Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.

abstract：:In contrast with speciation in terrestrial organisms, marine plankton frequently display gradual morphological change without lineage division (e.g., phyletic gradualism or gradual evolution), which has raised the possibility that a different mode of evolution dominates within pelagic environments. Here, we reexamine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hull PM,Norris RD

更新日期：2009-12-15 00:00:00

abstract：:Overexpression of the Gossypium hirsutum sucrose synthase (SuSy) gene under the control of 2 promoters was examined in hybrid poplar (Populus alba x grandidentata). Analysis of RNA transcript abundance, enzyme activity, cell wall composition, and soluble carbohydrates revealed significant changes in the transgenic lin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman HD,Yan J,Mansfield SD

更新日期：2009-08-04 00:00:00

abstract：:Epigenetic mechanisms are involved in the pathophysiology of depressive disorders and are unique potential targets for therapeutic intervention. The acetylating agent L-acetylcarnitine (LAC), a well-tolerated drug, behaves as an antidepressant by the epigenetic regulation of type 2 metabotropic glutamate (mGlu2) recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nasca C,Xenos D,Barone Y,Caruso A,Scaccianoce S,Matrisciano F,Battaglia G,Mathé AA,Pittaluga A,Lionetto L,Simmaco M,Nicoletti F

更新日期：2013-03-19 00:00:00

abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. The Rag heterodimer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen K,Sabatini DM

更新日期：2018-09-18 00:00:00

abstract：:Gene delivery to skeletal muscle is a promising strategy for the treatment of muscle disorders and for the systemic secretion of therapeutic proteins. However, present DNA delivery technologies have to be improved with regard to both the level of expression and interindividual variability. We report very efficient pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mir LM,Bureau MF,Gehl J,Rangara R,Rouy D,Caillaud JM,Delaere P,Branellec D,Schwartz B,Scherman D

更新日期：1999-04-13 00:00:00

abstract：:Etioplasts isolated from barley leaves and purified on a Sephadex G-50 (coarse) column were characterized by electron microscopy and nucleic acid analysis. The majority of etioplasts retained an intact outer envelope, and contamination by other fragments was extremely low. The level of gibberellin-like substances extr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans A,Smith H

更新日期：1976-01-01 00:00:00

abstract：:Homeostasis is indispensable to counteract the destabilizing effects of Hebbian plasticity. Although it is commonly assumed that homeostasis modulates synaptic strength, membrane excitability, and firing rates, its role at the neural circuit and network level is unknown. Here, we identify changes in higher-order netwo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YK,Hengen KB,Turrigiano GG,Gjorgjieva J

更新日期：2020-09-29 00:00:00

abstract：:Hypnotic analgesia in some respects resembles opiate analgesia. We tested the hypothesis that some features of hypnotic analgesia are mediated through neuronal pathways activating specific opiate receptors in brain. The opiate antagonist naloxone had no effect on hypnotic analgesia in three subjects. Thus, the hypothe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein A,Hilgard ER

更新日期：1975-06-01 00:00:00

abstract：:Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) is a putative fast-acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors (NMDARs) is one mechanism proposed to underlie ketamine's antidepressant and adverse effects, the potency of (2R,6R)-HNK to inhibit NMDARs has not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lumsden EW,Troppoli TA,Myers SJ,Zanos P,Aracava Y,Kehr J,Lovett J,Kim S,Wang FH,Schmidt S,Jenne CE,Yuan P,Morris PJ,Thomas CJ,Zarate CA Jr,Moaddel R,Traynelis SF,Pereira EFR,Thompson SM,Albuquerque EX,Gould TD

更新日期：2019-03-12 00:00:00

abstract：:Subunits A and B of chloroplast glyceraldehyde-3-phosphate dehydrogenase are synthesized as higher molecular weight precursors when polyadenylylated mRNA from angiosperm seedlings is translated in vitro by wheat germ ribosomes. The in vivo levels of mRNA coding for these precursors are strongly light dependent, and th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerff R,Kloppstech K

