BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription.

abstract：:ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moser AR,Mattes EM,Dove WF,Lindstrom MJ,Haag JD,Gould MN

更新日期：1993-10-01 00:00:00

abstract：:Modern practice for training classification deepnets involves a terminal phase of training (TPT), which begins at the epoch where training error first vanishes. During TPT, the training error stays effectively zero, while training loss is pushed toward zero. Direct measurements of TPT, for three prototypical deepnet a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papyan V,Han XY,Donoho DL

更新日期：2020-10-06 00:00:00

abstract：:p150(glued) belongs to a group of proteins accumulating at microtubule plus ends (+TIPs). It plays a key role in initiating retrograde transport by recruiting and tethering endosomes and dynein to microtubules. p150(glued) contains an N-terminal microtubule-binding cytoskeleton-associated protein glycine-rich (CAP-Gly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Q,Crevenna AH,Kunze I,Mizuno N

更新日期：2014-08-05 00:00:00

abstract：:T cells that have been immunized to express optimal levels of contact hypersensitivity upon adoptive transfer to normal animals can be inhibited from doing so by incubating them with an antigen-specific T suppressor factor. This factor is composed of at least two subunits which come from cells expressing different Ly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ptak W,Rosenstein RW,Gershon RK

更新日期：1982-04-01 00:00:00

abstract：:Antarctic ozone depletion is associated with enhanced chlorine from anthropogenic chlorofluorocarbons and heterogeneous chemistry under cold conditions. The deep Antarctic "hole" contrasts with the generally weaker depletions observed in the warmer Arctic. An unusually cold Arctic stratospheric season occurred in 2011...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Solomon S,Haskins J,Ivy DJ,Min F

更新日期：2014-04-29 00:00:00

abstract：:A single catalytic site model is proposed to account for the multiphasic kinetics of oxidation of ferrocytochrome c by cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1). This model involves nonproductive binding of substrate to sites near the catalytic site on cytochrome c oxidase for cytochro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Speck SH,Dye D,Margoliash E

更新日期：1984-01-01 00:00:00

abstract：:In this study, we demonstrate that fluid shear stress (FSS)-induced actin cytoskeletal reorganization and junctional formation in renal epithelial cells are nearly completely opposite the corresponding changes in vascular endothelial cells (ECs) [Thi MM et al. (2004) Proc Natl Acad Sci USA 101:16483-16488]. Mouse prox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duan Y,Gotoh N,Yan Q,Du Z,Weinstein AM,Wang T,Weinbaum S

更新日期：2008-08-12 00:00:00

abstract：:Purified cellular retinol-binding protein (CRBP), a potential mediator of vitamin A action, was found to enable retinol to bind in a specific manner to isolated nuclei from livers of vitamin A deficient rats. Binding was followed after complexing [3H]retinol with CRBP. The binding was specific, saturable, and temperat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takase S,Ong DE,Chytil F

更新日期：1979-05-01 00:00:00

abstract：:The developmental loss of neurons in sympathetic, sensory, and some parasympathetic ganglia in familial dysautonomia suggests an inherited defect in the action of beta-nerve growth factor (beta-NGF). The role of this growth factor in dysautonomia has been difficult to resolve as there is no known source of authentic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breakefield XO,Orloff G,Castiglione C,Coussens L,Axelrod FB,Ullrich A

更新日期：1984-07-01 00:00:00

abstract：:Metabolic engineering seeks to reprogram microbial cells to efficiently and sustainably produce value-added compounds. Since chemical production can be at odds with the cell's natural objectives, strategies have been developed to balance conflicting goals. For example, dynamic regulation modulates gene expression to f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinh CV,Prather KLJ

更新日期：2019-12-17 00:00:00

abstract：:Noniridescent coloration by the spongy keratin in parrot feather barbs has fascinated scientists. Nonetheless, its ultimate origin remains as yet unanswered, and a quantitative structural and optical description is still lacking. Here we report on structural and optical characterizations and numerical simulations of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yin H,Dong B,Liu X,Zhan T,Shi L,Zi J,Yablonovitch E

