Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen.

abstract：:Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of Jun probably results from transcriptional deregulation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu Sl,Bottoli I,Goller M,Vogt PK

更新日期：1999-05-11 00:00:00

abstract：:Aging and some pathological conditions are associated with the accumulation of altered (inactive or less active) forms of enzymes. It was suggested that these age-related alterations reflect spontaneous changes in protein conformation and/or posttranslational modifications (e.g., oxidation). Because changes in protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chao CC,Ma YS,Stadtman ER

更新日期：1997-04-01 00:00:00

abstract：:The protein dystrophin, normally found on the cytoplasmic surface of skeletal muscle cell membranes, is absent in patients with Duchenne muscular dystrophy as well as mdx (X-linked muscular dystrophy) mice. Although its primary structure has been determined, the precise functional role of dystrophin remains the subjec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrof BJ,Shrager JB,Stedman HH,Kelly AM,Sweeney HL

更新日期：1993-04-15 00:00:00

abstract：:Caseinolytic proteases (ClpPs) are large oligomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bacteria. Although most organisms possess a single ClpP protein, some organisms encode two or more ClpP isoforms. Here, we elucidated the crystal structures of ClpP1 and ClpP2 fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeiler E,List A,Alte F,Gersch M,Wachtel R,Poreba M,Drag M,Groll M,Sieber SA

更新日期：2013-07-09 00:00:00

abstract：:Two high molecular weight heat shock proteins, HSP90 (Mr, 90,000) and HSP100 (Mr, 100,000), were separately purified from extracts of cultured cells of a mouse lymphoma cell line, L5178Y. Both of the HSPs exist in homodimeric form under physiological conditions. Their physicochemical properties are quite similar to ea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koyasu S,Nishida E,Kadowaki T,Matsuzaki F,Iida K,Harada F,Kasuga M,Sakai H,Yahara I

更新日期：1986-11-01 00:00:00

abstract：:We previously reported that short-term immobilization stress of rats causes increased colonic mucin release, goblet cell depletion, prostaglandin E2 secretion, and colonic mast cell activation, as well as increased colonic motility. The purpose of this study was to investigate whether neurotensin (NT), a peptide expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castagliuolo I,Leeman SE,Bartolak-Suki E,Nikulasson S,Qiu B,Carraway RE,Pothoulakis C

更新日期：1996-10-29 00:00:00

abstract：:Elucidating the lineage relationships among different cell types is key to understanding human brain development. Here we developed parallel RNA and DNA analysis after deep sequencing (PRDD-seq), which combines RNA analysis of neuronal cell types with analysis of nested spontaneous DNA somatic mutations as cell lineag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang AY,Li P,Rodin RE,Kim SN,Dou Y,Kenny CJ,Akula SK,Hodge RD,Bakken TE,Miller JA,Lein ES,Park PJ,Lee EA,Walsh CA

更新日期：2020-06-23 00:00:00

abstract：:Thrombin induces platelet aggregation and formation of a fibrin clot in platelet-rich plasma; leupeptin, a protease inhibitor, partially inhibits platelet aggregation, but it does not inhibit fibrin clot formation. Indomethacin does not inhibit either thrombin-induced platelet aggregation or fibrin clot formation. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruggiero M,Lapetina EG

更新日期：1986-05-01 00:00:00

abstract：:Berninamycin is a member of the pyridine-containing thiopeptide class of antibiotics that undergoes massive posttranslational modifications from ribosomally generated preproteins. Berninamycin has a 2-oxazolyl-3-thiazolyl-pyridine core embedded in a 35-atom macrocycle rather than typical trithiazolylpyridine cores emb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malcolmson SJ,Young TS,Ruby JG,Skewes-Cox P,Walsh CT

更新日期：2013-05-21 00:00:00

abstract：:alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors undergo constitutive and ligand-induced internalization that requires dynamin and the clathrin adaptor complex AP-2. We report here that an atypical basic motif within the cytoplasmic tails of AMPA-type glutamate receptors directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kastning K,Kukhtina V,Kittler JT,Chen G,Pechstein A,Enders S,Lee SH,Sheng M,Yan Z,Haucke V

