Intercellular trafficking of a KNOTTED1 green fluorescent protein fusion in the leaf and shoot meristem of Arabidopsis.

abstract：:"Functional connectivity" techniques are commonplace tools for studying brain organization. A critical element of these analyses is to distinguish variance due to neurobiological signals from variance due to nonneurobiological signals. Multiecho fMRI techniques are a promising means for making such distinctions based ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Power JD,Plitt M,Gotts SJ,Kundu P,Voon V,Bandettini PA,Martin A

更新日期：2018-02-27 00:00:00

abstract：:Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs effective against all enzymes. Bisthiazolidines (BTZs) are carboxyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hinchliffe P,González MM,Mojica MF,González JM,Castillo V,Saiz C,Kosmopoulou M,Tooke CL,Llarrull LI,Mahler G,Bonomo RA,Vila AJ,Spencer J

更新日期：2016-06-28 00:00:00

abstract：:All decisions, whether they are personal, public, or business-related, are based on the decision maker's beliefs and values. Science can and should help decision makers by shaping their beliefs. Unfortunately, science is not easily accessible to decision makers, and scientists often do not understand decision makers' ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Winterfeldt D

更新日期：2013-08-20 00:00:00

abstract：:To investigate the evolution of the mammalian sex chromosomes, we have compared the gene content of the X chromosomes in the mammalian groups most distantly related to man (marsupials and monotremes). Previous work established that genes on the long arm of the human X chromosome are conserved on the X chromosomes in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watson JM,Spencer JA,Riggs AD,Graves JA

更新日期：1991-12-15 00:00:00

abstract：:The acid-sensing ion channel 1a (ASIC1a) is abundantly expressed in the amygdala complex and other brain regions associated with fear. Studies of mice with a disrupted ASIC1 gene suggested that ASIC1a may contribute to learned fear. To test this hypothesis, we generated mice overexpressing human ASIC1a by using the pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wemmie JA,Coryell MW,Askwith CC,Lamani E,Leonard AS,Sigmund CD,Welsh MJ

更新日期：2004-03-09 00:00:00

abstract：:Large changes in solvent accessibility to aspartate transcarbamylase (aspartate carbamoyltransferase, carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2), as monitored by tritium exchange, result from binding of substrates and substrate analogs to the catalytic subunit (c3), binding of nucleoside triphosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lennick M,Allewell NM

更新日期：1981-11-01 00:00:00

abstract：:Physiological and evolutionary adaptations operate at very different time scales. Nevertheless, there are reasons to believe there should be a strong relationship between the two, as together they modify the phenotype. Physiological adaptations change phenotype by altering certain microscopic parameters; evolutionary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milo R,Hou JH,Springer M,Brenner MP,Kirschner MW

更新日期：2007-10-23 00:00:00

abstract：:Leptin is an adipocytokine that plays a key role in the modulation of immune responses and the development and maintenance of inflammation. Circulating levels of leptin are elevated in systemic lupus erythematosus (SLE) patients, but it is not clear whether this association can reflect a direct influence of leptin on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lourenço EV,Liu A,Matarese G,La Cava A

更新日期：2016-09-20 00:00:00

abstract：:The antiangiogenic agent fumagillin (Fg) and its analog TNP-470 bind to intracellular metalloprotease methionine aminopeptidase-2 (MetAP-2) and inhibit endothelial cell growth in a p53-dependent manner. To confirm the role of MetAP-2 in endothelial cell proliferation and to validate it as a physiological target for th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh JJ,Ju R,Brdlik CM,Zhang W,Zhang Y,Matyskiela ME,Shotwell JD,Crews CM

更新日期：2006-07-05 00:00:00

abstract：:Human transcription factor IIA (TFIIA) is composed of three subunits (alpha, beta, and gamma). TFIIA interacts with the TATA-box binding protein and can overcome repression of transcription. TFIIA was found to be necessary for VP16-mediated transcriptional activation through a coactivator function. We have separated t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MA D,Olave I,Merino A,Reinberg D

更新日期：1996-06-25 00:00:00

abstract：:Biological polymers such as nucleic acids and proteins are constructed of only one-the d or l-of the two possible nonsuperimposable mirror images (enantiomers) of selected organic compounds. However, before the advent of life, it is generally assumed that chemical reactions produced 50:50 (racemic) mixtures of enantio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper G,Rios AC

