Eosinophils secrete IL-4 to facilitate liver regeneration.

abstract：:Global climate change is expected to have broad ecological consequences for species and communities. Attempts to forecast these consequences usually assume that changes in air or water temperature will translate into equivalent changes in a species' organismal body temperature. This simple change is unlikely because a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilman SE,Wethey DS,Helmuth B

更新日期：2006-06-20 00:00:00

abstract：:The study of development has relied primarily on the isolation of mutations in genes with specific functions in development and on the comparison of their expression patterns in normal and mutant phenotypes. Comparative evolutionary analyses can complement these approaches. Phylogenetic analyses of Sonic hedgehog (Shh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zardoya R,Abouheif E,Meyer A

更新日期：1996-11-12 00:00:00

abstract：:Alkylation of DNA by 7r,8t-dihydroxy,9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) forms mainly trans adducts (with respect to the C-9/10 positions). We recently described a halide-catalyzed pathway that preferentially generates cis adducts and now report that the trans chlorohydrin of anti-BPDE (trans-BP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meehan T,Wolfe AR,Negrete GR,Song Q

更新日期：1997-03-04 00:00:00

abstract：:For 2 < k [abstract: see text] we define lifts of cuspidal Poincaré series in S(k)(Gamma(0)(N)) to weight 2 - k harmonic weak Maass forms. This construction answers a question of Dyson by providing the general framework "explaining" Ramanujan's mock theta functions. As an application, we show that the number of partit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bringmann K,Ono K

更新日期：2007-03-06 00:00:00

abstract：:CD2 (T11, sheep erythrocyte receptor) is a surface antigen of the human T-lymphocyte lineage. cDNA clones encoding CD2 have been isolated by using the purified, denatured CD2 to raise a rat antiserum. Positive clones were recognized in a phage lambda gt11 expression library prepared from the human leukemia T-cell line...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sewell WA,Brown MH,Dunne J,Owen MJ,Crumpton MJ

更新日期：1986-11-01 00:00:00

abstract：:Sex differences influence brain morphology and physiology during both development and aging. Here we apply a machine learning algorithm to a multiparametric brain PET imaging dataset acquired in a cohort of 20- to 82-year-old, cognitively normal adults (n = 205) to define their metabolic brain age. We find that throug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goyal MS,Blazey TM,Su Y,Couture LE,Durbin TJ,Bateman RJ,Benzinger TL,Morris JC,Raichle ME,Vlassenko AG

更新日期：2019-02-19 00:00:00

abstract：:Mitochondrial protein kinases (mPKs) are molecular switches that down-regulate the oxidation of branched-chain alpha-ketoacids and pyruvate. Elevated levels of these metabolites are implicated in disease states such as insulin-resistant Type II diabetes, branched-chain ketoaciduria, and primary lactic acidosis. We rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machius M,Chuang JL,Wynn RM,Tomchick DR,Chuang DT

更新日期：2001-09-25 00:00:00

abstract：:The first essential step in protein photoreception is the capture and storage of energy from a photon. We have recently identified and isolated, from the purple photoautotrophic bacterium, Ectothiorhodospira halophila, a 13,000-dalton photoactive yellow protein (PYP) that has a photocycle with kinetics similar to sens...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McRee DE,Tainer JA,Meyer TE,Van Beeumen J,Cusanovich MA,Getzoff ED

更新日期：1989-09-01 00:00:00

abstract：:The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the mesenchyme. Here, we show that Kif26b, a kinesin family gene, is a downst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchiyama Y,Sakaguchi M,Terabayashi T,Inenaga T,Inoue S,Kobayashi C,Oshima N,Kiyonari H,Nakagata N,Sato Y,Sekiguchi K,Miki H,Araki E,Fujimura S,Tanaka SS,Nishinakamura R

更新日期：2010-05-18 00:00:00

abstract：:Heterochromatin protein 1 (HP1), first discovered in Drosophila melanogaster, is a highly conserved chromosomal protein implicated in both heterochromatin formation and gene silencing. We report here characterization of an HP1-interacting protein, heterochromatin protein 2 (HP2), which codistributes with HP1 in the pe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaffer CD,Stephens GE,Thompson BA,Funches L,Bernat JA,Craig CA,Elgin SC

