Induced nucleotide specificity in a GTPase.

abstract：:Selective culling in populations of most organisms is rank-order: individuals of low rank on a scale of potential fitnesses tend to be eliminated during early development, whereas surviving adults (whose number reflects the carrying capacity of the environment) are generally drawn from the distribution's upper end. Ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallace B

更新日期：1989-03-01 00:00:00

abstract：:Arabinose-binding protein, maltose-binding protein, and lambda receptor are synthesized in vitro on membrane-bound polysomes from Escherichia coli. All three proteins are exported from the cytoplasm of E. coli and all three are made in vitro in a form a few thousand daltons larger than the authentic protein. The large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randall LL,Hardy SJ,Josefsson LG

更新日期：1978-03-01 00:00:00

abstract：:Tridecaptin A1 (TriA1) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA1 exerts its bactericidal effect by binding to the bacterial cell-wall precursor lipid II on the inner membrane, disrupting the proton motive force. Biochemical and biophysic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cochrane SA,Findlay B,Bakhtiary A,Acedo JZ,Rodriguez-Lopez EM,Mercier P,Vederas JC

更新日期：2016-10-11 00:00:00

abstract：:Immunoglobulin kappa chain gene formation involves site-specific somatic recombination between one of several hundred germ-line variable region genes and a joining site (or "J segment") encoded close to the constant region gene. We have cloned and determined the nucleotide sequence of major portions of the recombinati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Max EE,Seidman JG,Leder P

更新日期：1979-07-01 00:00:00

abstract：:The plant hormones abscisic acid (ABA) and gibberellic acid (GA) are important regulators of the dormancy and germination of seeds. In cereals, GA enhances the synthesis and secretion of enzymes (principally alpha-amylases) in the aleurone cells of the endosperm, which then mobilize the storage reserves that fuel germ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritchie S,Gilroy S

更新日期：1998-03-03 00:00:00

abstract：:Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao W,Rovin BH,Friedman A

更新日期：2014-09-30 00:00:00

abstract：:The 158,000 Mr protein, previously designated C5c, present in fully assembled complement (C) membrane attack complexes (MC5b-9) has been identified as a disulfide-bonded dimer of C9. This conclusion was based on the observations that: (i) a portion of the 125I-radiolabeled precursor C9 incorporated into MC5b-9 complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ware CF,Kolb WP

更新日期：1981-10-01 00:00:00

abstract：:In many eukaryotic systems during immune responses, mitogen-activated protein kinases (MAPKs) link cytoplasmic signaling to chromatin events by targeting transcription factors, chromatin remodeling complexes, and the RNA polymerase machinery. So far, knowledge on these events is scarce in plants and no attempts have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayapuram N,Jarad M,Alhoraibi HM,Bigeard J,Abulfaraj AA,Völz R,Mariappan KG,Almeida-Trapp M,Schlöffel M,Lastrucci E,Bonhomme L,Gust AA,Mithöfer A,Arold ST,Pflieger D,Hirt H

更新日期：2021-01-19 00:00:00

abstract：:Earlier we have shown that oscillations with a long period ("supercycles") may arise in two-locus systems experiencing cyclical selection with a short period. However, this mode of complex limiting behavior appeared to be possible for narrow ranges of parameters. Here we demonstrate that a multilocus system subjected ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirzhner VM,Korol AB,Nevo E

更新日期：1996-06-25 00:00:00

abstract：:Treatment of a human breast cancer cell line (MDA-MB-435) in nude mice with a recombinant adenovirus containing the human interferon (IFN) consensus gene, IFN-con1 (ad5/IFN), resulted in tumor regression in 100% of the animals. Tumor regression occurred when virus was injected either within 24 hr of tumor cell implant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang JF,Hu C,Geng Y,Selm J,Klein SB,Orazi A,Taylor MW

更新日期：1996-04-30 00:00:00

abstract：:The complex prokaryote, Myxococcus xanthus, undergoes a program of multicellular development when starved for nutrients, culminating in sporulation. M. xanthus makes MglA, a 22-kDa, soluble protein that is required for both multicellular development and gliding motility. MglA is similar in sequence to the Saccharomyce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartzell PL

