Molecular, functional, and evolutionary analysis of sequences specific to Salmonella.

abstract：:The fate of two recently described human B lymphocyte-specific antigens (B1 and B2) was studied after B-cell activation in vivo and in vitro. Whereas both B1 and B2 were present on virtually all B cells from normal lymph nodes, B2 was absent from approximately 50% of B cells from hyperplastic lymph nodes. When B cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stashenko P,Nadler LM,Hardy R,Schlossman SF

更新日期：1981-06-01 00:00:00

abstract：:Delta5 and Delta6 fatty acid desaturases are critical enzymes in the pathways for the biosynthesis of the polyunsaturated fatty acids arachidonic, eicosapentaenoic, and docosahexaenoic acids. They are encoded by distinct genes in mammals and Caenorhabditis elegans. This paper describes a cDNA isolated from zebrafish (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hastings N,Agaba M,Tocher DR,Leaver MJ,Dick JR,Sargent JR,Teale AJ

更新日期：2001-12-04 00:00:00

abstract：:We compared intron-exon structures in 1,560 human-mouse orthologs and 360 mouse-rat orthologs. The origin of differences in intron positions between species was inferred by comparison with an outgroup, Fugu for human-mouse and human for mouse-rat. Among 10,020 intron positions in the human-mouse comparison, we found u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roy SW,Fedorov A,Gilbert W

更新日期：2003-06-10 00:00:00

abstract：:The transporter associated with antigen processing (TAP) is essential for intracellular transport of protein fragments into the endoplasmic reticulum for loading of major histocompatibility complex (MHC) class I molecules. On the cell surface, these peptide-MHC complexes are monitored by cytotoxic T lymphocytes. To st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorbulev S,Abele R,Tampé R

更新日期：2001-03-27 00:00:00

abstract：:Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD) most commonly through loss of protein expression. In a small subpopulation of patients, missense mutations can cause DMD, Becker muscular dystrophy, or X-linked cardiomyopathy. Nearly one-half of disease-causing missense mutations are located in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henderson DM,Lee A,Ervasti JM

更新日期：2010-05-25 00:00:00

abstract：:A closed duplex DNA molecule relaxed and containing nucleosomes has a different linking number from the same molecule relaxed and without nucleosomes. What does this say about the structure of the nucleosome? A mathematical study of this question is made, representing the DNA molecule by a ribbon. It is shown that the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuller FB

更新日期：1978-08-01 00:00:00

abstract：:p150(glued) belongs to a group of proteins accumulating at microtubule plus ends (+TIPs). It plays a key role in initiating retrograde transport by recruiting and tethering endosomes and dynein to microtubules. p150(glued) contains an N-terminal microtubule-binding cytoskeleton-associated protein glycine-rich (CAP-Gly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Q,Crevenna AH,Kunze I,Mizuno N

更新日期：2014-08-05 00:00:00

abstract：:The active conformation of native peroxisomal 3-ketoacyl-CoA thiolases (EC 2.3.1.16) is homodimeric. We have previously shown that a truncated Saccharomyces cerevisiae thiolase lacking its first 16 N-terminal amino acids fails to be translocated into peroxisomes but assembles into an enzymatically active form in the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glover JR,Andrews DW,Rachubinski RA

更新日期：1994-10-25 00:00:00

abstract：:Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency of bis-acridine co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： May BC,Fafarman AT,Hong SB,Rogers M,Deady LW,Prusiner SB,Cohen FE

更新日期：2003-03-18 00:00:00

abstract：:Protein 2.1 is a 210-kilodalton protein that connects erythrocyte spectrin to the NH2-terminal cytoplasmic domain of band 3 and thereby functions as the essential linkage between the membrane skeleton and the bilayer. We cleaved this protein into specific chemical domains by limited digestion with trypsin and alpha-ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallin R,Culp EN,Coleman DB,Goodman SR

更新日期：1984-07-01 00:00:00

abstract：:The appearance of jaws was a turning point in vertebrate evolution because it allowed primitive vertebrates to capture and process large, motile prey. The vertebrate jaw consists of separate dorsal and ventral skeletal elements connected by a joint. How this structure evolved from the unjointed gill bar of a jawless a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerny R,Cattell M,Sauka-Spengler T,Bronner-Fraser M,Yu F,Medeiros DM

