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Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors.

Abstract：

:Intracellular transport is based on molecular motors that pull cargos along cytoskeletal filaments. One motor species always moves in one direction, e.g., conventional kinesin moves to the microtubule plus end, whereas cytoplasmic dynein moves to the microtubule minus end. However, many cellular cargoes are observed to move bidirectionally, involving both plus- and minus-end-directed motors. The presumably simplest mechanism for such bidirectional transport is provided by a tug-of-war between the two motor species. This mechanism is studied theoretically using the load-dependent transport properties of individual motors as measured in single-molecule experiments. In contrast to previous expectations, such a tug-of-war is found to be highly cooperative and to exhibit seven different motility regimes depending on the precise values of the single motor parameters. The sensitivity of the transport process to small parameter changes can be used by the cell to regulate its cargo traffic.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Müller MJ,Klumpp S,Lipowsky R

doi

10.1073/pnas.0706825105

subject

Has Abstract

pub_date

2008-03-25 00:00:00

pages

4609-14

issue

12

eissn

0027-8424

issn

1091-6490

pii

0706825105

journal_volume

105

pub_type

杂志文章

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