Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane.

abstract：:Stressor exposure biases decision-making strategies from those based on the relationship between actions and their consequences to others restricted by stimulus-response associations. Chronic stressor exposure also desensitizes glucocorticoid receptors (GR) and diminishes motivation to acquire food reinforcement, alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gourley SL,Swanson AM,Jacobs AM,Howell JL,Mo M,Dileone RJ,Koleske AJ,Taylor JR

更新日期：2012-12-11 00:00:00

abstract：:Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and progression of CaP remain largely unknown. Recent studies have shown that some aberrantly expressed microRNAs (miRNAs) are involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi XB,Xue L,Yang J,Ma AH,Zhao J,Xu M,Tepper CG,Evans CP,Kung HJ,deVere White RW

更新日期：2007-12-11 00:00:00

abstract：:Tridecaptin A1 (TriA1) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA1 exerts its bactericidal effect by binding to the bacterial cell-wall precursor lipid II on the inner membrane, disrupting the proton motive force. Biochemical and biophysic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cochrane SA,Findlay B,Bakhtiary A,Acedo JZ,Rodriguez-Lopez EM,Mercier P,Vederas JC

更新日期：2016-10-11 00:00:00

abstract：:To generate transgenic planarians we used a set of versatile vectors for animal transgenesis based on the promiscuous transposons, mariner, Hermes and piggyBac, and a universal enhanced GFP (EGFP) marker system with three Pax6 dimeric binding sites, the 3xP3-EGFP developed by Berghammer et al. [Berghammer, A. J., Klin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： González-Estévez C,Momose T,Gehring WJ,Saló E

更新日期：2003-11-25 00:00:00

abstract：:In Escherichia coli, AK I- HDH I and AK II- HDH II are two bifunctional proteins, derived from a common ancestor, that catalyze the first and third reactions of the common pathway leading to threonine and methionine. An extensive amino acid sequence comparison of both molecules reveals two main features on each of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrara P,Duchange N,Zakin MM,Cohen GN

更新日期：1984-05-01 00:00:00

abstract：:Polycystic kidney disease (PKD) is the most common genetic cause of renal failure in humans. Several proteins that are encoded by genes associated with PKD have recently been identified in primary cilia in renal tubular epithelia. These findings have suggested that abnormalities in cilia formation and function may pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin F,Hiesberger T,Cordes K,Sinclair AM,Goldstein LS,Somlo S,Igarashi P

更新日期：2003-04-29 00:00:00

abstract：:The refractoriness of acute promyelocytic leukemia (APL) with t(11;17)(q23;q21) to all-trans retinoic acid (ATRA)-based therapy concerns clinicians and intrigues basic researchers. By using a murine leukemic model carrying both promyelocytic leukemia zinc finger/retinoic acid receptor-α (PLZF/RARα) and RARα/PLZF fusio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiao B,Ren ZH,Liu P,Chen LJ,Shi JY,Dong Y,Ablain J,Shi L,Gao L,Hu JP,Ren RB,de Thé H,Chen Z,Chen SJ

更新日期：2013-02-26 00:00:00

abstract：:Humans walk and run over a wide range of speeds with remarkable efficiency. For steady locomotion, moving at different speeds requires the muscle-tendon units of the leg to modulate the amount of mechanical power the limb absorbs and outputs in each step. How individual muscles adapt their behavior to modulate limb po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farris DJ,Sawicki GS

更新日期：2012-01-17 00:00:00

abstract：:Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known to impact neurogenesis. We aimed to identify molecular mediators of these effects, focusing on long-lasting epigenetic changes. In a hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Provençal N,Arloth J,Cattaneo A,Anacker C,Cattane N,Wiechmann T,Röh S,Ködel M,Klengel T,Czamara D,Müller NS,Lahti J,PREDO team.,Räikkönen K,Pariante CM,Binder EB

更新日期：2020-09-22 00:00:00

abstract：:An elegant expression is obtained for the product of the inverse Weierstrass-Laguerre transforms of two functions in terms of their convolution. It is also shown how the main result can be extended to hold for the product of the inverse Weierstrass-Laguerre transforms of several functions. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava HM

