Mycosporine-like amino acids are multifunctional molecules in sea hares and their marine community.

Abstract:

:Molecules of keystone significance are relatively rare, yet mediate a variety of interactions between organisms. They influence the distribution and abundance of species, the transfer of energy across multiple trophic levels, and thus they play significant roles in structuring ecosystems. Despite their potential importance in facilitating our understanding of ecological systems, only three molecules thus far have been proposed as molecules of keystone significance: saxitoxin and dimethyl sulfide in marine communities and tetrodotoxin in riparian communities. In the course of studying the neuroecology of chemical defenses, we identified three mycosporine-like amino acids (MAAs)--N-ethanol palythine (= asterina-330), N-isopropanol palythine (= aplysiapalythine A), and N-ethyl palythine (= aplysiapalythine B)--as intraspecific alarm cues for sea hares (Aplysia californica). These alarm cues are released in the ink secretion of sea hares and cause avoidance behaviors in neighboring conspecifics. Further, we show that these three bioactive MAAs, two [aplysiapalythine A (APA) and -B (APB)] being previously unknown molecules, are present in the algal diet of sea hares and are concentrated in their defensive secretion as well as in their skin. MAAs are known to be produced by algae, fungi, and cyanobacteria and are acquired by many aquatic animals through trophic interactions. MAAs are widely used as sunscreens, among other uses, but sea hares modify their function to serve a previously undocumented role, as intraspecific chemical cues. Our findings highlight the multifunctionality of MAAs and their role in ecological connectivity, suggesting that they may function as molecules of keystone significance in marine ecosystems.

authors

Kicklighter CE,Kamio M,Nguyen L,Germann MW,Derby CD

doi

10.1073/pnas.1103906108

subject

Has Abstract

pub_date

2011-07-12 00:00:00

pages

11494-9

issue

28

eissn

0027-8424

issn

1091-6490

pii

1103906108

journal_volume

108

pub_type

杂志文章
  • Interaction between like-charged colloidal spheres in electrolyte solutions.

    abstract::How colloidal particles interact with each other is one of the key issues that determines our ability to interpret experimental results for phase transitions in colloidal dispersions and our ability to apply colloid science to various industrial processes. The long-accepted theories for answering this question have be...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.26.15169

    authors: Wu J,Bratko D,Prausnitz JM

    更新日期:1998-12-22 00:00:00

  • Characterization of potential selenium-binding proteins in the selenophosphate synthetase system.

    abstract::Selenophosphate, an activated form of selenium that can serve as a selenium donor, is generated by the selD gene product, selenophosphate synthetase (SPS). Selenophosphate is required by several bacteria and by mammals for the specific synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. Although...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0409042102

    authors: Ogasawara Y,Lacourciere GM,Ishii K,Stadtman TC

    更新日期:2005-01-25 00:00:00

  • Zero-field remote detection of NMR with a microfabricated atomic magnetometer.

    abstract::We demonstrate remote detection of nuclear magnetic resonance (NMR) with a microchip sensor consisting of a microfluidic channel and a microfabricated vapor cell (the heart of an atomic magnetometer). Detection occurs at zero magnetic field, which allows operation of the magnetometer in the spin-exchange relaxation-fr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0711505105

    authors: Ledbetter MP,Savukov IM,Budker D,Shah V,Knappe S,Kitching J,Michalak DJ,Xu S,Pines A

    更新日期:2008-02-19 00:00:00

  • Planar-to-tubular structural transition in boron clusters: B20 as the embryo of single-walled boron nanotubes.

    abstract::Experimental and computational simulations revealed that boron clusters, which favor planar (2D) structures up to 18 atoms, prefer 3D structures beginning at 20 atoms. Using global optimization methods, we found that the B20 neutral cluster has a double-ring tubular structure with a diameter of 5.2 A. For the B(-)20 a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0408132102

    authors: Kiran B,Bulusu S,Zhai HJ,Yoo S,Zeng XC,Wang LS

    更新日期:2005-01-25 00:00:00

  • Opposing effects of estradiol and progesterone on oxytocin receptors in rabbit uterus.

    abstract::Estradiol-17beta administration to young (10- to 12-week-old) rabbits to produce the "estrogen-dominated" uterus increased the uterine contractile response to both oxytocin and methacholine in vitro. In "progesterone-dominated" uteri, obtained from rabbits that received progesterone for 4 days after estrogen pretreatm...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.75.4.2044

    authors: Nissenson R,Fluoret G,Hechter O

    更新日期:1978-04-01 00:00:00

  • Genetic evidence for a second domestication of barley (Hordeum vulgare) east of the Fertile Crescent.