更新日期：2007-02-20 00:00:00

abstract：:Atomic level characterization of proteins and other macromolecules in the living cell is challenging. Recent advances in NMR instrumentation and methods, however, have enabled in-cell studies with prospects for multidimensional spectral characterization of individual macromolecular components. We present NMR data on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Augustus AM,Reardon PN,Spicer LD

更新日期：2009-03-31 00:00:00

abstract：:The circadian clock modulates expression of a large fraction of the Arabidopsis genome and affects many aspects of plant growth and development. We have discovered one way in which the circadian system regulates hormone signaling, identifying a node that links the clock and auxin networks. Auxin plays key roles in dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawat R,Schwartz J,Jones MA,Sairanen I,Cheng Y,Andersson CR,Zhao Y,Ljung K,Harmer SL

更新日期：2009-09-29 00:00:00

abstract：:Several findings suggest that signals from tyrosine kinases are transduced, at least in part, through ras proteins. These findings include (i) blockage of the transforming activity of constitutively active tyrosine kinases by inhibiting ras function and (ii) genetic screens in Caenorhabditis elegans and in Drosophila ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowtell D,Fu P,Simon M,Senior P

更新日期：1992-07-15 00:00:00

abstract：:It is well known that polyelectrolyte complexes and coacervates can form on mixing oppositely charged polyelectrolytes in aqueous solutions, due to mainly electrostatic attraction between the oppositely charged polymers. Here, we report the first (to the best of our knowledge) complexation and coacervation of two posi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Huang J,Lee Y,Dutta S,Yoo HY,Jung YM,Jho Y,Zeng H,Hwang DS

更新日期：2016-02-16 00:00:00

abstract：:The reported isolation of nanobacteria from human kidney stones raises the intriguing possibility that these microorganisms are etiological agents of pathological extraskeletal calcification [Kajander, E. O. & Ciftçioglu, N. (1998) Proc. Natl. Acad. Sci. USA 95, 8274-8279]. Nanobacteria were previously isolated from F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cisar JO,Xu DQ,Thompson J,Swaim W,Hu L,Kopecko DJ

更新日期：2000-10-10 00:00:00

abstract：:We have isolated a major integral membrane protein from Golgi-derived coatomer-coated vesicles. This 24-kDa protein, p24, defines a family of integral membrane proteins with homologs present in yeast and humans. In addition to sequence similarity, all p24 family members contain a motif with the characteristic heptad r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamnes MA,Craighead MW,Hoe MH,Lampen N,Geromanos S,Tempst P,Rothman JE

更新日期：1995-08-15 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:The Escherichia coli RuvA and RuvB protein complex promotes branch migration of Holliday junctions during recombinational repair and homologous recombination and at stalled replication forks. The RuvB protein belongs to the AAA(+) (ATPase associated with various cellular activities) ATPase family and forms a hexameric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hishida T,Han YW,Fujimoto S,Iwasaki H,Shinagawa H

更新日期：2004-06-29 00:00:00

abstract：:A glycoprotein was isolated and purified to homogeneity from the serum of a patient with chronic non-A, non-B hepatitis. NaDodSO4/PAGE of the glycoprotein revealed a single major band at Mr approximately 77,000. Antibodies to this glycoprotein were shown to possess the following immunoreactivity: (i) they reacted by r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto B,Gerety RJ

更新日期：1985-08-01 00:00:00

abstract：:The long-term viability of a forest industry in the Amazon region of Brazil depends on the maintenance of adequate timber volume and growth in healthy forests. Using extensive high-resolution satellite analyses, we studied the forest damage caused by recent logging operations and the likelihood that logged forests wou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asner GP,Broadbent EN,Oliveira PJ,Keller M,Knapp DE,Silva JN

更新日期：2006-08-22 00:00:00

abstract：:Glutamatergic synaptic terminals harbor reluctant synaptic vesicles (SVs) that contribute little to synchronous release during action potentials but are release competent when stimulated by sucrose or by direct intracellular application of calcium. It has been noted that the proximity of a release-competent SV to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JS,Ho WK,Lee SH

