Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.

abstract：:In cat retina, antisera directed against tyrosine hydroxylase (tyrosine 3-monooxygenase; EC 1.14.16.2) labeled three morphologically distinct classes of neurons; amacrine cells, displaced amacrine cells, and interplexiform cells. These three cell populations differed not only in their morphologies but also in their nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oyster CW,Takahashi ES,Cilluffo M,Brecha NC

更新日期：1985-09-01 00:00:00

abstract：:Homeobox 9 (HOXB9), a nontransforming transcription factor overexpressed in breast cancer, alters tumor cell fate and promotes tumor progression and metastasis. Here we show that HOXB9 confers resistance to ionizing radiation by promoting DNA damage response. In nonirradiated cells, HOXB9 induces spontaneous DNA damag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiba N,Comaills V,Shiotani B,Takahashi F,Shimada T,Tajima K,Winokur D,Hayashida T,Willers H,Brachtel E,Vivanco MD,Haber DA,Zou L,Maheswaran S

更新日期：2012-02-21 00:00:00

abstract：:In the usual Darwinian case in which struggle for existence leads to density limitations on the environment's carrying capacity, R. A. Fisher's reproductive-value concept reduces to zero for every initial age group. To salvage some meaning for Fisher's notion, two variant reproductive-value concepts are defined here: ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelson PA

更新日期：1978-12-01 00:00:00

abstract：:Current structural genomics projects are yielding structures for proteins whose functions are unknown. Accordingly, there is a pressing requirement for computational methods for function prediction. Here we present PHUNCTIONER, an automatic method for structure-based function prediction using automatically extracted f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pazos F,Sternberg MJ

更新日期：2004-10-12 00:00:00

abstract：:Psychedelic drugs have a long history of use in healing ceremonies, but despite renewed interest in their therapeutic potential, we continue to know very little about how they work in the brain. Here we used psilocybin, a classic psychedelic found in magic mushrooms, and a task-free functional MRI (fMRI) protocol desi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carhart-Harris RL,Erritzoe D,Williams T,Stone JM,Reed LJ,Colasanti A,Tyacke RJ,Leech R,Malizia AL,Murphy K,Hobden P,Evans J,Feilding A,Wise RG,Nutt DJ

更新日期：2012-02-07 00:00:00

abstract：:The concentration of triglyceride-rich lipoproteins containing apolipoprotein (apo) B-48 (chylomicrons) and apo B-100 (very low density lipoproteins) was measured in blood plasma of healthy young men after an ordinary meal containing one-third of daily energy and fat. Plasma obtained in the postabsorptive state and at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneeman BO,Kotite L,Todd KM,Havel RJ

更新日期：1993-03-01 00:00:00

abstract：:ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moser AR,Mattes EM,Dove WF,Lindstrom MJ,Haag JD,Gould MN

更新日期：1993-10-01 00:00:00

abstract：:The rates of spontaneous mutation to 6-thioguanine resistance were determined in fibroblasts derived from normal and two Bloom syndrome individuals (GM 2548 and GM 1492). Two methods were utilized to determine the rates. Method I obtained the spontaneous mutation rate from the increase in the mutation frequency of a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren ST,Schultz RA,Chang CC,Wade MH,Trosko JE

更新日期：1981-05-01 00:00:00

abstract：:Previous studies have shown that binding of interleukin 1 (IL-1) to its receptor and intracellular processing of the IL-1/IL-1 receptor complex appear to be different in B- and T-lymphocyte cell lines. In this study we used a B-lymphoid cell line, 70Z/3, and T-lymphoid cell line, EL-4 6.1 C10, to explore further the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bomsztyk K,Sims JE,Stanton TH,Slack J,McMahan CJ,Valentine MA,Dower SK

更新日期：1989-10-01 00:00:00

abstract：:The secreted Bv8 protein has been recently characterized as a regulator of myeloid cell mobilization and a neutrophil-derived mediator of tumor angiogenesis in several xenografts, but its role in tumor progression in an endogenous setting was unknown. The rat insulin promoter (RIP)-T-antigen (Tag) is a well characteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shojaei F,Singh M,Thompson JD,Ferrara N

