Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction.

abstract：:A simple model is described for calculating the electrostatic energy of lipid domains at the air-water interface, taking account of dipole-dipole repulsions between the lipid molecules themselves, as well as interactions between the molecular dipoles and image dipoles in the subphase. The model assumes that the molecu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McConnell HM,Bazaliy YB

更新日期：1995-09-12 00:00:00

abstract：:The Zika virus (ZIKV) causes microcephaly and the Guillain-Barré syndrome. Little is known about how ZIKV causes these conditions or which ZIKV viral protein(s) is responsible for the associated ZIKV-induced cytopathic effects, including cell hypertrophy, growth restriction, cell-cycle dysregulation, and cell death. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li G,Poulsen M,Fenyvuesvolgyi C,Yashiroda Y,Yoshida M,Simard JM,Gallo RC,Zhao RY

更新日期：2017-01-17 00:00:00

abstract：:The trinucleotide CCA sequence is present at the 3' terminus of all mature tRNAs. Despite this high degree of conservation, we have been able to prepare in vitro transcripts of Escherichia coli tRNA(Val) with altered 3' termini that are readily aminoacylated and can function in polypeptide synthesis. Replacement of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu M,Horowitz J

更新日期：1994-10-25 00:00:00

abstract：:Cellular wound healing or the repair of plasma membrane/cell wall damage (plasma membrane damage) occurs frequently in nature. Although various cellular perturbations, such as DNA damage, spindle misalignment, and impaired daughter cell formation, are monitored by cell cycle checkpoint mechanisms in budding yeast, whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kono K,Al-Zain A,Schroeder L,Nakanishi M,Ikui AE

更新日期：2016-06-21 00:00:00

abstract：:A serpin was identified in normal mammary gland by differential cDNA sequencing. In situ hybridization has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammary epithelial side of the basement membrane and thus was named myoepithelium-derived serine proteinase inhibitor (MEP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao G,Liu YE,Gentz R,Sang QA,Ni J,Goldberg ID,Shi YE

更新日期：1999-03-30 00:00:00

abstract：:Voltage-gated KCNQ1 (Kv7.1) potassium channels are expressed abundantly in heart but they are also found in multiple other tissues. Differential coassembly with single transmembrane KCNE beta subunits in different cell types gives rise to a variety of biophysical properties, hence endowing distinct physiological roles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu H,Lin Z,Mattmann ME,Zou B,Terrenoire C,Zhang H,Wu M,McManus OB,Kass RS,Lindsley CW,Hopkins CR,Li M

更新日期：2013-05-21 00:00:00

abstract：:Anti-idiotype antibodies (Ab2) were purified from a cancer patient treated with NP-4, a murine monoclonal antibody to carcinoembryonic antigen (CEA). These Ab2 were specific for NP-4 and inhibited the binding between NP-4 and CEA. BALB/c mice immunized with these human Ab2 produced anti-Ab2 antibodies that were also r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Losman MJ,Hansen HJ,Sharkey RM,Goldenberg DM,Monestier M

更新日期：1991-04-15 00:00:00

abstract：:Copper is an essential micronutrient that plays a central role for a broad range of biological processes. Although there is compelling evidence that the intracellular milieu does not contain any free copper ions, the rapid kinetics of copper uptake and release suggests the presence of a labile intracellular copper poo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang L,McRae R,Henary MM,Patel R,Lai B,Vogt S,Fahrni CJ

更新日期：2005-08-09 00:00:00

abstract：:Promoter-proximal stalling, a general phenomenon observed during the expression of many RNA polymerase II transcribed genes, is dependent on transcription factor IIH (TFIIH). Reactions lacking TFIIH initiated transcription, but the transcription complex encountered a block to elongation proximal to the promoter. The a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar KP,Akoulitchev S,Reinberg D

更新日期：1998-08-18 00:00:00

abstract：:The X gene product encoded by the hepatitis B virus, termed pX, is a promiscuous transactivator of a variety of viral and cellular genes under the control of diverse cis-acting elements. Although pX does not appear to directly bind DNA, pX-responsive elements include the NF-kappa B, AP-1, and CRE (cAMP response elemen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JS,Andrisani OM

