Gene therapy of murine teratocarcinoma: separate functions for insulin-like growth factors I and II in immunogenicity and differentiation.

Abstract:

:Teratocarcinoma is a germ-line carcinoma giving rise to an embryoid tumor with structures derived from the three embryonic layers: mesoderm, endoderm, and ectoderm. Teratocarcinoma is widely used as an in vitro model system to study regulation of cell determination and differentiation during mammalian embryogenesis. Murine embryonic carcinoma (EC) PCC3 cells express insulin-like growth factor I(IGF-I) and its receptor, while all derivative tumor structures express IGF-I and IGF-II and their receptors. Therefore the system lends itself to dissect the role of these two growth factors during EC differentiation. With an episomal antisense strategy, we define a role for IGF-I in tumorigenicity and evasion of immune surveillance. Antisense IGF-I EC transfectants are shown to elicit a curative anti-tumor immune response with tumor regression at distal sites. In contrast, IGF-II is shown to drive determination and differentiation in EC cells. Since IGF-I and IGF-II bind to type I receptor and antisense sequence used for IGF-II cannot form duplex with endogenous IGF-I transcripts, it follows that this receptor is not involved in determination and differentiation.

authors

Trojan J,Johnson TR,Rudin SD,Blossey BK,Kelley KM,Shevelev A,Abdul-Karim FW,Anthony DD,Tykocinski ML,Ilan J

doi

10.1073/pnas.91.13.6088

subject

Has Abstract,Author List Incomplete

pub_date

1994-06-21 00:00:00

pages

6088-92

issue

13

eissn

0027-8424

issn

1091-6490

journal_volume

91

pub_type

杂志文章
  • Minimal sequence requirements for ribozyme activity.

    abstract::The hammerhead ribozyme, as engineered by J. Haseloff and W. L. Gerlach [(1988) Nature (London) 334, 585-591], is an RNA molecule containing two regions of conserved nucleotides, a double helix, called helix II, which connects the two conserved regions, and flanking arms of variable sequence, which hybridize the riboz...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.13.5710

    authors: McCall MJ,Hendry P,Jennings PA

    更新日期:1992-07-01 00:00:00

  • Ezrin-mediated apical integrity is required for intestinal homeostasis.

    abstract::Individual cell types are defined by architecturally and functionally specialized cortical domains. The Ezrin, Radixin, and Moesin (ERM) proteins play a major role in organizing cortical domains by assembling membrane protein complexes and linking them to the cortical actin cytoskeleton. Many studies have focused on t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1103418108

    authors: Casaletto JB,Saotome I,Curto M,McClatchey AI

    更新日期:2011-07-19 00:00:00

  • Metallacycle-cored supramolecular assemblies with tunable fluorescence including white-light emission.

    abstract::Control over the fluorescence of supramolecular assemblies is crucial for the development of chemosensors and light-emitting materials. Consequently, the postsynthetic modification of supramolecular structures via host-guest interactions has emerged as an efficient strategy in recent years that allows the facile tunin...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1702510114

    authors: Zhang M,Yin S,Zhang J,Zhou Z,Saha ML,Lu C,Stang PJ

    更新日期:2017-03-21 00:00:00

  • Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells.

    abstract::Tiazofurin (2-beta-D-ribofuranosyl-4-thiazole-carboxamide; NSC 286193), an antitumor carbon-linked nucleoside that inhibits IMP dehydrogenase (IMP:NAD+ oxidoreductase; EC 1.1.1.205) and depletes guanylate levels, can activate the erythroid differentiation program of K-562 human leukemia cells. Tiazofurin-mediated cell...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.17.6533

    authors: Olah E,Natsumeda Y,Ikegami T,Kote Z,Horanyi M,Szelenyi J,Paulik E,Kremmer T,Hollan SR,Sugar J

    更新日期:1988-09-01 00:00:00

  • Humans, water, and the colonization of Australia.

    abstract::The Pleistocene global dispersal of modern humans required the transit of arid and semiarid regions where the distribution of potable water provided a primary constraint on dispersal pathways. Here, we provide a spatially explicit continental-scale assessment of the opportunities for Pleistocene human occupation of Au...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1608470113

    authors: Bird MI,O'Grady D,Ulm S

    更新日期:2016-10-11 00:00:00

  • Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly.

