Methionine sulfoxide reductase A is a stereospecific methionine oxidase.

abstract：:Creative cognition requires mental exploration of remotely connected concepts while suppressing dominant ones. Across four experiments using different samples of participants, we provide evidence that right temporal alpha oscillations play a crucial role in inhibiting habitual thinking modes, thereby paving the way fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luft CDB,Zioga I,Thompson NM,Banissy MJ,Bhattacharya J

更新日期：2018-12-26 00:00:00

abstract：:Animal epithelial tissue becomes reproducibly colonized by specific environmental bacteria. The bacteria (microbiota) perform critical functions for the host's tissue development, immune system development, and nutrition; yet the processes by which bacterial diversity in the environment is selected to assemble the cor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks JF 2nd,Gyllborg MC,Cronin DC,Quillin SJ,Mallama CA,Foxall R,Whistler C,Goodman AL,Mandel MJ

更新日期：2014-12-02 00:00:00

abstract：:Members of the transforming growth factor-β superfamily play essential roles in various aspects of embryonic development and physiological organ function. Among them, bone morphogenetic protein (BMP) 9 and BMP10 regulate embryonic vascular development by activating their endothelial receptor ALK1 (activin receptor-lik...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Somekawa S,Imagawa K,Hayashi H,Sakabe M,Ioka T,Sato GE,Inada K,Iwamoto T,Mori T,Uemura S,Nakagawa O,Saito Y

更新日期：2012-07-24 00:00:00

abstract：:Hybrid dysgenesis in Drosophila is a syndrome of gonadal atrophy, sterility, and male recombination, and it occurs in the progeny of crosses between males that harbor certain transposable elements (TEs) and females that lack them. Known examples of hybrid dysgenesis in Drosophila melanogaster result from mobilization ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumenstiel JP,Hartl DL

更新日期：2005-11-01 00:00:00

abstract：:RNA of a common strain of tobacco mosaic virus was sequentially reconstituted first with protein of the same strain and then with protein of a tomato strain. The reconstituted particles were treated with specific antibodies against the two strain particles and were examined electron microscopically to locate the regio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Otsuki Y,Takebe I,Ohno T,Fukuda M,Okada Y

更新日期：1977-05-01 00:00:00

abstract：:Phosphoinositides are essential lipid regulators of trafficking and signaling pathways of all eukaryotic cells. Phosphatidylinositol 4-phosphate (PtdIns4P) is an intermediate in the synthesis of several important phosphoinositide species but also serves as a regulatory molecule in its own right. Phosphatidylinositol 4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szentpetery Z,Várnai P,Balla T

更新日期：2010-05-04 00:00:00

abstract：:To find the native conformation (fold), proteins sample a subspace that is typically hundreds of orders of magnitude smaller than their full conformational space. Whether such fast folding is intrinsic or the result of natural selection, and what is the longest foldable protein, are open questions. Here, we derive the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin MM,Zewail AH

更新日期：2012-06-19 00:00:00

abstract：:Tissue factor (TF) plays an important role in hemostasis, inflammation, angiogenesis, and the pathophysiology of atherosclerosis and cancer. In this article we uncover a mechanism in which protein S, which is well known as the cofactor of activated protein C, specifically inhibits TF activity by promoting the interact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hackeng TM,Seré KM,Tans G,Rosing J

更新日期：2006-02-28 00:00:00

abstract：:The method of matrix isolation has been used to investigate mechanisms of gas-phase chemical reactions, in particular the pyrolysis of some organomercury compounds. A molecular beam of pyrolysis products was condensed simultaneously with a large excess of rare gas at temperatures from 5 to 15 degrees K to form a matri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maltsev AK,Mikaelian RG,Nefedov OM,Hauge RH,Margrave JL

更新日期：1971-12-01 00:00:00

abstract：:Structural information about rat enteroglucagon, intestinal peptides containing the pancreatic glucagon sequence, has been based previously on cDNA, immunologic, and chromatographic data. Our interests in testing the physiological actions of synthetic enteroglucagon peptides in rats required that we identify precisely...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collie NL,Walsh JH,Wong HC,Shively JE,Davis MT,Lee TD,Reeve JR Jr

