Abstract:
:The fatty acids associated with phospholipids of cell membranes, and particularly their degree of unsaturation, contribute to the fluidity of their structure and hance determine many of their biological properties. We describe a technique for modulating membrane fluidity which consists of hydrogenating the unsaturated double bonds of membrane phospholipids. This has been accomplished using a homogeneous catalyst. The process has been applied to phospholipids in organic solvents, to phospholipids dispersed as multibilayers in aqueous systems, and also to sonicated preparations of phospholipids arranged as single bilayer vesicles. Preliminary experiments have also been performed with biological membranes. These results indicate that the process of homogeneous catalysis for the modulation of lipid fluidity of biological cell membranes may have considerable future biological and biochemical application.
journal_name
Proc Natl Acad Sci U S Aauthors
Chapman D,Quinn PJdoi
10.1073/pnas.73.11.3971keywords:
subject
Has Abstractpub_date
1976-11-01 00:00:00pages
3971-5issue
11eissn
0027-8424issn
1091-6490journal_volume
73pub_type
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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更新日期:2002-07-23 00:00:00