更新日期：1995-04-25 00:00:00

abstract：:We used cryo-electron tomography in conjunction with single-particle averaging techniques to study the structures of frozen-hydrated envelope glycoprotein (Env) complexes on intact Moloney murine leukemia retrovirus particles. Cryo-electron tomography allows 3D imaging of viruses in toto at a resolution sufficient to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Förster F,Medalia O,Zauberman N,Baumeister W,Fass D

更新日期：2005-03-29 00:00:00

abstract：:The type II cell of the alveolar epithelium of adult rats has been studied by electron microscopy to determine its ability to endocytose electron-dense tracers of differing molecular charge and size. The tracers studied were native (anionic) ferritin, cationic ferritin, 70-kilodalton dextran, and colloidal carbon. Alv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams MC

更新日期：1984-10-01 00:00:00

abstract：:This paper examines the relationship between various treatment parameters within a latent variable model when the effects of treatment depend on the recipient's observed and unobserved characteristics. We show how this relationship can be used to identify the treatment parameters when they are identified and to bound ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heckman JJ,Vytlacil EJ

更新日期：1999-04-13 00:00:00

abstract：:We study the distributions of citations received by a single publication within several disciplines, spanning broad areas of science. We show that the probability that an article is cited c times has large variations between different disciplines, but all distributions are rescaled on a universal curve when the relati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radicchi F,Fortunato S,Castellano C

更新日期：2008-11-11 00:00:00

abstract：:neurogenin2 (ngn2) encodes a basic helix-loop-helix transcription factor and plays an important role in neurogenesis from migratory neural crest cells. Its role in retinal development is poorly understood. We observed that in the developing chick retina, ngn2 was expressed in a subpopulation of proliferating progenito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan RT,Ma WX,Wang SZ

更新日期：2001-12-18 00:00:00

abstract：:Alpha-Klotho (alpha-Kl) and its homolog, beta-Klotho (beta-Kl) are key regulators of mineral homeostasis and bile acid/cholesterol metabolism, respectively. FGF15/ humanFGF19, FGF21, and FGF23, members of the FGF19 subfamily, are believed to act as circulating metabolic regulators. Analyses of functional interactions ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomiyama K,Maeda R,Urakawa I,Yamazaki Y,Tanaka T,Ito S,Nabeshima Y,Tomita T,Odori S,Hosoda K,Nakao K,Imura A,Nabeshima Y

更新日期：2010-01-26 00:00:00

abstract：:Adult stem cells represent unique populations of undifferentiated cells with self-renewal capacity. In many tissues, stem cells divide less often than their progeny. It has been widely speculated, but largely untested, that their undifferentiated and quiescent state may make stem cells more efficient as donors for clo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Greco V,Guasch G,Fuchs E,Mombaerts P

更新日期：2007-02-20 00:00:00

abstract：:Age-related macular degeneration (AMD) is the most common cause of blindness for individuals age 50 and above in the developed world. Abnormal growth of choroidal blood vessels, or choroidal neovascularization (CNV), is a hallmark of the neovascular (wet) form of advanced AMD and leads to significant vision loss. A gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasegawa E,Inafuku S,Mulki L,Okunuki Y,Yanai R,Smith KE,Kim CB,Klokman G,Bielenberg DR,Puli N,Falck JR,Husain D,Miller JW,Edin ML,Zeldin DC,Lee KSS,Hammock BD,Schunck WH,Connor KM

更新日期：2017-09-05 00:00:00

abstract：:Modern protein crystal structures are based nearly exclusively on X-ray data collected at cryogenic temperatures (generally 100 K). The cooling process is thought to introduce little bias in the functional interpretation of structural results, because cryogenic temperatures minimally perturb the overall protein backbo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraser JS,van den Bedem H,Samelson AJ,Lang PT,Holton JM,Echols N,Alber T

更新日期：2011-09-27 00:00:00

abstract：:Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eom J,Kim JJ,Yoon SG,Jeong H,Son S,Lee JB,Yoo J,Seo HJ,Cho Y,Kim KS,Choi KM,Kim IY,Lee HY,Nam KT,Cresswell P,Seong JK,Seo JY

更新日期：2019-08-27 00:00:00

abstract：:Alcohol dependence has traditionally been considered a brain disorder. Alteration in the composition of the gut microbiota has recently been shown to be present in psychiatric disorders, which suggests the possibility of gut-to-brain interactions in the development of alcohol dependence. The aim of the present study w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leclercq S,Matamoros S,Cani PD,Neyrinck AM,Jamar F,Stärkel P,Windey K,Tremaroli V,Bäckhed F,Verbeke K,de Timary P,Delzenne NM

