Single catalytic site model for the oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase.

abstract：:A stable free-radical polymeric derivative of prostaglandin B1 (PGBx) has been synthesized that exhibits regenerative effects on oxidative phosphorylation in aged mitochondria. The molecular weights of the most active preparations fall between 2000 and 2600. PGBx is characterized by a single-line electron spin resonan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polis BD,Polis E,Kwong S

更新日期：1979-04-01 00:00:00

abstract：:Golgi-associated cytoplasmic proteins, such as the coatomer protein complex, are required for vesicle budding and trafficking. We have previously described a cytoplasmic phosphoprotein, p200, which binds dynamically and specifically to Golgi membranes. The p200 protein is dissociated from Golgi membranes in the presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narula N,Stow JL

更新日期：1995-03-28 00:00:00

abstract：:Little is known about genetic regulation of the development of white matter. This knowledge is critical in understanding the pathophysiology of neurodevelopmental syndromes associated with altered cognition as well as in elucidating the genetics of normal human cognition. The hemideletion of approximately 25 genes on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marenco S,Siuta MA,Kippenhan JS,Grodofsky S,Chang WL,Kohn P,Mervis CB,Morris CA,Weinberger DR,Meyer-Lindenberg A,Pierpaoli C,Berman KF

更新日期：2007-09-18 00:00:00

abstract：:Complex gene regulatory circuits contain many interacting components. In principle, all of these components and interactions may be essential to the function of the circuit. Alternatively, some of them may be refinements to a simpler version of the circuit that improve its fitness. In this work, we have tested whether...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Babić AC,Little JW

更新日期：2007-11-06 00:00:00

abstract：:In the mammalian retina, extensive processing of spatiotemporal and chromatic information occurs. One key principle in signal transfer through the retina is parallel processing. Two of these parallel pathways are the ON- and OFF-channels transmitting light and dark signals. This dual system is created in the outer ple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hack I,Peichl L,Brandstätter JH

更新日期：1999-11-23 00:00:00

abstract：:The post-translational proteolytic conversion of somatostatin-14 precursors was studied to characterize the enzyme system responsible for the production of the tetradecapeptide either from its 15-kDa precursor protein or from its COOH-terminal fragment, somatostatin-28. A synthetic undecapeptide Pro-Arg-Glu-Arg-Lys-Al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gluschankof P,Morel A,Gomez S,Nicolas P,Fahy C,Cohen P

更新日期：1984-11-01 00:00:00

abstract：:Intrinsic horizontal axon collaterals in the striate cortex of adult cats specifically link columns having the same preferred orientation; consequently, retrograde tracer injections result in intrinsic labeling that is sharply clustered. We have previously shown that the normal development of this circuitry involves t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callaway EM,Katz LC

更新日期：1991-02-01 00:00:00

abstract：:In vitro, polynucleotide phosphorylase of Escherichia coli can both synthesize RNA by using nucleotide diphosphates as precursors and exonucleolytically degrade RNA in the presence of inorganic phosphate. However, because of the high in vivo concentration of inorganic phosphate in exponentially growing cells, it has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohanty BK,Kushner SR

更新日期：2000-10-24 00:00:00

abstract：:Single molecule studies, at constant force, of the separation of double-stranded DNA into two separated single strands may provide information relevant to the dynamics of DNA replication. At constant applied force, theory predicts that the unzipped length as a function of time is characterized by jumps during which th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danilowicz C,Coljee VW,Bouzigues C,Lubensky DK,Nelson DR,Prentiss M

更新日期：2003-02-18 00:00:00

abstract：:Antigenic variation of African trypanosomes results from the periodic activation of a single new variant cell surface glycoprotein (VSG) gene out of a repertoire of about a 1000 VSG genes. In spite of the apparently random genetic basis of the process of antigenic variation, the relapsing parasitemias are characterize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agur Z,Abiri D,Van der Ploeg LH

