Human--rat muscle somatic cell hybrids form myotubes and express human muscle gene products.

abstract：:Integrated single-crystal-like small and wide-angle X-ray diffraction images of a CdSe nanosheet under pressure provide direct experimental evidence for the detailed pathway of transformation of the CdSe from a wurtzite to a rock-salt structure. Two consecutive planar atomic slips [(001) {110} in parallel and (102) {1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Z,Wen XD,Hoffmann R,Son JS,Li R,Fang CC,Smilgies DM,Hyeon T

更新日期：2010-10-05 00:00:00

abstract：:Exposure of adipocytes to antibodies to the insulin receptor results in a blockade of (125)I-labeled insulin binding, stimulation of glucose oxidation, and many more insulin-like effects. Allowing for differences in purity, antireceptor antibody is equipotent with insulin on a molar basis. Both the bivalent F(ab')(2) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn CR,Baird KL,Jarrett DB,Flier JS

更新日期：1978-09-01 00:00:00

abstract：:Serotonin (5-HT) binding sites from bovine and rat cerebral cortex membranes share pharmacological properties that allow both to be subclassified by the same criteria. We show here that [3H]5-HT binding sites from human cortex also possess pharmacological properties that follow the same subclassification scheme as for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Todd RD,Ciaranello RD

更新日期：1985-01-01 00:00:00

abstract：:This study was undertaken to characterize bile acid metabolism in hereditary forms of hypertriglyceridemia. Ten hypertriglyceridemic patients (type IV phenotype) with familial combined hyperlipidemia and 7 patients with monogenic familial hypertriglyceridemia (FHTG) were compared with 18 healthy controls; all subjects...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angelin B,Hershon KS,Brunzell JD

更新日期：1987-08-01 00:00:00

abstract：:We describe a physical map of the end of the long arm of the human X chromosome encompassing the region from Xq27.2 to the q telomere, inclusive of the chromosomal band Xq28. This region is of particular interest, since it contains the highest density of genes associated with genetic diseases. The map covers a total o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poustka A,Dietrich A,Langenstein G,Toniolo D,Warren ST,Lehrach H

更新日期：1991-10-01 00:00:00

abstract：:Partial amino acid sequence of the Ia molecule encoded by the I-E or I-C (I-EC) subregion of the major histocompatibility complex of the mouse are presented. The Ia molecule appears to be comprised of two noncovalently associated polypeptides. The larger subunit, alpha, has an approximate molecular weight of 35,000 an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMillan M,Cecka JM,Murphy DB,McDevitt HO,Hood L

更新日期：1977-11-01 00:00:00

abstract：:Long-term, localized delivery of small molecules from a biodegradable thin film is challenging owing to their low molecular weight and poor charge density. Accomplishing highly extended controlled release can facilitate high therapeutic levels in specific regions of the body while significantly reducing the toxicity t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu BB,Park MH,Hagerman SR,Hammond PT

更新日期：2014-08-19 00:00:00

abstract：:Exposure of 3T3/A31 cells to serum-free medium, one type of apoptotic stimulus, causes a rapid increase in the sphingosine (Sph) level, which initiates a series of processes: (i) activation of caspase 3 through an enhanced "cascade" of caspases, (ii) release of the C-terminal-half kinase domain of PKCdelta (PKCdelta K...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki E,Handa K,Toledo MS,Hakomori S

更新日期：2004-10-12 00:00:00

abstract：:Schizosaccharomyces pombe cells were transformed with an S. pombe expression vector containing a full-length cDNA of the Chlorella hexose transporter. The transformed cells accumulated 3-O-methylglucose up to 10-fold, whereas wild-type S. pombe and control transformants could only equilibrate this sugar analogue. In a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauer N,Caspari T,Klebl F,Tanner W

更新日期：1990-10-01 00:00:00

abstract：:In flowering plants, extensive male-female interactions are required for successful fertilization in which various signaling cascades are involved. Prevacuolar compartments (PVC) and vacuoles are two types of subcellular compartments that terminate signal transduction by sequestrating signaling molecules in yeast and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao L,Liu J,Zhong S,Gu H,Qu LJ

