Abstract:
:The mature optic nerve cannot regenerate when injured, leaving victims of traumatic nerve damage or diseases such as glaucoma with irreversible visual losses. Recent studies have identified ways to stimulate retinal ganglion cells to regenerate axons part-way through the optic nerve, but it remains unknown whether mature axons can reenter the brain, navigate to appropriate target areas, or restore vision. We show here that with adequate stimulation, retinal ganglion cells are able to regenerate axons the full length of the visual pathway and on into the lateral geniculate nucleus, superior colliculus, and other visual centers. Regeneration partially restores the optomotor response, depth perception, and circadian photoentrainment, demonstrating the feasibility of reconstructing central circuitry for vision after optic nerve damage in mature mammals.
journal_name
Proc Natl Acad Sci U S Aauthors
de Lima S,Koriyama Y,Kurimoto T,Oliveira JT,Yin Y,Li Y,Gilbert HY,Fagiolini M,Martinez AM,Benowitz Ldoi
10.1073/pnas.1119449109subject
Has Abstractpub_date
2012-06-05 00:00:00pages
9149-54issue
23eissn
0027-8424issn
1091-6490pii
1119449109journal_volume
109pub_type
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