更新日期：2012-07-03 00:00:00

abstract：:When a local mechanical perturbation is applied to the surface of a thin film of a mechanically interlocked molecule (a rotaxane), the molecules self-organize into periodic arrays of discrete dots or lines. The dimensionality of the nanostructures depends on whether the mechanical stimulus acts along a 1D line or over...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biscarini F,Cavallini M,Kshirsagar R,Bottari G,Leigh DA,León S,Zerbetto F

更新日期：2006-11-21 00:00:00

abstract：:Enhanced transductional recombination between specialized transducing phage lambda plac5 and plasmid F42lac depends on cis- and trans-acting factors. By constructing a series of recombinant molecules, the cis-acting site required for enhanced recombination has been identified as oriT, the origin of conjugational trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seifert HS,Porter RD

更新日期：1984-12-01 00:00:00

abstract：:An effective metabolism is essential to all living organisms, including the important human pathogen Staphylococcus aureus. To establish successful infection, S. aureus must scavenge nutrients and coordinate its metabolism for proliferation. Meanwhile, it also must produce an array of virulence factors to interfere wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding Y,Liu X,Chen F,Di H,Xu B,Zhou L,Deng X,Wu M,Yang CG,Lan L

更新日期：2014-11-18 00:00:00

abstract：:We have isolated a set of regulatory mutants defective in transcription termination at the attenuator in the leader region of the Escherichia coli tryptophan (trp) operon. In vivo the mutants have 2- to 4-fold increased levels of expression of the trp operon above the level of the trpR parental strain. These levels ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stauffer GV,Zurawski G,Yanofsky C

更新日期：1978-10-01 00:00:00

abstract：:S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray crystal structure of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siddiquee K,Zhang S,Guida WC,Blaskovich MA,Greedy B,Lawrence HR,Yip ML,Jove R,McLaughlin MM,Lawrence NJ,Sebti SM,Turkson J

更新日期：2007-05-01 00:00:00

abstract：:As an alternative pathway of controlled cell death, necroptosis can be triggered by tumor necrosis factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase domain-like protein (MLKL). Upon activation, MLKL oligomerizes and integrates into the plasma membrane via its executioner domain. Here, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rübbelke M,Fiegen D,Bauer M,Binder F,Hamilton J,King J,Thamm S,Nar H,Zeeb M

更新日期：2020-12-29 00:00:00

abstract：:We present an automated laser tracking and optogenetic manipulation system (ALTOMS) for studying social memory in fruit flies (Drosophila melanogaster). ALTOMS comprises an intelligent central control module for high-speed fly behavior analysis and feedback laser scanning (∼40 frames per second) for targeting two lase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu MC,Chu LA,Hsiao PY,Lin YY,Chi CC,Liu TH,Fu CC,Chiang AS

更新日期：2014-04-08 00:00:00

abstract：:High-resolution crystal structures of editing complexes of both duplex and single-stranded DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four nucleotides of single-stranded DNA bound to the 3'-5' exonuclease active site and extending toward the polymerase active site. Melting of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freemont PS,Friedman JM,Beese LS,Sanderson MR,Steitz TA

更新日期：1988-12-01 00:00:00

abstract：:The heterogeneous RNA of the HeLa cell nucleus contains short internal poly(A) sequences which, in contrast to the longer poly(A) sequences at the 3' ends, are not found in messenger RNA of the cytoplasm. A distinct origin for each of these homologous sequences is evident when the effects of actinomycin D and 3'-deoxy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakazato H,Edmonds M,Kopp DW

更新日期：1974-01-01 00:00:00

abstract：:Theoretical distributions of genetic distance between reproductively isolated taxa are derived by means of computer simulation, taking into account mutation and random genetic drift. The distributions obtained are in good agreement with the observed distributions of interracial and interspecific genetic distances for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nei M,Tateno Y

