An alternative pathway for rod signals in the rodent retina: rod photoreceptors, cone bipolar cells, and the localization of glutamate receptors.

abstract：:Mobilization of the T-cell response against cancer has the potential to achieve long-lasting cures. However, it is not known how to harness antigen-presenting cells optimally to achieve an effective antitumor T-cell response. In this study, we show that anti-CD47 antibody-mediated phagocytosis of cancer by macrophages...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tseng D,Volkmer JP,Willingham SB,Contreras-Trujillo H,Fathman JW,Fernhoff NB,Seita J,Inlay MA,Weiskopf K,Miyanishi M,Weissman IL

更新日期：2013-07-02 00:00:00

abstract：:Functional MRI based on blood oxygenation level-dependent (BOLD) contrast is well established as a neuroimaging technique for detecting neural activity in the cortex of the human brain. While detection and characterization of BOLD signals, as well as their electrophysiological and hemodynamic/metabolic origins, have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding Z,Huang Y,Bailey SK,Gao Y,Cutting LE,Rogers BP,Newton AT,Gore JC

更新日期：2018-01-16 00:00:00

abstract：:This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac proteins critical to contractile function. Positioned at the ends of chromo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang ACY,Chang ACH,Kirillova A,Sasagawa K,Su W,Weber G,Lin J,Termglinchan V,Karakikes I,Seeger T,Dainis AM,Hinson JT,Seidman J,Seidman CE,Day JW,Ashley E,Wu JC,Blau HM

更新日期：2018-09-11 00:00:00

abstract：:Purified human platelet-derived growth factor (PDGF) induces an increase in amino acid uptake via system A in quiescent human diploid fibroblasts. Cells must be exposed to PDGF for 45 min to obtain maximum transport stimulation. Transport stimulation requires protein synthesis. Transient exposure to PDGF, alone, in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen AJ 3rd,Geyer RP,Antoniades HN

更新日期：1982-05-01 00:00:00

abstract：:Integrin-dependent adhesions mediate reciprocal exchange of force and information between the cell and the extracellular matrix. These effects are attributed to the "focal adhesion clutch," in which moving actin filaments transmit force to integrins via dynamic protein interactions. To elucidate these processes, we me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Driscoll TP,Ahn SJ,Huang B,Kumar A,Schwartz MA

更新日期：2020-12-22 00:00:00

abstract：:Bilateria are currently subdivided into three superclades: Deuterostomia, Ecdysozoa, and Lophotrochozoa. Within this new taxonomic frame, acoelomate Platyhelminthes, for a long time held to be basal bilaterians, are now considered spiralian lophotrochozoans. However, recent 18S rDNA [small subunit (SSU)] analyses have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Trillo I,Paps J,Loukota M,Ribera C,Jondelius U,Baguna J,Riutort M

更新日期：2002-08-20 00:00:00

abstract：:Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5' and the 3' untranslated regions and affecting the stability and translation efficiency of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devany E,Zhang X,Park JY,Tian B,Kleiman FE

更新日期：2013-02-26 00:00:00

abstract：:The exact role of the endocannabinoid system (ECS) during spermatogenesis has not been clarified. We used purified germ cell fractions representative of all phases of spermatogenesis and primary cultures of spermatogonia. This approach allowed the precise quantification of the cannabinoid receptor ligands, anandamide ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grimaldi P,Orlando P,Di Siena S,Lolicato F,Petrosino S,Bisogno T,Geremia R,De Petrocellis L,Di Marzo V

更新日期：2009-07-07 00:00:00

abstract：:The Cdc7p protein kinase is essential for the G1/S transition and initiation of DNA replication during the cell division cycle in Saccharomyces cerevisiae. Cdc7p appears to be an evolutionarily conserved protein, since a homolog Hsk1 has been isolated from Schizosaccharomyces pombe. Here, we report the isolation of a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang W,Hunter T

更新日期：1997-12-23 00:00:00

abstract：:The hyperactivity of the brain renin-angiotensin system (RAS) has been implicated in the development and maintenance of hypertension in several types of experimental and genetic hypertension animal models. We previously reported that in the murine brain, aminopeptidase A (APA) is involved in the conversion of angioten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fournie-Zaluski MC,Fassot C,Valentin B,Djordjijevic D,Reaux-Le Goazigo A,Corvol P,Roques BP,Llorens-Cortes C

