027-8424issn
1091-6490journal_volume
84pub_type
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