更新日期：2010-10-05 00:00:00

abstract：:The basidiomycete Ustilago maydis is the causative agent of the disease corn smut. To be pathogenic, strains of U. maydis must be heterozygous for a locus called "b," which appears to control both pathogenicity and sexual development. Two alleles of the b locus of U. maydis were isolated by complementation and hybridi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronstad JW,Leong SA

更新日期：1989-02-01 00:00:00

abstract：:We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moser MB,Moser EI,Forrest E,Andersen P,Morris RG

更新日期：1995-10-10 00:00:00

abstract：:Linear growth delay (stunting) affects roughly 155 million children under the age of 5 years worldwide. Treatment has been limited by a lack of understanding of the underlying pathophysiological mechanisms. Stunting is most likely associated with changes in the microbial community of the small intestine, a compartment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonaesch P,Morien E,Andrianonimiadana L,Sanke H,Mbecko JR,Huus KE,Naharimanananirina T,Gondje BP,Nigatoloum SN,Vondo SS,Kaleb Kandou JE,Randremanana R,Rakotondrainipiana M,Mazel F,Djorie SG,Gody JC,Finlay BB,Rubbo PA,

更新日期：2018-09-04 00:00:00

abstract：:Although the apoptotic role of caspases has been largely understood, accumulating evidence in Drosophila suggests that caspases also control other processes than apoptotic cell death. However, how caspases contribute to the development of the mammalian nervous system remains obscure. Here, we provide unique evidence t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohsawa S,Hamada S,Kuida K,Yoshida H,Igaki T,Miura M

更新日期：2010-07-27 00:00:00

abstract：:The ionophores A23187 and bromolasalocid (Br-X537A) acted synergistically in translocating Ca(2+) from an aqueous into an organic immiscible phase or in mediating Ca(2+) transport across the organic phase, the effects obtained in the simultaneous presence of both ionophores being greater than those expected from a sum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deleers M,Gelbcke M,Malaisse WJ

更新日期：1981-01-01 00:00:00

abstract：:Monoaminergic neurons use dopa decarboxylase (DDC; aromatic-L-amino-acid carboxy-lyase, EC 4.1.1.28) to form dopamine from L-3,4-dihydroxyphenylalanine (L-dopa). We measured regional dopa decarboxylase activity in brains of six healthy volunteers with 6-[18F]fluoro-L-dopa and positron emission tomography. We calculate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gjedde A,Reith J,Dyve S,Léger G,Guttman M,Diksic M,Evans A,Kuwabara H

更新日期：1991-04-01 00:00:00

abstract：:The G protein-coupled free fatty acid receptor-1 (FFA1/GPR40) plays a major role in the regulation of insulin secretion by fatty acids. GPR40 is considered a potential therapeutic target to enhance insulin secretion in type 2 diabetes; however, its mode of regulation is essentially unknown. The aims of this study were...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kebede M,Ferdaoussi M,Mancini A,Alquier T,Kulkarni RN,Walker MD,Poitout V

更新日期：2012-02-14 00:00:00

abstract：:In flowering plants, the asymmetrical division of the zygote is the first hallmark of apical-basal polarity of the embryo and is controlled by a MAP kinase pathway that includes the MAPKKK YODA (YDA). In Arabidopsis, YDA is activated by the membrane-associated pseudokinase SHORT SUSPENSOR (SSP) through an unusual pare...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neu A,Eilbert E,Asseck LY,Slane D,Henschen A,Wang K,Bürgel P,Hildebrandt M,Musielak TJ,Kolb M,Lukowitz W,Grefen C,Bayer M

更新日期：2019-03-19 00:00:00

abstract：:Replication and transcription of viral RNA genomes rely on host-donated proteins. Qbeta virus infects Escherichia coli and replicates and transcribes its own genomic RNA by Qbeta replicase. Qbeta replicase requires the virus-encoded RNA-dependent RNA polymerase (beta-subunit), and the host-donated translational elonga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeshita D,Tomita K