更新日期：2012-03-27 00:00:00

abstract：:A key functional event in eukaryotic gene activation is the formation of dynamic protein-protein interaction networks between transcriptional activators and transcriptional coactivators. Seemingly incongruent with the tight regulation of transcription, many biochemical and biophysical studies suggest that activators u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henley MJ,Linhares BM,Morgan BS,Cierpicki T,Fierke CA,Mapp AK

更新日期：2020-11-03 00:00:00

abstract：:On April 20, 2010, the Deepwater Horizon (DWH) blowout occurred, releasing more oil than any accidental spill in history. Oil release continued for 87 d and much of the oil and gas remained in, or returned to, the deep sea. A coral community significantly impacted by the spill was discovered in late 2010 at 1,370 m de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisher CR,Hsing PY,Kaiser CL,Yoerger DR,Roberts HH,Shedd WW,Cordes EE,Shank TM,Berlet SP,Saunders MG,Larcom EA,Brooks JM

更新日期：2014-08-12 00:00:00

abstract：:When deprived of D-glucose for 24 hr, chicken embryo fibroblasts exhibit a marked increase in hexose transport activity compared with that of control cells. Scatchard analysis of [3H]cytochalasin B binding to starved cell plasma membranes (46 pmol/mg) indicated a six-fold increase compared with fed cell plasma membran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pessin JE,Tillotson LG,Yamada K,Gitomer W,Carter-Su C,Mora R,Isselbacher KJ,Czech MP

更新日期：1982-04-01 00:00:00

abstract：:Ler, a homolog of H-NS in enteropathogenic Escherichia coli (EPEC), plays a critical role in the expression of virulence genes encoded by the pathogenic island, locus of enterocyte effacement (LEE). Although Ler acts as an antisilencer of multiple LEE operons by alleviating H-NS-mediated silencing, it represses its ow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhat A,Shin M,Jeong JH,Kim HJ,Lim HJ,Rhee JH,Paik SY,Takeyasu K,Tobe T,Yen H,Lee G,Choy HE

更新日期：2014-06-24 00:00:00

abstract：:Recent observations suggest that p53 mutations are responsible not only for growth of primary tumors but also for their dissemination. However, mechanisms involved in p53-mediated control of cell motility and invasion remain poorly understood. By using the primary ovarian surface epithelium cell culture, we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CI,Matoso A,Corney DC,Flesken-Nikitin A,Körner S,Wang W,Boccaccio C,Thorgeirsson SS,Comoglio PM,Hermeking H,Nikitin AY

更新日期：2011-08-23 00:00:00

abstract：:The electron spin resonance spectrum of the triplet excited state of Rhodopseudomonas spheroides R-26 reaction centers has been studied after excitation with the polarized narrow-bandwidth output of a tunable dye laser from 520 to 670 nm. A theory is developed relating experimental observables to the angles between th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boxer SG,Roelofs MG

更新日期：1979-11-01 00:00:00

abstract：:Appropriate expression of IL-2 plays a central role during the priming and differentiation of T cells. A tight balance between IL-2 and the effector cytokine IL-17A is essential for immune homeostasis. Epigenetic mechanisms have been documented as a key component of cytokine regulation during lineage commitment. The m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hedrich CM,Crispin JC,Rauen T,Ioannidis C,Apostolidis SA,Lo MS,Kyttaris VC,Tsokos GC

更新日期：2012-10-09 00:00:00

abstract：:This report establishes that increasing the activity of cyclic AMP-dependent protein kinase (protein kinase A; PKA) potentiates glucocorticoid-mediated signaling in embryonic day 5.5 (E5.5) chicken retina. Expression of a glutamine synthetase-chloramphenicol acetyltransferase (CAT) fusion gene is not induced by treatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Li YC,Young AP

更新日期：1993-05-01 00:00:00

abstract：:Hebb proposed that neuronal cell assemblies are critical for effective perception, cognition, and action. However, evidence for brain mechanisms that coordinate multiple coactive assemblies remains lacking. Neuronal oscillations have been suggested as one possible mechanism for cell assembly coordination. Prior studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canolty RT,Ganguly K,Kennerley SW,Cadieu CF,Koepsell K,Wallis JD,Carmena JM

更新日期：2010-10-05 00:00:00