    abstract::Cereal agriculture originated with the domestication of barley and early forms of wheat in the Fertile Crescent. There has long been speculation that barley was domesticated more than once. We use differences in haplotype frequency among geographic regions at multiple loci to infer at least two domestications of barle...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 历史文章,杂志文章

    doi:10.1073/pnas.0611377104

    authors: Morrell PL,Clegg MT

    更新日期:2007-02-27 00:00:00

  • Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers.

    abstract::The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers. The multiplicity and invasiveness of intestinal adenomas of Apc(Min/+) (Min) mice was enhanced by deficiency for p53. In addition, the occurrence of desm...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.050585597

    authors: Halberg RB,Katzung DS,Hoff PD,Moser AR,Cole CE,Lubet RA,Donehower LA,Jacoby RF,Dove WF

    更新日期:2000-03-28 00:00:00

  • A tryptophan synchronous and normal fluorescence study on bacteria inactivation mechanism.

    abstract::The UV photodissociation kinetics of tryptophan amino acid, Trp, attached to the membrane of bacteria, Escherichia coli and Bacillus subtilis, have been studied by means of normal and synchronous fluorescence. Our experimental data suggest that the fluorescence intensity of Trp increases during the first minute of irr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1909722116

    authors: Li R,Dhankhar D,Chen J,Cesario TC,Rentzepis PM

    更新日期:2019-09-17 00:00:00

  • Predicting disease-causing variant combinations.

    abstract::Notwithstanding important advances in the context of single-variant pathogenicity identification, novel breakthroughs in discerning the origins of many rare diseases require methods able to identify more complex genetic models. We present here the Variant Combinations Pathogenicity Predictor (VarCoPP), a machine-learn...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1815601116

    authors: Papadimitriou S,Gazzo A,Versbraegen N,Nachtegael C,Aerts J,Moreau Y,Van Dooren S,Nowé A,Smits G,Lenaerts T

    更新日期:2019-06-11 00:00:00

  • Cryptographic hashing using chaotic hydrodynamics.

    abstract::Fluids may store and manipulate information, enabling complex applications ranging from digital logic gates to algorithmic self-assembly. While controllable hydrodynamic chaos has previously been observed in viscous fluids and harnessed for efficient mixing, its application to the manipulation of digital information h...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1721852115

    authors: Gilpin W

    更新日期:2018-05-08 00:00:00

  • Biological spectra analysis: Linking biological activity profiles to molecular structure.

    abstract::Establishing quantitative relationships between molecular structure and broad biological effects has been a longstanding challenge in science. Currently, no method exists for forecasting broad biological activity profiles of medicinal agents even within narrow boundaries of structurally similar molecules. Starting fro...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0407790101

    authors: Fliri AF,Loging WT,Thadeio PF,Volkmann RA

    更新日期:2005-01-11 00:00:00

  • Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization.

    abstract::Redistribution of specialized molecules in migrating cells develops asymmetry between two opposite cell poles, the leading edge and the uropod. We show that acquisition of a motile phenotype in T lymphocytes results in the asymmetric redistribution of ganglioside GM3- and GM1-enriched raft domains to the leading edge ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.171160298

    authors: Gómez-Móuton C,Abad JL,Mira E,Lacalle RA,Gallardo E,Jiménez-Baranda S,Illa I,Bernad A,Mañes S,Martínez-A C

    更新日期:2001-08-14 00:00:00

  • Modern proteomes contain putative imprints of ancient shifts in trace metal geochemistry.

    abstract::Because of the rise in atmospheric oxygen 2.3 billion years ago (Gya) and the subsequent changes in oceanic redox state over the last 2.3-1 Gya, trace metal bioavailability in marine environments has changed dramatically. Although theorized to have influenced the biological usage of metals leaving discernable genomic ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0605798103

    authors: Dupont CL,Yang S,Palenik B,Bourne PE

    更新日期:2006-11-21 00:00:00

  • Accurately quantifying low-abundant targets amid similar sequences by revealing hidden correlations in oligonucleotide microarray data.