更新日期：1997-09-02 00:00:00

abstract：:Germ-line mutations of the BRCA2 tumor suppressor gene greatly increase the risk of developing breast and ovarian cancers. Here, we show that wild-type BRCA2, but not a tumor-specific truncated mutant BRCA2, synergizes with the nuclear receptor coactivator p160 GRIP1 to enhance transcriptional activation by androgen r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shin S,Verma IM

更新日期：2003-06-10 00:00:00

abstract：:Peptides bind MHC class I molecules by anchoring hydrophobic side chains into pockets in the peptide binding groove. Here, we report an immunogenic (in vitro and in vivo) MUC1 glycopeptide (MUC1-8-5GalNAc) bound to H-2Kb, fully crossreactive with the nonglycosylated variant. Molecular modeling showed that the central ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Apostolopoulos V,Yuriev E,Ramsland PA,Halton J,Osinski C,Li W,Plebanski M,Paulsen H,McKenzie IF

更新日期：2003-12-09 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) signaling has been shown to play a role in cardiac development as well as in the pathogenesis of cardiovascular disease. Prior studies have suggested a relationship between cholesterol metabolism and TGFbeta signaling. Here we demonstrate that induction of the cholesterol meta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park HJ,Galper JB

更新日期：1999-09-28 00:00:00

abstract：:Activation of P2X2 receptor channels by extracellular ATP is thought to play important roles in cochlear adaptation to elevated sound levels and protection from overstimulation. Each subunit of a trimeric P2X2 receptor is composed of intracellular N and C termini, a large extracellular domain containing the ATP bindin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： George B,Swartz KJ,Li M

更新日期：2019-11-05 00:00:00

abstract：:Topical application of phorbol myristate acetate (PMA) elicits intense local inflammation that facilitates outgrowth of premalignant lesions in skin after carcinogen exposure. The inflammatory response to PMA treatment activates immune stimulatory mechanisms. However, we show here that PMA exposure also induces plasma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muller AJ,Sharma MD,Chandler PR,Duhadaway JB,Everhart ME,Johnson BA 3rd,Kahler DJ,Pihkala J,Soler AP,Munn DH,Prendergast GC,Mellor AL

更新日期：2008-11-04 00:00:00

abstract：:We report the presence of protein kinase C (PKC) in ejaculated human sperm as revealed by enzymatic activity assay and indirect immunohistochemistry. PKC is localized in the equatorial segment and in the principal piece of the tail. Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotem R,Paz GF,Homonnai ZT,Kalina M,Naor Z

更新日期：1990-09-01 00:00:00

abstract：:Emerging genetic and clinical evidence suggests a link between Gaucher disease and the synucleinopathies Parkinson disease and dementia with Lewy bodies. Here, we provide evidence that a mouse model of Gaucher disease (Gba1(D409V/D409V)) exhibits characteristics of synucleinopathies, including progressive accumulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sardi SP,Clarke J,Kinnecom C,Tamsett TJ,Li L,Stanek LM,Passini MA,Grabowski GA,Schlossmacher MG,Sidman RL,Cheng SH,Shihabuddin LS

更新日期：2011-07-19 00:00:00

abstract：:MicroRNA-34a (miR-34a) is the most highly elevated hepatic miR in obese mice and is also substantially elevated in patients who have steatosis, but its role in obesity and metabolic dysfunction remains unclear. After a meal, FGF19 is secreted from the ileum; binds to a hepatic membrane receptor complex, FGF19 receptor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu T,Choi SE,Kim DH,Seok S,Suino-Powell KM,Xu HE,Kemper JK

更新日期：2012-10-02 00:00:00

abstract：:Transporters in the Golgi apparatus membrane translocate nucleotide sugars from the cytosol into the Golgi lumen before these can be substrates for the glycosylation of proteins, lipids, and proteoglycans. We have cloned the mammalian Golgi membrane transporter for uridine diphosphate-N-acetylglucosamine by phenotypic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guillen E,Abeijon C,Hirschberg CB