更新日期：1994-09-27 00:00:00

abstract：:The mature optic nerve cannot regenerate when injured, leaving victims of traumatic nerve damage or diseases such as glaucoma with irreversible visual losses. Recent studies have identified ways to stimulate retinal ganglion cells to regenerate axons part-way through the optic nerve, but it remains unknown whether mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Lima S,Koriyama Y,Kurimoto T,Oliveira JT,Yin Y,Li Y,Gilbert HY,Fagiolini M,Martinez AM,Benowitz L

更新日期：2012-06-05 00:00:00

abstract：:We show that supercoiling of a DNA trefoil, the simplest knotted ring, perturbs differently the spatial writhe of its two chiral forms. As a consequence, the negative-noded and positive-noded DNA trefoils can be resolved by gel electrophoresis. Analysis of the chirality of trefoils produced by cyclization of two linea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaw SY,Wang JC

更新日期：1997-03-04 00:00:00

abstract：:Discrete growing spiral modes are calculated, on the basis of principles of stellar dynamics, according to the recently developed asymptotic theory of density waves for spiral structure in galaxies. From the growth rates obtained, it appears likely that several spiral modes coexist in a given disk galaxy. General prop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bertin G,Lau YY,Lin CC,Mark JW,Sugiyama L

更新日期：1977-11-01 00:00:00

abstract：:This paper introduces the use of magnetic field tomography (MFT), a noninvasive technique based on distributed source analysis of magnetoencephalography data, which makes possible the three-dimensional reconstruction of dynamic brain activity in humans. MFT has a temporal resolution better than 1 msec and a spatial ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribary U,Ioannides AA,Singh KD,Hasson R,Bolton JP,Lado F,Mogilner A,Llinás R

更新日期：1991-12-15 00:00:00

abstract：:The orphan nuclear receptor Nur77/N10 has recently been demonstrated to be involved in apoptosis of T cell hybridomas. We report here that chronic expression of Nur77/N10 in thymocytes of transgenic mice results in a dramatic reduction of CD4+CD8+ double-positive as well as CD4+CD8- and CD4-CD8+ single-positive cell p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weih F,Ryseck RP,Chen L,Bravo R

更新日期：1996-05-28 00:00:00

abstract：:Targeted gene modification mediated by single-stranded oligonucleotides (SSOs) holds great potential for widespread use in a number of biological and biomedical fields, including functional genomics and gene therapy. By using this approach, specific genetic changes have been created in a number of prokaryotic and euka...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu XS,Xin L,Yin WX,Shang XY,Lu L,Watt RM,Cheah KS,Huang JD,Liu DP,Liang CC

更新日期：2005-02-15 00:00:00

abstract：:cDNAs made from polyadenylylated RNAs of the mouse lens were cloned by the G.C tailing procedure in the bacterial plasmid pBR322. Four recombinant DNAs containing gamma-crystallin sequences were identified by hybrid selection and translation. Sequence analysis of the in vivo-labeled gamma-crystallin polypeptides that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinohara T,Robinson EA,Appella E,Piatigorsky J

更新日期：1982-05-01 00:00:00

abstract：:Toxoplasma gondii is a highly successful protozoan parasite that infects all warm-blooded animals and causes severe disease in immunocompromised and immune-naïve humans. It has an unusual global population structure: In North America and Europe, isolated strains fall predominantly into four largely clonal lineages, bu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minot S,Melo MB,Li F,Lu D,Niedelman W,Levine SS,Saeij JP

更新日期：2012-08-14 00:00:00

abstract：:Adult rats were trained to detect the occurrence of a two-element sound sequence in a background of nine other nontarget sound pairs. Training resulted in a modest, enduring, static expansion of the cortical areas of representation of both target stimulus sounds. More importantly, once the initial stimulus A in the ta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou X,de Villers-Sidani E,Panizzutti R,Merzenich MM

更新日期：2010-08-17 00:00:00

abstract：:ROOT MERISTEM GROWTH FACTOR (RGF) 1 is an important peptide hormone that regulates root growth. Upon binding to its receptor, RGFR1, RGF1 regulates the expression of two transcription factors, PLETHORA 1 and 2 (PLT1/2), to influence root meristem development. Here, we show that the ubiquitin-specific proteases UBP12 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： An Z,Liu Y,Ou Y,Li J,Zhang B,Sun D,Sun Y,Tang W