    abstract::Microarrays have enabled the determination of how thousands of genes are expressed to coordinate function within single organisms. Yet applications to natural or engineered communities where different organisms interact to produce complex properties are hampered by theoretical and technological limitations. Here we de...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0601476103

    authors: Marcelino LA,Backman V,Donaldson A,Steadman C,Thompson JR,Preheim SP,Lien C,Lim E,Veneziano D,Polz MF

    更新日期:2006-09-12 00:00:00

  • Adaptive diversification of growth allometry in the plant Arabidopsis thaliana.

    abstract::Seed plants vary tremendously in size and morphology; however, variation and covariation in plant traits may be governed, at least in part, by universal biophysical laws and biological constants. Metabolic scaling theory (MST) posits that whole-organismal metabolism and growth rate are under stabilizing selection that...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1709141115

    authors: Vasseur F,Exposito-Alonso M,Ayala-Garay OJ,Wang G,Enquist BJ,Vile D,Violle C,Weigel D

    更新日期:2018-03-27 00:00:00

  • Adenovirus-vectored vaccine containing multidimensionally conserved parts of the HIV proteome is immunogenic in rhesus macaques.

    abstract::An effective vaccine that can protect against HIV infection does not exist. A major reason why a vaccine is not available is the high mutability of the virus, which enables it to evolve mutations that can evade human immune responses. This challenge is exacerbated by the ability of the virus to evolve compensatory mut...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2022496118

    authors: Murakowski DK,Barton JP,Peter L,Chandrashekar A,Bondzie E,Gao A,Barouch DH,Chakraborty AK

    更新日期:2021-02-02 00:00:00

  • Revisiting the structures of several antibiotics bound to the bacterial ribosome.

    abstract::The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures of antibiotic-ribosome complexes that are accurate enough to enable the rational design of novel ribosome-targeting therapeutics. Structures of many antibiotics in complex with both archaeal and eubacterial ribosomes have be...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1008685107

    authors: Bulkley D,Innis CA,Blaha G,Steitz TA

    更新日期:2010-10-05 00:00:00

  • Genetic mapping of Rhizobium meliloti.

    abstract::The drug resistance factor RP4, originally isolated in Pseudomonas, was transferred to Rhizobium meliloti. In that strain, RP4 promotes conjugational transfer of chromosomal markers to form haploid recombinants. This mating system has been used to construct a linkage map of R. meliloti. ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.74.5.2076

    authors: Meade HM,Signer ER

    更新日期:1977-05-01 00:00:00

  • Visual memory-deficit amnesia: a distinct amnesic presentation and etiology.

    abstract::We describe a form of amnesia, which we have called visual memory-deficit amnesia, that is caused by damage to areas of the visual system that store visual information. Because it is caused by a deficit in access to stored visual material and not by an impaired ability to encode or retrieve new material, it has the ot...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.9.5413

    authors: Rubin DC,Greenberg DL

    更新日期:1998-04-28 00:00:00

  • Cloning of the cDNA encoding a myosin heavy chain B isoform of Xenopus nonmuscle myosin with an insert in the head region.

    abstract::The complete amino acid sequence of Xenopus laevis nonmuscle myosin heavy chain B (MHC-B) has been deduced from overlapping cDNA clones isolated from an XTC cell library. RNA blots of various developmental stages, adult tissues, and XTC cells detect a single transcript of 7.5 kb which is expressed at similar levels th...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.7.2856

    authors: Bhatia-Dey N,Adelstein RS,Dawid IB

    更新日期:1993-04-01 00:00:00

  • Mixed-power scaling of whole-plant respiration from seedlings to giant trees.

    abstract::The scaling of respiratory metabolism with body mass is one of the most pervasive phenomena in biology. Using a single allometric equation to characterize empirical scaling relationships and to evaluate alternative hypotheses about mechanisms has been controversial. We developed a method to directly measure respiratio...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0902554107

    authors: Mori S,Yamaji K,Ishida A,Prokushkin SG,Masyagina OV,Hagihara A,Hoque AT,Suwa R,Osawa A,Nishizono T,Ueda T,Kinjo M,Miyagi T,Kajimoto T,Koike T,Matsuura Y,Toma T,Zyryanova OA,Abaimov AP,Awaya Y,Araki MG,Kawasaki T

    更新日期:2010-01-26 00:00:00

  • RNA virus microRNA that mimics a B-cell oncomiR.

