Transcriptional network underlying Caenorhabditis elegans vulval development.

abstract：:Investigation of retinal neurochemistry in a well-defined chick model of form-deprivation myopia indicated that dopamine and its metabolite 3,4-dihydroxyphenylacetic acid are reduced in myopic as compared to control eyes. The reduction in retinal dopamine is evident only during light adaptation and is accompanied by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stone RA,Lin T,Laties AM,Iuvone PM

更新日期：1989-01-01 00:00:00

abstract：:Human brain functional networks are embedded in anatomical space and have topological properties--small-worldness, modularity, fat-tailed degree distributions--that are comparable to many other complex networks. Although a sophisticated set of measures is available to describe the topology of brain networks, the selec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vértes PE,Alexander-Bloch AF,Gogtay N,Giedd JN,Rapoport JL,Bullmore ET

更新日期：2012-04-10 00:00:00

abstract：:In facultative photoperiodic flowering plants, noninductive photoperiods result in a delay in flowering, but such plants eventually flower, illustrating plasticity in an important developmental transition, flowering. The model plant, Arabidopsis, has a facultative photoperiod response. Although the inductive flowering...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DH,Sung S

更新日期：2010-09-28 00:00:00

abstract：:Studies in rodents and nonhuman primates have linked the activity of N-methyl-D-aspartate (NMDA) receptors within the hippocampus to animals' performance on memory-related tasks. However, whether these receptors are similarly essential for human memory is still an open question. Here we present evidence suggesting tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grunwald T,Beck H,Lehnertz K,Blümcke I,Pezer N,Kurthen M,Fernández G,Van Roost D,Heinze HJ,Kutas M,Elger CE

更新日期：1999-10-12 00:00:00

abstract：:Visual receptive fields (RFs) were mapped inside and outside the cortical representation of the optic disk in the striate cortex (area V1) of anesthetized and paralyzed Cebus monkeys. Unexpectedly, most cells were found to be binocularly driven, and the RFs mapped with contralateral-eye stimulation progressed in a top...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fiorani Júnior M,Rosa MG,Gattass R,Rocha-Miranda CE

更新日期：1992-09-15 00:00:00

abstract：:We developed two solid-phase reagent systems for microscopic visualization and characterization of melanocyte-stimulating hormone (MSH) receptors of melanoma cells. Multiple copies of [Nle-4,D-Phe-7]-alpha-MSH, a potent analog of alpha-MSH, were conjugated to microspheres (latex beads) or macrospheres (polyamide beads...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma SD,Jiang J,Hadley ME,Bentley DL,Hruby VJ

更新日期：1996-11-26 00:00:00

abstract：:Cytoskeletal filaments assemble into dense parallel, antiparallel, or disordered networks, providing a complex environment for active cargo transport and positioning by molecular motors. The interplay between the network architecture and intrinsic motor properties clearly affects transport properties but remains poorl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richard M,Blanch-Mercader C,Ennomani H,Cao W,De La Cruz EM,Joanny JF,Jülicher F,Blanchoin L,Martin P

更新日期：2019-07-23 00:00:00

abstract：:Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after nonselective growth. Rifampicin-resistant (Rif(r)) isolates were stable, suggesting that they had arisen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sánchez-Romero MA,Casadesús J

更新日期：2014-01-07 00:00:00

abstract：:Phytochromes (phy) are red/far-red-absorbing photoreceptors that regulate the adaption of plant growth and development to changes in ambient light conditions. The nuclear transport of the phytochromes upon light activation is regarded as a key step in phytochrome signaling. Although nuclear import of phyA is regulated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeiffer A,Nagel MK,Popp C,Wüst F,Bindics J,Viczián A,Hiltbrunner A,Nagy F,Kunkel T,Schäfer E

更新日期：2012-04-10 00:00:00

abstract：:To investigate the mechanisms of asbestos-induced carcinogenesis, expression of c-fos and c-jun protooncogenes was examined in rat pleural mesothelial cells and hamster tracheal epithelial cells after exposure to crocidolite or chrysotile asbestos. In contrast to phorbol 12-myristate 13-acetate, which induces rapid an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heintz NH,Janssen YM,Mossman BT