更新日期：1989-12-01 00:00:00

abstract：:Biodiversity responses to ongoing climate and atmospheric changes will affect both ecosystem processes and the delivery of ecosystem goods and services. Combined effects of co-occurring global changes on diversity, however, are poorly understood. We examined plant diversity responses in a California annual grassland t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zavaleta ES,Shaw MR,Chiariello NR,Mooney HA,Field CB

更新日期：2003-06-24 00:00:00

abstract：:An equation for the bond angles OC-M-CO for tetracarbonyl groups in which the transition metal atom M is enneacovalent, derived from the simple theory of hybrid sp(3)d(5) bond orbitals, is tested by comparison of the calculated values of the angles with the experimental values reported for many compounds containing M(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1978-02-01 00:00:00

abstract：:A new common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses was demonstrated by the use of rabbit antiserum against feline leukemia virus and the indirect membrane immunofluorescence test. Common cell-surface antigen was found in all leukemias of all strains of mice tested, in norma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshiki T,Mellors RC,Hardy WD Jr

更新日期：1973-06-01 00:00:00

abstract：:The cellular basis of the magnetic sense remains an unsolved scientific mystery. One theory that aims to explain how animals detect the magnetic field is the magnetite hypothesis. It argues that intracellular crystals of the iron oxide magnetite (Fe3O4) are coupled to mechanosensitive channels that elicit neuronal act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman NB,Fritz T,Nimpf S,Pichler P,Lauwers M,Hickman RW,Papadaki-Anastasopoulou A,Ushakova L,Heuser T,Resch GP,Saunders M,Shaw JA,Keays DA

更新日期：2015-01-06 00:00:00

abstract：:It has been a widely accepted hypothesis that the molecular clock slows down during evolution of higher primates. By molecular cloning and nucleotide sequence comparison of a rhesus macaque alpha-globin gene to its homologs in man, orangutan, olive baboon, and other mammals, we demonstrate a burst of evolution of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaw JP,Marks J,Shen CC,Shen CK

更新日期：1989-02-01 00:00:00

abstract：:The chemotherapeutic drug Taxol is known to interact within a specific site on beta-tubulin. Although the general location of the site has been defined by photoaffinity labeling and electron crystallography, the original data were insufficient to make an absolute determination of the bound conformation. We have now co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snyder JP,Nettles JH,Cornett B,Downing KH,Nogales E

更新日期：2001-04-24 00:00:00

abstract：:DNA origami enables the precise fabrication of nanoscale geometries. We demonstrate an approach to engineer complex and reversible motion of nanoscale DNA origami machine elements. We first design, fabricate, and characterize the mechanical behavior of flexible DNA origami rotational and linear joints that integrate s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marras AE,Zhou L,Su HJ,Castro CE

更新日期：2015-01-20 00:00:00

abstract：:We prepared a stable cell line expressing the glucagon receptor to characterize the effect of G(s)-coupled receptor stimulation on extracellular signal-regulated protein kinase 1/2 (ERK1/2) activity. Glucagon treatment of the cell line caused a dose-dependent increase in cAMP concentration, activation of cAMP-dependen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang Y,Cypess AM,Muse ED,Wu CR,Unson CG,Merrifield RB,Sakmar TP

更新日期：2001-08-28 00:00:00

abstract：:The three-dimensional structure of alpha-cobra-toxin, the "long" neurotoxin from the venom of Naja naja siamensis, has been determined at 2.8-A resolution. Crystals grown as hexagonal needles have space group P6522 with unit cell parameters a = b = 74.59 A, c = 42.89 A; one molecule per asymmetric unit. Phases were de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walkinshaw MD,Saenger W,Maelicke A

更新日期：1980-05-01 00:00:00

abstract：:Circumnutation and winding in plants are universal growth movements that allow plants to survive despite their sessile nature. However, the detailed molecular mechanisms controlling these phenomena remain unclear. We previously found that a gravitropic mutant of Japanese morning glory (Pharbitis nil or Ipomoea nil), S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitazawa D,Hatakeda Y,Kamada M,Fujii N,Miyazawa Y,Hoshino A,Iida S,Fukaki H,Morita MT,Tasaka M,Suge H,Takahashi H