更新日期：2014-10-21 00:00:00

abstract：:Much recent attention in the study of adaptation of organismal form has centered on developmental regulation. As such, the highly conserved respiratory machinery of eukaryotic cells might seem an unlikely target for selection supporting novel morphologies. We demonstrate that a dramatic molecular evolutionary rate inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jobson RW,Nielsen R,Laakkonen L,Wikström M,Albert VA

更新日期：2004-12-28 00:00:00

abstract：:Delayed implantation (embryonic diapause) occurs when the embryo at the blastocyst stage achieves a state of suspended animation. During this period, blastocyst growth is very slow, with minimal or no cell division. Nearly 100 mammals in seven different orders undergo delayed implantation, but the underlying molecular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamatani T,Daikoku T,Wang H,Matsumoto H,Carter MG,Ko MS,Dey SK

更新日期：2004-07-13 00:00:00

abstract：:The reduction in levels of the potentially toxic amyloid-beta peptide (Abeta) has emerged as one of the most important therapeutic goals in Alzheimer's disease. Key targets for this goal are factors that affect the expression and processing of the Abeta precursor protein (betaAPP). Earlier reports from our laboratory ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaw KT,Utsuki T,Rogers J,Yu QS,Sambamurti K,Brossi A,Ge YW,Lahiri DK,Greig NH

更新日期：2001-06-19 00:00:00

abstract：:The x-ray crystal structure of the tetrameric T-antigen-binding lectin from peanut, M(r) 110,000, has been determined by using the multiple isomorphous replacement method and refined to an R value of 0.218 for 22,155 reflections within the 10- to 2.95-A resolution range. Each subunit has essentially the same character...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee R,Mande SC,Ganesh V,Das K,Dhanaraj V,Mahanta SK,Suguna K,Surolia A,Vijayan M

更新日期：1994-01-04 00:00:00

abstract：:Transgenic mice have been used to address the issue of the oncogenic potential of mutant guanine nucleotide stimulatory factor (Gs) alpha subunit in the thyroid gland. The expression of the mutant Arg-201-->His Gs alpha subunit transgene has been directed to murine thyroid epithelial cells by bovine thyroglobulin prom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michiels FM,Caillou B,Talbot M,Dessarps-Freichey F,Maunoury MT,Schlumberger M,Mercken L,Monier R,Feunteun J

更新日期：1994-10-25 00:00:00

abstract：:It is generally thought that an effective vaccine to prevent HIV-1 infection should elicit both strong neutralizing antibody and cytotoxic T lymphocyte responses. We recently demonstrated that potent, boostable, long-lived HIV-1 envelope (Env)-specific cytotoxic T lymphocyte responses can be elicited in rhesus monkeys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Letvin NL,Montefiori DC,Yasutomi Y,Perry HC,Davies ME,Lekutis C,Alroy M,Freed DC,Lord CI,Handt LK,Liu MA,Shiver JW

更新日期：1997-08-19 00:00:00

abstract：:The soil-transmitted helminths or nematodes (hookworms, whipworms, and Ascaris) are roundworms that infect more than 1 billion of the poorest peoples and are leading causes of morbidity worldwide. Few anthelmintics are available for treatment, and only one is commonly used in mass drug administrations. New anthelminti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Y,Platzer EG,Bellier A,Aroian RV

更新日期：2010-03-30 00:00:00

abstract：:Malignant melanoma has one of the highest mortality rates of any cancer because of its aggressive nature and high metastatic potential. Clinical staging of the disease at the time of diagnosis is very important for the prognosis and outcome of melanoma treatment. In this study, we designed and synthesized the 18F-labe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyo A,Kim DY,Kim H,Lim D,Kwon SY,Kang SR,Kim HS,Bom HS,Min JJ

更新日期：2020-06-09 00:00:00

abstract：:Cooperativity in oligonucleotide-directed sequence-specific recognition of DNA by triple helix formation can be enhanced by the addition of discrete dimerization domains. The equilibrium association constants for cooperative binding of oligonucleotides that dimerize by Watson-Crick hydrogen bonds and occupy adjacent s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Distefano MD,Dervan PB

更新日期：1993-02-15 00:00:00