    abstract::Macrophages (M phi) are activated by IFN gamma and are important cellular targets for infection by human and murine cytomegalovirus (MCMV), making it advantageous for CMVs to block IFN gamma-induced M phi differentiation. We found that MCMV infection inhibited IFN gamma regulation of many genes in M phi. MCMV infectio...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1835673100

    authors: Popkin DL,Watson MA,Karaskov E,Dunn GP,Bremner R,Virgin HW 4th

    更新日期:2003-11-25 00:00:00

  • What does voice-processing technology support today?

    abstract::This paper describes the state of the art in applications of voice-processing technologies. In the first part, technologies concerning the implementation of speech recognition and synthesis algorithms are described. Hardware technologies such as microprocessors and DSPs (digital signal processors) are discussed. Softw...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.22.10023

    authors: Nakatsu R,Suzuki Y

    更新日期:1995-10-24 00:00:00

  • Delayed mortality effects cut the malaria transmission potential of insecticide-resistant mosquitoes.

    abstract::Malaria transmission has been substantially reduced across Africa through the distribution of long-lasting insecticidal nets (LLINs). However, the emergence of insecticide resistance within mosquito vectors risks jeopardizing the future efficacy of this control strategy. The severity of this threat is uncertain becaus...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1603431113

    authors: Viana M,Hughes A,Matthiopoulos J,Ranson H,Ferguson HM

    更新日期:2016-08-09 00:00:00

  • Stimulated Raman photoacoustic imaging.

    abstract::Achieving label-free, molecular-specific imaging with high spatial resolution in deep tissue is often considered the grand challenge of optical imaging. To accomplish this goal, significant optical scattering in tissues has to be overcome while achieving molecular specificity without resorting to extrinsic labeling. W...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1012432107

    authors: Yakovlev VV,Zhang HF,Noojin GD,Denton ML,Thomas RJ,Scully MO

    更新日期:2010-11-23 00:00:00

  • Two types of magnetic shape-memory effects from twinned microstructure and magneto-structural coupling in Fe1+y Te.

    abstract::A detailed experimental investigation of Fe1+y Te (y = 0.11, 0.12) using pulsed magnetic fields up to 60 T confirms remarkable magnetic shape-memory (MSM) effects. These effects result from magnetoelastic transformation processes in the low-temperature antiferromagnetic state of these materials. The observation of mod...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1905271116

    authors: Rößler S,Koz C,Wang Z,Skourski Y,Doerr M,Kasinathan D,Rosner H,Schmidt M,Schwarz U,Rößler UK,Wirth S

    更新日期:2019-08-20 00:00:00

  • Molecular and structural architecture of polyQ aggregates in yeast.

    abstract::Huntington's disease is caused by the expansion of a polyglutamine (polyQ) tract in the N-terminal exon of huntingtin (HttEx1), but the cellular mechanisms leading to neurodegeneration remain poorly understood. Here we present in situ structural studies by cryo-electron tomography of an established yeast model system ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1717978115

    authors: Gruber A,Hornburg D,Antonin M,Krahmer N,Collado J,Schaffer M,Zubaite G,Lüchtenborg C,Sachsenheimer T,Brügger B,Mann M,Baumeister W,Hartl FU,Hipp MS,Fernández-Busnadiego R

    更新日期:2018-04-10 00:00:00

  • The wisdom of crowds for visual search.

    abstract::Decision-making accuracy typically increases through collective integration of people's judgments into group decisions, a phenomenon known as the wisdom of crowds. For simple perceptual laboratory tasks, classic signal detection theory specifies the upper limit for collective integration benefits obtained by weighted ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1610732114

    authors: Juni MZ,Eckstein MP

    更新日期:2017-05-23 00:00:00

  • Biological formation of ethane and propane in the deep marine subsurface.

    abstract::Concentrations and isotopic compositions of ethane and propane in cold, deeply buried sediments from the southeastern Pacific are best explained by microbial production of these gases in situ. Reduction of acetate to ethane provides one feasible mechanism. Propane is enriched in (13)C relative to ethane. The amount is...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0606535103

    authors: Hinrichs KU,Hayes JM,Bach W,Spivack AJ,Hmelo LR,Holm NG,Johnson CG,Sylva SP

    更新日期:2006-10-03 00:00:00

  • Hormone-regulatable neoplastic transformation induced by a Jun-estrogen receptor chimera.