更新日期：2018-01-30 00:00:00

abstract：:The spatiotemporal regulation of neurotransmitter transporters involves proteins that interact with their intracellular domains. Using a proteomic approach, we identified several proteins that interact with the C terminus of the serotonin transporter (SERT). These included neuronal nitric oxide synthase (nNOS), a PSD-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chanrion B,Mannoury la Cour C,Bertaso F,Lerner-Natoli M,Freissmuth M,Millan MJ,Bockaert J,Marin P

更新日期：2007-05-08 00:00:00

abstract：:Defects in clearing apoptotic debris disrupt tissue and immunological homeostasis, leading to autoimmune and inflammatory diseases. Herein, we report that macrophages from lupus-prone MRL/lpr mice have impaired lysosomal maturation, resulting in heightened ROS production and attenuated lysosomal acidification. Impaire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monteith AJ,Kang S,Scott E,Hillman K,Rajfur Z,Jacobson K,Costello MJ,Vilen BJ

更新日期：2016-04-12 00:00:00

abstract：:Trypanosoma brucei parasites successfully evade the host immune system by periodically switching the dense coat of variant surface glycoprotein (VSG) at the cell surface. Each parasite expresses VSGs in a monoallelic fashion that is tightly regulated. The consequences of exposing multiple VSGs during an infection, in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aresta-Branco F,Sanches-Vaz M,Bento F,Rodrigues JA,Figueiredo LM

更新日期：2019-10-08 00:00:00

abstract：:Among yeasts that underwent whole-genome duplication (WGD), Kluyveromyces polysporus represents the lineage most distant from Saccharomyces cerevisiae. By sequencing the K. polysporus genome and comparing it with the S. cerevisiae genome using a likelihood model of gene loss, we show that these species diverged very s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scannell DR,Frank AC,Conant GC,Byrne KP,Woolfit M,Wolfe KH

更新日期：2007-05-15 00:00:00

abstract：:DNA was prepared from 15 different mouse and rat cell lines transformed by chemical carcinogens in vitro and in vivo. These DNAs were applied to NIH3T3 mouse fibroblast cultures by using the calcium phosphate transfection technique. DNAs of five donor lines were able to induce foci on the recipient monolayers. Ten oth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shih C,Shilo BZ,Goldfarb MP,Dannenberg A,Weinberg RA

更新日期：1979-11-01 00:00:00

abstract：:Any isospectral family of two-dimensional Euclidean domains is shown to be compact in the C(infinity) topology. Previously Melrose, using heat invariants, was able to establish the C(infinity) compactness of the curvature of the boundary curves. The additional ingredient used in this paper to obtain the compactness of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Osgood B,Phillips R,Sarnak P

更新日期：1988-08-01 00:00:00

abstract：:Treatment of lymphocytes with inducers of interferon alpha (IFN-alpha) results in the production of corticotropin (ACTH) and endorphin-like activities. The pro-opiomelanocortin-derived hormones ACTH and alpha-, beta-, and gamma-endorphin and the structurally related hormones [Leu]- and [Met]enkephalin were therefore t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson HM,Smith EM,Torres BA,Blalock JE

更新日期：1982-07-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the number of polyglutamine-encoding CAG repeats in the gene that encodes the huntingtin (htt) protein. A property of the mutant protein that is intimately involved in the development of the disease is the propensity of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colby DW,Chu Y,Cassady JP,Duennwald M,Zazulak H,Webster JM,Messer A,Lindquist S,Ingram VM,Wittrup KD

更新日期：2004-12-21 00:00:00

abstract：:High molecular weight polypeptides (HMWPs) of 270,000 to 340,000 were found to be major components of intermediate filaments prepared by Triton X-100 extraction after spreading of rat glioma C6, HeLa, Chinese hamster ovary, and simian virus 40-transformed Chinese hamster lung cells. C6 HMWPs were shown to resemble hig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pytela R,Wiche G

更新日期：1980-08-01 00:00:00

abstract：:Under anesthesia with sodium pentobarbital, the sciatic nerves of rats were transected bilaterally, and a catheter was inserted into the central end of the left renal artery. After an initial flush, an Alzet pump was attached to the catheter, containing various concentrations of glycyl-L-glutamine (Gly-Gln), methylpre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koelle GB,Han MS

更新日期：1990-12-01 00:00:00