Variant antigenic peptide promotes cytotoxic T lymphocyte adhesion to target cells without cytotoxicity.

abstract：:Accurate protein folding is essential for proper cellular and organismal function. In the cell, protein folding is carefully regulated; changes in folding homeostasis (proteostasis) can disrupt many cellular processes and have been implicated in various neurodegenerative diseases and other pathologies. For many protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samelson AJ,Jensen MK,Soto RA,Cate JH,Marqusee S

更新日期：2016-11-22 00:00:00

abstract：:At each stage of infection, the major coat protein of coliphage M13 binds to the E. coli cytoplasmic membrane with its antigenic site exposed to the cell exterior [Wickner, W. (1975) Proc. Nat. Acad. Sci. USA 72, 4749-4753]. This antigenic site is now shown to be at the amino-terminus of the protein. The amino-terminu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wickner W

更新日期：1976-04-01 00:00:00

abstract：:The traG protein of the F sex factor is an inner membrane protein with a molecular weight of 116,000. Mutants in traG (or in traN) are able to trigger conjugal DNA replication even though they cannot efficiently form stable mating aggregates with F(-) cells. The traG protein (and the traN protein) probably acts in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manning PA,Morelli G,Achtman M

更新日期：1981-12-01 00:00:00

abstract：:Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids can be combined in antiparallel side-by-side dimeric complexes for sequence-specific recognition in the minor groove of DNA. Six polyamides containing three to eight rings bind DNA sites 5-10 bp in length, respectively. Quantitative DNas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly JJ,Baird EE,Dervan PB

更新日期：1996-07-09 00:00:00

abstract：:The knowledge of tropical palaeoclimates is crucial for understanding global climate change, because it is a test bench for general circulation models that are ultimately used to predict future global warming. A longstanding issue concerning the last glacial maximum in the tropics is the discrepancy between the decrea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu H,Guiot J,Brewer S,Guo Z,Peng C

更新日期：2007-06-05 00:00:00

abstract：:Improper function of voltage-gated sodium channels (NaVs), obligatory membrane proteins for bioelectrical signaling, has been linked to a number of human pathologies. Small-molecule agents that target NaVs hold considerable promise for treatment of chronic disease. Absent a comprehensive understanding of channel struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Tran R,Du Bois J

更新日期：2016-05-24 00:00:00

abstract：:Heat-shock protein of 90 kDa (Hsp90) is an essential molecular chaperone that adopts different 3D structures associated with distinct nucleotide states: a wide-open, V-shaped dimer in the apo state and a twisted, N-terminally closed dimer with ATP. Although the N domain is known to mediate ATP binding, how Hsp90 sense...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sung N,Lee J,Kim JH,Chang C,Joachimiak A,Lee S,Tsai FT

更新日期：2016-03-15 00:00:00

abstract：:The molecular mechanism of tolerance to opiate drugs is poorly understood. We have used single-channel patch-clamp recordings to study opiate receptor effects on dissociated neurons from rat amygdala, a limbic region implicated in addiction processes. A 130-pS inwardly rectifying K(+)-preferring cation channel was act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Marrero HG,Murphy R,Lin YJ,Freedman JE

更新日期：2000-12-19 00:00:00

abstract：:Despite the widespread occurrence of spliceosomal introns in the genomes of higher eukaryotes, their origin remains controversial. One model proposes that the duplication of small genomic portions could have provided the boundaries for new introns. If this mechanism has occurred recently, the 5' and 3' boundaries of e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuo D,Madden R,Elela SA,Chabot B

更新日期：2007-01-16 00:00:00

abstract：:Replication of the single-stranded DNA genome of geminiviruses occurs via a double-stranded intermediate that is subsequently used as a template for rolling-circle replication of the viral strand. Only one of the proteins encoded by the virus, here referred to as replication initiator protein (Rep protein), is indispe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laufs J,Traut W,Heyraud F,Matzeit V,Rogers SG,Schell J,Gronenborn B

