c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles.

abstract：:Alternaria solani, the causal agent of early blight disease in potato, produces two host-specific, lipidlike toxins in culture. Both compounds are required in the leaf bioassay for the elicitation of typical early blight symptoms, but the compounds are individually inactive. The procedures for the preparation of both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matern U,Strobel G,Shepard J

更新日期：1978-10-01 00:00:00

abstract：:Preferential phosphorylation of specific proteins by cAMP-dependent protein kinase (PKA) may be mediated in part by the anchoring of PKA to a family of A-kinase anchor proteins (AKAPs) positioned in close proximity to target proteins. This interaction is thought to depend on binding of the type II regulatory (RII) sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burton KA,Johnson BD,Hausken ZE,Westenbroek RE,Idzerda RL,Scheuer T,Scott JD,Catterall WA,McKnight GS

更新日期：1997-09-30 00:00:00

abstract：:Allozyme, morphological, and PCR-generated mtDNA markers were used to analyze hybrid parentage and introgression between the neighboringly sympatric crustaceans Daphnia galeata mendotae and Daphnia rosea. mtDNA analysis of D. galeata mendotae from 15 lakes and of D. rosea from 8 lakes revealed species-specific fragmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor DJ,Hebert PD

更新日期：1993-08-01 00:00:00

abstract：:Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation through the acetylation of cyclooxygenase II. These aspirin-triggered lipoxins (ATL) may mediate some of ASA's beneficial actions and therefore are of interest in the search...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clish CB,O'Brien JA,Gronert K,Stahl GL,Petasis NA,Serhan CN

更新日期：1999-07-06 00:00:00

abstract：:Enolase genes from land plants and apicomplexa (intracellular parasites, including the malarial parasite, Plasmodium) share two short insertions. This observation has led to the suggestion that the apicomplexan enolase is the product of a lateral transfer event involving the algal endosymbiont from which the apicomple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keeling PJ,Palmer JD

更新日期：2001-09-11 00:00:00

abstract：:After males of Lasioglossum zephyrum (Hymenoptera: Halictidae) have first been exposed to a conspecific female, the attractiveness of a second female diminishes with increasing genealogical relationship between the two females. The most parsimonious explanation for this is a polygenically controlled female sex pheromo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith BH

更新日期：1983-07-01 00:00:00

abstract：:Molecules of keystone significance are relatively rare, yet mediate a variety of interactions between organisms. They influence the distribution and abundance of species, the transfer of energy across multiple trophic levels, and thus they play significant roles in structuring ecosystems. Despite their potential impor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kicklighter CE,Kamio M,Nguyen L,Germann MW,Derby CD

更新日期：2011-07-12 00:00:00

abstract：:Bacteriophage Mu was inserted into the unc genes of Escherichia coli. The resulting mutation AS12 had a polar effect on the unc operon: membranes of the mutant AS12 contained the dicyclohexylcarbodiimide-binding protein c and the protein a as sole subunits of the ATP synthase. It was shown by peptide mapping and amino...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friedl P,Bienhaus G,Hoppe J,Schairer HU

更新日期：1981-11-01 00:00:00

abstract：:Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or exacerbates lung fibrosis by (i) conditional expression of a mutant form of surfactant protein C (L188Q SFTPC) found in familial interstitial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawson WE,Cheng DS,Degryse AL,Tanjore H,Polosukhin VV,Xu XC,Newcomb DC,Jones BR,Roldan J,Lane KB,Morrisey EE,Beers MF,Yull FE,Blackwell TS

更新日期：2011-06-28 00:00:00

abstract：:A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding suggests that the Ub system may be involved in common mechanisms underlying these otherwise unrelated diseases. Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson KM,Li W,Ching KA,Batalov S,Tsai CC,Joazeiro CA

更新日期：2003-07-22 00:00:00

abstract：:The gene encoding human plakoglobin was mapped to chromosome 17q12-q22. An intragenic restriction fragment length polymorphism was used to localize the plakoglobin gene distal to locus KRT10 and proximal to the marker D17S858. The plakoglobin gene colocalizes with the polymorphic 17q21 marker UM8 on the same cosmid in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aberle H,Bierkamp C,Torchard D,Serova O,Wagner T,Natt E,Wirsching J,Heidkämper C,Montagna M,Lynch HT