更新日期：2002-10-29 00:00:00

abstract：:Forkhead box g1 (Foxg1) is a nuclear-cytosolic transcription factor essential for the forebrain development and involved in neurodevelopmental and cancer pathologies. Despite the importance of this protein, little is known about the modalities by which it exerts such a large number of cellular functions. Here we show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pancrazi L,Di Benedetto G,Colombaioni L,Della Sala G,Testa G,Olimpico F,Reyes A,Zeviani M,Pozzan T,Costa M

更新日期：2015-11-10 00:00:00

abstract：:Most evidence supports the view that ER alpha is responsible for estrogen (ovarian estradiol, E(2))-induced proliferation in the epithelial cells of the mammary gland, but despite this, proliferating epithelial cells do not express ER alpha. We have examined this apparent paradox by studying the role of ER alpha and E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng G,Weihua Z,Warner M,Gustafsson JA

更新日期：2004-03-16 00:00:00

abstract：:We report the discovery in Lake Cuitzeo in central Mexico of a black, carbon-rich, lacustrine layer, containing nanodiamonds, microspherules, and other unusual materials that date to the early Younger Dryas and are interpreted to result from an extraterrestrial impact. These proxies were found in a 27-m-long core as p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Israde-Alcántara I,Bischoff JL,Domínguez-Vázquez G,Li HC,DeCarli PS,Bunch TE,Wittke JH,Weaver JC,Firestone RB,West A,Kennett JP,Mercer C,Xie S,Richman EK,Kinzie CR,Wolbach WS

更新日期：2012-03-27 00:00:00

abstract：:Unconventional mRNA splicing on the endoplasmic reticulum (ER) membrane is the sole conserved mechanism in eukaryotes to transmit information regarding misfolded protein accumulation to the nucleus to activate the stress response. In metazoans, the unspliced form of X-box-binding protein 1 (XBP1u) mRNA is recruited to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanda S,Yanagitani K,Yokota Y,Esaki Y,Kohno K

更新日期：2016-10-04 00:00:00

abstract：:We have identified an adenovirus type 5(Ad5) early gene function located in early region 1 which is required for the production of early cytoplasmic mRNAs corresponding to early regions 2, 3, and 4. Mutant dl312 (lacks the segment between 1.5 and 4.5 map units) grows as well as wild-type virus in 293 cells (Ad5-trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones N,Shenk T

更新日期：1979-08-01 00:00:00

abstract：:While recent experiments revealed that some pioneer transcription factors (TFs) can bind to their target DNA sequences inside a nucleosome, the binding dynamics of their target recognitions are poorly understood. Here we used the latest coarse-grained models and molecular dynamics simulations to study the nucleosome-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan C,Takada S

更新日期：2020-08-25 00:00:00

abstract：:Although sexual selection theory has proved successful in explaining a wide array of male ornaments, the function of ornaments occurring in females is largely unknown. Traditionally, female ornaments have been considered nonfunctional, being merely a genetically correlated response to selection for male ornamentation....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amundsen T,Forsgren E

更新日期：2001-11-06 00:00:00

abstract：:The Atg20 and Snx4/Atg24 proteins have been identified in a screen for mutants defective in a type of selective macroautophagy/autophagy. Both proteins are connected to the Atg1 kinase complex, which is involved in autophagy initiation, and bind phosphatidylinositol-3-phosphate. Atg20 and Snx4 contain putative BAR dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popelka H,Damasio A,Hinshaw JE,Klionsky DJ,Ragusa MJ

更新日期：2017-11-21 00:00:00

abstract：:Stable isotope values of carbon (delta13C) and nitrogen (delta15N) in blood, feathers, eggshell, and bone have been used in seabird studies since the 1980s, providing a valuable source of information on diet, foraging patterns, and migratory behavior in these birds. These techniques can also be applied to fossil mater...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emslie SD,Patterson WP

更新日期：2007-07-10 00:00:00

abstract：:Depolarization of neuroblastoma cells causes a 70-fold increase in the apparent dissociation constant KD for scorpion toxin enhancement of activation of the action potential Na+ ionophore by veratridine and a large increase in the rate of reversal of scorpion toxin action. Depolarization also inhibits binding of 125I-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catterall WA,Ray R,Morrow CS