更新日期：2016-06-14 00:00:00

abstract：:Here we test the hypothesis that high-altitude native resident Tibetan women with genotypes for high oxygen saturation of hemoglobin, and thus less physiological hypoxic stress, have higher Darwinian fitness than women with low oxygen saturation genotypes. Oxygen saturation and genealogical data were collected from re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beall CM,Song K,Elston RC,Goldstein MC

更新日期：2004-09-28 00:00:00

abstract：:Although x-ray crystallography is the most widely used method for macromolecular structure determination, it does not provide dynamical information, and either experimental tricks or complementary experiments must be used to overcome the inherently static nature of crystallographic structures. Here we used specific x-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colletier JP,Bourgeois D,Sanson B,Fournier D,Sussman JL,Silman I,Weik M

更新日期：2008-08-19 00:00:00

abstract：:After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gais S,Albouy G,Boly M,Dang-Vu TT,Darsaud A,Desseilles M,Rauchs G,Schabus M,Sterpenich V,Vandewalle G,Maquet P,Peigneux P

更新日期：2007-11-20 00:00:00

abstract：:Previously, we reported that bilateral excitotoxic lesions of the basolateral nucleus of the amygdala (BLA) block the enhancing effects of posttraining systemic or intrahippocampal glucocorticoid administration on memory for inhibitory avoidance training. The present study further examined the basis of this permissive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roozendaal B,Nguyen BT,Power AE,McGaugh JL

更新日期：1999-09-28 00:00:00

abstract：:Variation between North Korean and Latin American isolates in the circumsporozoite (CS) protein encoding gene of the human malaria parasite Plasmodium vivax was studied. Polymorphic positions are confined to the central tandemly repeated sequences. Nucleotide substitutions in the tandem repeats produce variants; these...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnot DE,Barnwell JW,Stewart MJ

更新日期：1988-11-01 00:00:00

abstract：:Fluorescence spectroscopy was used to characterize blue light responses from chloroplasts of adaxial guard cells from Pima cotton (Gossypium barbadense) and coleoptile tips from corn (Zea mays). The chloroplast response to blue light was quantified by measurements of the blue light-induced enhancement of a red light-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quiñones MA,Lu Z,Zeiger E

更新日期：1996-03-05 00:00:00

abstract：:Reptiles and fish have robust regenerative powers for tooth renewal. However, extant mammals can either renew their teeth one time (diphyodont dentition) or not at all (monophyodont dentition). Humans replace their milk teeth with permanent teeth and then lose their ability for tooth renewal. Here, we study tooth rene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu P,Wu X,Jiang TX,Elsey RM,Temple BL,Divers SJ,Glenn TC,Yuan K,Chen MH,Widelitz RB,Chuong CM

更新日期：2013-05-28 00:00:00

abstract：:Creatine, a nitrogenous organic acid, replenishes cytoplasmic ATP at the expense of mitochondrial ATP via the phosphocreatine shuttle. Creatine levels are maintained by diet and endogenous synthesis from arginine and glycine. Glycine amidinotransferase (GATM) catalyzes the rate-limiting step of creatine biosynthesis: ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turer E,McAlpine W,Wang KW,Lu T,Li X,Tang M,Zhan X,Wang T,Zhan X,Bu CH,Murray AR,Beutler B

更新日期：2017-02-14 00:00:00

abstract：:We have engineered the ecdysone-inducible mammalian expression system for general retroviral delivery to cultured mammalian cells. We inducibly expressed PTEN in the glioblastoma cell line, U87MG, lacking this gene. Because nearly all cells are recruited on induction, we find both up- and down-regulated genes by cDNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stolarov J,Chang K,Reiner A,Rodgers L,Hannon GJ,Wigler MH,Mittal V

更新日期：2001-11-06 00:00:00

abstract：:The technique of self-sustained sequence replication allows isothermal amplification of DNA and RNA molecules in vitro. This method relies on the activities of a reverse transcriptase and a DNA-dependent RNA polymerase to amplify specific nucleic acid sequences. We have modified this protocol to allow selective amplif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breaker RR,Joyce GF