更新日期：2008-02-19 00:00:00

abstract：:By using single-molecule multiparameter fluorescence detection, fluorescence resonance energy transfer experiments, and newly developed data analysis methods, this study demonstrates directly the existence of three structurally distinct forms of reverse transcriptase (RT):nucleic acid complexes in solution. Single-mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothwell PJ,Berger S,Kensch O,Felekyan S,Antonik M,Wöhrl BM,Restle T,Goody RS,Seidel CA

更新日期：2003-02-18 00:00:00

abstract：:We report the presence of protein kinase C (PKC) in ejaculated human sperm as revealed by enzymatic activity assay and indirect immunohistochemistry. PKC is localized in the equatorial segment and in the principal piece of the tail. Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotem R,Paz GF,Homonnai ZT,Kalina M,Naor Z

更新日期：1990-09-01 00:00:00

abstract：:In a subclone derived from mouse L(tk-) cells, we found a plasmid present in a high copy number (greater than 5000 copies per cell) that was stably maintained extrachromosomally without any cytopathic effect to the host cells. This plasmid, termed L factor, has two forms: 5.3 and 5.5 kilobase pairs. DNA sequencing and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kusano T,Uehara H,Saito H,Segawa K,Oishi M

更新日期：1987-04-01 00:00:00

abstract：:Following proteolytic conversion of fibrinogen to fibrin, clot assembly commences with formation of double-stranded fibrils that subsequently branch extensively in forming a three-dimensional network. Plasmin digests of fibrin clots that had first been covalently crosslinked by plasma transglutaminase (factor XIIIa) c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosesson MW,Siebenlist KR,Amrani DL,DiOrio JP

更新日期：1989-02-01 00:00:00

abstract：:In skeletal muscle, dihydropyridine receptors are functionally coupled to ryanodine receptors of the sarcoplasmic reticulum in triadic or diadic junctional complexes. In cardiac muscle direct physical or functional couplings have not been demonstrated. We have tested the hypothesis of functional coupling of L-type Ca2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sham JS,Cleemann L,Morad M

更新日期：1995-01-03 00:00:00

abstract：:Thyroid hormone is a critical mediator of central nervous system (CNS) development, acting through nuclear receptors to modulate the expression of specific genes. Transcription of the rat hairless (hr) gene is highly up-regulated by thyroid hormone in the developing CNS; we show here that hr is directly induced by thy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson CC,Bottcher MC

更新日期：1997-08-05 00:00:00

abstract：:Quaking(viable) (qk(v)) is a recessive neurological mouse mutation with severe dysmyelination of the CNS and spermiogenesis failure. The molecular lesion in the qk(v) mutant is a deletion of approximately 1 Mb on mouse chromosome 17 that alters the expression of the qk gene in oligodendrocytes. Complementation analysi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lorenzetti D,Bishop CE,Justice MJ

更新日期：2004-06-01 00:00:00

abstract：:Peanut or groundnut (Arachis hypogaea L.), a legume of South American origin, has high seed oil content (45-56%) and is a staple crop in semiarid tropical and subtropical regions, partially because of drought tolerance conferred by its geocarpic reproductive strategy. We present a draft genome of the peanut A-genome p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Li H,Pandey MK,Yang Q,Wang X,Garg V,Li H,Chi X,Doddamani D,Hong Y,Upadhyaya H,Guo H,Khan AW,Zhu F,Zhang X,Pan L,Pierce GJ,Zhou G,Krishnamohan KA,Chen M,Zhong N,Agarwal G,Li S,Chitikineni A,Zhang GQ

更新日期：2016-06-14 00:00:00

abstract：:Porcine aortic endothelial cells were isolated and maintained in Dulbecco's modified Eagle's medium (DME medium)/10% citrate-treated human plasma. They were stimulated by DME medium/10% human serum to grow from a density of 10,100 +/- 500 per well to a final density of 83,000 +/- 1,800 per well over a 9-day period. On...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clemmons DR,Isley WL,Brown MT

更新日期：1983-03-01 00:00:00

abstract：:B-1a cells reside in both the peritoneal cavity and the spleen. LPS stimulates splenic B-1a to differentiate to plasma cells producing natural IgM specific for microbial and self antigens. However, there are conflicting views as to whether the B-1a cells divide before this differentiation occurs, and hence how the res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Tung JW,Ghosn EE,Herzenberg LA,Herzenberg LA