更新日期：1993-04-15 00:00:00

abstract：:Immunoglobulin kappa chain gene formation involves site-specific somatic recombination between one of several hundred germ-line variable region genes and a joining site (or "J segment") encoded close to the constant region gene. We have cloned and determined the nucleotide sequence of major portions of the recombinati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Max EE,Seidman JG,Leder P

更新日期：1979-07-01 00:00:00

abstract：:Nucleosomes are the fundamental structural unit of chromatin. In addition to stabilizing the DNA polymer, nucleosomes are modified in ways that reflect and affect gene expression in their vicinity. It has long been assumed that nucleosomes can transmit memory of gene expression through their covalent posttranslational...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlissel G,Rine J

更新日期：2019-10-08 00:00:00

abstract：:Huntington's disease (HD) is an untreatable neurological disorder caused by selective and progressive degeneration of the caudate nucleus and putamen of the basal ganglia. Although the etiology of HD pathology is not fully understood, the observed loss of neuronal cells is thought to occur primarily through apoptosis....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keene CD,Rodrigues CM,Eich T,Chhabra MS,Steer CJ,Low WC

更新日期：2002-08-06 00:00:00

abstract：:Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compartment. In this rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merion M,Schlesinger P,Brooks RM,Moehring JM,Moehring TJ,Sly WS

更新日期：1983-09-01 00:00:00

abstract：:For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous gamma-aminobutyric acid (GABA) with postsynaptic depolarization or pairing of pre- and postsynaptic stimulation. Current- and vol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alkon DL,Sánchez-Andrés JV,Ito E,Oka K,Yoshioka T,Collin C

更新日期：1992-12-15 00:00:00

abstract：:We previously identified rat8 in the pathway involved in epithelial cell differentiation that occurs in the rat mammary gland at pregnancy when tubules and alveoli are formed. rat8, which encodes an IFN-inducible membrane protein, is the rat homologue of the mouse gene fragilis. By differential detergent extraction an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zucchi I,Prinetti A,Scotti M,Valsecchi V,Valaperta R,Mento E,Reinbold R,Vezzoni P,Sonnino S,Albertini A,Dulbecco R

更新日期：2004-02-17 00:00:00

abstract：:The polyhedral borane ion [n-B20H18]2- reacts with liquid ammonia in the presence of a suitable base to produce an apical-equatorial (ae) isomer of the [B20H17NH3]3- ion, [1-(2'-B10H9)-2-NH3B10H8]3-. The structure of this product has been confirmed by 11B NMR spectroscopy and x-ray crystallography. This species underg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feakes DA,Shelly K,Knobler CB,Hawthorne MF

更新日期：1994-04-12 00:00:00

abstract：:Stimulation of the phosphatidylinositol cycle by neurotransmitters generates diacylglycerol, an activator of protein kinase C, which may regulate some forms of neurotransmission. Phorbol esters, potent inflammatory and tumor-promoting compounds, also activate protein kinase C. We demonstrate potent and selective effec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraban JM,Gould RJ,Peroutka SJ,Snyder SH

更新日期：1985-01-01 00:00:00

abstract：:Host species have evolved mechanisms that can inhibit pathogen replication even after a cell has been successfully invaded. Here we show that tripartite-motif protein 21 (TRIM21), a ubiquitously expressed E3 ubiquitin ligase that targets viruses inside the cytosol, protects mice against fatal viral infection. Upon inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaysburd M,Watkinson RE,Cooper H,Reed M,O'Connell K,Smith J,Cruickshanks J,James LC

更新日期：2013-07-23 00:00:00

abstract：:The immunoglobulin heavy-chain variable region (VH) locus in a phylogenetically primitive teleost (Elops saurus) has been characterized by a strategy that relied initially on cross-hybridization between genomic VH segments and a murine VH probe. Using a homologous (Elops) VH probe and DNA sequencing, this gene family ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amemiya CT,Litman GW

更新日期：1990-01-01 00:00:00

abstract：:Many nearshore fish and invertebrate populations are overexploited even when apparently coherent management structures are in place. One potential cause of mismanagement may be a poor understanding and accounting of stochasticity, particularly for stock recruitment. Many of the fishes and invertebrates that comprise n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siegel DA,Mitarai S,Costello CJ,Gaines SD,Kendall BE,Warner RR,Winters KB