更新日期：1998-07-07 00:00:00

abstract：:Degradable polymers are beginning to play an increasing role as materials for environmental and medical applications. Understanding factors that control erosion, such as bond cleavage and the dissolution and diffusion of degradation products, will be critical to the future development of these materials. Erosion kinet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamada JA,Langer R

更新日期：1993-01-15 00:00:00

abstract：:In a recently discovered class of oncogenes, GTPase-inhibiting mutations constitutively activate alpha subunits of signal-transducing guanine nucleotide-binding proteins (G proteins). Somatic mutations in a subclass of endocrine tumors are found in the arginine-179 codon of the alpha subunit of Gi2 (alpha i2), creatin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace AM,Wong YH,Bourne HR

更新日期：1991-08-15 00:00:00

abstract：:The TATA box-binding activity of transcription factor IID (TFIID) is autoinhibited by the N-terminal domain of the Drosophila TATA box-binding protein- (TBP) associated factor 230/yeast TBP-associated factor 145 subunit, which binds to the TATA box-binding domain of TBP by mimicking the TATA box structure. Here, we pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotani T,Banno K,Ikura M,Hinnebusch AG,Nakatani Y,Kawaichi M,Kokubo T

更新日期：2000-06-20 00:00:00

abstract：:Euplotes raikovi of the wild-type strain 13 was found to be heterozygous (mat-1/mat-2) for the genetic locus mat, which is supposed to control the mating-type specificity of freely released mating pheromones ("euplomones"), and capable of yielding the two types of corresponding homozygotes (mat-1/mat-1, mat-2/mat-2). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luporini P,Raffioni S,Concetti A,Miceli C

更新日期：1986-05-01 00:00:00

abstract：:We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated endocytosis to carry DNA macromolecules into cells. We accomplished this by conjugating the iron-transport protein transferrin to polycations that bind nucleic acids. Human transferrin, as well as the chicken homologue conalbu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Zenke M,Cotten M,Beug H,Birnstiel ML

更新日期：1990-05-01 00:00:00

abstract：:Learning and memory rely on dopamine and downstream cAMP-dependent plasticity across diverse organisms. Despite the central role of cAMP signaling, it is not known how cAMP-dependent plasticity drives coherent changes in neuronal physiology that encode the memory trace, or engram. In Drosophila, the mushroom body (MB)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Louis T,Stahl A,Boto T,Tomchik SM

更新日期：2018-01-16 00:00:00

abstract：:Herpesviruses are dsDNA viruses, but their virions may additionally contain RNAs that can be transduced to recipient cells. The biological functions of herpes virion RNA species are unknown. Here we address this issue for EBV, a widespread human herpesvirus with oncogenic potential. We show that EBV-derived particles ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jochum S,Ruiss R,Moosmann A,Hammerschmidt W,Zeidler R

更新日期：2012-05-22 00:00:00

abstract：:The production of the staphylococcal exotoxin toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus has been associated with essentially all cases of menstruation-associated toxic shock syndrome (TSS). In this work, we show that the human vaginal isolate Lactobacillus reuteri RC-14 produces small signaling mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Wang W,Xu SX,Magarvey NA,McCormick JK

更新日期：2011-02-22 00:00:00

abstract：:Malaria transmission has been substantially reduced across Africa through the distribution of long-lasting insecticidal nets (LLINs). However, the emergence of insecticide resistance within mosquito vectors risks jeopardizing the future efficacy of this control strategy. The severity of this threat is uncertain becaus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Viana M,Hughes A,Matthiopoulos J,Ranson H,Ferguson HM

更新日期：2016-08-09 00:00:00

abstract：:Myosins are molecular motors that power diverse cellular processes, such as rapid organelle transport, muscle contraction, and tension-sensitive anchoring. The structural adaptations in the motor that allow for this functional diversity are not known, due, in part, to the lack of high-resolution structures of highly t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shuman H,Greenberg MJ,Zwolak A,Lin T,Sindelar CV,Dominguez R,Ostap EM

更新日期：2014-02-11 00:00:00