更新日期：1971-03-01 00:00:00

abstract：:We have examined the extent of tyrosine phosphorylation of talin, a component of the cytoskeleton localized in the focal adhesions and, therefore, a potential substrate of p60v-src, the transforming protein of Rous sarcoma virus. p60v-src is a tyrosine kinase that induces high levels of phosphotyrosine and the disorga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pasquale EB,Maher PA,Singer SJ

更新日期：1986-08-01 00:00:00

abstract：:To better understand how the relatively flat antigen-combining sites of antibodies interact with the concave shaped substrate-binding clefts of proteases, we determined the structures of two antibodies in complex with the trypsin-like hepatocyte growth-factor activator (HGFA). The two inhibitory antibodies, Ab58 and A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Eigenbrot C,Liang WC,Stawicki S,Shia S,Fan B,Ganesan R,Lipari MT,Kirchhofer D

更新日期：2007-12-11 00:00:00

abstract：:Animal foraging and competition are defined by the partitioning of three primary niche axes: space, time, and resources. Human disturbance is rapidly altering the spatial and temporal niches of animals, but the impact of humans on resource consumption and partitioning-arguably the most important niche axis-is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manlick PJ,Pauli JN

更新日期：2020-10-27 00:00:00

abstract：:The crystal structure of the decapeptide Boc-Aib-Glu(OBzl)-Leu-Aib-Ala-Leu-Aib-Ala-Lys(Z)-Aib-OMe (where Aib is alpha-aminoisobutyryl, Boc is t-butoxycarbonyl, OBzl is benzyl ester, and Z is benzyloxycarbonyl) illustrates a parallel zipper arrangement of interacting helical peptide columns. Head-to-tail NH...OC hydrog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karle IL,Flippen-Anderson JL,Uma K,Balaram P

更新日期：1990-10-01 00:00:00

abstract：:Yeast to directly convert cellulose and, especially, the microcrystalline cellulose into bioethanol, was engineered through display of minicellulosomes on the cell surface of Saccharomyces cerevisiae. The construction and cell surface attachment of cellulosomes were accomplished with two individual miniscaffoldins to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan LH,Zhang ZJ,Yu XY,Xue YX,Tan TW

更新日期：2012-08-14 00:00:00

abstract：:The numbers and proportion of neurons in areas and regions of cortex were determined for a single cortical hemisphere from two prosimian galagos, one New World owl monkey, one Old World macaque monkey, and one baboon. The results suggest that there is a common plan of cortical organization across the species examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins CE,Airey DC,Young NA,Leitch DB,Kaas JH

更新日期：2010-09-07 00:00:00

abstract：:We measured the superconducting transition temperature of (6)Li between 16 and 26 GPa, and report the lightest system to exhibit superconductivity to date. The superconducting phase diagram of (6)Li is compared with that of (7)Li through simultaneous measurement in a diamond anvil cell (DAC). Below 21 GPa, Li exhibits...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaeffer AM,Temple SR,Bishop JK,Deemyad S

更新日期：2015-01-06 00:00:00

abstract：:Antigen stimulation of mast cells via FcepsilonRI, the high-affinity receptor for IgE, triggers a signaling cascade that requires Ca(2+) mobilization for exocytosis of secretory granules during an allergic response. This study investigates critical signaling components by using mutant RBL mast cells that are defective...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong-Geller E,Holowka D,Siraganian RP,Baird B,Cerione RA

更新日期：2001-01-30 00:00:00

abstract：:Genome editing with engineered site-specific endonucleases involves nonhomologous end-joining, leading to reading frame disruption. The approach is applicable to dominant negative disorders, which can be treated simply by knocking out the mutant allele, while leaving the normal allele intact. We applied this strategy ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinkuma S,Guo Z,Christiano AM

更新日期：2016-05-17 00:00:00

abstract：:Solid-state cross-polarization/magic-angle sample-spinning (13)C NMR spectra have been recorded on chlorophyll a-water aggregates, methyl pyrochlorophyllide a, and methyl pyropheophorbide a (derivatives that lack a phytyl chain). Spectra have also been collected under a decoupling regime in which resonances of certain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown CE,Spencer RB,Burger VT,Katz JJ