更新日期：1995-07-03 00:00:00

abstract：:Two brefeldin A (BFA)-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors, 200-kDa BIG1 and 190-kDa BIG2, were copurified from bovine brain cytosol associated with >670-kDa macromolecular complexes. When observed by immunofluorescence in HeLa S3 and HepG2 cells, endogenous BIG1 and coexpressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaji R,Adamik R,Takeda K,Togawa A,Pacheco-Rodriguez G,Ferrans VJ,Moss J,Vaughan M

更新日期：2000-03-14 00:00:00

abstract：:CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5' cis-regulatory region of CCR5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamshad MJ,Mummidi S,Gonzalez E,Ahuja SS,Dunn DM,Watkins WS,Wooding S,Stone AC,Jorde LB,Weiss RB,Ahuja SK

更新日期：2002-08-06 00:00:00

abstract：:The visual system of the macaque monkey has provided a useful model for understanding the neural basis of human vision, yet, there are few detailed comparisons of neural populations other than photoreceptors for the two species. Using intracellular staining in an in vitro preparation of the isolated and intact human r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dacey DM,Petersen MR

更新日期：1992-10-15 00:00:00

abstract：:Lung adenocarcinomas harboring activating mutations in the epidermal growth factor receptor (EGFR) represent a common molecular subset of non-small cell lung cancer (NSCLC) cases. EGFR mutations predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs) and thus represent a dependency in NSCLCs harboring these alte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharifnia T,Rusu V,Piccioni F,Bagul M,Imielinski M,Cherniack AD,Pedamallu CS,Wong B,Wilson FH,Garraway LA,Altshuler D,Golub TR,Root DE,Subramanian A,Meyerson M

更新日期：2014-12-30 00:00:00

abstract：:We have generated transgenic mice harboring a glycine-to-cysteine mutation in residue 85 of the triple helical domain of mouse type II collagen. The offspring of different founders displayed a phenotype of severe chondrodysplasia characterized by short limbs and trunk, cranio-facial deformities, and cleft palate. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garofalo S,Vuorio E,Metsaranta M,Rosati R,Toman D,Vaughan J,Lozano G,Mayne R,Ellard J,Horton W

更新日期：1991-11-01 00:00:00

abstract：:For study of the basis of an X-linked form of gout in man, several clonal lines deficient in hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) were selected from the human lymphoblast line WI-L2 by spontaneous and mutagen-induced resistance to 10 muM 8-azaguanine. Three groups could be defined: (1) clones wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lever JE,Nuki G,Seegmiller JE

更新日期：1974-07-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) signaling has been shown to play a role in cardiac development as well as in the pathogenesis of cardiovascular disease. Prior studies have suggested a relationship between cholesterol metabolism and TGFbeta signaling. Here we demonstrate that induction of the cholesterol meta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park HJ,Galper JB

更新日期：1999-09-28 00:00:00

abstract：:Two photochromic activators of the electrogenic membrane of the electroplax of Electrophorus electricus are described. Trans-3,3'-bis[alpha-(trimethylammonium)methyl]azobenzene dibromide (Bis-Q), one of the most potent ever reported, is active at concentrations of less than 10(-7) M. Its cis isomer, which is obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartels E,Wassermann NH,Erlanger BF

更新日期：1971-08-01 00:00:00

abstract：:Procedures are described for the isolation of conditional lethal mutants of mouse L-60T cells. The mutant lines were temperature sensitive by the following criteria: (a) colony-forming ability, (b) growth in suspension culture, and (c) rate of uptake of tritiated-thymidine. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson LH,Mankovitz R,Baker RM,Till JE,Siminovitch L,Whitmore GF