    abstract::The v-jun oncogene encodes a nuclear DNA binding protein that functions as a transcription factor and is part of the activator protein 1 complex. Oncogenic transformation by v-jun is thought to be mediated by the aberrant expression of specific target genes. To identify such Jun-regulated genes and to explore the mech...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.23.12396

    authors: Kruse U,Iacovoni JS,Goller ME,Vogt PK

    更新日期:1997-11-11 00:00:00

  • Target inference from collections of genomic intervals.

    abstract::Finding regions of the genome that are significantly recurrent in noisy data are a common but difficult problem in present day computational biology. Cores of recurrent events (CORE) is a computational approach to solving this problem that is based on a formalized notion by which "core" intervals explain the observed ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1306909110

    authors: Krasnitz A,Sun G,Andrews P,Wigler M

    更新日期:2013-06-18 00:00:00

  • Parental imprinting studied by allele-specific primer extension after PCR: paternal X chromosome-linked genes are transcribed prior to preferential paternal X chromosome inactivation.

    abstract::The preferential inactivation of the paternal X chromosome in extraembryonic cells during early mouse development is an example of parental imprinting, but it has not been studied at the transcriptional level because standard methods of measuring RNA levels do not allow detection of allele-specific RNAs in individual ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.21.10469

    authors: Singer-Sam J,Chapman V,LeBon JM,Riggs AD

    更新日期:1992-11-01 00:00:00

  • Biological impact on mineral dissolution: application of the lichen model to understanding mineral weathering in the rhizosphere.

    abstract::Microorganisms modify rates and mechanisms of chemical and physical weathering and clay growth, thus playing fundamental roles in soil and sediment formation. Because processes in soils are inherently complex and difficult to study, we employ a model based on the lichen-mineral system to identify the fundamental inter...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.7.3404

    authors: Banfield JF,Barker WW,Welch SA,Taunton A

    更新日期:1999-03-30 00:00:00

  • Global configuration of single titin molecules observed through chain-associated rhodamine dimers.

    abstract::The global configuration of individual, surface-adsorbed molecules of the giant muscle protein titin, labeled with rhodamine conjugates, was followed with confocal microscopy. Fluorescence-emission intensity was reduced because of self-quenching caused by the close spacing between rhodamine dye molecules that formed d...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.191494098

    authors: Grama L,Somogyi B,Kellermayer MS

    更新日期:2001-12-04 00:00:00

  • Three-dimensional structure of a protein from scorpion venom: a new structural class of neurotoxins.

    abstract::The three-dimensional crystal structure of variant-3 toxin from the scorpion Centruroides sculpturatus Ewing has been determined at 3 A resolution. Phases were obtained by use of K2PtCl4 and K2IrCl6 derivatives. The most prominent secondary structural features are two and a half turns of alpha-helix and a three-strand...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.77.11.6496

    authors: Fontecilla-Camps JC,Almassy RJ,Suddath FL,Watt DD,Bugg CE

    更新日期:1980-11-01 00:00:00

  • The peptide-catalyzed stereospecific synthesis of tetroses: a possible model for prebiotic molecular evolution.

    abstract::Using a water-based prebiotic model of sugar synthesis involving glycolaldehyde self-condensation, we demonstrate that homochiral L-dipeptide catalysts lead to the stereospecific syntheses of tetroses. The asymmetric effect is largest for erythrose, which may reach a D-enantiomeric excess of >80% with L-Val-L-Val cata...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0602320103

    authors: Weber AL,Pizzarello S

    更新日期:2006-08-22 00:00:00

  • Control of excision frequency of maize transposable element Ds in Petunia protoplasts.

    abstract::The complete coding region of maize transposable element Ac and truncated but active derivatives of it were placed under the control of promoters of different strength and tested for the ability to excise transposable element Ds from a beta-glucuronidase reporter gene in a cotransfection assay in Petunia protoplasts. ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.12.5552

    authors: Becker D,Lütticke R,Li M,Starlinger P

    更新日期:1992-06-15 00:00:00

  • Effect of increasing doses of angiotensin II infused into normal and hypertensive Wistar rats on low density lipoprotein and fibrinogen uptake by aortic walls.