更新日期：2005-12-20 00:00:00

abstract：:Defining the processes of autoimmune attack of tissues is important for inhibiting continued tissue destruction. In type 1 diabetes, it is not known how cytotoxic effector T cell responses evolve over time in the pancreatic islets targeted for destruction. We used two-photon microscopy of live, intact, individual isle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friedman RS,Lindsay RS,Lilly JK,Nguyen V,Sorensen CM,Jacobelli J,Krummel MF

更新日期：2014-06-24 00:00:00

abstract：:The ability of lysosomes to move within the cytoplasm is important for many cellular functions. This ability is particularly critical in neurons, which comprise vast, highly differentiated domains such as the axon and dendrites. The mechanisms that control lysosome movement in these domains, however, remain poorly und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farías GG,Guardia CM,De Pace R,Britt DJ,Bonifacino JS

更新日期：2017-04-04 00:00:00

abstract：:After collision with their host cells, virus particles may remain mobile on cell surfaces until they become attached at firm binding sites. We propose that a virion will arrive within a typical median time at such a site, generating a membrane signal such as an increased membrane fluorescence in cells labeled with the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bayer ME,Bayer MH

更新日期：1981-09-01 00:00:00

abstract：:Social media sites are rapidly becoming one of the most important forums for public deliberation about advocacy issues. However, social scientists have not explained why some advocacy organizations produce social media messages that inspire far-ranging conversation among social media users, whereas the vast majority o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bail CA

更新日期：2016-10-18 00:00:00

abstract：:Natal philopatry, the return of individuals to their natal area for reproduction, has advantages and disadvantages for animal populations. Natal philopatry may generate local genetic adaptation, but it may also increase the probability of inbreeding that can compromise persistence. Although natal philopatry is well do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salles OC,Pujol B,Maynard JA,Almany GR,Berumen ML,Jones GP,Saenz-Agudelo P,Srinivasan M,Thorrold SR,Planes S

更新日期：2016-11-15 00:00:00

abstract：:A diverse range of neural cell types is generated from a pool of dividing stem and progenitor cells in an orderly manner during development. Little is known of the molecular and cellular biology underpinning the intrinsic control of this process. We have used a nonbiased method to purify populations of neural progenit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livesey FJ,Young TL,Cepko CL

更新日期：2004-02-03 00:00:00

abstract：:Skeletal muscle L-type Ca2+ channels respond to trains of brief depolarizations with a strong shift of the voltage dependence of channel activation toward more negative membrane potentials and slowing of channel deactivation. Increased Ca2+ entry resulting from this potentiation of channel activity may increase contra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson BD,Scheuer T,Catterall WA

更新日期：1994-11-22 00:00:00

abstract：:To define the gene content of the HLA class I region, cDNA selection was applied to three overlapping yeast artificial chromosomes (YACs) that spanned 1 megabase (Mb) of this region of the human major histocompatibility complex. These YACs extended from the region centromeric to HLA-E to the region telomeric to HLA-F....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei H,Fan WF,Xu H,Parimoo S,Shukla H,Chaplin DD,Weissman SM

更新日期：1993-12-15 00:00:00

abstract：:PTEN is an important tumor-suppressor gene associated with many cancers. Through expression profiling of glioblastoma tissue samples and prostate cancer xenografts, we identified a molecular signature for loss of the PTEN tumor suppressor in glioblastoma and prostate tumors. The PTEN signature consists of a minimum of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehrian-Shai R,Chen CD,Shi T,Horvath S,Nelson SF,Reichardt JK,Sawyers CL

更新日期：2007-03-27 00:00:00

abstract：:Low-frequency thalamocortical oscillations that underlie drowsiness and slow-wave sleep depend on rhythmic inhibition of relay cells by neurons in the reticular nucleus (RTN) under the influence of corticothalamic fibers that branch to innervate RTN neurons and relay neurons. To generate oscillations, input to RTN pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Golshani P,Liu XB,Jones EG

更新日期：2001-03-27 00:00:00