更新日期：1995-04-25 00:00:00

abstract：:The human gut is home to trillions of microbes, thousands of bacterial phylotypes, as well as hydrogen-consuming methanogenic archaea. Studies in gnotobiotic mice indicate that Methanobrevibacter smithii, the dominant archaeon in the human gut ecosystem, affects the specificity and efficiency of bacterial digestion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuel BS,Hansen EE,Manchester JK,Coutinho PM,Henrissat B,Fulton R,Latreille P,Kim K,Wilson RK,Gordon JI

更新日期：2007-06-19 00:00:00

abstract：:B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG/ Transducer of ErbB2 gene family and is induced by genotoxic stress in a p53- and Checkpoint kinase 1 (CHK1)-dependent manner. Down-regulation of BTG3 has been observed in human cancers, suggesting that it plays an important role in tumor supp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng YC,Lin TY,Shieh SY

更新日期：2013-04-09 00:00:00

abstract：:Two subjects, of 11,000 healthy individuals screened, were found to be missing three and four immunoglobulin isotypes, respectively (IgA1, IgG2, and IgG4; IgA1, IgG2, IgG4, and IgE), and have been analyzed at the DNA level by means of Southern blotting and Ig heavy-chain-specific probes. A broad deletion within the he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Migone N,Oliviero S,de Lange G,Delacroix DL,Boschis D,Altruda F,Silengo L,DeMarchi M,Carbonara AO

更新日期：1984-09-01 00:00:00

abstract：:Food is a powerful entrainment cue for circadian clocks in peripheral tissues, and changes in the composition of nutrients have been demonstrated to metabolically reprogram peripheral clocks. However, how food challenges may influence circadian metabolism of the master clock in the suprachiasmatic nucleus (SCN) or in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tognini P,Samad M,Kinouchi K,Liu Y,Helbling JC,Moisan MP,Eckel-Mahan KL,Baldi P,Sassone-Corsi P

更新日期：2020-11-24 00:00:00

abstract：:Mutant, but not wild-type p53 binds with high affinity to a variety of MAR-DNA elements (MARs), suggesting that MAR-binding of mutant p53 relates to the dominant-oncogenic activities proposed for mutant p53. MARs recognized by mutant p53 share AT richness and contain variations of an AATATATTT "DNA-unwinding motif," w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will K,Warnecke G,Wiesmüller L,Deppert W

更新日期：1998-11-10 00:00:00

abstract：:The kinetics of refolding of Escherichia coli dihydrofolate reductase (EC 1.5.1.3) have been examined upon dilution of unfolded enzyme in 4.5 M urea to 1.29 M urea in 0.02 M phosphate buffer (pH 7.2) at 10 degrees C. Changes in the intrinsic protein fluorescence on refolding are characterized by four phases. Based on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frieden C

更新日期：1990-06-01 00:00:00

abstract：:Long-term, localized delivery of small molecules from a biodegradable thin film is challenging owing to their low molecular weight and poor charge density. Accomplishing highly extended controlled release can facilitate high therapeutic levels in specific regions of the body while significantly reducing the toxicity t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu BB,Park MH,Hagerman SR,Hammond PT

更新日期：2014-08-19 00:00:00

abstract：:NIH 3T3 mouse cells were transfected with plasmids that induce efficient expression of either (i) the Rous sarcoma virus v-src gene, (ii) the chicken c-src gene, or (iii) a recombinant gene combining the 5' portion of c-src with the 3' end of v-src. Focus formation in tissue culture and formation of large colonies in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shalloway D,Coussens PM,Yaciuk P

更新日期：1984-11-01 00:00:00

abstract：:We use sequential large-scale crawl data to empirically investigate and validate the dynamics that underlie the evolution of the structure of the web. We find that the overall structure of the web is defined by an intricate interplay between experience or entitlement of the pages (as measured by the number of inbound ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong JS,Sarshar N,Roychowdhury VP

更新日期：2008-09-16 00:00:00

abstract：:Magnetotactic bacteria synthesize highly uniform intracellular magnetite nanoparticles through the action of several key biomineralization proteins. These proteins are present in a unique lipid-bound organelle (the magnetosome) that functions as a nanosized reactor in which the particle is formed. A master regulator p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawlings AE,Bramble JP,Walker R,Bain J,Galloway JM,Staniland SS