    abstract::MicroRNAs (miRNAs) are small RNAs that play a regulatory role in numerous and diverse eukaryotic cellular processes. Virus-encoded miRNAs have garnered much interest, although the functions of most remain to be deciphered. To date, readily detectable, evolutionarily conserved natural miRNAs have only been identified f...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1116107109

    authors: Kincaid RP,Burke JM,Sullivan CS

    更新日期:2012-02-21 00:00:00

  • The autophagic machinery ensures nonlytic transmission of mycobacteria.

    abstract::In contrast to mechanisms mediating uptake of intracellular bacterial pathogens, bacterial egress and cell-to-cell transmission are poorly understood. Previously, we showed that the transmission of pathogenic mycobacteria between phagocytic cells also depends on nonlytic ejection through an F-actin based structure, ca...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1423318112

    authors: Gerstenmaier L,Pilla R,Herrmann L,Herrmann H,Prado M,Villafano GJ,Kolonko M,Reimer R,Soldati T,King JS,Hagedorn M

    更新日期:2015-02-17 00:00:00

  • Structural origins of adenine-tract bending.

    abstract::DNA sequences containing short adenine tracts are intrinsically curved and play a role in transcriptional regulation. Despite many high-resolution NMR and x-ray studies, the origins of curvature remain disputed. Long-range restraints provided by 85 residual dipolar couplings were measured for a DNA decamer containing ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0437877100

    authors: Barbic A,Zimmer DP,Crothers DM

    更新日期:2003-03-04 00:00:00

  • A defined protein-detergent-lipid complex for crystallization of integral membrane proteins: The cytochrome b6f complex of oxygenic photosynthesis.

    abstract::The paucity of integral membrane protein structures creates a major bioinformatics gap, whose origin is the difficulty of crystallizing these detergent-solubilized proteins. The problem is particularly formidable for hetero-oligomeric integral membrane proteins, where crystallization is impeded by the heterogeneity an...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0931431100

    authors: Zhang H,Kurisu G,Smith JL,Cramer WA

    更新日期:2003-04-29 00:00:00

  • Methionine sulfoxide reductase A is a stereospecific methionine oxidase.

    abstract::Methionine sulfoxide reductase A (MsrA) catalyzes the reduction of methionine sulfoxide to methionine and is specific for the S epimer of methionine sulfoxide. The enzyme participates in defense against oxidative stresses by reducing methionine sulfoxide residues in proteins back to methionine. Because oxidation of me...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1101275108

    authors: Lim JC,You Z,Kim G,Levine RL

    更新日期:2011-06-28 00:00:00

  • Effect of rectangle length on velocity thresholds for real movement.

    abstract::New data are reported on the influence of size on the velocity threshold for real movement. As the length of a narrow stimulus object increases, width remaining constant, the velocity threshold also increases. These findings are discussed in relation to some psychophysical experiments on contrast and some physiologica...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.65.3.516

    authors: Mates B,Graham CH

    更新日期:1970-03-01 00:00:00

  • Evolutionary and genetic implications of sequence variation in two nonallelic HLA-DR beta-chain cDNA sequences.

    abstract::Most HLA haplotypes carry two expressed DR beta-chain genes; in the DR4 haplotype, the polymorphic locus has been called DR beta 1 and the apparently nonpolymorphic locus has been called DR beta 2. We have isolated nearly full-length DR beta-chain cDNA clones representing each of these two loci from a cell line homozy...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.84.1.209

    authors: Curtsinger JM,Hilden JM,Cairns JS,Bach FH

    更新日期:1987-01-01 00:00:00

  • A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly.

    abstract::We have isolated a cold-sensitive mutant of Saccharomyces cerevisiae in which there is a deficit of 60S ribosomal subunits. Cold sensitivity and the assembly defect are recessive and cosegregate, defining a single essential gene that we designated DRS1 (deficiency of ribosomal subunits). The wild-type DRS1 gene was cl...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.23.11131

    authors: Ripmaster TL,Vaughn GP,Woolford JL Jr

    更新日期:1992-12-01 00:00:00

  • Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis.

    abstract::The intracellular signaling mechanisms regulating the generation and long-term persistence of memory T cells in vivo remain unclear. In this study, we used mouse models with conditional deletion of the key T cell receptor (TCR)-coupled adaptor molecule SH2-domain-containing phosphoprotein of 76 kDa (SLP-76), to analyz...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0908126107

    authors: Bushar ND,Corbo E,Schmidt M,Maltzman JS,Farber DL

    更新日期:2010-01-12 00:00:00