更新日期：1976-08-01 00:00:00

abstract：:To test whether a 30S ribosomal subunitformylmethionyl-tRNA-mRNA complex is an obligatory intermediate in protein synthesis, 70S ribosomes from Escherichia coli were crosslinked with the bifunctional imidoester, dimethylsuberimidate. Crosslinked ribosomes contained covelently joined 30S and 50S subunits, as judged by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slobin LI

更新日期：1972-12-01 00:00:00

abstract：:The transacting activator of transduction (TAT) protein plays a key role in the progression of AIDS. Studies have shown that a +8 charged sequence of amino acids in the protein, called the TAT peptide, enables the TAT protein to penetrate cell membranes. To probe mechanisms of binding and translocation of the TAT pept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao Y,Kwok SJ,Lombardi J,Turro NJ,Eisenthal KB

更新日期：2014-09-02 00:00:00

abstract：:Antibody raised against the human erythrocyte glucose transporter identified a recombinant lambda gt11 bacteriophage in a cDNA library prepared from immunoselected polysomal RNA from adult rat brain. The cDNA predicts a 492-amino acid protein that demonstrates 97.6% identity to the human hepatoma hexose carrier. The t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birnbaum MJ,Haspel HC,Rosen OM

更新日期：1986-08-01 00:00:00

abstract：:We study static and dynamical properties that distinguish 2D crystals constrained to lie on a curved substrate from their flat-space counterparts. A generic mechanism of dislocation unbinding in the presence of varying Gaussian curvature is presented in the context of a model surface amenable to full analytical treatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vitelli V,Lucks JB,Nelson DR

更新日期：2006-08-15 00:00:00

abstract：:Parts of the primary structure of the NAD-specific glutamate dehydrogenase [L-glutamate:NAD oxidoreductase (deaminating), EC 1.4.1.2] from Neurospora crassa are presented. Segments of the sequence representing 886 unique amino-acid residues have been determined; the largest contains 267 residues. There are only short ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austen BM,Nyc JF,Degani Y,Smith EL

更新日期：1975-12-01 00:00:00

abstract：:The structure of the non-self-complementary DNA heptamer d(CGACGAC) at low pH has been determined by the quantitative NMR refinement procedure designated SPEDREF (SPEctral-Driven REFinement). Acid-base titration of the molecule indicated a prominent n = 2 pKa near 6.8. In the pH range up to 6.0, the heptamer forms a r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson H,Wang AH

更新日期：1993-06-01 00:00:00

abstract：:Molecular imaging probes have potential for in vivo identification of apoptosis and other intracellular processes. TcapQ, a cell-penetrating, near-infrared fluorescent peptide probe designed to be optically silent through intramolecular fluorescence quenching and activated by effector caspases, has been previously des...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnett EM,Zhang X,Maxwell D,Chang Q,Piwnica-Worms D

更新日期：2009-06-09 00:00:00

abstract：:HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential. Here we present the synthesis of unnatural unique polyketide-alkaloid hybrid molecules by exploiting the enzyme reaction using precursor-directed and structure-based approaches. HsPKS1 prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morita H,Yamashita M,Shi SP,Wakimoto T,Kondo S,Kato R,Sugio S,Kohno T,Abe I

更新日期：2011-08-16 00:00:00

abstract：:The dramatic increase in healthcare cost has become a significant burden to the world. Many patients are denied the accessibility of medication because of the high price of drugs. Total biosynthesis of chiral drug intermediates is an environmentally friendly approach that helps provide more affordable pharmaceuticals....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang K,Li H,Cho KM,Liao JC

更新日期：2010-04-06 00:00:00

abstract：:To determine the importance of the thrombin substrate recognition exosite for fibrinogen binding in the formation of both arterial and venous thrombi, we evaluated the antithrombotic effects of the tyrosine-sulfated dodecapeptide from residues 53-64 of hirudin (H peptide) in a nonhuman primate model. This peptide was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cadroy Y,Maraganore JM,Hanson SR,Harker LA

更新日期：1991-02-15 00:00:00