更新日期：1982-12-01 00:00:00

abstract：:Mycobacterium abscessus (Mabs) is a rapidly growing Mycobacterium and an emerging pathogen in humans. Transitioning from a smooth (S) high-glycopeptidolipid (GPL) producer to a rough (R) low-GPL producer is associated with increased virulence in zebrafish, which involves the formation of massive serpentine cords, absc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halloum I,Carrère-Kremer S,Blaise M,Viljoen A,Bernut A,Le Moigne V,Vilchèze C,Guérardel Y,Lutfalla G,Herrmann JL,Jacobs WR Jr,Kremer L

更新日期：2016-07-19 00:00:00

abstract：:We have examined the extent of tyrosine phosphorylation of talin, a component of the cytoskeleton localized in the focal adhesions and, therefore, a potential substrate of p60v-src, the transforming protein of Rous sarcoma virus. p60v-src is a tyrosine kinase that induces high levels of phosphotyrosine and the disorga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pasquale EB,Maher PA,Singer SJ

更新日期：1986-08-01 00:00:00

abstract：:The in vivo biological activities of IgG antibodies result from their bifunctional nature, in which antigen recognition by the Fab is coupled to the effector and immunomodulatory diversity found in the Fc domain. This diversity, resulting from both amino acid and glycan heterogeneity, is translated into cellular respo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith P,DiLillo DJ,Bournazos S,Li F,Ravetch JV

更新日期：2012-04-17 00:00:00

abstract：:Transposition is a multistep process in which a transposable element DNA sequence moves from its original genetic location to a new site. Early steps in this process include the formation of a transposition complex in which the end sequences of the transposable element are brought together in a structurally precise fa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goryshin IYu,Kil YV,Reznikoff WS

更新日期：1994-11-08 00:00:00

abstract：:We established stable COS-7 cell lines overexpressing recombinant PTPMEG and an inactive mutant form in which the active site cysteine is mutated to serine (PTPMEGCS). We found that both endogenous and recombinant enzyme were primarily located in the membrane and cytoskeletal fractions of COS-7 cells. Endogenous PTPME...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu M,Meng K,Majerus PW

更新日期：1996-11-12 00:00:00

abstract：:Intermolecular electronic coupling dictates the optical properties of molecular aggregate systems. Of particular interest are photosynthetic pigment-protein complexes that absorb sunlight then efficiently direct energy toward the photosynthetic reaction center. Two-dimensional (2D) ultrafast spectroscopy has been used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Read EL,Engel GS,Calhoun TR,Mancal T,Ahn TK,Blankenship RE,Fleming GR

更新日期：2007-09-04 00:00:00

abstract：:An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti, was en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise de Valdez MR,Nimmo D,Betz J,Gong HF,James AA,Alphey L,Black WC 4th

更新日期：2011-03-22 00:00:00

abstract：:The effect of 6 days' s.c. infusions of angiotensin II at increasing doses was determined on the uptake of rat or human low density lipoprotein (LDL) and of human fibrinogen by aorta in normal and spontaneously hypertensive rats. Rat or human LDL or human fibrinogen was injected i.v. 5 days after the start of infusion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardona-Sanclemente LE,Medina R,Born GV

更新日期：1994-04-12 00:00:00

abstract：:The Bacillus subtilis phage SP01, whose DNA contains 5-hydroxymethyluracil (hmUra) in place of thymine, codes for an abundant, small, basic protein called TF1. TF1 binds preferentially to hydroxymethyluracil-containing DNA and thereby selectively inhibits transcription of such DNA in vitro. The gene for TF1 has been s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greene JR,Brennan SM,Andrew DJ,Thompson CC,Richards SH,Heinrikson RL,Geiduschek EP

更新日期：1984-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) mediate apoptosis in many different cell types. We have previously shown that the antioxidant Mn(III) tetrakis(5,10,15,20-benzoic acid)porphyrin (MnTBAP) decreased intracellular ROS and prevented the apoptosis of activated T cells in vitro. To determine the mechanism(s) by which MnTBAP af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hildeman DA,Mitchell T,Aronow B,Wojciechowski S,Kappler J,Marrack P