更新日期：2008-07-01 00:00:00

abstract：:The transport of moisture in the tropics is a critical process for the global energy budget and on geologic timescales, has markedly influenced continental landscapes, migratory pathways, and biological evolution. Here we present a continuous, first-of-its-kind 1.3-My record of continental hydroclimate and lake-level ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyons RP,Scholz CA,Cohen AS,King JW,Brown ET,Ivory SJ,Johnson TC,Deino AL,Reinthal PN,McGlue MM,Blome MW

更新日期：2015-12-22 00:00:00

abstract：:Molecular imaging probes have potential for in vivo identification of apoptosis and other intracellular processes. TcapQ, a cell-penetrating, near-infrared fluorescent peptide probe designed to be optically silent through intramolecular fluorescence quenching and activated by effector caspases, has been previously des...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnett EM,Zhang X,Maxwell D,Chang Q,Piwnica-Worms D

更新日期：2009-06-09 00:00:00

abstract：:Entropic effects have often been invoked to explain the extraordinary catalytic power of enzymes. In particular, the hypothesis that enzymes can use part of the substrate-binding free energy to reduce the entropic penalty associated with the subsequent chemical transformation has been very influential. The enzymatic r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kazemi M,Himo F,Åqvist J

更新日期：2016-03-01 00:00:00

abstract：:Insulin and insulin-like growth factor 1 (IGF1) are ubiquitous growth factors that regulate proliferation in most mammalian tissues including pancreatic islets. To explore the specificity of insulin receptors in compensatory beta-cell growth, we examined two models of insulin resistance. In the first model, we used li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada T,Liew CW,Hu J,Hinault C,Michael MD,Krtzfeldt J,Yin C,Holzenberger M,Stoffel M,Kulkarni RN

更新日期：2007-05-22 00:00:00

abstract：:Cumulative distributions of the number of doublings undergone by mixed megakaryocytic/erythroblastic colonies and by pure megakaryocytic colonies were determined from plasma clot cultures of bone marrow (from C57BL/6 mice) supplemented with erythropoietin. Analysis of these distributions suggests that these colonies a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulus JM,Prenant M,Deschamps JF,Henry-Amar M

更新日期：1982-07-01 00:00:00

abstract：:The mouse skeletal muscle acetylcholine receptor is regulated, at least in part, by transcriptional mechanisms. As a first step toward defining the cis- and trans-acting factors involved in acetylcholine receptor transcriptional regulation, we examined mouse muscle and fibroblast cells for the presence of DNase I-hype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crowder CM,Merlie JP

更新日期：1986-11-01 00:00:00

abstract：:The substance P (SP)-preferring receptor neurokinin-1 receptor (NK-1R) has two forms: a full-length receptor consisting of 407 aa and a truncated receptor consisting of 311 aa. These two receptors differ in the length of the C terminus of NK-1R. We studied the undifferentiated and phorbol myristate acetate (PMA)-diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai JP,Ho WZ,Kilpatrick LE,Wang X,Tuluc F,Korchak HM,Douglas SD

更新日期：2006-05-16 00:00:00

abstract：:Although current theories of color vision differ in many respects, they all assume the existence of a uniquely defined neutral point in chromaticity space. It generally is assumed that this point satisfies several criteria simultaneously. One of these criteria is that it is perceived as achromatic. A further criterion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ekroll V,Faul F,Niederée R,Richter E

更新日期：2002-10-01 00:00:00

abstract：:Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides has been used as antitumor supplement, but the mechanism of immune response has rarely been studied. Here, we show that the mice immunized with a l-f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao SF,Liang CH,Ho MY,Hsu TL,Tsai TI,Hsieh YS,Tsai CM,Li ST,Cheng YY,Tsao SM,Lin TY,Lin ZY,Yang WB,Ren CT,Lin KI,Khoo KH,Lin CH,Hsu HY,Wu CY,Wong CH

更新日期：2013-08-20 00:00:00