更新日期：2004-05-18 00:00:00

abstract：:According to the Dobzhansky-Muller model, hybrid sterility is a consequence of the independent evolution of related taxa resulting in incompatible genomic interactions of their hybrids. The model implies that the incompatibilities evolve randomly, unless a particular gene or nongenic sequence diverges much faster than...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharyya T,Gregorova S,Mihola O,Anger M,Sebestova J,Denny P,Simecek P,Forejt J

更新日期：2013-02-05 00:00:00

abstract：:A vestigial, nonphotosynthetic plastid has been identified recently in protozoan parasites of the phylum Apicomplexa. The apicomplexan plastid, or "apicoplast," is indispensable, but the complete sequence of both the Plasmodium falciparum and Toxoplasma gondii apicoplast genomes has offered no clue as to what essentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waller RF,Keeling PJ,Donald RG,Striepen B,Handman E,Lang-Unnasch N,Cowman AF,Besra GS,Roos DS,McFadden GI

更新日期：1998-10-13 00:00:00

abstract：:A target protein for nalidixic and oxolinic acids in Escherichia coli, the nalA gene product (Pnal), was purified to homogeneity as judged by gel electrophoresis, using an in vitro complementation assay. It is a dimer of identical 110,000-dalton subunits. A polypeptide of this molecular weight is uniquely induced by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugino A,Peebles CL,Kreuzer KN,Cozzarelli NR

更新日期：1977-11-01 00:00:00

abstract：:The vulval development of Caenorhabditis elegans provides an opportunity to investigate genetic networks that control gene expression during organogenesis. During the fourth larval stage (L4), seven vulval cell types are produced, each of which executes a distinct gene expression program. We analyze how the expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue T,Wang M,Ririe TO,Fernandes JS,Sternberg PW

更新日期：2005-04-05 00:00:00

abstract：:In the past 15 years, the adoption of subnational immigration policies in the United States, such as those established by individual states, has gone from nearly zero to over 300 per year. These include welcoming policies aimed at attracting and incorporating immigrants, as well as unwelcoming policies directed at den...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huo YJ,Dovidio JF,Jiménez TR,Schildkraut DJ

更新日期：2018-01-30 00:00:00

abstract：:Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in Alzheimer's disease (AD). However, the mechanism of synaptic damage remains incompletely understood. Here, using FRET-based glutamate sensor imaging, we show that amyloid-β peptide (Aβ) engages α7 nicotinic acetylcholine receptors to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Talantova M,Sanz-Blasco S,Zhang X,Xia P,Akhtar MW,Okamoto S,Dziewczapolski G,Nakamura T,Cao G,Pratt AE,Kang YJ,Tu S,Molokanova E,McKercher SR,Hires SA,Sason H,Stouffer DG,Buczynski MW,Solomon JP,Michael S,Powers E

更新日期：2013-07-02 00:00:00

abstract：:III-V compound semiconductors are widely used for electronic and optoelectronic applications. However, interfacing III-Vs with other materials has been fundamentally limited by the high growth temperatures and lattice-match requirements of traditional deposition processes. Recently, we developed the templated liquid-p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hettick M,Li H,Lien DH,Yeh M,Yang TY,Amani M,Gupta N,Chrzan DC,Chueh YL,Javey A

更新日期：2020-01-14 00:00:00

abstract：:Duodenal bicarbonate secretion (DBS) is accepted as the primary mucosal defense against acid discharged from the stomach and is impaired in patients with duodenal ulcer disease. The secretory response to luminal acid is the main physiological stimulus for DBS and involves mediation by PGE2 produced by mucosal cells. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leppilampi M,Parkkila S,Karttunen T,Gut MO,Gros G,Sjöblom M

更新日期：2005-10-18 00:00:00

abstract：:A panel of 20 recombinant Fab fragments reactive with the surface glycoprotein gp120 of human type 1 immunodeficiency virus (HIV-1) were examined for their ability to neutralize MN and IIIB strains of the virus. Neutralization was determined as the ability of the Fab fragments to inhibit infection as measured in both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbas CF 3rd,Björling E,Chiodi F,Dunlop N,Cababa D,Jones TM,Zebedee SL,Persson MA,Nara PL,Norrby E