更新日期：2016-05-31 00:00:00

abstract：:Physical and biological systems are often involved with coupled processes of different time scales. In the system with electronic and atomic motions, for example, the interplay between the atomic motion along the same energy landscape and the electronic hopping between different landscapes is critical: the system beha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang K,Sasai M,Wang J

更新日期：2013-09-10 00:00:00

abstract：:Two 1,4-benzoquinone derivatives, found in the venom of the scorpion Diplocentrus melici following exposure to air, have been isolated, characterized, synthesized, and assessed for antimicrobial activities. Initially a white, viscous liquid, the extracted venom colors within minutes under ambient conditions. From this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo-Noriega EN,Sathyamoorthi S,Banerjee S,Gnanamani E,Mendoza-Trujillo M,Mata-Espinosa D,Hernández-Pando R,Veytia-Bucheli JI,Possani LD,Zare RN

更新日期：2019-06-25 00:00:00

abstract：:In 1944, Freeman Dyson conjectured the existence of a "crank" function for partitions that would provide a combinatorial proof of Ramanujan's congruence modulo 11. Forty years later, Andrews and Garvan successfully found such a function and proved the celebrated result that the crank simultaneously "explains" the thre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahlburg K

更新日期：2005-10-25 00:00:00

abstract：:Despite extensive studies, the structural basis for the mechanochemical coupling in the rotary molecular motor F1-ATPase (F1) is still incomplete. We performed single-molecule FRET measurements to monitor conformational changes in the stator ring-α3β3, while simultaneously monitoring rotations of the central shaft-γ. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugawa M,Okazaki K,Kobayashi M,Matsui T,Hummer G,Masaike T,Nishizaka T

更新日期：2016-05-24 00:00:00

abstract：:Spreading depression (SD), a slow diffusion-mediated self-sustained wave of depolarization that severely disrupts neuronal function, has been implicated as a cause of cellular injury in a number of central nervous system pathologies, including blind spots in the retina. Here we show that in the hypoglycemic chicken re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Y,Santos LM,Mattiace LA,Costa ML,Ferreira LC,Benabou K,Kim AH,Abrahams J,Bennett MV,Rozental R

更新日期：2012-02-14 00:00:00

abstract：:DNA-based identification depends on the probability that two different individuals have the same phenotype, which is given by kinship theory. Together with the large and consistent body of evidence on human population structure, kinship theory provides a sound basis for forensic use of DNA markers. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton NE

更新日期：1992-04-01 00:00:00

abstract：:Small proteins can fold remarkably rapidly, even in μs. What limits their rate of folding? The Engrailed homeodomain is a particularly well-characterized example, which folds ultrafast via an intermediate, I, of solved structure. It is a puzzle that the helix2-turn-helix3 motif of the 3-helix bundle forms in approxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neuweiler H,Banachewicz W,Fersht AR

更新日期：2010-12-21 00:00:00

abstract：:A major challenge in research on executive control is to reveal its functional decomposition into underlying neural mechanisms. A typical assumption is that this decomposition occurs solely through anatomically based dissociations. Here we tested an alternative hypothesis that different cognitive control processes may...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braver TS,Paxton JL,Locke HS,Barch DM

更新日期：2009-05-05 00:00:00

abstract：:The properties of the virus synthesized by each of three morphologically different cell lines originating from DBA/2J fetal liver cells transformed by the anemic strain of Friend leukemia virus in vitro were analyzed. The cells of line G-1 are malignant in syngeneic DBA/2 mice, grow in suspension, and are erythroid in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuei D,Pogo BG,Friend C

更新日期：1980-10-01 00:00:00

abstract：:Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K(+) or by tetrodotoxin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman AW,Coleman JR,Griffin JD,Weltman JK,Chapman KM

更新日期：1972-03-01 00:00:00

abstract：:Bacteriophage lambda integrates into the chromosome of its Escherichia coli host by means of a site-specific recombination between a locus on the phage chromosome (phage att site) and a locus on the bacterial chromosome (bacterial att site). The nucleotide sequence of four lambda att sites altered in site-specific rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoess RH,Landy A