更新日期：2014-11-11 00:00:00

abstract：:Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in the lung. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alder JK,Chen JJ,Lancaster L,Danoff S,Su SC,Cogan JD,Vulto I,Xie M,Qi X,Tuder RM,Phillips JA 3rd,Lansdorp PM,Loyd JE,Armanios MY

更新日期：2008-09-02 00:00:00

abstract：:The SecY protein of Escherichia coli is an integral membrane component of the protein export apparatus. Suppressor mutations in the secY gene (prlA alleles) have been isolated that restore the secretion of precursor proteins with defective signal sequences. These mutations have never been shown to affect the transloca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nouwen N,de Kruijff B,Tommassen J

更新日期：1996-06-11 00:00:00

abstract：:In biological processes, such as fission, fusion and trafficking, it has been shown that lipids of different shapes are sorted into regions with different membrane curvatures. This lipid sorting has been hypothesized to be due to the coupling between the membrane curvature and the lipid's spontaneous curvature, which ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamal MM,Mills D,Grzybek M,Howard J

更新日期：2009-12-29 00:00:00

abstract：:Cyclic nucleotide metabolism was investigated in growing kidneys of rats during compensatory hypertrophy and during neonatal development. After unilateral nephrectomy a mild and short-lasting decrease in cyclic 3':5" adenosine monophosphate (cAMP) was observed in the hypertrophying kidney. In contrast, cyclic 3':5' gu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlondorff D,Weber H

更新日期：1976-02-01 00:00:00

abstract：:Prenylated Rab GTPases regulate intracellular vesicle trafficking in eukaryotic cells by associating with specific membranes and recruiting a multitude of Rab-specific effector proteins. Prenylation, membrane delivery, and recycling of all 60 members of the Rab GTPase family are regulated by two related molecules, Rab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YW,Tan KT,Waldmann H,Goody RS,Alexandrov K

更新日期：2007-07-24 00:00:00

abstract：:When purified dimers of hemagglutinin-neuraminidase molecules released by protease digestion from three strains of human parainfluenza virus 1 were used in crystallization trials, long thin needle crystals formed. Electron microscopic analysis of these needle crystals revealed that they are composed of stacks of tripl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murti KG,Takimoto T,Laver WG,Portner A

更新日期：1993-02-15 00:00:00

abstract：:Agrobacterium tumefaciens causes crown gall tumors on various plants by delivering transferred DNA (T-DNA) and virulence proteins into host plant cells. Under laboratory conditions, the bacterium is widely used as a vector to genetically modify a wide range of organisms, including plants, yeasts, fungi, and algae. Var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Q,Li X,Tu H,Pan SQ

更新日期：2017-03-14 00:00:00

abstract：:Cardiolipin is important for bacterial and mitochondrial stability and function. The final step in cardiolipin biosynthesis is catalyzed by cardiolipin synthase and differs mechanistically between prokaryotes and eukaryotes. To study the importance of cardiolipin synthesis for mitochondrial integrity, membrane protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serricchio M,Bütikofer P

更新日期：2012-04-17 00:00:00

abstract：:GLQ223 is a highly purified, formulated preparation of trichosanthin, a 26-kDa plant-derived ribosome-inactivating protein with potent inhibitory activity against human immunodeficiency virus (HIV) in vitro. The compound produced concentration-dependent inhibition of HIV replication in acutely infected cultures of T-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGrath MS,Hwang KM,Caldwell SE,Gaston I,Luk KC,Wu P,Ng VL,Crowe S,Daniels J,Marsh J

更新日期：1989-04-01 00:00:00

abstract：:Telomeric repeat-containing RNA (referred to as TERRA), a noncoding RNA molecule, has recently been found in mammalian cells. The detailed structural features and function of the TERRA RNA at human chromosome ends remain unclear, although this RNA molecule may be a key component of the telomere machinery. In the prese...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Y,Suzuki Y,Ito K,Komiyama M

更新日期：2010-08-17 00:00:00