更新日期：1970-06-01 00:00:00

abstract：:A discussion of the expected mechanism of radical reduction of carbonyl compounds by dihydroflavin as it relates to the structure of the carbonyl compound is provided. Factors which must be taken into account are the free energies of formation of the radical anions (CR2O), THE ACIDITY OF THE CONJUGATE ACID OF THE CARB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams RF,Shinkai S,Bruice TC

更新日期：1975-05-01 00:00:00

abstract：:Oxygen-derived free radicals have been implicated in the pathogenesis of vasogenic edema and infarction caused by ischemia and reperfusion injury. In earlier studies, exogenously supplied liposome-entrapped CuZn superoxide dismutase (CuZn-SOD) ameliorated ischemic brain edema and infarction in rats following focal cer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinouchi H,Epstein CJ,Mizui T,Carlson E,Chen SF,Chan PH

更新日期：1991-12-15 00:00:00

abstract：:Mechanical signals are important influences on the development and morphology of higher plants. Using tobacco transformed with the Ca(2+)-sensitive luminescent protein aequorin, we recently reported the effects of mechanical signals of touch and wind on the luminescence and thus intracellular calcium of young seedling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haley A,Russell AJ,Wood N,Allan AC,Knight M,Campbell AK,Trewavas AJ

更新日期：1995-05-09 00:00:00

abstract：:A complementarity-determining region (CDR) of the mouse monoclonal antibody (mAb) F58 was constructed with specificity to a neutralization-inducing region of human immunodeficiency virus type 1 (HIV-1). The mAb has its major reactivity to the amino acid sequence I--GPGRA in the V3 viral envelope region. All CDRs inclu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levi M,Sällberg M,Rudén U,Herlyn D,Maruyama H,Wigzell H,Marks J,Wahren B

更新日期：1993-05-15 00:00:00

abstract：:Evidence had been provided that a disulfide-linked [125I]iodotyramine/poly(D-lysine) conjugate was reductively cleaved when bound nonspecifically to the surface of Chinese hamster ovary (CHO) cells and that this cleavage was abolished by membrane-impermeant sulfhydryl blockers. The same blockers were subsequently foun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandel R,Ryser HJ,Ghani F,Wu M,Peak D

更新日期：1993-05-01 00:00:00

abstract：:Foreign DNA molecules and chromosomal fragments are generally eliminated from proliferating cells, but we know little about how mammalian cells prevent their propagation. Here, we show that dividing human and canine cells partition transfected plasmid DNA asymmetrically, preferentially into the daughter cell harboring...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Le N,Denoth-Lippuner A,Barral Y,Kroschewski R

更新日期：2016-06-28 00:00:00

abstract：:Biological processes such as circadian rhythms, cell division, metabolism, and development occur as ordered sequences of events. The synchronization of these coordinated events is essential for proper cell function, and hence the determination of critical time points in biological processes is an important component o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnan N,Tadepalli S,Watson LT,Helm RF,Antoniotti M,Mishra B

更新日期：2010-07-13 00:00:00

abstract：:Human and murine MHC nonclassical class Ib-restricted invariant T (iT) cell subsets, such as invariant natural killer T cells (iNKT) and mucosal-associated invariant T cells, have specialized functions early in immune responses, especially in modulating subsequent adaptive immune responses. Here, we characterize a pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edholm ES,Albertorio Saez LM,Gill AL,Gill SR,Grayfer L,Haynes N,Myers JR,Robert J

更新日期：2013-08-27 00:00:00

abstract：:We have established empirical limits for the circular dichroism spectra appropriate for aqueous solutions of the B, C, and A forms of calf-thymus DNA and have analyzed DNA conformations in biological structures. The circular dichroism spectrum above 250 nm of purified calf-thymus chromatin can be satisfactorily accoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanlon S,Johnson RS,Wolf B,Chan A

更新日期：1972-11-01 00:00:00

abstract：:Activating region I of GAL4 protein is a stretch of amino acids, positioned adjacent to the DNA-binding region, that activates transcription in yeast and, as we show here, in mammalian cells. Here we describe mutations located throughout a 65-amino acid region that increase the activation function of region I. Most of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gill G,Sadowski I,Ptashne M

更新日期：1990-03-01 00:00:00