更新日期：1978-11-01 00:00:00

abstract：:All organisms contain thioredoxin (TRX), a regulatory thiol:disulfide protein that reduces disulfide bonds in target proteins. Unlike animals and yeast, plants contain numerous TRXs for which no function has been assigned in vivo. Recent in vitro proteomic approaches have opened the way to the identification of >100 T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vignols F,Bréhélin C,Surdin-Kerjan Y,Thomas D,Meyer Y

更新日期：2005-11-15 00:00:00

abstract：:Retinoic acid is a morphogenetic signaling molecule derived from vitamin A and involved in vertebrate development. Two groups of receptors, retinoic acid receptors and retinoid X receptors (RXRs), have been identified. All-trans-retinoic acid is the high-affinity ligand for retinoic acid receptors, and 9-cis-retinoic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Vacchio MS,Ashwell JD

更新日期：1993-07-01 00:00:00

abstract：:Crop species experienced strong selective pressure directed at genes controlling traits of agronomic importance during their domestication and subsequent episodes of selective breeding. Consequently, these genes are expected to exhibit the signature of selection. We screened 501 maize genes for the signature of select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vigouroux Y,McMullen M,Hittinger CT,Houchins K,Schulz L,Kresovich S,Matsuoka Y,Doebley J

更新日期：2002-07-23 00:00:00

abstract：:The Drake Passage (DP) is the major geographic constriction for the Antarctic Circumpolar Current (ACC) and exerts a strong control on the exchange of physical, chemical, and biological properties between the Atlantic, Pacific, and Indian Ocean basins. Resolving changes in the flow of circumpolar water masses through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamy F,Arz HW,Kilian R,Lange CB,Lembke-Jene L,Wengler M,Kaiser J,Baeza-Urrea O,Hall IR,Harada N,Tiedemann R

更新日期：2015-11-03 00:00:00

abstract：:The suprachiasmatic nucleus (SCN), the master circadian clock in mammals, sends major output signals to the subparaventricular zone (SPZ) and further to the paraventricular nucleus (PVN), the neural mechanism of which is largely unknown. In this study, the intracellular calcium levels were measured continuously in cul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YE,Enoki R,Oda Y,Huang ZL,Honma KI,Honma S

更新日期：2018-10-02 00:00:00

abstract：:A purified rabbit liver membrane protein that binds desialylated glycoproteins has been shown to be a mitogen for human peripheral lymphocytes. The mitogenic activity is specific for desialylated thymus-derived (T)-cells. The loss of mitogenicity upon exposure of the binding protein to neuraminidase and the inhibitory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novogrodsky A,Ashwell G

更新日期：1977-02-01 00:00:00

abstract：:We suggested to 228 subjects in two experiments that, as children, they had had negative experiences with a fattening food. An additional 107 subjects received no such suggestion and served as controls. In Experiment 1, a minority of subjects came to believe that they had felt ill after eating strawberry ice cream as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bernstein DM,Laney C,Morris EK,Loftus EF

更新日期：2005-09-27 00:00:00

abstract：:The mangrove killifish (Kryptolebias marmoratus) is the only vertebrate known to be capable of self-fertilization. Its gonad is typically an ovotestis that simultaneously produces eggs and sperm, and fertilization is internal. Although most populations of this species consist primarily or exclusively of hermaphroditic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackiewicz M,Tatarenkov A,Taylor DS,Turner BJ,Avise JC

更新日期：2006-06-27 00:00:00

abstract：:In 100 primary colorectal carcinomas, we demonstrate by array comparative genomic hybridization (aCGH) that 33% show DNA copy number (DCN) loss involving PARK2, the gene encoding PARKIN, the E3 ubiquitin ligase whose deficiency is responsible for a form of autosomal recessive juvenile parkinsonism. PARK2 is located on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulogiannis G,McIntyre RE,Dimitriadi M,Apps JR,Wilson CH,Ichimura K,Luo F,Cantley LC,Wyllie AH,Adams DJ,Arends MJ

更新日期：2010-08-24 00:00:00