更新日期：1992-10-01 00:00:00

abstract：:Parasponia, a woody member of the elm family, is the only nonlegume genus whose members are known to form an effective nitrogen-fixing symbiosis with a Rhizobium species. The bacterial strain RP501 is a slow-growing strain of Rhizobium isolated from Parasponia nodules. Strain RP501 also nodulates the legumes siratro (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marvel DJ,Kuldau G,Hirsch A,Richards E,Torrey JG,Ausubel FM

更新日期：1985-09-01 00:00:00

abstract：:The dorsolateral striatum (DLS) is essential for motor and procedure learning, but the role of DLS spiny projection neurons (SPNs) of direct and indirect pathways, as marked, respectively, by D1 and D2 receptor (D1R and D2R) expression, remains to be clarified. Long-term two-photon calcium imaging of the same neuronal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng MJ,Lu D,Shen ZM,Poo MM

更新日期：2019-05-28 00:00:00

abstract：:DNA methylation at CpG dinucleotides is an important epigenetic regulator common to virtually all mammalian cell types, but recent evidence indicates that during early postnatal development neuronal genomes also accumulate uniquely high levels of two alternative forms of methylation, non-CpG methylation and hydroxymet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinde B,Gabel HW,Gilbert CS,Griffith EC,Greenberg ME

更新日期：2015-06-02 00:00:00

abstract：:Attending to a stimulus is known to enhance the neural responses to that stimulus. Recent experiments on visual attention have shown that this modulation can have object-based characteristics, such that, when certain parts of a visual object are attended, other parts automatically also receive enhanced processing. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busse L,Roberts KC,Crist RE,Weissman DH,Woldorff MG

更新日期：2005-12-20 00:00:00

abstract：:Loss of a whole chromosome 5 or a deletion of its long arm (5q) is a recurring abnormality in malignant myeloid neoplasms. To determine the location of genes on 5q that may be involved in leukemogenesis, we examined the deleted chromosome 5 homologs in a series of 135 patients with malignant myeloid diseases. By compa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Beau MM,Espinosa R 3rd,Neuman WL,Stock W,Roulston D,Larson RA,Keinanen M,Westbrook CA

更新日期：1993-06-15 00:00:00

abstract：:A sensitive assay using biotinylated ubiquitin revealed extensive ubiquitination of the large subunit of RNA polymerase II during incubations of transcription reactions in vitro. Phosphorylation of the repetitive carboxyl-terminal domain of the large subunit was a signal for ubiquitination. Specific inhibitors of cycl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsui A,Sharp PA

更新日期：1999-05-25 00:00:00

abstract：:Fast lateral proton migration along membranes is of vital importance for cellular energy homeostasis and various proton-coupled transport processes. It can only occur if attractive forces keep the proton at the interface. How to reconcile this high affinity to the membrane surface with high proton mobility is unclear....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Knyazev DG,Vereshaga YA,Ippoliti E,Nguyen TH,Carloni P,Pohl P

更新日期：2012-06-19 00:00:00

abstract：:RNA polymerase pausing represents an important mechanism of transcriptional regulation. In this study, we use a single-molecule transcription assay to investigate the effect of template base-pair composition on pausing by RNA polymerase II and the evolutionarily distinct mitochondrial polymerase Rpo41. For both enzyme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamft B,Bintu L,Ishibashi T,Bustamante C

更新日期：2012-06-05 00:00:00

abstract：:3T3 cells that have undergone adipose differentiation in vitro secrete into the culture medium a potent growth stimulatory activity for bovine aortic endothelial cells. When medium containing 2% fetal calf serum, which does not support significant endothelial cell growth, is conditioned by 3T3-F442A adipocytes, the en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castellot JJ Jr,Karnovsky MJ,Spiegelman BM

更新日期：1980-10-01 00:00:00

abstract：:Population outbreaks in tundra rodents have intrigued scientists for a century as a result of their spectacular appearances and their general lessons in ecology. One outstanding question that has led to competing hypotheses is why sympatric lemmings and voles differ in regularity and shape of their outbreaks. Lemming ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ims RA,Yoccoz NG,Killengreen ST

更新日期：2011-02-01 00:00:00

abstract：:Contemporary climate change is characterized both by increasing mean temperature and increasing climate variability such as heat waves, storms, and floods. How populations and communities cope with such climatic extremes is a question central to contemporary ecology and biodiversity conservation. Previous work has sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reusch TB,Ehlers A,Hämmerli A,Worm B

更新日期：2005-02-22 00:00:00