更新日期：1994-06-21 00:00:00

abstract：:Alkylation of DNA by 7r,8t-dihydroxy,9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) forms mainly trans adducts (with respect to the C-9/10 positions). We recently described a halide-catalyzed pathway that preferentially generates cis adducts and now report that the trans chlorohydrin of anti-BPDE (trans-BP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meehan T,Wolfe AR,Negrete GR,Song Q

更新日期：1997-03-04 00:00:00

abstract：:Methylmalonyl-CoA mutase (2-methylmalonyl-CoA CoA-carbonylmutase, EC 5.4.99.2) is a mitochondrial enzyme whose deficiency in man leads to several biochemically and clinically heterogenous++ forms of methylmalonic acidemia. Intact fibroblasts from 21 patients with mutase apoenzyme deficiency have been pulse-labeled wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fenton WA,Hack AM,Kraus JP,Rosenberg LE

更新日期：1987-03-01 00:00:00

abstract：:The MYC family of cellular oncogenes includes c-Myc, N-myc, and L-myc, which encode transcriptional regulators involved in the control of cell proliferation and death. Accordingly, these genes become aberrantly activated and expressed in specific types of cancers. For example, c-Myc translocations occur frequently in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gostissa M,Ranganath S,Bianco JM,Alt FW

更新日期：2009-02-17 00:00:00

abstract：:Type 1A diabetes (T1D) is an autoimmune disorder the risk of which is increased by specific HLA DR/DQ alleles [e.g., DRB1*03-DQB1*0201 (DR3) or DRB1*04-DQB1*0302 (DR4)]. The genotype associated with the highest risk for T1D is the DR3/4-DQ8 (DQ8 is DQA1*0301, DQB1*0302) heterozygous genotype. We determined HLA-DR and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aly TA,Ide A,Jahromi MM,Barker JM,Fernando MS,Babu SR,Yu L,Miao D,Erlich HA,Fain PR,Barriga KJ,Norris JM,Rewers MJ,Eisenbarth GS

更新日期：2006-09-19 00:00:00

abstract：:The rabbit kappa light chain gene family is characterized by the presence of two constant region (C kappa) genes; the C kappa 1 gene encodes the constant region of the principal rabbit immunoglobulin light chain, the C kappa 2 gene being not or very poorly expressed in domestic rabbits. There exist four major K1 allel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akimenko MA,Mariamé B,Rougeon F

更新日期：1986-07-01 00:00:00

abstract：:The dominant theories of human placebo effects rely on a notion that consciously perceptible cues, such as verbal information or distinct stimuli in classical conditioning, provide signals that activate placebo effects. However, growing evidence suggest that behavior can be triggered by stimuli presented outside of co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jensen KB,Kaptchuk TJ,Kirsch I,Raicek J,Lindstrom KM,Berna C,Gollub RL,Ingvar M,Kong J

更新日期：2012-09-25 00:00:00

abstract：:The heavy chains of both botulinum neurotoxin type B and tetanus toxin form channels in planar bilayer membranes. These channels have pH-dependent and voltage-dependent properties that are remarkably similar to those previously described for diphtheria toxin. Selectivity experiments with anions and cations show that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoch DH,Romero-Mira M,Ehrlich BE,Finkelstein A,DasGupta BR,Simpson LL

更新日期：1985-03-01 00:00:00

abstract：:We identify a gene, organ boundary1 (OBO1), by its unique pattern of enhancer- driven GFP expression at the boundaries between the apical meristems and lateral organs in Arabidopsis embryos, seedlings, and mature plants. OBO1 also is expressed at the root apical meristem and in distinct cell files surrounding this are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho E,Zambryski PC

更新日期：2011-02-01 00:00:00

abstract：:The structure of the gene encoding human hexabrachion (tenascin) has been determined from overlapping clones isolated from a human genomic bacteriophage library. The genomic inserts were characterized by restriction mapping, Southern blot analysis, PCR, and DNA sequencing. The coding region of the hexabrachion gene sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gulcher JR,Nies DE,Alexakos MJ,Ravikant NA,Sturgill ME,Marton LS,Stefansson K

更新日期：1991-11-01 00:00:00