    abstract::The effect of 6 days' s.c. infusions of angiotensin II at increasing doses was determined on the uptake of rat or human low density lipoprotein (LDL) and of human fibrinogen by aorta in normal and spontaneously hypertensive rats. Rat or human LDL or human fibrinogen was injected i.v. 5 days after the start of infusion...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.91.8.3285

    authors: Cardona-Sanclemente LE,Medina R,Born GV

    更新日期:1994-04-12 00:00:00

  • Species-fragmented area relationship.

    abstract::The species-area relationship (SAR) gives a quantitative description of the increasing number of species in a community with increasing area of habitat. In conservation, SARs have been used to predict the number of extinctions when the area of habitat is reduced. Such predictions are most needed for landscapes rather ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1311491110

    authors: Hanski I,Zurita GA,Bellocq MI,Rybicki J

    更新日期:2013-07-30 00:00:00

  • CDK5 activator protein p25 preferentially binds and activates GSK3β.

    abstract::Glycogen synthase kinase 3β (GSK3β) and cyclin-dependent kinase 5 (CDK5) are tau kinases and have been proposed to contribute to the pathogenesis of Alzheimer's disease. The 3D structures of these kinases are remarkably similar, which led us to hypothesize that both might be capable of binding cyclin proteins--the act...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1402627111

    authors: Chow HM,Guo D,Zhou JC,Zhang GY,Li HF,Herrup K,Zhang J

    更新日期:2014-11-11 00:00:00

  • Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization.

    abstract::Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly (LIS1), we deleted the first coding exon from the mouse Lis1 gene. The deletion resulted in a shorter protein (sLIS1) that initiates from the second methionine, a unique situation because most LIS1 mutati...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.101122598

    authors: Cahana A,Escamez T,Nowakowski RS,Hayes NL,Giacobini M,von Holst A,Shmueli O,Sapir T,McConnell SK,Wurst W,Martinez S,Reiner O

    更新日期:2001-05-22 00:00:00

  • Species specificity of cholecystokinin in gut and brain of several mammalian species.

    abstract::Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the monkey, dog, and pig, by using an antiserum with equivalent sensitivities for detecting the octapeptide in free form or incorporated in the intact molecule. The failure to detect intact chole...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.75.1.486

    authors: Straus E,Yalow RS

    更新日期:1978-01-01 00:00:00

  • Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning.

    abstract::C1q, a member of the immune complement cascade, is implicated in the selective pruning of synapses by microglial phagocytosis. C1q-mediated synapse elimination has been shown to occur during brain development, while increased activation and complement-dependent synapse loss is observed in neurodegenerative diseases. H...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1722613115

    authors: Györffy BA,Kun J,Török G,Bulyáki É,Borhegyi Z,Gulyássy P,Kis V,Szocsics P,Micsonai A,Matkó J,Drahos L,Juhász G,Kékesi KA,Kardos J

    更新日期:2018-06-12 00:00:00

  • Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.

    abstract::Studies of tumors from human familial adenomatous polyposis, sporadic colon cancer, and mouse and rat models of intestinal cancer indicate that the majority of early adenomas develop through loss of normal function of the Adenomatous polyposis coli (APC) gene. In murine models of familial adenomatous polyposis, specif...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1120753109

    authors: Amos-Landgraf JM,Irving AA,Hartman C,Hunter A,Laube B,Chen X,Clipson L,Newton MA,Dove WF

    更新日期:2012-02-07 00:00:00

  • Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex.

    abstract::Dehydroepiandrosterone (DHEA) is a neurosteroid with potential effects on neurogenesis and neuronal survival in humans. However, most studies on DHEA have been performed in rodents, and there is little direct evidence for biological effects on the human nervous system. Furthermore, the mechanism of its action is unkno...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0307325101

    authors: Suzuki M,Wright LS,Marwah P,Lardy HA,Svendsen CN

    更新日期:2004-03-02 00:00:00

  • Base insertion and deletion mutations induced in an Escherichia coli plasmid by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.

    abstract::Mutations induced by (+/-)trans-benzo-[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BaP-diol epoxide-1) were selected by using a recombinant plasmid vector system designed for the study of transcription termination signals. The plasmid contains a transcription terminator positioned between a promotor signal and the Escheric...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.78.11.6817

    authors: Mizusawa H,Lee CH,Kakefuda T,McKenney K,Shimatake H,Rosenberg M

    更新日期:1981-11-01 00:00:00