更新日期：1975-07-01 00:00:00

abstract：:The mouse insulin-like growth factor 2 (Igf2) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at this locus is regulated by parental imprinting. However, despite the existence of putative imprinting control elements in the Igf2 upstream region, imprinted tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Constancia M,Zubair M,Bailleul B,Feil R,Sasaki H,Reik W

更新日期：1997-11-11 00:00:00

abstract：:There are defined medullary, mesencephalic, hypothalamic, and thalamic functions in regulation of respiration, but knowledge of cortical control and the elements subserving the consciousness of breathlessness and air hunger is limited. In nine young adults, air hunger was produced acutely by CO(2) inhalation. Comparis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brannan S,Liotti M,Egan G,Shade R,Madden L,Robillard R,Abplanalp B,Stofer K,Denton D,Fox PT

更新日期：2001-02-13 00:00:00

abstract：:The starting point for the study of adverse experiences is that some have enduring consequences that continue after the period of exposure to the adversity. That raises four basic issues: whether social adversities can be considered homogeneous, whether the crucial effect lies in the "objective" or subjectively percei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rutter M

更新日期：2012-10-16 00:00:00

abstract：:The chloride permeability of airway and sweat ductal epithelium of cystic fibrosis (CF) patients is decreased. This abnormality could represent an intrinsic characteristic of the epithelial cell or the response to a tonic extrinsic stimulus, in vivo. We cultured airway epithelial cells derived from CF and non-CF indiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stutts MJ,Cotton CU,Yankaskas JR,Cheng E,Knowles MR,Gatzy JT,Boucher RC

更新日期：1985-10-01 00:00:00

abstract：:We report on the design and characterization of a class of biomolecular interfaces based on derivatized poly(l-lysine)-grafted poly(ethylene glycol) copolymers adsorbed on negatively charged surfaces. As a model system, we synthesized biotin-derivatized poly(l-lysine)-grafted poly(ethylene glycol) copolymers, PLL-g-[(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Taylor LA,Martin TL,Zaugg FG,Witte K,Indermuhle P,Nock S,Wagner P

更新日期：2001-01-30 00:00:00

abstract：:HLA-DO (DO) is a nonclassic class II heterodimer that inhibits the action of the class II peptide exchange catalyst, HLA-DM (DM), and influences DM localization within late endosomes and exosomes. In addition, DM acts as a chaperone for DO and is required for its egress from the endoplasmic reticulum (ER). These recip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoon T,Macmillan H,Mortimer SE,Jiang W,Rinderknecht CH,Stern LJ,Mellins ED

更新日期：2012-07-10 00:00:00

abstract：:Werner syndrome and Bloom syndrome result from defects in the RecQ helicases Werner (WRN) and Bloom (BLM), respectively, and display premature aging phenotypes. Similarly, XFE progeroid syndrome results from defects in the ERCC1-XPF DNA repair endonuclease. To gain insight into the origin of cellular senescence and hu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagelstrom RT,Blagoev KB,Niedernhofer LJ,Goodwin EH,Bailey SM

更新日期：2010-09-07 00:00:00

abstract：:The proteasome regulates cellular processes as diverse as cell cycle progression and NF-kappaB activation. In this study, we show that the potent antitumor natural product epoxomicin specifically targets the proteasome. Utilizing biotinylated-epoxomicin as a molecular probe, we demonstrate that epoxomicin covalently b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng L,Mohan R,Kwok BH,Elofsson M,Sin N,Crews CM

更新日期：1999-08-31 00:00:00

abstract：:The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The balance between its active and inactive form is tightly controlled to ensure cellular integrity. We report that the transcriptional repressor C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherrier T,Le Douce V,Eilebrecht S,Riclet R,Marban C,Dequiedt F,Goumon Y,Paillart JC,Mericskay M,Parlakian A,Bausero P,Abbas W,Herbein G,Kurdistani SK,Grana X,Van Driessche B,Schwartz C,Candolfi E,Benecke AG,Van Lin

更新日期：2013-07-30 00:00:00