更新日期：1984-01-01 00:00:00

abstract：:Loss-of-function mutations in the regulatory gene areA of Aspergillus nidulans prevent the utilization of a wide variety of nitrogen sources. The phenotypes of nit-2 mutants of Neurospora crassa suggest that this gene may be analogous to the areA gene. Transformation has been used to introduce a plasmid containing the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis MA,Hynes MJ

更新日期：1987-06-01 00:00:00

abstract：:Murine suppressor T-cell hybridoma cells (231F1) secrete not only bioactive glycosylation-inhibiting factor (GIF) but also an inactive peptide comparable to bioactive GIF peptide in its molecular size and reactivity with anti-GIF; the amino acid sequence of the inactive peptide is identical to that of the bioactive ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano T,Liu YC,Mikayama T,Watarai H,Taniguchi M,Ishizaka K

更新日期：1995-09-26 00:00:00

abstract：:Selenophosphate, an activated form of selenium that can serve as a selenium donor, is generated by the selD gene product, selenophosphate synthetase (SPS). Selenophosphate is required by several bacteria and by mammals for the specific synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. Although...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogasawara Y,Lacourciere GM,Ishii K,Stadtman TC

更新日期：2005-01-25 00:00:00

abstract：:Mammalian thalamus is a critical site where early perception of sensorimotor signals is dynamically regulated by acetylcholine in a behavioral state-dependent manner. In this study, we examined how synaptic transmission is modulated by acetylcholine in auditory thalamus where sensory relay neurons form parallel lemnis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mooney DM,Zhang L,Basile C,Senatorov VV,Ngsee J,Omar A,Hu B

更新日期：2004-01-06 00:00:00

abstract：:Pyrroline-carboxy-lysine (Pcl) is a demethylated form of pyrrolysine that is generated by the pyrrolysine biosynthetic enzymes when the growth media is supplemented with D-ornithine. Pcl is readily incorporated by the unmodified pyrrolysyl-tRNA/tRNA synthetase pair into proteins expressed in Escherichia coli and in ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ou W,Uno T,Chiu HP,Grünewald J,Cellitti SE,Crossgrove T,Hao X,Fan Q,Quinn LL,Patterson P,Okach L,Jones DH,Lesley SA,Brock A,Geierstanger BH

更新日期：2011-06-28 00:00:00

abstract：:In experiments originally designed to examine selective turnover of methylated "caps" in renal mRNA, we observed that [3H]methyl label decayed from mRNA containing poly(A) with a half-life of 1-2 hr. (Caps are blocked, methylated mRNA sequences of the general structure m7GpppNm p(1 or 2)Np.). To distinguish between me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouellette AJ,Reed SL,Malt RA

更新日期：1976-08-01 00:00:00

abstract：:Most of the activities of IFN-gamma are the result of STAT1-mediated transcriptional responses. In this study, we show that the BRCA1 tumor suppressor acts in concert with STAT1 to differentially activate transcription of a subset of IFN-gamma target genes and mediates growth inhibition by this cytokine. After IFN-gam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouchi T,Lee SW,Ouchi M,Aaronson SA,Horvath CM

更新日期：2000-05-09 00:00:00

abstract：:The Escherichia coli recQ gene, a member of the RecF recombination gene family, was set in an overexpression plasmid, and its product was purified to near-homogeneity. The purified RecQ protein exhibited a DNA-dependent ATPase and a helicase activity. Without DNA, no ATPase activity was detected. The capacity as ATPas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Umezu K,Nakayama K,Nakayama H

更新日期：1990-07-01 00:00:00

abstract：:Statistically significant declines in chronic disability prevalence rates were observed in the elderly United States population between the 1982 and 1989 National Long Term Care Surveys (NLTCS). The 1994 NLTCS was used to investigate whether disability rate declines continued to 1994. The 1982, 1984, 1989, and 1994 NL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manton KG,Corder L,Stallard E

更新日期：1997-03-18 00:00:00

abstract：:Aggregation of p53 is initiated by first-order processes that generate an aggregation-prone state with parallel pathways of major or partial unfolding. Here, we elaborate the mechanism and explore its consequences, beginning with the core domain and extending to the full-length p53 mutant Y220C. Production of large li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang G,Fersht AR

更新日期：2012-08-21 00:00:00