更新日期：2007-03-13 00:00:00

abstract：:Agrobacterium tumefaciens transfers the T-DNA portion of its Ti plasmid to the nuclear genome of plant cells. Upon cocultivation of A. tumefaciens strain A348 with regenerating tobacco leaf protoplasts, restriction endonuclease fragments of the T-DNA were generated that are consistent with double-stranded cleavage of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veluthambi K,Jayaswal RK,Gelvin SB

更新日期：1987-04-01 00:00:00

abstract：:We present a mandible recovered in 2003 from the Aurora Stratum of the TD6 level of the Gran Dolina site (Sierra de Atapuerca, northern Spain). The specimen, catalogued as ATD6-96, adds to the hominin sample recovered from this site in 1994-1996, and assigned to Homo antecessor. ATD6-96 is the left half of a gracile m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carbonell E,Bermúdez de Castro JM,Arsuaga JL,Allue E,Bastir M,Benito A,Cáceres I,Canals T,Díez JC,van der Made J,Mosquera M,Ollé A,Pérez-González A,Rodríguez J,Rodríguez XP,Rosas A,Rosell J,Sala R,Vallverdú J,Vergés

更新日期：2005-04-19 00:00:00

abstract：:Barth, Larsen, and others showed that complex submanifolds of complex projective space, CP(N), of small codimension strongly resemble CP(N) both homotopically and cohomologically. These results are generalized to yield analogous results for complex subspaces of arbitrary homogeneous complex manifolds. One very special...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommese AJ

更新日期：1977-04-01 00:00:00

abstract：:The structure of respiratory cytochrome c551 of Pseudomonas aeruginosa, with 82 amino acids, has been solved by x-ray analysis and refined to a crystallographic R factor of 16.2%. It has the same basic folding pattern and hydrophobic heme environment as cytochromes c, c2, and c550, except for a large deletion at the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Almassy RJ,Dickerson RE

更新日期：1978-06-01 00:00:00

abstract：:Expression of the human beta amyloid peptide (A beta) in transgenic Caenorhabditis elegans animals can lead to the formation of intracellular immunoreactive deposits as well as the formation of intracellular amyloid. We have used this model to identify proteins that interact with intracellular A beta in vivo. Mass spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fonte V,Kapulkin WJ,Taft A,Fluet A,Friedman D,Link CD

更新日期：2002-07-09 00:00:00

abstract：:Methionine sulfoxide reductase A (MsrA) catalyzes the reduction of methionine sulfoxide to methionine and is specific for the S epimer of methionine sulfoxide. The enzyme participates in defense against oxidative stresses by reducing methionine sulfoxide residues in proteins back to methionine. Because oxidation of me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lim JC,You Z,Kim G,Levine RL

更新日期：2011-06-28 00:00:00

abstract：:Whole-cell and single-channel recording techniques were used to study the action of the anticonvulsant drug MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine maleate) on responses to excitatory amino acids in rat neocortical neurons in cell culture. MK-801 caused a progressive, long-lasting bl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huettner JE,Bean BP

更新日期：1988-02-01 00:00:00

abstract：:Proper resolution of inflammation is vital for repair and restoration of homeostasis after tissue damage, and its dysregulation underlies various noncommunicable diseases, such as cardiovascular and metabolic diseases. Macrophages play diverse roles throughout initial inflammation, its resolution, and tissue repair. D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama Y,Fujiu K,Yuki R,Oishi Y,Morioka MS,Isagawa T,Matsuda J,Oshima T,Matsubara T,Sugita J,Kudo F,Kaneda A,Endo Y,Nakayama T,Nagai R,Komuro I,Manabe I

更新日期：2020-06-23 00:00:00

abstract：:Somatic crossing-over was used in heterozygous Drosophila melanogaster to effect clonal homozygosity for three mutants (h, Hw, ac). In these mutants, one type of process, chaetae, replaces another type, trichomes, in specific patterns on the adult fly. Heterozygous individuals were irradiated at different larval or pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia-Bellido A,Merriam JR

更新日期：1971-09-01 00:00:00

abstract：:Laminin, an ∼800-kDa heterotrimeric protein, is a major functional component of the extracellular matrix, contributing to tissue development and maintenance. The unique architecture of laminin is not currently amenable to determination at high resolution, as its flexible and narrow segments complicate both crystalliza...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armony G,Jacob E,Moran T,Levin Y,Mehlman T,Levy Y,Fass D

更新日期：2016-11-22 00:00:00