更新日期：2010-09-07 00:00:00

abstract：:Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum. In this study, cloned parasites were examined serologically and biochemically for the expression of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biggs BA,Goozé L,Wycherley K,Wollish W,Southwell B,Leech JH,Brown GV

更新日期：1991-10-15 00:00:00

abstract：:We have synthesized two sets of 15-base-long oligodeoxyribonucleotides corresponding to all possible coding sequences for a small portion of human beta 2-microglobulin. Labeled oligonucleotides were used as hybridization probes to screen bacterial clones containing cDNA sequences primed with oligo(dT) and inserted int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suggs SV,Wallace RB,Hirose T,Kawashima EH,Itakura K

更新日期：1981-11-01 00:00:00

abstract：:There is considerable evidence that links the activation of cellular genes to oncogenesis. We previously reported that structural rearrangements in the cellular oncogene c-erbB correlate with the development of erythroblastosis induced by avian leukosis virus (ALV). c-erbB recently has been shown to be related to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raines MA,Lewis WG,Crittenden LB,Kung HJ

更新日期：1985-04-01 00:00:00

abstract：:The expansion of machine learning to high-stakes application domains such as medicine, finance, and criminal justice, where making informed decisions requires clear understanding of the model, has increased the interest in interpretable machine learning. The widely used Classification and Regression Trees (CART) have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luna JM,Gennatas ED,Ungar LH,Eaton E,Diffenderfer ES,Jensen ST,Simone CB 2nd,Friedman JH,Solberg TD,Valdes G

更新日期：2019-10-01 00:00:00

abstract：:Murine fetal thymus lobes isolated from both normal and scid/scid mice can be colonized by donor cells from either human bone marrow or human umbilical cord blood in vitro. Subsequent organ culture results in a transient production of a few CD4+ CD8+ (double-positive) cells and then the accumulation of CD4+ or CD8+ (s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeoman H,Gress RE,Bare CV,Leary AG,Boyse EA,Bard J,Shultz LD,Harris DT,DeLuca D

更新日期：1993-11-15 00:00:00

abstract：:Finding regions of the genome that are significantly recurrent in noisy data are a common but difficult problem in present day computational biology. Cores of recurrent events (CORE) is a computational approach to solving this problem that is based on a formalized notion by which "core" intervals explain the observed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krasnitz A,Sun G,Andrews P,Wigler M

更新日期：2013-06-18 00:00:00

abstract：:In the last 60,000 y humans have expanded across the globe and now occupy a wider range than any other terrestrial species. Our ability to successfully adapt to such a diverse range of habitats is often explained in terms of our cognitive ability. Humans have relatively bigger brains and more computing power than othe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd R,Richerson PJ,Henrich J

更新日期：2011-06-28 00:00:00

abstract：:Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ros-Bernal F,Hunot S,Herrero MT,Parnadeau S,Corvol JC,Lu L,Alvarez-Fischer D,Carrillo-de Sauvage MA,Saurini F,Coussieu C,Kinugawa K,Prigent A,Höglinger G,Hamon M,Tronche F,Hirsch EC,Vyas S

更新日期：2011-04-19 00:00:00

abstract：:In vitro and in vivo triplet state electron paramagnetic resonance (epr) spectra of bacteriochlorophylls (Bchls) show important differences in (a) electron spin polarization (esp), and (b) zero field splitting (ZFS) parameters. The unusual esp and ZFS properties of the observed in vivo triplet state are best interpret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thurnauer MC,Katz JJ,Norris JR

更新日期：1975-09-01 00:00:00

abstract：:Seasonal oxygen depletion (hypoxia) in coastal bottom waters can lead to the release and persistence of free sulfide (euxinia), which is highly detrimental to marine life. Although coastal hypoxia is relatively common, reports of euxinia are less frequent, which suggests that certain environmental controls can delay t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seitaj D,Schauer R,Sulu-Gambari F,Hidalgo-Martinez S,Malkin SY,Burdorf LD,Slomp CP,Meysman FJ

更新日期：2015-10-27 00:00:00