更新日期：2003-12-09 00:00:00

abstract：:Allergic asthma is an inflammatory disease of the lung characterized by abnormal T helper-2 (T(H)2) lymphocyte responses to inhaled antigens. The molecular mechanisms leading to the generation of T(H)2 responses remain unclear, although toll-like receptors (TLRs) present on innate immune cells play a pivotal role in s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mattes J,Collison A,Plank M,Phipps S,Foster PS

更新日期：2009-11-03 00:00:00

abstract：:Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger carcinogenic events for reasons that are not well understood. Here, we used an in situ method to directly monitor induction and repair of clustered DNA lesions in individual cells. We showed, consistent with biophysical modeling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asaithamby A,Hu B,Chen DJ

更新日期：2011-05-17 00:00:00

abstract：:Amyloid fibrils were concentrated from the kidney, thyroid, and peripheral nerve of six patients with familial amyloidotic polyneuropathy (FAP). The fibril concentrates were solubilized in 6 M guanidine.HCl and fractionated on Sephadex G-100 columns. The elution profile of all FAP amyloid fibril concentrates revealed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costa PP,Figueira AS,Bravo FR

更新日期：1978-09-01 00:00:00

abstract：:Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of Jun probably results from transcriptional deregulation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu Sl,Bottoli I,Goller M,Vogt PK

更新日期：1999-05-11 00:00:00

abstract：:Phylogenetic comparison of rRNA sequences has suggested that a pseudoknot structure exists in the central domain of small-subunit rRNA. In Escherichia coli 16S rRNA, this pseudoknot would form when positions 570 and 571 pair with positions 865 and 866. Mutations were introduced into this pseudoknot at the phylogenetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vila A,Viril-Farley J,Tapprich WE

更新日期：1994-11-08 00:00:00

abstract：:There are two competing hypotheses for the origin of megaliths in Europe. The conventional view from the late 19th and early 20th centuries was of a single-source diffusion of megaliths in Europe from the Near East through the Mediterranean and along the Atlantic coast. Following early radiocarbon dating in the 1970s,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz Paulsson B

更新日期：2019-02-26 00:00:00

abstract：:CHD7 encodes an ATP-dependent chromatin remodeling factor. Mutation of this gene causes multiple developmental disorders, including CHARGE (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth/development, Genital abnormalities, and Ear anomalies) syndrome, in which conotruncal anomalies a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan S,Thienthanasit R,Chen D,Engelen E,Brühl J,Crossman DK,Kesterson R,Wang Q,Bouazoune K,Jiao K

更新日期：2020-11-17 00:00:00

abstract：:Whereas NF-kappaB has potent antiapoptotic function in most cell types, it was reported that in pancreatic beta cells it serves a proapoptotic function and may contribute to the pathogenesis of autoimmune type 1 diabetes. To investigate the role of beta cell NF-kappaB in autoimmune diabetes, we produced transgenic mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Millet I,Kim HS,Kim JY,Han MS,Lee MK,Kim KW,Sherwin RS,Karin M,Lee MS

更新日期：2007-02-06 00:00:00

abstract：:We explored the conformational landscape of the proteinogenic amino acid serine [CH(2)OH CH(NH(2)) COOH] in the gas phase. Solid serine was vaporized by laser ablation, expanded in a supersonic jet, and characterized by Fourier transform microwave spectroscopy. In the isolation conditions of the jet there have been di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blanco S,Sanz ME,López JC,Alonso JL

更新日期：2007-12-18 00:00:00

abstract：:The mechanisms that regulate the ubiquitin (Ub)-proteasome system's own components, although critically important, are largely unknown. Ub, a principal component of the system, must be maintained at adequate levels to support cellular homeostasis under basal and stressed conditions. It was suggested that Ub is degrade...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shabek N,Herman-Bachinsky Y,Ciechanover A

更新日期：2009-07-21 00:00:00